CY1113470T1 - Παραγωγα ν-(αμινο-ετεροαρυλ)-1η-ινδολο-2-καρβοξαμιδιων ως ανταγωνιστες υποδοχεων τυπου trpv1 ή vr1 - Google Patents
Παραγωγα ν-(αμινο-ετεροαρυλ)-1η-ινδολο-2-καρβοξαμιδιων ως ανταγωνιστες υποδοχεων τυπου trpv1 ή vr1Info
- Publication number
- CY1113470T1 CY1113470T1 CY20121101063T CY121101063T CY1113470T1 CY 1113470 T1 CY1113470 T1 CY 1113470T1 CY 20121101063 T CY20121101063 T CY 20121101063T CY 121101063 T CY121101063 T CY 121101063T CY 1113470 T1 CY1113470 T1 CY 1113470T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cycloalkyl
- aryl
- alkylene
- alkyl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Η εφεύρεση αφορά ενώσεις του γενικού χημικού τύπου (I): όπου το Χ1 αντιπροσωπεύει ένα άτομο υδρογόνου ή αλογόνου ή ένα (C1-C6)-αλκυλ, (C3-C7)-κυκλοαλκυλ, (C3-C7)-κυκλοαλκυλ-(C1-C3)-αλκυλεν, (C1-C6)-φθοροαλκυλ, κυανο, C(O)NR1R2, άζωτο, (C1-C6)-θειοαλκυλ, -S(O)-(C1-C6)-αλκυλ, -S(O)2-(C1-C6)-αλκυλ, SO2NR1R2, αρυλ-(C1-C6)-αλκυλεν, αρυλ ή ομάδα ετεροαρυλ, όπου το αρυλ και το ετεροαρυλ είναι ενδεχομένως υποκατεστημένα∙ το Χ2 αντιπροσωπεύει ένα άτομο υδρογόνου ή αλογόνου ή ένα (C1-C6)-αλκυλ, (C3-C7)-κυκλοαλκυλ, (C3-C7)-κυκλοαλκυλ-(C1-C3)-αλκυλεν, (C1-C6)-φθοροαλκυλ, (C1-C6)-αλκοξυλ, (C3-C7)-κυκλοαλκυλ-(C1-C6)-αλκυλεν-O-, (C1-C6)-φθοροαλκοξυλ, κυανό, C(O)NR1R2, (C1-C6)-θειοαλκυλ, -S(O)-(C1-C6)-αλκυλ, -S(O)2-(C1-C6)-αλκυλ, SO2NR1,R2, αρυλ-(C1-C6)-αλκυλεν, αρυλ ή μια ομάδα ετεροαρυλ, όπου το αρυλ και το ετεροαρυλ είναι ενδεχομένως υποκατεστημένα∙ τα Χ3 και Χ4 αντιπροσωπεύουν, ανεξάρτητα το ένα από το άλλο, ένα άτομο υδρογόνου ή αλογόνου ή μια ομάδα (C1-C6)-αλκυλ, (C3-C7)-κυκλοαλκυλ, (C3-C7)-κυκλοαλκυλ-(C1-C3)-αλκυλεν, (C1-C6)-φθοροαλκυλ, (C1-C6)-αλκοξυλ, (C3-C7)-κυκλοαλκυλ-(C1-C6)-αλκυλεν-Ο-, (C1-C6)-φθοροαλκοξυλ, κυανό, C(O)NR1R2, άζωτο, NR1,R2, (C1-C6)-θειοαλκυλ, -S(O)-(C1-C6)-αλκυλ, -S(O)2-(C1-C6)-αλκυλ, SO2NR1,R2, NR3COR4, NR3SO2R5, αρυλ-(C1-C6)-αλκυλεν, αρυλ ή ομάδα ετεροαρυλ, όπου το αρυλ και το ετεροαρυλ είναι ενδεχομένως υποκατεστημένα∙ τα Ζ1, Ζ2, Ζ3 και Ζ4 αντιπροσωπεύουν, ανεξάρτητα το ένα από το άλλο, ένα άτομο αζώτου ή μια ομάδα C(R6) ∙ το n ισούται με 0,1,2 ή 3∙ το Υ αντιπροσωπεύει ένα ενδεχομένως υποκατεστημένο αρυλ ή ένα ετεροαρυλ∙ τα Ra και Rb αντιπροσωπεύουν, ανεξάρτητα το ένα από το άλλο, ένα άτομο υδρογόνου ή ένα (C1-C6)-αλκυλ, (C3-C7)-κυκλοαλκυλ, (C3-C7)-κυκλοαλκυλ-(C1-C3)-αλκυλεν, (C1-C6)-φθοροαλκυλ, υδροξυλ, (C1-C6)-αλκοξυλ, (C3-C7)-κυκλοαλκυλ-(C1-C6)-αλκυλεν-Ο-, (C1-C6)-φθοροαλκοξυλ, αρυλ ή μια ομάδα ετεροαρυλ, όπου τα Ra και Rb μπορούν ενδεχομένως να υποκατασταθούν∙ σε κατάσταση βάσης ή άλατος προσθήκης σε ένα οξύ, καθώς και σε κατάσταση υδρίτη ή διαλύτη. Διαδικασία παρασκευής και εφαρμογή στη θεραπευτική αγωγή.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0606742A FR2903985B1 (fr) | 2006-07-24 | 2006-07-24 | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| EP07823311A EP2046775B1 (fr) | 2006-07-24 | 2007-07-20 | Derives de n- (amino-heteroaryl) - 1h-indole-2 -carboxamides comme antagonistes des recepteurs de type trpv1 ou vr1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113470T1 true CY1113470T1 (el) | 2016-06-22 |
