MX2007012438A - Forma cristalina de un compuesto de quinolinona-carboxamida. - Google Patents

Forma cristalina de un compuesto de quinolinona-carboxamida.

Info

Publication number
MX2007012438A
MX2007012438A MX2007012438A MX2007012438A MX2007012438A MX 2007012438 A MX2007012438 A MX 2007012438A MX 2007012438 A MX2007012438 A MX 2007012438A MX 2007012438 A MX2007012438 A MX 2007012438A MX 2007012438 A MX2007012438 A MX 2007012438A
Authority
MX
Mexico
Prior art keywords
quinolinone
salt forms
crystalline form
crystalline
carboxamide compound
Prior art date
Application number
MX2007012438A
Other languages
English (en)
Inventor
Paul R Fatheree
Daniel Genov
Adam Goldblum
Turner S Derek
Robert Chao
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of MX2007012438A publication Critical patent/MX2007012438A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Una sal clorhidrato cristalina de {(1S, 3R, 5R)-8-[(R)-2-hidroxi-3 -(metansulfonil-metil-amino)propil-8-azabiciclo [3.2.1] oct-3-il}amida de acido 1-isopropil-2-oxo-1,2-dihidroquinolin- 3-carboxilico o un solvato del mismo. Composiciones farmaceuticas que comprenden dichas formas salinas cristalinas, metodos para utilizar dichas formas salinas cristalinas para tratar enfermedades asociadas con la actividad del receptor 5-HT4, y procesos utiles para preparar dichas formas salinas cristalinas.
MX2007012438A 2005-04-06 2006-04-05 Forma cristalina de un compuesto de quinolinona-carboxamida. MX2007012438A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66878005P 2005-04-06 2005-04-06
PCT/US2006/012978 WO2006108127A2 (en) 2005-04-06 2006-04-05 Crystalline form of a quinolinone-carboxamide compound

Publications (1)

Publication Number Publication Date
MX2007012438A true MX2007012438A (es) 2007-12-05

Family

ID=37074104

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007012438A MX2007012438A (es) 2005-04-06 2006-04-05 Forma cristalina de un compuesto de quinolinona-carboxamida.

Country Status (30)

Country Link
US (4) US7728004B2 (es)
EP (1) EP1874766B1 (es)
JP (2) JP5230407B2 (es)
KR (1) KR101322873B1 (es)
CN (1) CN101151264B (es)
AR (2) AR053208A1 (es)
AT (1) ATE479682T1 (es)
AU (1) AU2006232129B2 (es)
BR (1) BRPI0610657A2 (es)
CA (1) CA2603654C (es)
CY (1) CY1111275T1 (es)
DE (1) DE602006016586D1 (es)
DK (1) DK1874766T3 (es)
EA (1) EA012115B1 (es)
ES (1) ES2350495T3 (es)
HK (1) HK1110866A1 (es)
HR (1) HRP20100629T1 (es)
IL (1) IL186023A (es)
MA (1) MA29403B1 (es)
MX (1) MX2007012438A (es)
MY (1) MY151075A (es)
NO (1) NO339699B1 (es)
NZ (1) NZ561900A (es)
PE (1) PE20061310A1 (es)
PL (1) PL1874766T3 (es)
PT (1) PT1874766E (es)
SI (1) SI1874766T1 (es)
TW (1) TWI377206B (es)
WO (1) WO2006108127A2 (es)
ZA (1) ZA200708071B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7063671B2 (en) * 2002-06-21 2006-06-20 Boston Scientific Scimed, Inc. Electronically activated capture device
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
DE602005016446D1 (de) * 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
DE602005014566D1 (de) 2004-11-05 2009-07-02 Theravance Inc Chinolinon-carboxamid-verbindungen
TWI377206B (en) * 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
SI2395002T1 (sl) 2005-11-08 2014-10-30 Vertex Pharmaceuticals Incorporated Farmacevtski sestavek, vsebujoč heterociklični modulator prenašalcev z ATP-vezavno kaseto
JP2010527357A (ja) * 2007-05-17 2010-08-12 セラヴァンス， インコーポレーテッド 腸の前処置のための運動促進剤
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
SI2225230T1 (sl) * 2007-12-07 2017-03-31 Vertex Pharmaceuticals Incorporated Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
PL2419104T3 (pl) * 2009-04-13 2018-04-30 Theravance Biopharma R&D Ip, Llc Kombinacje agonistów receptora 5-HT4 i inhibitorów acetylocholinoesterazy do leczenia zaburzeń poznawczych
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
WO2011095450A1 (en) 2010-02-02 2011-08-11 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
JP2013523833A (ja) 2010-04-07 2013-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の医薬組成物およびその投与
RU2016122882A (ru) 2013-11-12 2017-12-19 Вертекс Фармасьютикалз Инкорпорейтед Способ получения фармацевтических композиций для лечения опосредованных cftr заболеваний
US11642339B2 (en) * 2017-07-31 2023-05-09 Theravance Biopharma R&D Ip, Llc Methods of treating symptoms of gastroparesis using velusetrag
WO2024061960A1 (en) 2022-09-20 2024-03-28 Alfasigma S.P.A. Velusetrag for use in the treatment of chronic intestinal pseudo-obstruction (cipo)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3122671B2 (ja) 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
ES2080482T3 (es) * 1990-12-28 1996-02-01 Kyowa Hakko Kogyo Kk Derivado de quinoleina.
US5571820A (en) 1992-11-20 1996-11-05 Taisho Pharmaceutical Co., Ltd. Heterocyclic compound
JP3829879B2 (ja) 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
US7105195B2 (en) * 2003-07-25 2006-09-12 General Mills, Inc. Reduced trans fat product
ES2338882T3 (es) 2003-11-24 2010-05-13 Pfizer, Inc. Compuestos de acido quinolona-carboxilico que tienen actividad agonista del receptor 5-ht4.
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
DE602005016446D1 (de) 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
DE602005014566D1 (de) 2004-11-05 2009-07-02 Theravance Inc Chinolinon-carboxamid-verbindungen
JP2008530225A (ja) 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
NZ560828A (en) 2005-03-02 2011-01-28 Theravance Inc Quinolinone compounds as 5-HT4 receptor agonists
TWI377206B (en) * 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound

Also Published As

Publication number Publication date
HRP20100629T1 (hr) 2010-12-31
MY151075A (en) 2014-03-31
US7728004B2 (en) 2010-06-01
TW200643020A (en) 2006-12-16
ZA200708071B (en) 2008-10-29
AR053208A1 (es) 2007-04-25
WO2006108127A3 (en) 2007-01-04
US20100197728A1 (en) 2010-08-05
CA2603654C (en) 2014-05-27
US8658671B2 (en) 2014-02-25
US9402840B2 (en) 2016-08-02
PT1874766E (pt) 2010-11-30
US20160095849A1 (en) 2016-04-07
PL1874766T3 (pl) 2011-02-28
EA200702161A1 (ru) 2008-04-28
WO2006108127A2 (en) 2006-10-12
KR101322873B1 (ko) 2013-10-30
AU2006232129A1 (en) 2006-10-12
ATE479682T1 (de) 2010-09-15
JP2012153725A (ja) 2012-08-16
EA012115B1 (ru) 2009-08-28
KR20070116988A (ko) 2007-12-11
NO339699B1 (no) 2017-01-23
SI1874766T1 (sl) 2010-12-31
BRPI0610657A2 (pt) 2010-07-13
ES2350495T3 (es) 2011-01-24
JP2008535848A (ja) 2008-09-04
AR110019A2 (es) 2019-02-13
DK1874766T3 (da) 2010-12-06
EP1874766B1 (en) 2010-09-01
NO20075574L (no) 2007-11-02
NZ561900A (en) 2010-12-24
PE20061310A1 (es) 2007-01-23
US20060229332A1 (en) 2006-10-12
CN101151264B (zh) 2011-07-06
US20140256769A1 (en) 2014-09-11
US9126994B2 (en) 2015-09-08
HK1110866A1 (en) 2008-07-25
IL186023A (en) 2011-09-27
AU2006232129B2 (en) 2012-07-12
MA29403B1 (fr) 2008-04-01
DE602006016586D1 (de) 2010-10-14
EP1874766A2 (en) 2008-01-09
JP5230407B2 (ja) 2013-07-10
IL186023A0 (en) 2008-01-20
TWI377206B (en) 2012-11-21
CN101151264A (zh) 2008-03-26
CA2603654A1 (en) 2006-10-12
CY1111275T1 (el) 2015-08-05

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