WO2006106432A3 - 4-arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of cns disorders - Google Patents

4-arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of cns disorders Download PDF

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Publication number
WO2006106432A3
WO2006106432A3 PCT/IB2006/000998 IB2006000998W WO2006106432A3 WO 2006106432 A3 WO2006106432 A3 WO 2006106432A3 IB 2006000998 W IB2006000998 W IB 2006000998W WO 2006106432 A3 WO2006106432 A3 WO 2006106432A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
medicament
preparing
treatment
arylpiperidine
Prior art date
Application number
PCT/IB2006/000998
Other languages
French (fr)
Other versions
WO2006106432A2 (en
WO2006106432A8 (en
Inventor
Susanna Nencetti
Annalina Lapucci
Elisabetta Orlandini
Aldo Balsamo
Maria Rosa Mazzoni
Original Assignee
Univ Pisa
Susanna Nencetti
Annalina Lapucci
Elisabetta Orlandini
Aldo Balsamo
Maria Rosa Mazzoni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pisa, Susanna Nencetti, Annalina Lapucci, Elisabetta Orlandini, Aldo Balsamo, Maria Rosa Mazzoni filed Critical Univ Pisa
Publication of WO2006106432A2 publication Critical patent/WO2006106432A2/en
Publication of WO2006106432A8 publication Critical patent/WO2006106432A8/en
Publication of WO2006106432A3 publication Critical patent/WO2006106432A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Abstract

The invention relates to novel 4-arylpiperidine derivatives and organic or inorganic acid addition salts thereof. The compounds of the invention and the salts thereof display pharmacological activity towards the central nervous system, particularly antidepressant activity. The invention further relates to pharmaceutical compositions comprising a 4-arylpiperidine derivative of the invention or a pharmaceutically acceptable salt thereof, as well as a process for the preparation of said derivatives.
PCT/IB2006/000998 2005-04-08 2006-04-06 4-arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of cns disorders WO2006106432A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITTO2005A000234 2005-04-08
IT000234A ITTO20050234A1 (en) 2005-04-08 2005-04-08 4-ARILPIPERIDHINE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF DISORDERS OF THE CNS

Publications (3)

Publication Number Publication Date
WO2006106432A2 WO2006106432A2 (en) 2006-10-12
WO2006106432A8 WO2006106432A8 (en) 2007-03-22
WO2006106432A3 true WO2006106432A3 (en) 2007-05-03

Family

ID=37073833

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/000998 WO2006106432A2 (en) 2005-04-08 2006-04-06 4-arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of cns disorders

Country Status (2)

Country Link
IT (1) ITTO20050234A1 (en)
WO (1) WO2006106432A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102766080B (en) * 2011-05-06 2015-09-23 上海医药工业研究院 One class pyrrolidin derivatives, its preparation method and application
CN102766079B (en) * 2011-05-06 2015-04-08 上海医药工业研究院 Pyrrolidine derivative, its preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3846M (en) * 1963-04-22 1966-01-17 Thomae Gmbh Dr K New 4-amino-piperidines.
EP0023706A1 (en) * 1979-08-03 1981-02-11 Byk Gulden Lomberg Chemische Fabrik GmbH 4-Phenoxy piperidines, process for their preparation, their use and medicaments containing them
GB2060619A (en) * 1979-09-14 1981-05-07 Wyeth John & Brother Ltd 4-Aryl-4-Aryloxypiperidines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3846M (en) * 1963-04-22 1966-01-17 Thomae Gmbh Dr K New 4-amino-piperidines.
EP0023706A1 (en) * 1979-08-03 1981-02-11 Byk Gulden Lomberg Chemische Fabrik GmbH 4-Phenoxy piperidines, process for their preparation, their use and medicaments containing them
GB2060619A (en) * 1979-09-14 1981-05-07 Wyeth John & Brother Ltd 4-Aryl-4-Aryloxypiperidines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARTIN L L ET AL: "SYNTHESIS OF SPIROÚISOBENZOFURAN-1(3H),4'-PIPERIDINES AS POTENTIAL CENTRAL NERVOUS SYSTEM AGENTS 5. CONFORMATIONALLY MOBILE ANALOGUES DERIVED BY FURAN RING OPENING", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 22, no. 11, 1 November 1979 (1979-11-01), pages 1347 - 1354, XP000607796, ISSN: 0022-2623 *
ONG H H ET AL: "NOVEL TETRA CYCLIC SPIRO PIPERIDINES 1. 3 ARYL-1 3 DI HYDRO SPIRO BENZO-C-THIOPHENE-1 4' PIPERIDINES AS POTENTIAL ANTI DEPRESSANTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 24, no. 1, 1981, pages 74 - 79, XP002406459, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2006106432A2 (en) 2006-10-12
ITTO20050234A1 (en) 2006-10-09
WO2006106432A8 (en) 2007-03-22

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