Family
ID=37734283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121101063T CY1113470T1 (el) | 2006-07-24 | 2012-11-08 | Παραγωγα ν-(αμινο-ετεροαρυλ)-1η-ινδολο-2-καρβοξαμιδιων ως ανταγωνιστες υποδοχεων τυπου trpv1 ή vr1 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8227489B2 (el) |
| EP (1) | EP2046775B1 (el) |
| JP (1) | JP5265541B2 (el) |
| KR (1) | KR20090042239A (el) |
| CN (1) | CN101495469B (el) |
| AR (1) | AR061946A1 (el) |
| AU (1) | AU2007279166C1 (el) |
| BR (1) | BRPI0714559A2 (el) |
| CA (1) | CA2656716C (el) |
| CO (1) | CO6150146A2 (el) |
| CY (1) | CY1113470T1 (el) |
| DK (1) | DK2046775T3 (el) |
| EA (1) | EA016829B1 (el) |
| ES (1) | ES2393630T3 (el) |
| FR (1) | FR2903985B1 (el) |
| IL (1) | IL196113A0 (el) |
| MA (1) | MA30694B1 (el) |
| ME (1) | ME00584A (el) |
| MX (1) | MX2009000649A (el) |
| MY (1) | MY147465A (el) |
| NO (1) | NO20090726L (el) |
| NZ (1) | NZ574265A (el) |
| PE (1) | PE20080947A1 (el) |
| PL (1) | PL2046775T3 (el) |
| PT (1) | PT2046775E (el) |
| SI (1) | SI2046775T1 (el) |
| TW (1) | TWI388554B (el) |
| WO (1) | WO2008012418A1 (el) |
| ZA (1) | ZA200900228B (el) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2926553B1 (fr) * | 2008-01-23 | 2010-02-19 | Sanofi Aventis | Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique |
| TWI622578B (zh) | 2011-12-21 | 2018-05-01 | 諾維拉治療公司 | Ｂ型肝炎抗病毒劑 |
| BR112015004192B1 (pt) | 2012-08-28 | 2021-02-09 | Janssen Sciences Ireland Uc | sulfamoíl-arilamidas, composição farmacêutica que os compreende e uso das mesmas no tratamento da hepatite b |
| WO2014131847A1 (en) | 2013-02-28 | 2014-09-04 | Janssen R&D Ireland | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| BR112015025052A2 (pt) | 2013-04-03 | 2021-07-06 | Janssen Sciences Ireland Uc | derivados de n-fenil-carboxamida e o seu uso como medicamentos para o tratamento da hepatite b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| EA035500B1 (ru) | 2013-05-17 | 2020-06-25 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b |
| EP3357906B1 (en) | 2013-07-25 | 2019-12-04 | Janssen Sciences Ireland Unlimited Company | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| WO2015120178A1 (en) | 2014-02-05 | 2015-08-13 | Novira Therapeutics, Inc. | Combination therapy for treatment of hbv infections |
| CN105980378B (zh) | 2014-02-06 | 2019-09-27 | 爱尔兰詹森科学公司 | 氨磺酰基吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
