DK1511752T5 - Camptotheciner med modificeret lactonring - Google Patents

Camptotheciner med modificeret lactonring

Info

Publication number
DK1511752T5
DK1511752T5 DK03730480.5T DK03730480T DK1511752T5 DK 1511752 T5 DK1511752 T5 DK 1511752T5 DK 03730480 T DK03730480 T DK 03730480T DK 1511752 T5 DK1511752 T5 DK 1511752T5
Authority
DK
Denmark
Prior art keywords
camptothecins
lactone ring
modified lactone
modified
ring
Prior art date
Application number
DK03730480.5T
Other languages
English (en)
Other versions
DK1511752T3 (da
Inventor
Walter Cabri
Martin Gomez Patricio
Elena Marastoni
Tamara Danelli
Marco Alpegiani
Sergio Penco
Mauro Marzi
Claudio Pisano
Maria O Tinti
Loredana Vesci
Franco Zunino
Domenico Vergani
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK1511752T3 publication Critical patent/DK1511752T3/da
Publication of DK1511752T5 publication Critical patent/DK1511752T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
DK03730480.5T 2002-05-31 2003-05-28 Camptotheciner med modificeret lactonring DK1511752T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.
PCT/IT2003/000328 WO2003101995A2 (en) 2002-05-31 2003-05-28 Camptothecins with a modified lactone ring

Publications (2)

Publication Number Publication Date
DK1511752T3 DK1511752T3 (da) 2007-01-29
DK1511752T5 true DK1511752T5 (da) 2010-06-14

Family

ID=11456338

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03730480.5T DK1511752T5 (da) 2002-05-31 2003-05-28 Camptotheciner med modificeret lactonring
DK06116366T DK1719775T3 (da) 2002-05-31 2003-05-28 Camptotheciner med en modificeret lactonring

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK06116366T DK1719775T3 (da) 2002-05-31 2003-05-28 Camptotheciner med en modificeret lactonring

Country Status (22)

Country Link
US (1) US7273873B2 (da)
EP (2) EP1511752B3 (da)
JP (1) JP4693410B2 (da)
KR (1) KR101042042B1 (da)
CN (1) CN1656100A (da)
AR (1) AR040139A1 (da)
AT (2) ATE403659T1 (da)
AU (2) AU2003241160B2 (da)
BR (2) BR0311333A (da)
CA (2) CA2706635A1 (da)
CY (2) CY1107311T1 (da)
DE (2) DE60322754D1 (da)
DK (2) DK1511752T5 (da)
ES (2) ES2273002T7 (da)
IT (1) ITRM20020305A1 (da)
MX (1) MXPA04011682A (da)
PE (1) PE20050120A1 (da)
PL (1) PL374346A1 (da)
PT (2) PT1511752E (da)
SI (2) SI1719775T1 (da)
TW (1) TWI325866B (da)
WO (1) WO2003101995A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
WO2009016068A1 (en) * 2007-08-01 2009-02-05 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Crystalline form ii of 7-(dimethoxy-methyl) camptothecin, its use as intermediate and products obtained therefrom
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
CA3138197A1 (en) 2019-05-14 2020-11-19 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
EP4058464A1 (en) 2019-11-13 2022-09-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
US11834458B2 (en) 2021-03-23 2023-12-05 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
EP0835258B1 (fr) * 1995-06-21 2002-09-25 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
ATE216998T1 (de) * 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung

Also Published As

Publication number Publication date
EP1511752A2 (en) 2005-03-09
DE60308368D1 (de) 2006-10-26
AU2009236044B2 (en) 2011-03-24
US20050154003A1 (en) 2005-07-14
AU2009236044A8 (en) 2011-07-21
TWI325866B (en) 2010-06-11
SI1719775T1 (sl) 2009-04-30
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
ES2312090T3 (es) 2009-02-16
EP1511752B8 (en) 2007-04-18
CA2706635A1 (en) 2003-12-11
PT1511752E (pt) 2007-01-31
JP2005531602A (ja) 2005-10-20
DE60322754D1 (de) 2008-09-18
WO2003101995A2 (en) 2003-12-11
PT1719775E (pt) 2008-09-30
CY1108793T1 (el) 2014-04-09
EP1511752B1 (en) 2006-09-13
CY1107311T1 (el) 2012-11-21
TW200404806A (en) 2004-04-01
AU2009236044A1 (en) 2009-12-03
KR101042042B1 (ko) 2011-06-16
SI1511752T1 (sl) 2007-02-28
PE20050120A1 (es) 2005-03-04
JP4693410B2 (ja) 2011-06-01
DE60308368T3 (de) 2010-09-16
ES2273002T7 (es) 2011-08-01
WO2003101995A3 (en) 2004-02-19
EP1511752B3 (en) 2010-03-10
AU2003241160B2 (en) 2009-08-20
ATE403659T1 (de) 2008-08-15
CA2485201C (en) 2010-11-02
KR20050036909A (ko) 2005-04-20
AU2003241160A1 (en) 2003-12-19
ITRM20020305A1 (it) 2003-12-01
EP1719775B1 (en) 2008-08-06
CN1656100A (zh) 2005-08-17
ATE339422T1 (de) 2006-10-15
AR040139A1 (es) 2005-03-16
US7273873B2 (en) 2007-09-25
BR0311333A (pt) 2005-03-15
DK1511752T3 (da) 2007-01-29
BR0311329A (pt) 2005-02-22
ITRM20020305A0 (it) 2002-05-31
MXPA04011682A (es) 2005-03-31
PL374346A1 (en) 2005-10-17
WO2003101995A8 (en) 2004-12-23
AU2009236044B8 (en) 2011-07-21
CA2485201A1 (en) 2003-12-11
ES2273002T3 (es) 2007-05-01
EP1719775A1 (en) 2006-11-08

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