BR0311329A - Camptotecinas com um anel de lactona modificado - Google Patents

Camptotecinas com um anel de lactona modificado

Info

Publication number
BR0311329A
BR0311329A BR0311329-9A BR0311329A BR0311329A BR 0311329 A BR0311329 A BR 0311329A BR 0311329 A BR0311329 A BR 0311329A BR 0311329 A BR0311329 A BR 0311329A
Authority
BR
Brazil
Prior art keywords
camptothecins
lactone ring
modified
modified lactone
compounds
Prior art date
Application number
BR0311329-9A
Other languages
English (en)
Inventor
Mauro Marzi
Elena Marastoni
Sergio Penco
Claudio Pisano
Maria Ornella Tinti
Loredana Vesci
Franco Zunino
Domenico Vergani
Walter Cabri
Marco Alpegiani
Martin Gomez Patricio
Tamara Danelli
Original Assignee
Sigma Tau Ind Famaceutiche Riu
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Famaceutiche Riu, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Famaceutiche Riu
Publication of BR0311329A publication Critical patent/BR0311329A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)

Abstract

"CAMPTOTECINAS COM UM ANEL DE LACTONA MODIFICADO". A invenção refere-se a compostos de fórmula (I) ou (II) que são descritos: onde os grupos são como definidos na descrição aqui acima, as misturas racêmicas, seus enanciómeros individuais, seus diastereoisómeros individuais, suas misturas, e seus sais farmaceuticamente aceitáveis. Os referidos compostos são inibidores de topoisomerase I.
BR0311329-9A 2002-05-31 2003-05-28 Camptotecinas com um anel de lactona modificado BR0311329A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.
PCT/IT2003/000328 WO2003101995A2 (en) 2002-05-31 2003-05-28 Camptothecins with a modified lactone ring

Publications (1)

Publication Number Publication Date
BR0311329A true BR0311329A (pt) 2005-02-22

Family

ID=11456338

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0311329-9A BR0311329A (pt) 2002-05-31 2003-05-28 Camptotecinas com um anel de lactona modificado
BR0311333-7A BR0311333A (pt) 2002-05-31 2003-05-28 ésteres na posição 20 de camptotecinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0311333-7A BR0311333A (pt) 2002-05-31 2003-05-28 ésteres na posição 20 de camptotecinas

Country Status (22)

Country Link
US (1) US7273873B2 (pt)
EP (2) EP1719775B1 (pt)
JP (1) JP4693410B2 (pt)
KR (1) KR101042042B1 (pt)
CN (1) CN1656100A (pt)
AR (1) AR040139A1 (pt)
AT (2) ATE339422T1 (pt)
AU (2) AU2003241160B2 (pt)
BR (2) BR0311329A (pt)
CA (2) CA2706635A1 (pt)
CY (2) CY1107311T1 (pt)
DE (2) DE60308368T3 (pt)
DK (2) DK1511752T5 (pt)
ES (2) ES2273002T7 (pt)
IT (1) ITRM20020305A1 (pt)
MX (1) MXPA04011682A (pt)
PE (1) PE20050120A1 (pt)
PL (1) PL374346A1 (pt)
PT (2) PT1719775E (pt)
SI (2) SI1511752T1 (pt)
TW (1) TWI325866B (pt)
WO (1) WO2003101995A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
EP2170900B1 (en) 2007-08-01 2012-12-12 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Crystalline form ii of 7-(dimethoxy-methyl) camptothecin, its use as intermediate and products obtained therefrom
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
SG11202111402PA (en) 2019-05-14 2021-11-29 Nuvation Bio Inc Anti-cancer nuclear hormone receptor-targeting compounds
US11952349B2 (en) 2019-11-13 2024-04-09 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CA3214408A1 (en) * 2021-03-23 2022-09-29 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
US12006314B2 (en) 2021-05-03 2024-06-11 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
WO2024073626A2 (en) * 2022-09-28 2024-04-04 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
AU716377B2 (en) * 1995-06-21 2000-02-24 Ipsen Pharma S.A.S. New analogues of camptothecin, preparation processes, their use as medicaments and the pharmaceutical compositions containing them
PT1044977E (pt) * 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral

Also Published As

Publication number Publication date
DE60308368D1 (de) 2006-10-26
AU2009236044B8 (en) 2011-07-21
US20050154003A1 (en) 2005-07-14
CA2485201A1 (en) 2003-12-11
BR0311333A (pt) 2005-03-15
ES2273002T7 (es) 2011-08-01
ATE339422T1 (de) 2006-10-15
ATE403659T1 (de) 2008-08-15
PL374346A1 (en) 2005-10-17
KR101042042B1 (ko) 2011-06-16
CN1656100A (zh) 2005-08-17
PE20050120A1 (es) 2005-03-04
WO2003101995A2 (en) 2003-12-11
AU2003241160B2 (en) 2009-08-20
AU2003241160A1 (en) 2003-12-19
ES2273002T3 (es) 2007-05-01
TWI325866B (en) 2010-06-11
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
TW200404806A (en) 2004-04-01
PT1719775E (pt) 2008-09-30
DK1511752T5 (da) 2010-06-14
SI1511752T1 (sl) 2007-02-28
CY1107311T1 (el) 2012-11-21
JP2005531602A (ja) 2005-10-20
CA2485201C (en) 2010-11-02
US7273873B2 (en) 2007-09-25
DK1511752T3 (da) 2007-01-29
SI1719775T1 (sl) 2009-04-30
AU2009236044A1 (en) 2009-12-03
EP1511752A2 (en) 2005-03-09
EP1719775B1 (en) 2008-08-06
DE60308368T3 (de) 2010-09-16
KR20050036909A (ko) 2005-04-20
AU2009236044A8 (en) 2011-07-21
ES2312090T3 (es) 2009-02-16
PT1511752E (pt) 2007-01-31
CA2706635A1 (en) 2003-12-11
WO2003101995A8 (en) 2004-12-23
WO2003101995A3 (en) 2004-02-19
CY1108793T1 (el) 2014-04-09
EP1511752B8 (en) 2007-04-18
JP4693410B2 (ja) 2011-06-01
EP1511752B1 (en) 2006-09-13
EP1719775A1 (en) 2006-11-08
AU2009236044B2 (en) 2011-03-24
ITRM20020305A0 (it) 2002-05-31
EP1511752B3 (en) 2010-03-10
DE60322754D1 (de) 2008-09-18
ITRM20020305A1 (it) 2003-12-01
MXPA04011682A (es) 2005-03-31
AR040139A1 (es) 2005-03-16

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 491/22, C07D 471/14, A61K 31/47, A61P 35/00, A61P 31/00

Ipc: C07D 491/22 (2011.01), C07D 471/14 (2011.01), A61K

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 10A E 11A ANUIDADES.

B07F Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette]

Free format text: NOTIFICACAO DE NAO ANUENCIA RELACIONADA COM O ART. 229 DA LPI

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2258 DE 15/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 10A, 11A, 12A, 13A, 14A, 15A, 16A E 17A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.