| CN107847762A (zh) | 2015-03-19 | 2018-03-27 | 诺维拉治疗公司 | 氮杂环辛烷和氮杂环壬烷衍生物以及治疗乙型肝炎感染的方法 |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| PL3319959T3 (pl) | 2015-07-06 | 2022-02-14 | Alkermes, Inc. | Hetero-haloinhibitory deacetylazy histonowej |
| CN105295896B (zh) * | 2015-09-11 | 2017-12-29 | 浙江大学 | 一种特异性标记的辣椒素荧光探针及其合成方法和应用 |
| EP3356328A1 (en) | 2015-09-29 | 2018-08-08 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis b antiviral agent |
| SG11201808949SA (en) | 2016-04-15 | 2018-11-29 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
| WO2018132533A1 (en) | 2017-01-11 | 2018-07-19 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
| SI3664802T1 (sl) | 2017-08-07 | 2022-10-28 | Alkermes, Inc. | Biciklični zaviralci histon deacetilaze |
| AU2019235522A1 (en) | 2018-03-14 | 2020-09-03 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| MA55020A (fr) | 2019-02-22 | 2021-12-29 | Janssen Sciences Ireland Unlimited Co | Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b |
| AR119732A1 (es) | 2019-05-06 | 2022-01-05 | Janssen Sciences Ireland Unlimited Co | Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NL248308A (el) | 1958-09-30 | |||
| US4104385A (en) | 1976-08-19 | 1978-08-01 | Sterling Drug Inc. | Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalonates |
| JPS609062B2 (ja) * | 1977-08-03 | 1985-03-07 | 広栄化学工業株式会社 | 新規な２−置換アミノ−５−γ−ピコリン類またはこれらの塩およびそれらの製造法とそれらを含有する角質繊維用染料 |
| DE60115092T2 (de) | 2000-12-12 | 2006-03-30 | Neurogen Corp., Brandford | Spiro[isobenzofuran-1,4'-piperidin]-3-one und 3h-spiroisobenzofuran-1,4'-piperidine |
| DE10147672A1 (de) * | 2001-09-27 | 2003-04-10 | Bayer Ag | Substituierte 2,5-Diamidoindole und ihre Verwendung |
| MY141521A (en) | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
| US20060183753A1 (en) * | 2002-12-20 | 2006-08-17 | Bayer Healthcare Ag | Use of substituted 2,5-diamidoindoles for the treatment of urological diseases |
| EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| EP1583531B1 (en) | 2003-01-16 | 2007-04-18 | SB Pharmco Puerto Rico Inc | Heteroaryl-substituted pyrrolo[2, 3- b]pyridine derivatives as crf receptor antagonists |
| GB0314136D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| NZ545934A (en) | 2003-09-17 | 2009-05-31 | Ono Pharmaceutical Co | Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient |
| GB0322016D0 (en) * | 2003-09-19 | 2003-10-22 | Merck Sharp & Dohme | New compounds |
| WO2005028452A1 (en) | 2003-09-22 | 2005-03-31 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
| WO2005035526A1 (en) | 2003-10-09 | 2005-04-21 | Argenta Discovery Ltd. | Bicyclic compounds and their therapeutic use |
| JP2008515960A (ja) | 2004-10-12 | 2008-05-15 | アストラゼネカ アクチボラグ | キノリン誘導体 |
