EA200900244A1 - Модуляторы активности хемокиновых рецепторов, их кристаллические формы и способ их получения - Google Patents

Модуляторы активности хемокиновых рецепторов, их кристаллические формы и способ их получения

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Publication number
EA200900244A1
EA200900244A1 EA200900244A EA200900244A EA200900244A1 EA 200900244 A1 EA200900244 A1 EA 200900244A1 EA 200900244 A EA200900244 A EA 200900244A EA 200900244 A EA200900244 A EA 200900244A EA 200900244 A1 EA200900244 A1 EA 200900244A1
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Prior art keywords
compounds
crystalline forms
receptor activity
reception
chemokine receptor
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EA200900244A
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English (en)
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EA014960B1 (ru
Inventor
Майкл Г. Ян
Роберт Дж. Черни
Мартин Г. Истгейт
Джейл Маслхиддиноглу
Цили Сяо
Шива Джосиула Прасад
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Бристол-Маерс Сквибб Компани
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Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA200900244A1 publication Critical patent/EA200900244A1/ru
Publication of EA014960B1 publication Critical patent/EA014960B1/ru

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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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Abstract

Настоящее изобретение включает новый антагонист или частичные агонисты/антагонисты МСР-1 рецепторной активности: N-((1R,2S,5R)-5-(изопропил(метил)амино)-2-((S)-2-оксо-3-(6-трифторметил)хиназолин-4-иламино)пирролидин-1-ил)циклогексил)ацетамид или его фармацевтически приемлемую соль, сольват или пролекарство, проявляющие неожиданное сочетание нужных фармакологических характеристик. Также охватываются кристаллические формы соединений по настоящему изобретению. Также целью данного изобретения являются фармацевтические композиции, содержащие эти соединения, и способы их применения в качестве агентов для лечения воспалительных заболеваний, аллергических, аутоиммунных, метаболических, раковых и/или сердечно-сосудистых заболеваний. Настоящее раскрытие также включает способ получения соединений формулы (I), включая N-((1R,2S,5R)-5-(изопропил(метил)амино)-2-((S)-2-оксо-3-(6-трифторметил)хиназолин-4-иламино)пирролидин-1-ил)циклогексил)ацетамид, где R, R, R, Rи структура (а) представлены в данном описании. Также в данное описание включаются соединения, применимые в способе получения в качестве интермедиатов.
EA200900244A 2006-07-28 2007-07-26 Модуляторы активности хемокиновых рецепторов, их кристаллические формы и способ их получения EA014960B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83423506P 2006-07-28 2006-07-28
US89602607P 2007-03-21 2007-03-21
US11/782,704 US7671062B2 (en) 2006-07-28 2007-07-25 Modulators of chemokine receptor activity, crystalline forms and process
PCT/US2007/074438 WO2008014381A2 (en) 2006-07-28 2007-07-26 Modulators of chemokine receptor activity, crystalline forms and process

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EA200900244A1 true EA200900244A1 (ru) 2009-08-28
EA014960B1 EA014960B1 (ru) 2011-04-29

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US (1) US7671062B2 (ru)
EP (2) EP2049477B1 (ru)
JP (1) JP2009544758A (ru)
KR (1) KR20090035036A (ru)
CN (1) CN101511822A (ru)
AR (1) AR062114A1 (ru)
AT (1) ATE471928T1 (ru)
AU (1) AU2007279256A1 (ru)
BR (1) BRPI0715066A2 (ru)
CA (1) CA2659259A1 (ru)
CL (3) CL2007002194A1 (ru)
CO (1) CO6190527A2 (ru)
CY (1) CY1110785T1 (ru)
DE (1) DE602007007335D1 (ru)
DK (1) DK2049477T3 (ru)
EA (1) EA014960B1 (ru)
ES (1) ES2346591T3 (ru)
HK (1) HK1125931A1 (ru)
HR (1) HRP20100371T1 (ru)
IL (1) IL196518A0 (ru)
MX (1) MX2009000803A (ru)
NO (1) NO20090256L (ru)
NZ (1) NZ574656A (ru)
PE (1) PE20080838A1 (ru)
PL (1) PL2049477T3 (ru)
PT (1) PT2049477E (ru)
SG (1) SG158925A1 (ru)
SI (1) SI2049477T1 (ru)
TW (1) TW200823203A (ru)
WO (1) WO2008014381A2 (ru)

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CO6190527A2 (es) 2010-08-19
WO2008014381A3 (en) 2008-12-31
SG158925A1 (en) 2010-02-26
DE602007007335D1 (de) 2010-08-05
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