CU24674B1 - Derivados de fenil-n-quinolina y proceso para su preparación - Google Patents
Derivados de fenil-n-quinolina y proceso para su preparaciónInfo
- Publication number
- CU24674B1 CU24674B1 CU2021000006A CU20210006A CU24674B1 CU 24674 B1 CU24674 B1 CU 24674B1 CU 2021000006 A CU2021000006 A CU 2021000006A CU 20210006 A CU20210006 A CU 20210006A CU 24674 B1 CU24674 B1 CU 24674B1
- Authority
- CU
- Cuba
- Prior art keywords
- group
- phenyl
- cycloalkyl
- preparation
- orc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
<p>La presente invención se refiere a un compuesto de fórmula (I) o a la sal trifluoroacetato del mismo </p> <p>ESPACIO PARA LA FÓRMULA</p> <p>en donde R3 representa un átomo de cloro o un átomo de hidrógeno, R representa un grupo alquilo (C1-C4), un grupo cicloalquilo (C3-C6), un átomo de halógeno, un grupo alcoxi (C1-C5), un grupo -SO2-NRaRb, un grupo -SO3H, un grupo -OH, un grupo -O-SO2-ORc o un grupo -OP (= O) - (ORc) (ORd), R1 representa (i) un grupo CF3, (ii) un grupo alquilo (C1-C10), (iii) un grupo cicloalquilo (C3-C6) o un grupo heterocicloalquilo (C3-C6) o (iv) un grupo fenilo o un grupo naftilo, y R2 representa un átomo de hidrógeno, un grupo alquilo (C1-C10), un cicloalquilo (C3-C6) o un grupo heterocicloalquilo (C3-C6). La presente invención se refiere además a nuevos compuestos y al proceso de síntesis para manufacturarlos.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18305910.4A EP3594206A1 (en) | 2018-07-09 | 2018-07-09 | Phenyl-n-quinoline derivatives for treating a rna virus infection |
PCT/EP2019/068459 WO2020011810A1 (en) | 2018-07-09 | 2019-07-09 | Phenyl-n-quinoline derivatives for treating a rna virus infection |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20210006A7 CU20210006A7 (es) | 2021-08-06 |
CU24674B1 true CU24674B1 (es) | 2023-08-08 |
Family
ID=63035966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2021000006A CU24674B1 (es) | 2018-07-09 | 2019-07-09 | Derivados de fenil-n-quinolina y proceso para su preparación |
Country Status (10)
Country | Link |
---|---|
US (2) | US12084422B2 (es) |
EP (2) | EP3594206A1 (es) |
JP (2) | JP7504409B2 (es) |
KR (1) | KR20210052432A (es) |
CN (1) | CN112566899B (es) |
BR (1) | BR112021000331A2 (es) |
CA (1) | CA3103867A1 (es) |
CU (1) | CU24674B1 (es) |
MX (1) | MX2021000089A (es) |
WO (1) | WO2020011810A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3881844A1 (en) | 2020-03-20 | 2021-09-22 | Abivax | Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection |
EP3884946A1 (en) | 2020-03-25 | 2021-09-29 | Abivax | Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection |
EP4121053A1 (en) | 2020-03-20 | 2023-01-25 | Abivax | Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
FR2830862A1 (fr) | 2001-10-16 | 2003-04-18 | Lipha | Derives nitroso de la diphenylamine a fonction ether ou thioether, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments |
FR2836917B1 (fr) | 2002-03-11 | 2006-02-24 | Lipha | Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif |
KR20060119871A (ko) | 2003-08-21 | 2006-11-24 | 오에스아이 파마슈티컬스, 인코포레이티드 | N3―치환된 이미다조피리딘 c―kit 억제제 |
FR2859474B1 (fr) | 2003-09-04 | 2006-01-13 | Centre Nat Rech Scient | Utilisation de composes derives d'indole pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage |
BRPI0417811A (pt) | 2003-12-18 | 2007-03-27 | Tibotec Pharm Ltd | aminobenzimidazóis e benzimidazóis como inibidores da replicação do vìrus sincicial respiratório |
FR2866647B1 (fr) * | 2004-02-20 | 2006-10-27 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