| FR2880625B1 (fr) * | 2005-01-07 | 2007-03-09 | Sanofi Aventis Sa | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| EP1907398A1 (en) | 2005-07-15 | 2008-04-09 | AstraZeneca AB | Therapeutic agents |
| KR20080063865A (ko) | 2005-11-28 | 2008-07-07 | 에프. 호프만-라 로슈 아게 | 다이아실글리세롤 아실전이효소(ｄｇａｔ)의 저해제 |
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2006
- 2006-07-24 FR FR0606742A patent/FR2903985B1/fr not_active Expired - Fee Related
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2007
- 2007-07-19 TW TW096126382A patent/TWI388554B/zh not_active IP Right Cessation
- 2007-07-20 EP EP07823311A patent/EP2046775B1/fr active Active
- 2007-07-20 CA CA2656716A patent/CA2656716C/fr not_active Expired - Fee Related
- 2007-07-20 ZA ZA200900228A patent/ZA200900228B/xx unknown
- 2007-07-20 JP JP2009521291A patent/JP5265541B2/ja not_active Expired - Fee Related
- 2007-07-20 EA EA200970149A patent/EA016829B1/ru not_active IP Right Cessation
- 2007-07-20 CN CN200780028161XA patent/CN101495469B/zh not_active Expired - Fee Related
- 2007-07-20 MY MYPI20090316A patent/MY147465A/en unknown
- 2007-07-20 SI SI200731056T patent/SI2046775T1/sl unknown
- 2007-07-20 PL PL07823311T patent/PL2046775T3/pl unknown
- 2007-07-20 MX MX2009000649A patent/MX2009000649A/es active IP Right Grant
- 2007-07-20 KR KR1020097001656A patent/KR20090042239A/ko not_active Application Discontinuation
- 2007-07-20 DK DK07823311.1T patent/DK2046775T3/da active
- 2007-07-20 AR ARP070103239A patent/AR061946A1/es not_active Application Discontinuation
- 2007-07-20 ES ES07823311T patent/ES2393630T3/es active Active
- 2007-07-20 BR BRPI0714559-4A2A patent/BRPI0714559A2/pt not_active IP Right Cessation
- 2007-07-20 ME MEP-18/09A patent/ME00584A/xx unknown
- 2007-07-20 NZ NZ574265A patent/NZ574265A/en not_active IP Right Cessation
- 2007-07-20 PT PT07823311T patent/PT2046775E/pt unknown
- 2007-07-20 PE PE2007000947A patent/PE20080947A1/es not_active Application Discontinuation
- 2007-07-20 AU AU2007279166A patent/AU2007279166C1/en not_active Ceased
- 2007-07-20 WO PCT/FR2007/001250 patent/WO2008012418A1/fr active Application Filing
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2008
- 2008-12-22 IL IL196113A patent/IL196113A0/en not_active IP Right Cessation
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2009
- 2009-01-15 CO CO09002769A patent/CO6150146A2/es unknown
- 2009-01-23 US US12/358,639 patent/US8227489B2/en not_active Expired - Fee Related
- 2009-02-13 NO NO20090726A patent/NO20090726L/no not_active Application Discontinuation
- 2009-02-13 MA MA31637A patent/MA30694B1/fr unknown
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2012
- 2012-06-22 US US13/530,261 patent/US8481745B2/en not_active Expired - Fee Related
- 2012-11-08 CY CY20121101063T patent/CY1113470T1/el unknown
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