EA200702161A1 - Кристаллическая форма хинолинон-карбоксамидного соединения - Google Patents

Кристаллическая форма хинолинон-карбоксамидного соединения

Info

Publication number
EA200702161A1
EA200702161A1 EA200702161A EA200702161A EA200702161A1 EA 200702161 A1 EA200702161 A1 EA 200702161A1 EA 200702161 A EA200702161 A EA 200702161A EA 200702161 A EA200702161 A EA 200702161A EA 200702161 A1 EA200702161 A1 EA 200702161A1
Authority
EA
Eurasian Patent Office
Prior art keywords
quinolinon
crystal form
carboxamide compound
salt forms
crystalline
Prior art date
Application number
EA200702161A
Other languages
English (en)
Other versions
EA012115B1 (ru
Inventor
Пол Р. Фазери
С. Дерек Тернер
Адам Голдблум
Роберт Чао
Дэниэл Дженов
Original Assignee
Тереванс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тереванс, Инк. filed Critical Тереванс, Инк.
Publication of EA200702161A1 publication Critical patent/EA200702161A1/ru
Publication of EA012115B1 publication Critical patent/EA012115B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к кристаллическому гидрохлориду {(1S,3R,5R)-8-[(R)-2-гидрокси-3- (метансульфонилметиламино)пропил]-8-азабицикло[3.2.1]окт-3-ил}амида 1-изопропил-2-оксо-1,2-дигидрохинолин-3-карбоновой кислоты или сольвату этой соли. Изобретение также предлагает фармацевтические композиции, содержащие такие кристаллические солевые формы, способы применения таких кристаллических солевых форм для лечения расстройств, ассоциированных с активностью рецепторов 5-НТ, а также способы получения таких кристаллических солевых форм.
EA200702161A 2005-04-06 2006-04-05 Кристаллическая форма хинолинон-карбоксамидного соединения EA012115B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66878005P 2005-04-06 2005-04-06
PCT/US2006/012978 WO2006108127A2 (en) 2005-04-06 2006-04-05 Crystalline form of a quinolinone-carboxamide compound

Publications (2)

Publication Number Publication Date
EA200702161A1 true EA200702161A1 (ru) 2008-04-28
EA012115B1 EA012115B1 (ru) 2009-08-28

Family

ID=37074104

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702161A EA012115B1 (ru) 2005-04-06 2006-04-05 Кристаллическая форма хинолинон-карбоксамидного соединения

Country Status (30)

Country Link
US (4) US7728004B2 (ru)
EP (1) EP1874766B1 (ru)
JP (2) JP5230407B2 (ru)
KR (1) KR101322873B1 (ru)
CN (1) CN101151264B (ru)
AR (2) AR053208A1 (ru)
AT (1) ATE479682T1 (ru)
AU (1) AU2006232129B2 (ru)
BR (1) BRPI0610657A2 (ru)
CA (1) CA2603654C (ru)
CY (1) CY1111275T1 (ru)
DE (1) DE602006016586D1 (ru)
DK (1) DK1874766T3 (ru)
EA (1) EA012115B1 (ru)
ES (1) ES2350495T3 (ru)
HK (1) HK1110866A1 (ru)
HR (1) HRP20100629T1 (ru)
IL (1) IL186023A (ru)
MA (1) MA29403B1 (ru)
MX (1) MX2007012438A (ru)
MY (1) MY151075A (ru)
NO (1) NO339699B1 (ru)
NZ (1) NZ561900A (ru)
PE (1) PE20061310A1 (ru)
PL (1) PL1874766T3 (ru)
PT (1) PT1874766E (ru)
SI (1) SI1874766T1 (ru)
TW (1) TWI377206B (ru)
WO (1) WO2006108127A2 (ru)
ZA (1) ZA200708071B (ru)

Families Citing this family (19)