EP1794135A1 (en) | 2004-09-27 | 2007-06-13 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
WO2006097534A1 (en) | 2005-03-17 | 2006-09-21 | Tibotec Pharmaceuticals Ltd | 1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication |
US9409856B2 (en) | 2005-11-28 | 2016-08-09 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
DE602006015861D1 (de) | 2005-12-21 | 2010-09-09 | Abbott Lab | Antivirale verbindungen |
ES2395386T3 (es) | 2005-12-21 | 2013-02-12 | Abbott Laboratories | Compuestos antivirales |
FR2901273B1 (fr) | 2006-05-19 | 2010-12-24 | Anaconda Pharma | Inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant |
FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
US20140187641A1 (en) | 2012-08-23 | 2014-07-03 | Gtx | Estrogen receptor ligands and methods of use thereof |
KR101982461B1 (ko) | 2009-06-12 | 2019-05-24 | 아비박스 | 조기 노화, 구체적으로 조로증을 치료하는데 유용한 화합물 |
UY33463A (es) | 2010-06-24 | 2012-01-31 | Takeda Pharmaceutical | Compuestos heterocíclicos fusionados |
EP2465502A1 (en) * | 2010-12-15 | 2012-06-20 | Société Splicos | Compounds useful for treating AIDS |
EP2505198A1 (en) | 2011-04-01 | 2012-10-03 | Société Splicos | Compounds for use as therapeutic agents affecting p53 expression and/or activity |
WO2014164667A1 (en) | 2013-03-11 | 2014-10-09 | Georgetown University | Dengue and west nile virus protease inhibitors |
HRP20211839T1 (hr) * | 2013-07-05 | 2022-03-04 | Abivax | Biciklički spojevi korisni za liječenje bolesti uzrokovanih retrovirusima |
RU2628800C2 (ru) | 2014-03-12 | 2017-08-22 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами |
EP3058940A1 (en) * | 2015-02-23 | 2016-08-24 | Abivax | Quinoline derivatives for use in the treatment or prevention of viral infection |
EP3059591A1 (en) * | 2015-02-23 | 2016-08-24 | Abivax | Methods for screening compounds for treating or preventing a viral infection or a virus-related condition |
ES2899926T3 (es) | 2016-03-18 | 2022-03-15 | Prosynergia S A R L | Procedimiento para preparar derivados de quinolin-2-il-fenilamina y sus sales |
-
2018
- 2018-07-09 EP EP18305910.4A patent/EP3594206A1/en not_active Ceased
-
2019
- 2019-07-09 CN CN201980045917.4A patent/CN112566899B/zh active Active
- 2019-07-09 EP EP19737536.3A patent/EP3820852A1/en active Pending
- 2019-07-09 KR KR1020217001298A patent/KR20210052432A/ko not_active Application Discontinuation
- 2019-07-09 CA CA3103867A patent/CA3103867A1/en active Pending
- 2019-07-09 BR BR112021000331-2A patent/BR112021000331A2/pt unknown
- 2019-07-09 CU CU2021000006A patent/CU24674B1/es unknown
- 2019-07-09 US US17/259,364 patent/US12084422B2/en active Active
- 2019-07-09 WO PCT/EP2019/068459 patent/WO2020011810A1/en active Application Filing
- 2019-07-09 JP JP2021500215A patent/JP7504409B2/ja active Active
- 2019-07-09 MX MX2021000089A patent/MX2021000089A/es unknown
-
2023
- 2023-10-17 JP JP2023179000A patent/JP2024053563A/ja active Pending
-
2024
- 2024-05-10 US US18/660,578 patent/US20240308964A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3820852A1 (en) | 2021-05-19 |
AU2019300100A1 (en) | 2021-01-21 |
JP2024053563A (ja) | 2024-04-15 |
JP7504409B2 (ja) | 2024-06-24 |
US12084422B2 (en) | 2024-09-10 |
EP3594206A1 (en) | 2020-01-15 |
KR20210052432A (ko) | 2021-05-10 |
CU20210006A7 (es) | 2021-08-06 |
WO2020011810A1 (en) | 2020-01-16 |
JP2021524481A (ja) | 2021-09-13 |
US20210309611A1 (en) | 2021-10-07 |
CN112566899B (zh) | 2024-01-30 |
BR112021000331A2 (pt) | 2021-04-06 |
CA3103867A1 (en) | 2020-01-16 |
CN112566899A (zh) | 2021-03-26 |
MX2021000089A (es) | 2021-03-25 |
US20240308964A1 (en) | 2024-09-19 |
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