JP2005502621A - インターロイキン２阻害剤および抗菌剤を含む局所投与用組成物 - Google Patents
インターロイキン２阻害剤および抗菌剤を含む局所投与用組成物 Download PDFInfo
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- JP2005502621A JP2005502621A JP2003510107A JP2003510107A JP2005502621A JP 2005502621 A JP2005502621 A JP 2005502621A JP 2003510107 A JP2003510107 A JP 2003510107A JP 2003510107 A JP2003510107 A JP 2003510107A JP 2005502621 A JP2005502621 A JP 2005502621A
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- Prior art keywords
- hydrogen atom
- hydroxy
- alkyl
- antibacterial agent
- inhibitor
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- 239000000203 mixture Substances 0.000 title claims abstract description 39
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- 239000004480 active ingredient Substances 0.000 claims abstract description 16
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- 238000000034 method Methods 0.000 claims abstract description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 53
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 46
- 125000000217 alkyl group Chemical group 0.000 claims description 42
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- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims description 24
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- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 10
- 125000000623 heterocyclic group Chemical group 0.000 claims description 9
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- WUWFMDMBOJLQIV-UHFFFAOYSA-N 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Chemical compound C1C(N)CCN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1=CC=C(F)C=C1F WUWFMDMBOJLQIV-UHFFFAOYSA-N 0.000 claims description 5
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 claims description 5
- GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 claims description 5
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- XBJBPGROQZJDOJ-UHFFFAOYSA-N fleroxacin Chemical compound C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN(CCF)C2=C1F XBJBPGROQZJDOJ-UHFFFAOYSA-N 0.000 claims description 5
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- 229960003376 levofloxacin Drugs 0.000 claims description 5
- ZEKZLJVOYLTDKK-UHFFFAOYSA-N lomefloxacin Chemical compound FC1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNC(C)C1 ZEKZLJVOYLTDKK-UHFFFAOYSA-N 0.000 claims description 5
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 claims description 5
- 229960001180 norfloxacin Drugs 0.000 claims description 5
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 claims description 5
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- 229920006395 saturated elastomer Polymers 0.000 claims description 5
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- 229950008187 tosufloxacin Drugs 0.000 claims description 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 229960004954 sparfloxacin Drugs 0.000 claims description 4
- DZZWHBIBMUVIIW-DTORHVGOSA-N sparfloxacin Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=C(F)C(N)=C2C(=O)C(C(O)=O)=CN(C3CC3)C2=C1F DZZWHBIBMUVIIW-DTORHVGOSA-N 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims description 4
- -1 3,4-dioxocyclohexyl Chemical group 0.000 description 85
- 108010002350 Interleukin-2 Proteins 0.000 description 18
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- 238000012360 testing method Methods 0.000 description 11
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 9
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- 125000001424 substituent group Chemical group 0.000 description 9
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- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 7
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- SVSARCCKBMZNMR-UHFFFAOYSA-N [1-[2-[methyl-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethyl]amino]ethyl]pyridin-4-ylidene]methyl-oxoazanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1CCN(C)CCN1C=CC(=C[NH+]=O)C=C1 SVSARCCKBMZNMR-UHFFFAOYSA-N 0.000 description 4
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Otolaryngology (AREA)
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- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| US30314801P | 2001-07-06 | 2001-07-06 | |
