BRPI0408204A - derivados de quinolinona/benzoxazinona e usos dos mesmos - Google Patents
derivados de quinolinona/benzoxazinona e usos dos mesmosInfo
- Publication number
- BRPI0408204A BRPI0408204A BRPI0408204-4A BRPI0408204A BRPI0408204A BR PI0408204 A BRPI0408204 A BR PI0408204A BR PI0408204 A BRPI0408204 A BR PI0408204A BR PI0408204 A BRPI0408204 A BR PI0408204A
- Authority
- BR
- Brazil
- Prior art keywords
- quinolinone
- benzoxazinone derivatives
- compounds
- formula
- benzoxazinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
"DERIVADOS DE QUINOLINONA/BENZOXAZINONA E USOS DOS MESMOS". A presente invenção refere-se a compostos da fórmula: (I) e sais farmaceuticamente aceitáveis ou pró-fármacos destes, em que m, p, q, r, A, E, X, Y, R¬1¬, R¬ 4¬, R¬ 5¬, R¬ 6¬, R¬ 7¬, R¬ 8¬, R¬ 9¬ e são como definidos aqui. A invenção também fornece métodos para preparar, composições compreendendo e métodos para usar, os compostos da fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45357403P | 2003-03-11 | 2003-03-11 | |
PCT/EP2004/002340 WO2004080969A1 (en) | 2003-03-11 | 2004-03-08 | Quinolinone / benzoxazinone derivatives and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0408204A true BRPI0408204A (pt) | 2006-02-14 |
Family
ID=32990787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0408204-4A BRPI0408204A (pt) | 2003-03-11 | 2004-03-08 | derivados de quinolinona/benzoxazinona e usos dos mesmos |
Country Status (23)
Country | Link |
---|---|
US (2) | US6943169B2 (pt) |
EP (1) | EP1603880B1 (pt) |
JP (1) | JP4404893B2 (pt) |
KR (1) | KR100691090B1 (pt) |
CN (1) | CN100455570C (pt) |
AR (1) | AR043510A1 (pt) |
AT (1) | ATE394377T1 (pt) |
AU (1) | AU2004220388B9 (pt) |
BR (1) | BRPI0408204A (pt) |
CA (1) | CA2518403A1 (pt) |
CL (1) | CL2004000450A1 (pt) |
CO (1) | CO5601030A2 (pt) |
DE (1) | DE602004013560D1 (pt) |
ES (1) | ES2305742T3 (pt) |
HR (1) | HRP20050775A2 (pt) |
MX (1) | MXPA05009523A (pt) |
MY (1) | MY135470A (pt) |
NO (1) | NO20054135L (pt) |
NZ (1) | NZ541642A (pt) |
RU (1) | RU2333204C2 (pt) |
TW (1) | TWI289141B (pt) |
WO (1) | WO2004080969A1 (pt) |
ZA (1) | ZA200506831B (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL164108A0 (en) | 2002-03-27 | 2005-12-18 | Glaxo Group Ltd | Quinoline derivatives and their useas 5-ht6 ligands |
RS20060035A (en) | 2003-07-22 | 2008-08-07 | Arena Pharmaceuticals Inc., | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
US7592457B2 (en) * | 2004-10-20 | 2009-09-22 | Korea Research Institute Of Chemical Technology | 3-aryl-3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same |
RU2497819C2 (ru) * | 2007-05-21 | 2013-11-10 | Ривайва Фармасьютикалс, Инк. | Композиции, синтез и способы применения атипичных нейролептиков на основе хинолина |
CN101772341A (zh) * | 2007-07-11 | 2010-07-07 | 陶氏康宁公司 | 用于递送药物的组合物 |
EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
EP2163541A1 (en) * | 2008-09-12 | 2010-03-17 | Bayer Schering Pharma Aktiengesellschaft | Piperazine derivatives for binding and imaging amyloid plaques and their use |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
US9290488B2 (en) | 2011-12-01 | 2016-03-22 | Purdue Pharma L.P. | Azetidine-substituted quinoxalines as opioid receptor like-1 modulators |
JP2018516992A (ja) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーAxovant Sciences Gmbh | レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体 |
BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
WO2023192430A1 (en) * | 2022-03-30 | 2023-10-05 | University Of Florida Research Foundation, Incorported | Compounds for treating psychostimulant misuse |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3733321A (en) | 1971-07-06 | 1973-05-15 | Squibb & Sons Inc | 1,4-benzothiazin-3-ones |
