MD3519398T2 - Compus de piridină - Google Patents
Compus de piridinăInfo
- Publication number
- MD3519398T2 MD3519398T2 MDE20190863T MDE20190863T MD3519398T2 MD 3519398 T2 MD3519398 T2 MD 3519398T2 MD E20190863 T MDE20190863 T MD E20190863T MD E20190863 T MDE20190863 T MD E20190863T MD 3519398 T2 MD3519398 T2 MD 3519398T2
- Authority
- MD
- Moldova
- Prior art keywords
- pharmaceutically acceptable
- acceptable salts
- relates
- pyridine compound
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Prezenta invenţie se referă la un compus care are activitate inhibitorie selectivă a RET kinază şi sărurile acceptate farmaceutic. Această invenţie se referă, de asemenea, la metode de fabricare a unor astfel de compuşi şi a compoziţiilor farmaceutice care conţin astfel de compuşi utile în tratamentul bolilor cum ar fi cancerul.În special un compus reprezentat de formula generală (I), definită aici:sau sărurile acceptate farmaceutic
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016191725A JP2018052878A (ja) | 2016-09-29 | 2016-09-29 | ピリジン化合物 |
| PCT/GB2017/052913 WO2018060714A1 (en) | 2016-09-29 | 2017-09-28 | Pyridine compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD3519398T2 true MD3519398T2 (ro) | 2021-05-31 |
Family
ID=60020249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDE20190863T MD3519398T2 (ro) | 2016-09-29 | 2017-09-28 | Compus de piridină |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10851092B2 (ro) |
| EP (2) | EP3519398B1 (ro) |
| JP (2) | JP2018052878A (ro) |
| KR (1) | KR102520543B1 (ro) |
| CN (2) | CN113788824A (ro) |
| AU (2) | AU2017335242C1 (ro) |
| BR (1) | BR112019006047A2 (ro) |
| CA (1) | CA3035860A1 (ro) |
| CL (1) | CL2019000844A1 (ro) |
| CO (1) | CO2019004034A2 (ro) |
| CY (1) | CY1123988T1 (ro) |
| DK (1) | DK3519398T3 (ro) |
| EA (1) | EA037103B1 (ro) |
| EC (1) | ECSP19030134A (ro) |
| ES (1) | ES2868748T3 (ro) |
| HR (1) | HRP20210447T1 (ro) |
| HU (1) | HUE054824T2 (ro) |
| IL (1) | IL265630B (ro) |
| LT (1) | LT3519398T (ro) |
| MA (2) | MA46337B1 (ro) |
| MD (1) | MD3519398T2 (ro) |
| MX (1) | MX2019003747A (ro) |
| PE (1) | PE20190805A1 (ro) |
| PH (1) | PH12019500480A1 (ro) |
| PL (1) | PL3519398T3 (ro) |
| PT (1) | PT3519398T (ro) |
| RS (1) | RS61640B1 (ro) |
| SG (1) | SG11201901937WA (ro) |
| SI (1) | SI3519398T1 (ro) |
| UA (1) | UA123964C2 (ro) |
| WO (1) | WO2018060714A1 (ro) |
| ZA (1) | ZA201902232B (ro) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3371171T (lt) | 2015-11-02 | 2024-01-10 | Blueprint Medicines Corporation | Ret inhibitoriai |
| JP2018052878A (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| EP3740486A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| WO2019143977A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| EP3773589B1 (en) | 2018-04-03 | 2023-11-01 | Blueprint Medicines Corporation | Ret inhibitor for use in treating cancer having a ret alteration |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| AU2020389184A1 (en) * | 2019-11-18 | 2022-06-02 | Chugai Seiyaku Kabushiki Kaisha | Combination drug |
| CN113121524B (zh) | 2019-12-31 | 2023-04-25 | 南京创济生物医药有限公司 | 杂环亚砜亚胺化合物及其中间体、制备方法和应用 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| JP7461605B2 (ja) | 2020-02-20 | 2024-04-04 | 広州白雲山医薬集団股▲フン▼有限公司白雲山制薬総廠 | キノリン系化合物 |
| WO2021164741A1 (zh) * | 2020-02-20 | 2021-08-26 | 南京明德新药研发有限公司 | 苯基双酰胺类化合物 |
| WO2022238706A1 (en) | 2021-05-14 | 2022-11-17 | Bp Asset Viii, Inc. | Ret inhibitor for the treatment of ret altered medullary thyroid cancer or ret altered non-small cell lung cancer |
| CA3234317A1 (en) | 2021-10-22 | 2023-12-14 | Wa Xian | Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues |
| CN115090331B (zh) * | 2022-07-21 | 2023-05-16 | 扬州大学 | 超分子手性催化剂、其制备方法及其催化d-a反应的应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI284639B (en) | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| EP1670787B1 (en) | 2003-09-11 | 2012-05-30 | iTherX Pharma, Inc. | Cytokine inhibitors |
| US20090076075A1 (en) | 2006-03-02 | 2009-03-19 | Frederic Henri Jung | Quinoline derivatives |
| JP2009528335A (ja) | 2006-03-02 | 2009-08-06 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
| WO2007113548A1 (en) | 2006-04-06 | 2007-10-11 | Astrazeneca Ab | Naphthyridine derivatives |
| WO2007113565A1 (en) | 2006-04-06 | 2007-10-11 | Astrazeneca Ab | Naphthyridine derivatives as anti-cancer agents |
| FR2933700B1 (fr) | 2008-07-08 | 2010-07-30 | Sanofi Aventis | Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique |
| CN102333765B (zh) * | 2009-02-27 | 2015-01-14 | 帝人制药株式会社 | 基于使用过渡金属催化剂的偶联法的苯基取代杂环衍生物的制造方法 |
| KR20120059558A (ko) | 2009-08-19 | 2012-06-08 | 암비트 바이오사이언시즈 코포레이션 | 바이아릴 화합물 및 이의 사용 방법 |
| HUE029094T2 (hu) | 2009-08-25 | 2017-02-28 | Abraxis Bioscience Llc | Kombinációs terápia egy taxánt és egy albumint tartalmazó nanorészecskéket magába foglaló készítménnyel |
| AU2011242689B2 (en) | 2010-04-23 | 2015-09-17 | Kineta, Inc. | Anti-viral compounds |
| US9073895B2 (en) | 2010-12-16 | 2015-07-07 | Boehringer Ingelheim International Gmbh | Biarylamide inhibitors of leukotriene production |
| AU2013289938A1 (en) | 2012-07-13 | 2015-01-29 | Indiana University Research & Technology Corporation | Compounds for treatment of spinal muscular atrophy |
| ME02664B (me) | 2013-03-15 | 2017-06-20 | Glaxosmithkline Ip Dev Ltd | Derivati premeštanja piridina u toku transfekcije inhibitora (ret) kinaze |
| SG11201601341QA (en) * | 2013-08-30 | 2016-03-30 | Ambit Biosciences Corp | Biaryl acetamide compounds and methods of use thereof |
| GB201321146D0 (en) | 2013-11-29 | 2014-01-15 | Cancer Rec Tech Ltd | Quinazoline compounds |
| WO2015163435A1 (ja) * | 2014-04-24 | 2015-10-29 | 田辺三菱製薬株式会社 | 新規２－アミノ－ピリジン及び２－アミノ－ピリミジン誘導体及びその医薬用途 |
| CN107074768B (zh) * | 2014-09-10 | 2019-12-10 | 葛兰素史克知识产权发展有限公司 | 作为转染重排(ret)激酶抑制剂的吡啶酮衍生物 |
| BR112017004897A2 (pt) * | 2014-09-10 | 2017-12-12 | Glaxosmithkline Ip Dev Ltd | compostos inovadores como inibidores rearranjados durante a transfecção (ret) |
| JP6899323B2 (ja) | 2014-10-14 | 2021-07-07 | ラ ホーヤ インスティテュート オブ アレルギー アンド イミュノロジー | 低分子量タンパク質チロシンホスファターゼの阻害剤、及びその使用 |
| CN104844589B (zh) | 2014-12-26 | 2018-04-20 | 中国科学院合肥物质科学研究院 | 一种pi3k激酶抑制剂 |
| WO2016127074A1 (en) * | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| PT3322706T (pt) | 2015-07-16 | 2021-03-08 | Array Biopharma Inc | Compostos de pirazolo[1,5-a]piridina substituídos como inibidores da quinase do ret |
| JP2018052878A (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
-
2016
- 2016-09-29 JP JP2016191725A patent/JP2018052878A/ja active Pending
-
2017
- 2017-09-28 MD MDE20190863T patent/MD3519398T2/ro unknown
- 2017-09-28 SI SI201730683T patent/SI3519398T1/sl unknown
- 2017-09-28 PT PT177801693T patent/PT3519398T/pt unknown
- 2017-09-28 EP EP17780169.3A patent/EP3519398B1/en active Active
- 2017-09-28 LT LTEP17780169.3T patent/LT3519398T/lt unknown
- 2017-09-28 CN CN202111188408.2A patent/CN113788824A/zh active Pending
- 2017-09-28 US US16/337,896 patent/US10851092B2/en active Active
- 2017-09-28 CA CA3035860A patent/CA3035860A1/en active Pending
- 2017-09-28 UA UAA201904549A patent/UA123964C2/uk unknown
- 2017-09-28 PE PE2019000730A patent/PE20190805A1/es unknown
- 2017-09-28 ES ES17780169T patent/ES2868748T3/es active Active
- 2017-09-28 EA EA201990833A patent/EA037103B1/ru unknown
- 2017-09-28 HU HUE17780169A patent/HUE054824T2/hu unknown
- 2017-09-28 PL PL17780169T patent/PL3519398T3/pl unknown
- 2017-09-28 SG SG11201901937WA patent/SG11201901937WA/en unknown
- 2017-09-28 JP JP2019516670A patent/JP7098609B2/ja active Active
- 2017-09-28 CN CN201780074582.XA patent/CN110036007B/zh active Active
- 2017-09-28 MA MA46337A patent/MA46337B1/fr unknown
- 2017-09-28 DK DK17780169.3T patent/DK3519398T3/da active
- 2017-09-28 WO PCT/GB2017/052913 patent/WO2018060714A1/en unknown
- 2017-09-28 EP EP21151210.8A patent/EP3828178A1/en not_active Withdrawn
- 2017-09-28 MA MA054910A patent/MA54910A/fr unknown
- 2017-09-28 BR BR112019006047A patent/BR112019006047A2/pt not_active Application Discontinuation
- 2017-09-28 AU AU2017335242A patent/AU2017335242C1/en active Active
- 2017-09-28 RS RS20210332A patent/RS61640B1/sr unknown
- 2017-09-28 KR KR1020197012323A patent/KR102520543B1/ko active IP Right Grant
- 2017-09-28 MX MX2019003747A patent/MX2019003747A/es unknown
-
2019
- 2019-03-05 PH PH12019500480A patent/PH12019500480A1/en unknown
- 2019-03-26 IL IL265630A patent/IL265630B/en unknown
- 2019-03-28 CL CL2019000844A patent/CL2019000844A1/es unknown
- 2019-04-09 ZA ZA2019/02232A patent/ZA201902232B/en unknown
- 2019-04-23 CO CONC2019/0004034A patent/CO2019004034A2/es unknown
- 2019-04-29 EC ECSENADI201930134A patent/ECSP19030134A/es unknown
-
2020
- 2020-11-24 US US17/103,515 patent/US20210163464A1/en not_active Abandoned
-
2021
- 2021-03-17 CY CY20211100228T patent/CY1123988T1/el unknown
- 2021-03-17 HR HRP20210447TT patent/HRP20210447T1/hr unknown
- 2021-11-03 AU AU2021261899A patent/AU2021261899A1/en not_active Abandoned
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