MX337258B - Compuestos utiles para tratar sindrome de inmunodeficiencia adquirida (sida). - Google Patents

Compuestos utiles para tratar sindrome de inmunodeficiencia adquirida (sida).

Info

Publication number
MX337258B
MX337258B MX2013006322A MX2013006322A MX337258B MX 337258 B MX337258 B MX 337258B MX 2013006322 A MX2013006322 A MX 2013006322A MX 2013006322 A MX2013006322 A MX 2013006322A MX 337258 B MX337258 B MX 337258B
Authority
MX
Mexico
Prior art keywords
group
nrarb
hydrogen atom
nra
treating aids
Prior art date
Application number
MX2013006322A
Other languages
English (en)
Other versions
MX2013006322A (es
Inventor
Jamal Tazi
Florence Mahuteau
Romain Najman
Didier Scherrer
Noëlie Campos
Aude Garcel
Original Assignee
Abivax
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abivax filed Critical Abivax
Publication of MX2013006322A publication Critical patent/MX2013006322A/es
Publication of MX337258B publication Critical patent/MX337258B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

La presente invención se refiere a un compuesto de fórmula (I) para uso como un agente que previene, inhibe o trata el SIDA. La presente invención además se refiere a compuestos de fórmula (I), en donde: X es CR0 o N; R0, R1, R2, R3, R4, R7 y R8 representan independientemente un átomo de hidrógeno, un átomo de halógeno o un grupo elegido entre un grupo alquilo (C1-C5), un grupo cicloalquilo (C3.C6), un grupo fluoroalquilo (C1-C5), un grupo alcoxi (C1-C5), un grupo fluoroalcoxi (C1-C5), un grupo -CN, un grupo COORa, un grupo -NO2, un grupo -NRaRb, un grupo -NRa-SO2-NRaRb, un grupo -NRa- SO2Ra, un grupo -NRa-C (=O) -Ra, un grupo -NRaC (=O) -NRaRb, un grupo -SO2-NRaRb, un grupo -SO3H, un grupo -OH, un grupo -O- SO2-ORc, un grupo -O-P(=O) - (ORc) (ORd), un grupo -O-CH2-COORc y puede ser además un grupo elegido entre: (Ila), (IIIa), R5 representa un átomo de hidrógeno, un grupo alquilo (C1-C5) o un grupo cicloalquilo (C3-C6); R10 es un átomo de hidrógeno o un átomo de cloro, y R11 es un átomo de hidrógeno o un grupo alquilo (C1-C4), o cualquiera de sus sales farmacéuticamente aceptables.
MX2013006322A 2010-12-15 2011-12-13 Compuestos utiles para tratar sindrome de inmunodeficiencia adquirida (sida). MX337258B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10306417A EP2465502A1 (en) 2010-12-15 2010-12-15 Compounds useful for treating AIDS
PCT/IB2011/055643 WO2012080953A1 (en) 2010-12-15 2011-12-13 Compounds useful for treating aids

Publications (2)

Publication Number Publication Date
MX2013006322A MX2013006322A (es) 2013-10-25
MX337258B true MX337258B (es) 2016-02-22

Family

ID=43755105

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006322A MX337258B (es) 2010-12-15 2011-12-13 Compuestos utiles para tratar sindrome de inmunodeficiencia adquirida (sida).

Country Status (19)

Country Link
US (1) US9061999B2 (es)
EP (2) EP2465502A1 (es)
JP (1) JP6049630B2 (es)
KR (1) KR101749232B1 (es)
CN (1) CN103415290B (es)
AR (1) AR084277A1 (es)
AU (1) AU2011342826B2 (es)
BR (1) BR112013014943B1 (es)
CA (1) CA2819317C (es)
CU (1) CU20130080A7 (es)
DK (1) DK2651416T3 (es)
ES (1) ES2681539T3 (es)
HR (1) HRP20181190T1 (es)
MX (1) MX337258B (es)
PL (1) PL2651416T3 (es)
PT (1) PT2651416T (es)
RU (1) RU2598845C2 (es)
WO (1) WO2012080953A1 (es)
ZA (1) ZA201303922B (es)

