PE20080947A1 - Derivados de n-(amino-heteroaril)-1h-indol-2-carboxamidas como antagonistas de receptores de tipo trpv1 - Google Patents

Derivados de n-(amino-heteroaril)-1h-indol-2-carboxamidas como antagonistas de receptores de tipo trpv1

Info

Publication number
PE20080947A1
PE20080947A1 PE2007000947A PE2007000947A PE20080947A1 PE 20080947 A1 PE20080947 A1 PE 20080947A1 PE 2007000947 A PE2007000947 A PE 2007000947A PE 2007000947 A PE2007000947 A PE 2007000947A PE 20080947 A1 PE20080947 A1 PE 20080947A1
Authority
PE
Peru
Prior art keywords
indol
halogen
alkyl
heteroaryl
derivatives
Prior art date
Application number
PE2007000947A
Other languages
English (en)
Inventor
Laurent Dubois
Yannick Evanno
Andre Malanda
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20080947A1 publication Critical patent/PE20080947A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE N-(AMINO-HETEROARIL)-1H-INDOL-2-CARBOXAMIDA DE FORMULA (I), EN DONDE X1 ES H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; X2 ES H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; X3 Y X4 SON INDEPENDIENTEMENTE H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; Z1, Z2, Z3 Y Z4 SON INDEPENDIENTEMENTEN, C(R6); n ES 0,1,2 O 3; Y ES ARILO, HETEROARILO SUSTITUIDOS O NO SUSTITUIDOS; R6 ES H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS. SON PREFERIDOS: N[6-(METILAMINO)PIRIDIN-3-IL]-5-FLUORO-1-(3-FLUOROBENCIL)-1H-INDOL-2-CARBOXAMIDA; N-[6-(DIMETILAMINO)PIRIDIN-3-IL]-5-TRIFLUOROMETIL-1-(3-FLUOROBENCIL)-1H-INDOL-2-CARBOXAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS TIENEN ACTIVIDAD ANTAGONISTA FRENTE A LOS RECEPTORES DE TIPO TRPV1 POR LO CUAL SON UTILES EN EL TRATAMIENTO DE DOLOR, INFLAMACION, TRASTORNOS UROLOGICOS, HERPES, PRURITO, IRRITACIONES DERMICAS
PE2007000947A 2006-07-24 2007-07-20 Derivados de n-(amino-heteroaril)-1h-indol-2-carboxamidas como antagonistas de receptores de tipo trpv1 PE20080947A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0606742A FR2903985B1 (fr) 2006-07-24 2006-07-24 Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PE20080947A1 true PE20080947A1 (es) 2008-09-04

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Country Status (29)

Country Link
US (2) US8227489B2 (es)
EP (1) EP2046775B1 (es)
JP (1) JP5265541B2 (es)
KR (1) KR20090042239A (es)
CN (1) CN101495469B (es)
AR (1) AR061946A1 (es)
AU (1) AU2007279166C1 (es)
BR (1) BRPI0714559A2 (es)
CA (1) CA2656716C (es)
CO (1) CO6150146A2 (es)
CY (1) CY1113470T1 (es)
DK (1) DK2046775T3 (es)
EA (1) EA016829B1 (es)
ES (1) ES2393630T3 (es)
FR (1) FR2903985B1 (es)
IL (1) IL196113A0 (es)
MA (1) MA30694B1 (es)
ME (1) ME00584A (es)
MX (1) MX2009000649A (es)
MY (1) MY147465A (es)
NO (1) NO20090726L (es)
NZ (1) NZ574265A (es)
PE (1) PE20080947A1 (es)
PL (1) PL2046775T3 (es)
PT (1) PT2046775E (es)
SI (1) SI2046775T1 (es)
TW (1) TWI388554B (es)
WO (1) WO2008012418A1 (es)
ZA (1) ZA200900228B (es)

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AU2014267235B2 (en) 2013-05-17 2017-10-05 Janssen Sciences Ireland Uc Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
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DK3060547T3 (en) 2013-10-23 2018-01-15 Janssen Sciences Ireland Uc CARBOXAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATMENT OF HEPATITS B
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
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BR112021015618A2 (pt) 2019-02-22 2021-10-05 Janssen Sciences Ireland Unlimited Company Derivados de amida úteis no tratamento da infecção pelo hbv ou doenças induzidas pelo hbv
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Also Published As

Publication number Publication date
NZ574265A (en) 2011-11-25
AU2007279166B2 (en) 2012-11-01
PL2046775T3 (pl) 2013-01-31
PT2046775E (pt) 2012-11-23
AR061946A1 (es) 2008-10-01
SI2046775T1 (sl) 2012-12-31
EA016829B1 (ru) 2012-07-30
FR2903985A1 (fr) 2008-01-25
CY1113470T1 (el) 2016-06-22
JP2009544669A (ja) 2009-12-17
CA2656716C (fr) 2014-10-14
DK2046775T3 (da) 2012-12-10
EA200970149A1 (ru) 2009-06-30
CO6150146A2 (es) 2010-04-20
WO2008012418A1 (fr) 2008-01-31
US20120264944A1 (en) 2012-10-18
NO20090726L (no) 2009-02-25
US20090156809A1 (en) 2009-06-18
EP2046775A1 (fr) 2009-04-15
ZA200900228B (en) 2010-03-31
BRPI0714559A2 (pt) 2014-05-20
MA30694B1 (fr) 2009-09-01
AU2007279166A1 (en) 2008-01-31
IL196113A0 (en) 2009-09-01
CA2656716A1 (fr) 2008-01-31
MY147465A (en) 2012-12-14
MX2009000649A (es) 2009-01-30
US8227489B2 (en) 2012-07-24
CN101495469B (zh) 2013-05-01
JP5265541B2 (ja) 2013-08-14
AU2007279166C1 (en) 2013-03-14
EP2046775B1 (fr) 2012-08-22
ME00584A (en) 2011-12-20
ES2393630T3 (es) 2012-12-26
TWI388554B (zh) 2013-03-11
US8481745B2 (en) 2013-07-09
FR2903985B1 (fr) 2008-09-05
TW200813013A (en) 2008-03-16
KR20090042239A (ko) 2009-04-29
CN101495469A (zh) 2009-07-29

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