| PCT/JP2002/006670 WO2003004098A1 (en) | 2001-07-06 | 2002-07-02 | Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent |
Publications (2)
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| JP2005502621A true JP2005502621A (ja) | 2005-01-27 |
| JP2005502621A5 JP2005502621A5 (enExample) | 2006-01-05 |
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| EP (1) | EP1406700A1 (enExample) |
| JP (1) | JP2005502621A (enExample) |
| KR (1) | KR20040019034A (enExample) |
| CN (1) | CN1259049C (enExample) |
| AR (1) | AR036127A1 (enExample) |
| CA (1) | CA2452372A1 (enExample) |
| NZ (1) | NZ530845A (enExample) |
| WO (1) | WO2003004098A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016516761A (ja) * | 2013-04-09 | 2016-06-09 | クレスセット バイオモレキュラー ディスカバリー リミテッド | 炎症性眼疾患の局所治療 |
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| EP1406700A1 (en) | 2001-07-06 | 2004-04-14 | Sucampo AG | Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent |
| BR0313425A (pt) * | 2002-08-09 | 2005-07-05 | Sucampo Pharmaceuticals Inc | Composição oftálmica para tratamento de alergia ocular, uso do composto de macrolìdeo e pacote comercial |
| US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| GB0307862D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| US7083802B2 (en) | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| JP2007505932A (ja) * | 2003-09-18 | 2007-03-15 | マクサイト， インコーポレイテッド | 経強膜送達 |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| KR101140039B1 (ko) * | 2004-01-26 | 2012-05-02 | (주)아모레퍼시픽 | 진세노사이드 ｆ1 또는 화합물 ｋ를 함유하는 피부외용제조성물 |
| US7135455B2 (en) * | 2004-11-15 | 2006-11-14 | Allergan, Inc | Methods for the therapeutic use of cyclosporine components |
| US7151085B2 (en) | 2004-11-15 | 2006-12-19 | Allergan, Inc. | Therapeutic methods using cyclosporine components |
| US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| CA2597590A1 (en) | 2005-02-09 | 2006-08-17 | Macusight, Inc. | Formulations for ocular treatment |
| KR101478164B1 (ko) | 2006-02-09 | 2014-12-31 | 산텐 세이야꾸 가부시키가이샤 | 안정한 제제와 그 제조 및 사용 방법 |
| AU2007230964B2 (en) | 2006-03-23 | 2012-07-19 | Santen Pharmaceutical Co., Ltd. | Formulations and methods for vascular permeability-related diseases or conditions |
| CA2654510C (en) | 2006-06-16 | 2015-03-17 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
| JP5668476B2 (ja) | 2007-10-08 | 2015-02-12 | オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物 |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| EP2440185B1 (en) * | 2009-06-09 | 2015-04-08 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| CA2824515C (en) | 2011-01-18 | 2022-09-13 | Bioniz, Llc | Compositions and methods for modulating gamma-c-cytokine activity |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| EP3978512A1 (en) | 2015-10-09 | 2022-04-06 | Bioniz, LLC | Modulating gamma-c-cytokine activity |
| KR20210157427A (ko) | 2015-12-03 | 2021-12-28 | 리제너론 파마슈티칼스 인코포레이티드 | 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법 |
| KR102707650B1 (ko) | 2017-04-07 | 2024-09-19 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-c-사이토카인 활성의 안정한 조절자 |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| BR112021021878A2 (pt) | 2019-05-03 | 2022-01-18 | Bioniz Llc | Modulação dos efeitos de sinalização da gama-c-citocina para tratamento da alopecia e distúrbios associados |
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| US4117118A (en) | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| FI65914C (fi) | 1978-03-07 | 1984-08-10 | Sandoz Ag | Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a |
| US4215199A (en) | 1978-06-05 | 1980-07-29 | Sandoz Ltd. | Antibiotic production |
| SE448386B (sv) | 1978-10-18 | 1987-02-16 | Sandoz Ag | Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem |
| ES2099112T3 (es) | 1990-09-04 | 1997-05-16 | Fujisawa Pharmaceutical Co | Pomadas que contienen un compuesto triciclico. |
| US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
| US5348966A (en) * | 1990-10-24 | 1994-09-20 | Fujisawa Pharmaceutical Co., Ltd. | Method for treating pyoderma and Sezary's syndrome using FK 506 and related compounds |
| ES2154262T3 (es) | 1991-04-26 | 2001-04-01 | Fujisawa Pharmaceutical Co | Uso de compuestos macrolidos para enfermedades oculares. |
| IT1253711B (it) * | 1991-12-17 | 1995-08-23 | Alfa Wassermann Spa | Formulazioni farmaceutiche vaginali contenenti rifaximin e loro uso nel trattamento delle infezioni vaginali |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5340572A (en) * | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
| JPH06345646A (ja) * | 1993-06-08 | 1994-12-20 | Fujisawa Pharmaceut Co Ltd | ローション剤 |
| US5489435A (en) * | 1993-07-06 | 1996-02-06 | Ratcliff; Perry A. | Composition for treatment of abnormal conditions of the epithelium of bodily orifices |
| CA2194049A1 (en) * | 1994-06-28 | 1996-01-11 | Georgi Stankov | Novel clinical uses of polyene macrolides |
| US6087358A (en) * | 1995-06-26 | 2000-07-11 | Pathogenesis Corporation | Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof |
| US5885601A (en) * | 1996-04-05 | 1999-03-23 | Family Health International | Use of macrolide antibiotics for nonsurgical female sterilization and endometrial ablation |
| US5929086A (en) * | 1996-05-10 | 1999-07-27 | Pharmacia & Upjohn Company | Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases |
| US6248776B1 (en) * | 1997-08-26 | 2001-06-19 | Bioavailability Systems, L.L.C. | Anti-first-pass effect compounds |
| US5912255A (en) * | 1998-02-27 | 1999-06-15 | Bussell; Letantia | Topical fluoroquinolone antibiotics combined with benzoyl peroxide |
| US6312715B1 (en) * | 1998-05-01 | 2001-11-06 | 3M Innovative Properties Company | Adhesive microsphere drug delivery composition |
| AUPP437698A0 (en) * | 1998-06-30 | 1998-07-23 | Baumgart, Karl | Methods for treatment of coronary, carotid and other vascular disease |
| US6864232B1 (en) * | 1998-12-24 | 2005-03-08 | Sucampo Ag | Agent for treating visual cell function disorder |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6174859B1 (en) * | 1999-04-06 | 2001-01-16 | J & D Sciences, Inc. | Method of treatment |
| US7063857B1 (en) * | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
| CZ20013769A3 (cs) | 1999-04-30 | 2002-03-13 | Sucampo Ag | Činidlo pro léčbu suchého oka |
| DE60006262T2 (de) * | 1999-09-24 | 2004-05-13 | Alcon, Inc. | Topische suspensionsformulierungen enthaltend ciprofloxacin und dexamethason |
| AR033151A1 (es) | 2001-04-12 | 2003-12-03 | Sucampo Pharmaceuticals Inc | Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares |
| EP1406700A1 (en) | 2001-07-06 | 2004-04-14 | Sucampo AG | Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent |
| US20030114416A1 (en) * | 2001-08-14 | 2003-06-19 | Pharmacia Corporation | Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate |
| AU2002366028A1 (en) * | 2001-11-21 | 2003-06-10 | Sucampo Ag | Use of fk506 and analogues for treating allergic diseases |
| JP2006503812A (ja) * | 2002-07-17 | 2006-02-02 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | アロステリックカルボキシルマトリックスメタロプロテイナーゼ−１３阻害薬とセレコキシブまたはバルデコキシブではない選択的シクロオキシゲナーゼ−２阻害薬との組み合わせ |
| BR0313425A (pt) * | 2002-08-09 | 2005-07-05 | Sucampo Pharmaceuticals Inc | Composição oftálmica para tratamento de alergia ocular, uso do composto de macrolìdeo e pacote comercial |
| AR042890A1 (es) * | 2003-01-16 | 2005-07-06 | Sucampo Pharmaceuticals Inc | Metodo de tratamiento del ojo seco con una composicion oftalmica que contiene un compuesto macrolido |
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2002
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- 2002-07-02 WO PCT/JP2002/006670 patent/WO2003004098A1/en not_active Ceased
- 2002-07-02 CN CNB028135768A patent/CN1259049C/zh not_active Expired - Fee Related
- 2002-07-02 CA CA002452372A patent/CA2452372A1/en not_active Abandoned
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016516761A (ja) * | 2013-04-09 | 2016-06-09 | クレスセット バイオモレキュラー ディスカバリー リミテッド | 炎症性眼疾患の局所治療 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1524003A (zh) | 2004-08-25 |
| AR036127A1 (es) | 2004-08-11 |
| WO2003004098A8 (en) | 2003-02-27 |
| WO2003004098A1 (en) | 2003-01-16 |
| EP1406700A1 (en) | 2004-04-14 |
| US20030044452A1 (en) | 2003-03-06 |
| US20060034892A1 (en) | 2006-02-16 |
| KR20040019034A (ko) | 2004-03-04 |
| CA2452372A1 (en) | 2003-01-16 |
| NZ530845A (en) | 2006-03-31 |
| US7033604B2 (en) | 2006-04-25 |
| CN1259049C (zh) | 2006-06-14 |
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