ATE339422T1 - Camptothecine mit modifiziertem lactonring - Google Patents

Camptothecine mit modifiziertem lactonring

Info

Publication number
ATE339422T1
ATE339422T1 AT03730480T AT03730480T ATE339422T1 AT E339422 T1 ATE339422 T1 AT E339422T1 AT 03730480 T AT03730480 T AT 03730480T AT 03730480 T AT03730480 T AT 03730480T AT E339422 T1 ATE339422 T1 AT E339422T1
Authority
AT
Austria
Prior art keywords
camptothecine
lactone ring
modified lactone
modified
ring
Prior art date
Application number
AT03730480T
Other languages
English (en)
Inventor
Mauro Marzi
Elena Marastoni
Sergio Penco
Claudio Pisano
Maria O Tinti
Loredana Vesci
Franco Zunino
Domenico Vergani
Tamara Danelli
Walter Cabri
Marco Alpegiani
Martin Gomez Patricio
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE339422T1 publication Critical patent/ATE339422T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
AT03730480T 2002-05-31 2003-05-28 Camptothecine mit modifiziertem lactonring ATE339422T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.

Publications (1)

Publication Number Publication Date
ATE339422T1 true ATE339422T1 (de) 2006-10-15

Family

ID=11456338

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06116366T ATE403659T1 (de) 2002-05-31 2003-05-28 Camptothecine mit modifiziertem lactonring
AT03730480T ATE339422T1 (de) 2002-05-31 2003-05-28 Camptothecine mit modifiziertem lactonring

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06116366T ATE403659T1 (de) 2002-05-31 2003-05-28 Camptothecine mit modifiziertem lactonring

Country Status (22)

Country Link
US (1) US7273873B2 (de)
EP (2) EP1511752B3 (de)
JP (1) JP4693410B2 (de)
KR (1) KR101042042B1 (de)
CN (1) CN1656100A (de)
AR (1) AR040139A1 (de)
AT (2) ATE403659T1 (de)
AU (2) AU2003241160B2 (de)
BR (2) BR0311333A (de)
CA (2) CA2706635A1 (de)
CY (2) CY1107311T1 (de)
DE (2) DE60322754D1 (de)
DK (2) DK1511752T5 (de)
ES (2) ES2273002T7 (de)
IT (1) ITRM20020305A1 (de)
MX (1) MXPA04011682A (de)
PE (1) PE20050120A1 (de)
PL (1) PL374346A1 (de)
PT (2) PT1511752E (de)
SI (2) SI1719775T1 (de)
TW (1) TWI325866B (de)
WO (1) WO2003101995A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
WO2009016068A1 (en) * 2007-08-01 2009-02-05 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Crystalline form ii of 7-(dimethoxy-methyl) camptothecin, its use as intermediate and products obtained therefrom
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
CA3138197A1 (en) 2019-05-14 2020-11-19 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
EP4058464A1 (de) 2019-11-13 2022-09-21 Nuvation Bio Inc. Auf nuklearhormonrezeptor abzielende antikrebsverbindungen
US11834458B2 (en) 2021-03-23 2023-12-05 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
EP0835258B1 (de) * 1995-06-21 2002-09-25 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Camptothecinanaloge, verfahren zur ihrer herstellung, ihre verwendungals arzneimittel und diese enthaltende pharmazeutische zusammenfassungen
ATE216998T1 (de) * 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung

Also Published As

Publication number Publication date
EP1511752A2 (de) 2005-03-09
DE60308368D1 (de) 2006-10-26
AU2009236044B2 (en) 2011-03-24
US20050154003A1 (en) 2005-07-14
AU2009236044A8 (en) 2011-07-21
TWI325866B (en) 2010-06-11
SI1719775T1 (sl) 2009-04-30
DK1511752T5 (da) 2010-06-14
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
ES2312090T3 (es) 2009-02-16
EP1511752B8 (de) 2007-04-18
CA2706635A1 (en) 2003-12-11
PT1511752E (pt) 2007-01-31
JP2005531602A (ja) 2005-10-20
DE60322754D1 (de) 2008-09-18
WO2003101995A2 (en) 2003-12-11
PT1719775E (pt) 2008-09-30
CY1108793T1 (el) 2014-04-09
EP1511752B1 (de) 2006-09-13
CY1107311T1 (el) 2012-11-21
TW200404806A (en) 2004-04-01
AU2009236044A1 (en) 2009-12-03
KR101042042B1 (ko) 2011-06-16
SI1511752T1 (sl) 2007-02-28
PE20050120A1 (es) 2005-03-04
JP4693410B2 (ja) 2011-06-01
DE60308368T3 (de) 2010-09-16
ES2273002T7 (es) 2011-08-01
WO2003101995A3 (en) 2004-02-19
EP1511752B3 (de) 2010-03-10
AU2003241160B2 (en) 2009-08-20
ATE403659T1 (de) 2008-08-15
CA2485201C (en) 2010-11-02
KR20050036909A (ko) 2005-04-20
AU2003241160A1 (en) 2003-12-19
ITRM20020305A1 (it) 2003-12-01
EP1719775B1 (de) 2008-08-06
CN1656100A (zh) 2005-08-17
AR040139A1 (es) 2005-03-16
US7273873B2 (en) 2007-09-25
BR0311333A (pt) 2005-03-15
DK1511752T3 (da) 2007-01-29
BR0311329A (pt) 2005-02-22
ITRM20020305A0 (it) 2002-05-31
MXPA04011682A (es) 2005-03-31
PL374346A1 (en) 2005-10-17
WO2003101995A8 (en) 2004-12-23
AU2009236044B8 (en) 2011-07-21
CA2485201A1 (en) 2003-12-11
ES2273002T3 (es) 2007-05-01
EP1719775A1 (de) 2006-11-08

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