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US7063671B2 (en) * 2002-06-21 2006-06-20 Boston Scientific Scimed, Inc. Electronically activated capture device
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
JP5042028B2 (ja) 2004-11-05 2012-10-03 セラヴァンス， インコーポレーテッド キノリノン−カルボキサミド化合物
ATE441646T1 (de) * 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
TWI377206B (en) * 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
ES2439736T3 (es) 2005-11-08 2014-01-24 Vertex Pharmaceuticals Incorporated Moduladores heterocíclicos de transportadores de casete de unión a ATP
WO2008143916A2 (en) * 2007-05-17 2008-11-27 Theravance, Inc. Prokinetic agent for bowel preparation
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN101910156B (zh) 2007-12-07 2013-12-04 沃泰克斯药物股份有限公司 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的固体形式
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
LT2419104T (lt) * 2009-04-13 2018-02-12 Theravance Biopharma R&D Ip, Llc 5-ht4 receptoriaus agonistų ir acetilcholinesterazės inhibitorių deriniai, skirti pažinimo sutrikimų gydymui
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
AR080055A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
DK3150198T3 (da) 2010-04-07 2021-11-01 Vertex Pharma Farmaceutiske sammensætninger af 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-yl)-cyclopropancarboxamido)-3-methylpyriodin-2-yl)benzoesyre og indgivelse deraf
US10231932B2 (en) 2013-11-12 2019-03-19 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases
IL272023B1 (en) * 2017-07-31 2024-08-01 Theravance Biopharma R& D Ip Llc Methods for treating the symptoms of gastric dysfunction using Velostrag
WO2024061960A1 (en) 2022-09-20 2024-03-28 Alfasigma S.P.A. Velusetrag for use in the treatment of chronic intestinal pseudo-obstruction (cipo)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3122671B2 (ja) 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
US5319085A (en) 1990-12-28 1994-06-07 Kyowa Hakko Kogyo Co., Ltd. Quinoline derivative having serotonin-3 receptor antagonizing activity
US5571820A (en) 1992-11-20 1996-11-05 Taisho Pharmaceutical Co., Ltd. Heterocyclic compound
JP3829879B2 (ja) 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
US7105195B2 (en) * 2003-07-25 2006-09-12 General Mills, Inc. Reduced trans fat product
EP1689742B1 (en) 2003-11-24 2010-03-17 Pfizer, Inc. Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity
US7728006B2 (en) 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ATE441646T1 (de) 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
JP5042028B2 (ja) 2004-11-05 2012-10-03 セラヴァンス， インコーポレーテッド キノリノン−カルボキサミド化合物
JP2008530225A (ja) 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
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TWI377206B (en) * 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound

Also Published As

Publication number Publication date
ZA200708071B (en) 2008-10-29
WO2006108127A3 (en) 2007-01-04
CN101151264A (zh) 2008-03-26
MX2007012438A (es) 2007-12-05
ES2350495T3 (es) 2011-01-24
AU2006232129A1 (en) 2006-10-12
HRP20100629T1 (hr) 2010-12-31
MA29403B1 (fr) 2008-04-01
WO2006108127A2 (en) 2006-10-12
IL186023A (en) 2011-09-27
NZ561900A (en) 2010-12-24
US7728004B2 (en) 2010-06-01
TW200643020A (en) 2006-12-16
JP5230407B2 (ja) 2013-07-10
BRPI0610657A2 (pt) 2010-07-13
PT1874766E (pt) 2010-11-30
PE20061310A1 (es) 2007-01-23
AU2006232129B2 (en) 2012-07-12
US8658671B2 (en) 2014-02-25
US9402840B2 (en) 2016-08-02
KR101322873B1 (ko) 2013-10-30
ATE479682T1 (de) 2010-09-15
MY151075A (en) 2014-03-31
DK1874766T3 (da) 2010-12-06
EP1874766B1 (en) 2010-09-01
TWI377206B (en) 2012-11-21
US20160095849A1 (en) 2016-04-07
JP2008535848A (ja) 2008-09-04
JP2012153725A (ja) 2012-08-16
NO20075574L (no) 2007-11-02
CA2603654A1 (en) 2006-10-12
IL186023A0 (en) 2008-01-20
US20140256769A1 (en) 2014-09-11
US20060229332A1 (en) 2006-10-12
DE602006016586D1 (de) 2010-10-14
US9126994B2 (en) 2015-09-08
HK1110866A1 (en) 2008-07-25
US20100197728A1 (en) 2010-08-05
AR053208A1 (es) 2007-04-25
EP1874766A2 (en) 2008-01-09
KR20070116988A (ko) 2007-12-11
CY1111275T1 (el) 2015-08-05
PL1874766T3 (pl) 2011-02-28
CA2603654C (en) 2014-05-27
EA012115B1 (ru) 2009-08-28
SI1874766T1 (sl) 2010-12-31
AR110019A2 (es) 2019-02-13
CN101151264B (zh) 2011-07-06
NO339699B1 (no) 2017-01-23

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