CA2701868C - Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors - Google Patents

Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors Download PDF

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CA2701868C
CA2701868C CA2701868A CA2701868A CA2701868C CA 2701868 C CA2701868 C CA 2701868C CA 2701868 A CA2701868 A CA 2701868A CA 2701868 A CA2701868 A CA 2701868A CA 2701868 C CA2701868 C CA 2701868C
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CA2701868A1 (en
Inventor
Gordon Saxty
Valerio Berdini
Christopher William Murray
Charlotte Mary Griffiths-Jones
Emma Vickerstaffe
Gilbert Ebai Besong
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00Drugs for disorders of the respiratory system
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    • A61P11/00Drugs for disorders of the respiratory system
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    • A61P35/00Antineoplastic agents
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    • A61P35/00Antineoplastic agents
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    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
CA2701868A 2007-10-12 2008-10-10 Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors Active CA2701868C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US97958907P 2007-10-12 2007-10-12
GBGB0720038.9A GB0720038D0 (en) 2007-10-12 2007-10-12 New compounds
GB0720038.9 2007-10-12
US60/979,589 2007-10-12
US6117208P 2008-06-13 2008-06-13
US61/061,172 2008-06-13
PCT/GB2008/003439 WO2009047522A1 (en) 2007-10-12 2008-10-10 Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
CA2701868A1 CA2701868A1 (en) 2009-04-16
CA2701868C true CA2701868C (en) 2016-07-19

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2701868A Active CA2701868C (en) 2007-10-12 2008-10-10 Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors

Country Status (16)

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US (2) US8071614B2 (enExample)
EP (1) EP2203449B1 (enExample)
JP (1) JP5562858B2 (enExample)
AU (1) AU2008309342C1 (enExample)
CA (1) CA2701868C (enExample)
CY (1) CY1117820T1 (enExample)
ES (1) ES2585352T3 (enExample)
GB (1) GB0720038D0 (enExample)
HR (1) HRP20160852T1 (enExample)
HU (1) HUE028999T2 (enExample)
ME (1) ME02815B (enExample)
PL (1) PL2203449T3 (enExample)
PT (1) PT2203449T (enExample)
RS (1) RS55045B1 (enExample)
SI (1) SI2203449T1 (enExample)
WO (1) WO2009047522A1 (enExample)

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