US4078062A (en) | 1976-10-28 | 1978-03-07 | E. R. Squibb & Sons, Inc. | Substituted 2H-1,4-benzothiazin-3(4H)-ones |
DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
NZ501258A (en) * | 1997-07-11 | 2001-07-27 | Smithkline Beecham P | Benzenesulfonamide compounds with 5HT6 receptor antagonist activity for treating anxiety and/or depression |
NZ505921A (en) | 1998-03-31 | 2003-08-29 | Warner Lambert Co | 1-[5-(2,6-Dimethylpiperidino)pentyl] substituted quinolone serine protease inhibitors and their use for treating thrombin related disorders |
EP1068191A1 (en) | 1998-03-31 | 2001-01-17 | Warner-Lambert Company Llc | Benzoxazinones/benzothiazinones as serine protease inhibitors |
PL343321A1 (en) | 1998-03-31 | 2001-08-13 | Warner Lambert Co | Quinoxalinones as serine protease inhibitors such as factor xa and thrombin |
GB9919411D0 (en) | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
EP1263754A1 (en) | 2000-02-01 | 2002-12-11 | Millennium Pharmaceuticals, Inc. | INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa |
AU2001236606A1 (en) | 2000-02-01 | 2001-08-14 | Cor Therapeutics, Inc. | 3,4-dihydro-2h-benzo(1,4)oxazine inhibitors of factor xa |
FR2807038B1 (fr) | 2000-04-03 | 2002-08-16 | Sanofi Synthelabo | Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant |
DE60122767T2 (de) * | 2000-11-24 | 2007-09-13 | Smithkline Beecham P.L.C., Brentford | Indoly-lsulphonyl-verbindungen zur behandlung von störungen des zns |
EP1423106B1 (en) * | 2001-08-10 | 2008-12-17 | F. Hoffmann-La Roche Ag | Arylsulfonyl derivatives with 5-ht 6 receptor affinity |
US7943639B2 (en) | 2002-06-20 | 2011-05-17 | Proximagen Limited | Compounds |
-
2004
- 2004-03-05 TW TW093105911A patent/TWI289141B/zh not_active IP Right Cessation
- 2004-03-08 CN CNB2004800065778A patent/CN100455570C/zh not_active Expired - Fee Related
- 2004-03-08 ES ES04718298T patent/ES2305742T3/es not_active Expired - Lifetime
- 2004-03-08 WO PCT/EP2004/002340 patent/WO2004080969A1/en active IP Right Grant
- 2004-03-08 BR BRPI0408204-4A patent/BRPI0408204A/pt not_active IP Right Cessation
- 2004-03-08 KR KR1020057016880A patent/KR100691090B1/ko not_active IP Right Cessation
- 2004-03-08 JP JP2006500055A patent/JP4404893B2/ja not_active Expired - Fee Related
- 2004-03-08 AT AT04718298T patent/ATE394377T1/de not_active IP Right Cessation
- 2004-03-08 CA CA002518403A patent/CA2518403A1/en not_active Abandoned
- 2004-03-08 DE DE602004013560T patent/DE602004013560D1/de not_active Expired - Lifetime
- 2004-03-08 RU RU2005131172/04A patent/RU2333204C2/ru not_active IP Right Cessation
- 2004-03-08 CL CL200400450A patent/CL2004000450A1/es unknown
- 2004-03-08 EP EP04718298A patent/EP1603880B1/en not_active Expired - Lifetime
- 2004-03-08 NZ NZ541642A patent/NZ541642A/en unknown
- 2004-03-08 MX MXPA05009523A patent/MXPA05009523A/es active IP Right Grant
- 2004-03-08 AU AU2004220388A patent/AU2004220388B9/en not_active Ceased
- 2004-03-09 AR ARP040100739A patent/AR043510A1/es not_active Application Discontinuation
- 2004-03-10 US US10/797,545 patent/US6943169B2/en not_active Expired - Fee Related
- 2004-03-10 MY MYPI20040829A patent/MY135470A/en unknown
-
2005
- 2005-07-27 US US11/191,092 patent/US7476675B2/en not_active Expired - Fee Related
- 2005-08-25 ZA ZA200506831A patent/ZA200506831B/en unknown
- 2005-08-25 CO CO05085018A patent/CO5601030A2/es not_active Application Discontinuation
- 2005-09-05 HR HR20050775A patent/HRP20050775A2/xx not_active Application Discontinuation
- 2005-09-06 NO NO20054135A patent/NO20054135L/no not_active Application Discontinuation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: C07D 215/22, C07D 405/06, C07D 265/36, C07D 223/16, A61K 31/4704, A61P 25/00 Ipc: C07D 215/22 (2011.01), C07D 405/06 (2011.01), C07D |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |