CY1123988T1 - Ενωση πυριδινης - Google Patents
Ενωση πυριδινηςInfo
- Publication number
- CY1123988T1 CY1123988T1 CY20211100228T CY211100228T CY1123988T1 CY 1123988 T1 CY1123988 T1 CY 1123988T1 CY 20211100228 T CY20211100228 T CY 20211100228T CY 211100228 T CY211100228 T CY 211100228T CY 1123988 T1 CY1123988 T1 CY 1123988T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyridine compound
- pharmaceutically acceptable
- acceptable salt
- compound
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μια ένωση που έχει δραστικότητα αναστολής της κινάσης RET, ή αναφέρεται σε ένα φαρμακευτικά αποδεκτό άλας αυτής, η οποία είναι χρήσιμη στη θεραπεία ασθενειών, όπως ο καρκίνος. Ειδικότερα μια ένωση που αντιπροσωπεύεται από τον ακόλουθο γενικό χημικό τύπο (Ι) όπως ορίζεται στο παρόν: (Ι) ή ένα φαρμακευτικά αποδεκτό άλας αυτής.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016191725A JP2018052878A (ja) | 2016-09-29 | 2016-09-29 | ピリジン化合物 |
| PCT/GB2017/052913 WO2018060714A1 (en) | 2016-09-29 | 2017-09-28 | Pyridine compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123988T1 true CY1123988T1 (el) | 2022-05-27 |
Family
ID=60020249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100228T CY1123988T1 (el) | 2016-09-29 | 2021-03-17 | Ενωση πυριδινης |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10851092B2 (el) |
| EP (2) | EP3519398B1 (el) |
| JP (2) | JP2018052878A (el) |
| KR (1) | KR102520543B1 (el) |
| CN (2) | CN113788824A (el) |
| AU (2) | AU2017335242C1 (el) |
| BR (1) | BR112019006047A2 (el) |
| CA (1) | CA3035860A1 (el) |
| CL (1) | CL2019000844A1 (el) |
| CO (1) | CO2019004034A2 (el) |
| CY (1) | CY1123988T1 (el) |
| DK (1) | DK3519398T3 (el) |
| EA (1) | EA037103B1 (el) |
| EC (1) | ECSP19030134A (el) |
| ES (1) | ES2868748T3 (el) |
| HR (1) | HRP20210447T1 (el) |
| HU (1) | HUE054824T2 (el) |
| IL (1) | IL265630B (el) |
| LT (1) | LT3519398T (el) |
| MA (2) | MA54910A (el) |
| MD (1) | MD3519398T2 (el) |
| MX (1) | MX2019003747A (el) |
| PE (1) | PE20190805A1 (el) |
| PH (1) | PH12019500480A1 (el) |
| PL (1) | PL3519398T3 (el) |
| PT (1) | PT3519398T (el) |
| RS (1) | RS61640B1 (el) |
| SG (1) | SG11201901937WA (el) |
| SI (1) | SI3519398T1 (el) |
| UA (1) | UA123964C2 (el) |
| WO (1) | WO2018060714A1 (el) |
| ZA (1) | ZA201902232B (el) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI787018B (zh) | 2015-11-02 | 2022-12-11 | 美商纜圖藥品公司 | 轉染過程重排之抑制劑 |
| JP2018052878A (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CA3087972C (en) | 2018-01-18 | 2023-01-10 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| LT3773589T (lt) | 2018-04-03 | 2024-02-12 | Blueprint Medicines Corporation | Ret inhibitorius, skirtas naudoti vėžiui gydyti, esant ret pakitimui |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| EP4062938A4 (en) * | 2019-11-18 | 2023-11-29 | Chugai Seiyaku Kabushiki Kaisha | COMBINATION MEDICINAL PRODUCTS |
| CN113121524B (zh) | 2019-12-31 | 2023-04-25 | 南京创济生物医药有限公司 | 杂环亚砜亚胺化合物及其中间体、制备方法和应用 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2021164741A1 (zh) * | 2020-02-20 | 2021-08-26 | 南京明德新药研发有限公司 | 苯基双酰胺类化合物 |
| JP7461605B2 (ja) | 2020-02-20 | 2024-04-04 | 広州白雲山医薬集団股▲フン▼有限公司白雲山制薬総廠 | キノリン系化合物 |
| WO2022238706A1 (en) | 2021-05-14 | 2022-11-17 | Bp Asset Viii, Inc. | Ret inhibitor for the treatment of ret altered medullary thyroid cancer or ret altered non-small cell lung cancer |
| WO2023239422A2 (en) | 2021-10-22 | 2023-12-14 | University Of Houston System | Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues |
| CN115090331B (zh) * | 2022-07-21 | 2023-05-16 | 扬州大学 | 超分子手性催化剂、其制备方法及其催化d-a反应的应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI284639B (en) | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| AU2004270733B2 (en) | 2003-09-11 | 2011-05-19 | Itherx Pharma, Inc. | Cytokine inhibitors |
| EP1994023A1 (en) | 2006-03-02 | 2008-11-26 | AstraZeneca AB | Quinazoline derivatives |
| WO2007099323A2 (en) | 2006-03-02 | 2007-09-07 | Astrazeneca Ab | Quinoline derivatives |
| WO2007113565A1 (en) | 2006-04-06 | 2007-10-11 | Astrazeneca Ab | Naphthyridine derivatives as anti-cancer agents |
| WO2007113548A1 (en) | 2006-04-06 | 2007-10-11 | Astrazeneca Ab | Naphthyridine derivatives |
| FR2933700B1 (fr) | 2008-07-08 | 2010-07-30 | Sanofi Aventis | Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique |
| CN102333765B (zh) * | 2009-02-27 | 2015-01-14 | 帝人制药株式会社 | 基于使用过渡金属催化剂的偶联法的苯基取代杂环衍生物的制造方法 |
| JP2013502429A (ja) | 2009-08-19 | 2013-01-24 | アムビト ビオスシエンセス コルポラチオン | ビアリール化合物及びその使用方法 |
| EP2470173B1 (en) | 2009-08-25 | 2016-04-27 | Abraxis BioScience, LLC | Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors |
| CA2798209A1 (en) | 2010-04-23 | 2011-10-27 | Kineta, Inc. | Anti-viral compounds |
| EP2651930B1 (en) | 2010-12-16 | 2015-10-28 | Boehringer Ingelheim International GmbH | Biarylamide inhibitors of leukotriene production |
| AU2013289938A1 (en) | 2012-07-13 | 2015-01-29 | Indiana University Research & Technology Corporation | Compounds for treatment of spinal muscular atrophy |
| CN105051027A (zh) | 2013-03-15 | 2015-11-11 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 |
| SG11201601341QA (en) * | 2013-08-30 | 2016-03-30 | Ambit Biosciences Corp | Biaryl acetamide compounds and methods of use thereof |
| GB201321146D0 (en) | 2013-11-29 | 2014-01-15 | Cancer Rec Tech Ltd | Quinazoline compounds |
| EP3135667A4 (en) * | 2014-04-24 | 2017-11-01 | Mitsubishi Tanabe Pharma Corporation | Novel 2-amino-pyridine and 2-amino-pyrimidine derivatives and medicinal use thereof |
| EP3191450B1 (en) * | 2014-09-10 | 2019-04-10 | GlaxoSmithKline Intellectual Property Development Limited | Pyridone derivatives as rearranged during transfection (ret) kinase inhibitors |
| MY187169A (en) * | 2014-09-10 | 2021-09-07 | Glaxosmithkline Ip Dev Ltd | Novel compounds as rearranged during transfection (ret) inhibitors |
| US10626094B2 (en) | 2014-10-14 | 2020-04-21 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof |
| CN104844589B (zh) | 2014-12-26 | 2018-04-20 | 中国科学院合肥物质科学研究院 | 一种pi3k激酶抑制剂 |
| US10202365B2 (en) * | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| EP3322706B1 (en) | 2015-07-16 | 2020-11-11 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
| JP2018052878A (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
-
2016
- 2016-09-29 JP JP2016191725A patent/JP2018052878A/ja active Pending
-
2017
- 2017-09-28 WO PCT/GB2017/052913 patent/WO2018060714A1/en unknown
- 2017-09-28 EA EA201990833A patent/EA037103B1/ru unknown
- 2017-09-28 KR KR1020197012323A patent/KR102520543B1/ko active IP Right Grant
- 2017-09-28 SG SG11201901937WA patent/SG11201901937WA/en unknown
- 2017-09-28 RS RS20210332A patent/RS61640B1/sr unknown
- 2017-09-28 MA MA054910A patent/MA54910A/fr unknown
- 2017-09-28 PE PE2019000730A patent/PE20190805A1/es unknown
- 2017-09-28 CN CN202111188408.2A patent/CN113788824A/zh active Pending
- 2017-09-28 MA MA46337A patent/MA46337B1/fr unknown
- 2017-09-28 BR BR112019006047A patent/BR112019006047A2/pt not_active Application Discontinuation
- 2017-09-28 ES ES17780169T patent/ES2868748T3/es active Active
- 2017-09-28 AU AU2017335242A patent/AU2017335242C1/en active Active
- 2017-09-28 EP EP17780169.3A patent/EP3519398B1/en active Active
- 2017-09-28 SI SI201730683T patent/SI3519398T1/sl unknown
- 2017-09-28 CA CA3035860A patent/CA3035860A1/en active Pending
- 2017-09-28 JP JP2019516670A patent/JP7098609B2/ja active Active
- 2017-09-28 MX MX2019003747A patent/MX2019003747A/es unknown
- 2017-09-28 DK DK17780169.3T patent/DK3519398T3/da active
- 2017-09-28 CN CN201780074582.XA patent/CN110036007B/zh active Active
- 2017-09-28 UA UAA201904549A patent/UA123964C2/uk unknown
- 2017-09-28 PL PL17780169T patent/PL3519398T3/pl unknown
- 2017-09-28 LT LTEP17780169.3T patent/LT3519398T/lt unknown
- 2017-09-28 HU HUE17780169A patent/HUE054824T2/hu unknown
- 2017-09-28 MD MDE20190863T patent/MD3519398T2/ro unknown
- 2017-09-28 US US16/337,896 patent/US10851092B2/en active Active
- 2017-09-28 EP EP21151210.8A patent/EP3828178A1/en not_active Withdrawn
- 2017-09-28 PT PT177801693T patent/PT3519398T/pt unknown
-
2019
- 2019-03-05 PH PH12019500480A patent/PH12019500480A1/en unknown
- 2019-03-26 IL IL265630A patent/IL265630B/en unknown
- 2019-03-28 CL CL2019000844A patent/CL2019000844A1/es unknown
- 2019-04-09 ZA ZA2019/02232A patent/ZA201902232B/en unknown
- 2019-04-23 CO CONC2019/0004034A patent/CO2019004034A2/es unknown
- 2019-04-29 EC ECSENADI201930134A patent/ECSP19030134A/es unknown
-
2020
- 2020-11-24 US US17/103,515 patent/US20210163464A1/en not_active Abandoned
-
2021
- 2021-03-17 CY CY20211100228T patent/CY1123988T1/el unknown
- 2021-03-17 HR HRP20210447TT patent/HRP20210447T1/hr unknown
- 2021-11-03 AU AU2021261899A patent/AU2021261899A1/en active Pending
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