PE20151776A1 - Compuestos de heteroarilo y sus usos - Google Patents
Compuestos de heteroarilo y sus usosInfo
- Publication number
- PE20151776A1 PE20151776A1 PE2015002022A PE2015002022A PE20151776A1 PE 20151776 A1 PE20151776 A1 PE 20151776A1 PE 2015002022 A PE2015002022 A PE 2015002022A PE 2015002022 A PE2015002022 A PE 2015002022A PE 20151776 A1 PE20151776 A1 PE 20151776A1
- Authority
- PE
- Peru
- Prior art keywords
- diseases
- optionally substituted
- compounds
- bivalent
- halogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, EN LOS CUALES X1 ES NH, N, CH2 o CH, ENTRE OTROS; X2 ES NH, N, CH2 o CH, ENTRE OTROS; X3 Y X4 SON INDEPENDIENTEMENTE N o CH, ENTRE OTROS; X5 ES N, C o CH; EN DONDE AL MENOS UNO DE X1, X2, X3, X4 o X5 ES N; G ES H, O, OH o NH2, ENTRE OTROS; A ES FENILO OPCIONALMENTE SUSTITUIDO, UN ANILLO CARBOCICLICO C3-8 OPCIONALMENTE SUSTITUIDO, O UN ANILLO HETEROCICLICO DE 4-7 MIEMBROS CONTENIENDO 1-4 HETEROATOMOS (O, N o S) OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R1 ES -L-Y, DONDE L ES UNA CADENA DE HIDROCARBURO C2-8 BIVALENTE, ENTRE OTROS, E Y ES H, HALOGENO, NO2 O CN, ENTRE OTROS; CADA R2 ES INDEPENDIENTEMENTE H, HALOGENO, OH, SH, CN, NO2, SO2H, C(O)H, C(O)OH, C(O)NH2, NH2, ENTRE OTROS; R3 ESTA AUSENTE, O ES H, ALQUENILO C2-6 O ALQUILO C1-6, ENTRE OTROS; Y ES O o NH, ENTRE OTROS; T ES UN ENLACE COVALENTE O UNA CADENA DE HIDROCARBURO C1-6 BIVALENTE, ENTRE OTROS; Y q ES 0-6. DICHOS COMPUESTOS SON INHIBIDORES DE UNA O VARIAS PROTEINAS CINASAS (EN PARTICULAR DE FGFR4) QUE CONTIENEN UN RESIDUO DE CISTEINA EN EL SITIO DE UNION A ATP, POR LO CUAL SON UTILES EN LA TERAPIA DE UNA VARIEDAD DE ENFERMEDADES, TRASTORNOS O AFECCIONES ASICOADAS CON RESPUESTAS CELULARES ANORMALES DESENCADENADAS POR EVENTOS MEDIADOS POR PROTEINAS CINASAS, PARTICULARMENTE PREVENIR EL CRECIMIENTO O INDUCIR LA APOPTOSIS DE TUMORES, EN ESPECIAL AL INHIBIR LA ANGIOGENESIS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361793113P | 2013-03-15 | 2013-03-15 | |
EP14305361 | 2014-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20151776A1 true PE20151776A1 (es) | 2015-12-11 |
Family
ID=50390019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015002022A PE20151776A1 (es) | 2013-03-15 | 2014-03-14 | Compuestos de heteroarilo y sus usos |
Country Status (13)
Country | Link |
---|---|
US (1) | US9663524B2 (es) |
EP (1) | EP2968337B1 (es) |
JP (1) | JP6576325B2 (es) |
KR (1) | KR102219695B1 (es) |
CN (2) | CN111793068A (es) |
AU (1) | AU2014228746B2 (es) |
BR (1) | BR112015022191A8 (es) |
EA (1) | EA036160B1 (es) |
MA (1) | MA38393B1 (es) |
MX (1) | MX2015011514A (es) |
PE (1) | PE20151776A1 (es) |
SG (1) | SG11201507478VA (es) |
WO (1) | WO2014144737A1 (es) |
Families Citing this family (61)
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GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
PT3176170T (pt) | 2012-06-13 | 2019-02-05 | Incyte Holdings Corp | Compostos tricíclicos substituídos como inibidores de fgfr |
ES2916220T3 (es) | 2012-07-11 | 2022-06-29 | Blueprint Medicines Corp | Inhibidores del receptor de factor de crecimiento de fibroblasto |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
MX2015011514A (es) | 2013-03-15 | 2016-08-11 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y sus usos. |
TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
CA2907243C (en) | 2013-03-15 | 2021-12-28 | Celgene Avilomics Research, Inc. | Substituted dihydropyrimidopyrimidinone compounds and pharmaceutical compositions thereof use fgfr4 inhibitor |
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PE20160546A1 (es) | 2013-10-25 | 2016-05-26 | Novartis Ag | Compuestos derivados de piridilo biciclicos fusionados a anillo como inhibidores de fgfr4 |
US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
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CN111936493B (zh) * | 2018-06-19 | 2023-05-26 | 上海和誉生物医药科技有限公司 | 一种高选择性FGFRi抑制剂及其制备方法和应用 |
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EP2968337B1 (en) | 2021-07-21 |
CN105307657A (zh) | 2016-02-03 |
WO2014144737A1 (en) | 2014-09-18 |
KR102219695B1 (ko) | 2021-02-25 |
AU2014228746B2 (en) | 2018-08-30 |
AU2014228746A1 (en) | 2015-09-10 |
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JP2016519673A (ja) | 2016-07-07 |
MA38393B1 (fr) | 2018-11-30 |
EP2968337A4 (en) | 2016-10-19 |
BR112015022191A2 (pt) | 2017-10-10 |
CN105307657B (zh) | 2020-07-10 |
EP2968337A1 (en) | 2016-01-20 |
US9663524B2 (en) | 2017-05-30 |
MA38393A3 (fr) | 2018-05-31 |
CN111793068A (zh) | 2020-10-20 |
BR112015022191A8 (pt) | 2018-01-23 |
MX2015011514A (es) | 2016-08-11 |
JP6576325B2 (ja) | 2019-09-18 |
US20160046634A1 (en) | 2016-02-18 |
KR20150131237A (ko) | 2015-11-24 |
SG11201507478VA (en) | 2015-10-29 |
EA201591420A1 (ru) | 2016-02-29 |
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