CY1123514T1 - Κρυσταλλικο 2-φθορο-3-νιτροτολουολιο και διαδικασια για την παρασκευη του - Google Patents

Κρυσταλλικο 2-φθορο-3-νιτροτολουολιο και διαδικασια για την παρασκευη του

Info

Publication number
CY1123514T1
CY1123514T1 CY20201100873T CY201100873T CY1123514T1 CY 1123514 T1 CY1123514 T1 CY 1123514T1 CY 20201100873 T CY20201100873 T CY 20201100873T CY 201100873 T CY201100873 T CY 201100873T CY 1123514 T1 CY1123514 T1 CY 1123514T1
Authority
CY
Cyprus
Prior art keywords
fluoro
nitrotoluene
crystalline
preparation
formula
Prior art date
Application number
CY20201100873T
Other languages
English (en)
Inventor
Elena Brasola
Marco Di Silvestro
Original Assignee
F.I.S.- Fabbrica Italiana Sintetici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.I.S.- Fabbrica Italiana Sintetici S.P.A. filed Critical F.I.S.- Fabbrica Italiana Sintetici S.P.A.
Publication of CY1123514T1 publication Critical patent/CY1123514T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/16—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μια ένωση κρυσταλλικού 2-φθορο-3-νιτροτολουολίου του τύπου (Ι) και σε μια διαδικασία για την παρασκευή του. Περαιτέρω, η παρούσα εφεύρεση αναφέρεται σε μια διαδικασία για τη σύνθεση μιας ένωσης του τύπου (II) ή αλάτων αυτής μέσω του κρυσταλλικού 2-φθορο-3-νιτροτολουολίου.
CY20201100873T 2018-07-09 2020-09-15 Κρυσταλλικο 2-φθορο-3-νιτροτολουολιο και διαδικασια για την παρασκευη του CY1123514T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18182368.3A EP3594199B1 (en) 2018-07-09 2018-07-09 Crystalline 2-fluoro-3-nitrotoluene and process for the preparation thereof

Publications (1)

Publication Number Publication Date
CY1123514T1 true CY1123514T1 (el) 2022-03-24

Family

ID=62904314

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100873T CY1123514T1 (el) 2018-07-09 2020-09-15 Κρυσταλλικο 2-φθορο-3-νιτροτολουολιο και διαδικασια για την παρασκευη του

Country Status (17)

Country Link
US (1) US20210292271A1 (el)
EP (1) EP3594199B1 (el)
JP (1) JP7407166B2 (el)
CN (1) CN112654602A (el)
AU (1) AU2019303323B2 (el)
CA (1) CA3105559A1 (el)
CY (1) CY1123514T1 (el)
DK (1) DK3594199T3 (el)
ES (1) ES2815899T3 (el)
HR (1) HRP20201198T1 (el)
HU (1) HUE052049T2 (el)
LT (1) LT3594199T (el)
MX (1) MX2021000348A (el)
PL (1) PL3594199T3 (el)
PT (1) PT3594199T (el)
SI (1) SI3594199T1 (el)
WO (1) WO2020011626A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35449A (es) 2013-03-14 2014-09-30 Amgen Inc Compuestos heterocíclicos y sus usos
SI3645518T1 (sl) 2017-06-30 2021-11-30 Amgen Inc. Sinteza omekamtiv mekarbila
BR112019028046A2 (pt) 2017-06-30 2020-07-07 Amgen Inc. métodos de tratamento da insuficiência cardíaca com ativadores de sarcômeros cardíacos
EP3681882A1 (en) 2017-09-13 2020-07-22 Amgen Inc. Bisamide sarcomere activating compounds and uses thereof
MX2021001792A (es) 2018-08-17 2021-05-27 Amgen Inc Sales y formas cristalinas de omecamtiv mecarbil.
MX2023010558A (es) 2021-03-10 2023-11-24 Amgen Inc Sintesis de omecamtiv mecarbil.
WO2024081611A1 (en) 2022-10-11 2024-04-18 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR059339A1 (es) * 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
CN101177400A (zh) 2006-11-06 2008-05-14 吕铁环 一种生产2-氟-3-硝基甲苯的方法
US8569378B2 (en) 2007-07-20 2013-10-29 Toshiyuki Sakai p27 protein inducer
TWI648273B (zh) * 2013-02-15 2019-01-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類（三）
UY35449A (es) 2013-03-14 2014-09-30 Amgen Inc Compuestos heterocíclicos y sus usos

Also Published As

Publication number Publication date
CA3105559A1 (en) 2020-01-16
HUE052049T2 (hu) 2021-04-28
AU2019303323B2 (en) 2024-08-22
US20210292271A1 (en) 2021-09-23
EP3594199A1 (en) 2020-01-15
PL3594199T3 (pl) 2020-11-16
AU2019303323A1 (en) 2021-01-28
CN112654602A (zh) 2021-04-13
HRP20201198T1 (hr) 2020-11-13
MX2021000348A (es) 2021-06-08
EP3594199B1 (en) 2020-07-01
SI3594199T1 (sl) 2020-10-30
DK3594199T3 (da) 2020-09-14
JP7407166B2 (ja) 2023-12-28
JP2021532076A (ja) 2021-11-25
WO2020011626A1 (en) 2020-01-16
ES2815899T3 (es) 2021-03-31
PT3594199T (pt) 2020-09-04
LT3594199T (lt) 2020-11-10

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