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KR101982461B1 (ko) 2009-06-12 2019-05-24 아비박스 조기 노화, 구체적으로 조로증을 치료하는데 유용한 화합물
US10253020B2 (en) 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
EP2757161A1 (en) 2013-01-17 2014-07-23 Splicos miRNA-124 as a biomarker of viral infection
HRP20211839T1 (hr) * 2013-07-05 2022-03-04 Abivax Biciklički spojevi korisni za liječenje bolesti uzrokovanih retrovirusima
EP2974729A1 (en) * 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
EP2975034A1 (en) * 2014-07-17 2016-01-20 Abivax A quinoline derivative for the treatment of inflammatory diseases and AIDS
EP3059236A1 (en) 2015-02-23 2016-08-24 Abivax A new quinoline derivative for use in the treatment and prevention of viral infections
EP3058940A1 (en) * 2015-02-23 2016-08-24 Abivax Quinoline derivatives for use in the treatment or prevention of viral infection
EP3059591A1 (en) * 2015-02-23 2016-08-24 Abivax Methods for screening compounds for treating or preventing a viral infection or a virus-related condition
US11130736B2 (en) * 2015-08-21 2021-09-28 University Of Kansas Human TLR8-selective agonists
ES2899926T3 (es) * 2016-03-18 2022-03-15 Prosynergia S A R L Procedimiento para preparar derivados de quinolin-2-il-fenilamina y sus sales
KR101966351B1 (ko) * 2016-06-08 2019-04-08 한국과학기술연구원 히스톤 메틸전달효소 저해용 퀴놀린 유도체 및 이의 용도
US10323289B2 (en) 2017-06-26 2019-06-18 Institut Pasteur Treatments to eliminate HIV reservoirs and reduce viral load
WO2019186277A1 (en) 2018-03-28 2019-10-03 Institut Pasteur Ultrasensitive hiv-1 p24 detection assay
EP3594206A1 (en) * 2018-07-09 2020-01-15 Abivax Phenyl-n-quinoline derivatives for treating a rna virus infection
EP3594205A1 (en) 2018-07-09 2020-01-15 Abivax Phenyl-n-aryl derivatives for treating a rna virus infection
EP3669874A1 (en) * 2018-12-20 2020-06-24 Abivax Quinoline derivatives for use in the treatment or prevention of cancer
EP3669873A1 (en) 2018-12-20 2020-06-24 Abivax Quinoline derivatives for use ine the traeatment of inflammation diseases
WO2020128033A1 (en) 2018-12-20 2020-06-25 Institut Pasteur Cellular metabolism of hiv-1 reservoir seeding in cd4+ t cells
CN109776498B (zh) * 2019-03-13 2020-04-07 浙江永宁药业股份有限公司 一种西洛他唑的制备方法
EP4063351A1 (en) * 2021-03-26 2022-09-28 Abivax Preparation method of quinoline derivative compounds
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
EP4215196A1 (en) 2022-01-24 2023-07-26 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a jak inhibitor
WO2024109936A1 (zh) * 2022-11-25 2024-05-30 江苏恒瑞医药股份有限公司 一种喹啉胺类化合物晶型及其制备方法

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Also Published As

Publication number Publication date
ZA201303922B (en) 2014-07-30
JP6049630B2 (ja) 2016-12-21
EP2651416A1 (en) 2013-10-23
AR084277A1 (es) 2013-05-02
ES2681539T3 (es) 2018-09-13
BR112013014943A2 (pt) 2016-09-13
BR112013014943B1 (pt) 2022-05-03
KR101749232B1 (ko) 2017-07-03
KR20140041402A (ko) 2014-04-04
BR112013014943A8 (pt) 2018-06-12
RU2598845C2 (ru) 2016-09-27
CA2819317C (en) 2017-02-28
CN103415290B (zh) 2016-09-14
US20130267703A1 (en) 2013-10-10
PT2651416T (pt) 2018-07-30
CU20130080A7 (es) 2013-08-29
WO2012080953A1 (en) 2012-06-21
HRP20181190T1 (hr) 2019-03-08
AU2011342826A1 (en) 2013-07-04
EP2651416B1 (en) 2018-05-09
AU2011342826B2 (en) 2016-02-11
CA2819317A1 (en) 2012-06-21
US9061999B2 (en) 2015-06-23
EP2465502A1 (en) 2012-06-20
CN103415290A (zh) 2013-11-27
RU2013126947A (ru) 2015-01-20
MX2013006322A (es) 2013-10-25
PL2651416T3 (pl) 2018-09-28
JP2013545798A (ja) 2013-12-26
DK2651416T3 (en) 2018-08-06

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