MX2017000208A - Derivados de quinolizinona como inhibidores de pi3k. - Google Patents
Derivados de quinolizinona como inhibidores de pi3k.Info
- Publication number
- MX2017000208A MX2017000208A MX2017000208A MX2017000208A MX2017000208A MX 2017000208 A MX2017000208 A MX 2017000208A MX 2017000208 A MX2017000208 A MX 2017000208A MX 2017000208 A MX2017000208 A MX 2017000208A MX 2017000208 A MX2017000208 A MX 2017000208A
- Authority
- MX
- Mexico
- Prior art keywords
- pi3k inhibitors
- quinolizinone derivatives
- quinolizinone
- derivatives
- tautomer
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se divulgan compuestos de la fórmula I, sus formas tautoméricas, estereoisómeros y sales farmacéuticamente aceptables de los mismos, en donde R1-R4 y n son como se define en la descripción, las composiciones farmacéuticas incluyen un compuesto, tautómero, estereoisómero o sal del mismo, y métodos para el tratamiento o prevención de enfermedades o trastornos, por ejemplo, cáncer, que son susceptibles de tratamiento o prevención inhibiendo la enzima PI3K de un sujeto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2182MU2014 | 2014-07-04 | ||
PCT/IB2015/054958 WO2016001855A1 (en) | 2014-07-04 | 2015-07-01 | Quinolizinone derivatives as pi3k inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017000208A true MX2017000208A (es) | 2017-05-01 |
Family
ID=53716533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017000208A MX2017000208A (es) | 2014-07-04 | 2015-07-01 | Derivados de quinolizinona como inhibidores de pi3k. |
Country Status (25)
Country | Link |
---|---|
US (1) | US9944639B2 (es) |
EP (1) | EP3164400A1 (es) |
JP (1) | JP6291601B2 (es) |
KR (1) | KR20170082490A (es) |
CN (1) | CN106470996B (es) |
AP (1) | AP2016009661A0 (es) |
AU (1) | AU2015283671B2 (es) |
BR (1) | BR112017000132A2 (es) |
CA (1) | CA2954231A1 (es) |
CL (1) | CL2017000006A1 (es) |
CO (1) | CO2017000011A2 (es) |
CR (1) | CR20160600A (es) |
CU (1) | CU24428B1 (es) |
EA (1) | EA201692557A1 (es) |
GE (1) | GEP20186934B (es) |
HK (1) | HK1232227A1 (es) |
IL (1) | IL249674B (es) |
MA (1) | MA40250A (es) |
MX (1) | MX2017000208A (es) |
PE (1) | PE20170640A1 (es) |
PH (1) | PH12017500007A1 (es) |
SG (1) | SG11201610770PA (es) |
SV (1) | SV2017005354A (es) |
UA (1) | UA115296C2 (es) |
WO (1) | WO2016001855A1 (es) |
Families Citing this family (7)
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US10328060B2 (en) * | 2014-11-01 | 2019-06-25 | Shanghai Fochon Pharmaceutical Co., Ltd. | Certain protein kinase inhibitors |
WO2017103825A1 (en) | 2015-12-18 | 2017-06-22 | Lupin Limited | Quinolizinone derivatives as pi3k inhibitors |
CA3083040A1 (en) | 2018-01-20 | 2019-07-25 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine compounds and methods of use |
EP3828184A4 (en) * | 2018-08-21 | 2022-05-04 | Medshine Discovery Inc. | PYRAZOLOPYRIMIDI DERIVATIVES AND USE THEREOF AS A PI3K INHIBITOR |
KR20220004105A (ko) * | 2019-04-23 | 2022-01-11 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
WO2021164789A1 (zh) * | 2020-02-21 | 2021-08-26 | 南京明德新药研发有限公司 | 一种吡唑并嘧啶类化合物的晶型及其应用 |
CR20240045A (es) * | 2021-08-09 | 2024-02-20 | Scorpion Therapeutics Inc | Compuestos que inhiben la isoforma alfa de pi3k y métodos para tratar el cáncer |
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MX2016012021A (es) | 2014-03-19 | 2017-04-13 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma. |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
CN105130966B (zh) | 2014-05-07 | 2019-05-24 | 广东东阳光药业有限公司 | 炔基化合物及其使用方法和用途 |
WO2015175579A1 (en) | 2014-05-15 | 2015-11-19 | Calitor Sciences, Llc | Alkynyl compounds and methods of use |
ES2833025T3 (es) | 2014-06-13 | 2021-06-14 | Gilead Sciences Inc | Inhibidores de fosfatidilinositol 3-quinasa |
KR20170010063A (ko) | 2014-06-13 | 2017-01-25 | 길리애드 사이언시즈, 인코포레이티드 | 포스파티딜이노시톨 3-키나제 억제제 |
BR112016028642A2 (pt) | 2014-06-13 | 2017-08-22 | Gilead Sciences Inc | composto, composição farmacêutica, método de tratamento de uma doença ou condição, método de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase, método de inibição de reações imunes ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, e, uso de um composto, de um sal, de um isômero ou de uma mistura farmaceuticamente aceitável do mesmo. |
JP6391718B2 (ja) | 2014-06-24 | 2018-09-19 | ギリアード サイエンシーズ, インコーポレイテッド | ホスファチジルイノシトール3−キナーゼ阻害剤 |
US10328060B2 (en) * | 2014-11-01 | 2019-06-25 | Shanghai Fochon Pharmaceutical Co., Ltd. | Certain protein kinase inhibitors |
CN105130984B (zh) | 2015-09-23 | 2017-03-29 | 前湾医药科技(深圳)有限公司 | 一种咪唑并吡啶类化合物与在制备pi3k抑制剂中的应用 |
-
2015
- 2015-07-01 BR BR112017000132A patent/BR112017000132A2/pt not_active Application Discontinuation
- 2015-07-01 GE GEAP201514408A patent/GEP20186934B/en unknown
- 2015-07-01 EA EA201692557A patent/EA201692557A1/ru unknown
- 2015-07-01 MX MX2017000208A patent/MX2017000208A/es unknown
- 2015-07-01 CN CN201580036482.9A patent/CN106470996B/zh not_active Expired - Fee Related
- 2015-07-01 SG SG11201610770PA patent/SG11201610770PA/en unknown
- 2015-07-01 EP EP15739683.9A patent/EP3164400A1/en not_active Withdrawn
- 2015-07-01 AU AU2015283671A patent/AU2015283671B2/en not_active Ceased
- 2015-07-01 MA MA040250A patent/MA40250A/fr unknown
- 2015-07-01 CU CU2016000195A patent/CU24428B1/es unknown
- 2015-07-01 JP JP2016575554A patent/JP6291601B2/ja not_active Expired - Fee Related
- 2015-07-01 US US15/323,565 patent/US9944639B2/en not_active Expired - Fee Related
- 2015-07-01 UA UAA201701013A patent/UA115296C2/uk unknown
- 2015-07-01 WO PCT/IB2015/054958 patent/WO2016001855A1/en active Application Filing
- 2015-07-01 CR CR20160600A patent/CR20160600A/es unknown
- 2015-07-01 AP AP2016009661A patent/AP2016009661A0/en unknown
- 2015-07-01 PE PE2016002810A patent/PE20170640A1/es unknown
- 2015-07-01 CA CA2954231A patent/CA2954231A1/en not_active Abandoned
- 2015-07-01 KR KR1020177003196A patent/KR20170082490A/ko unknown
-
2016
- 2016-12-20 IL IL249674A patent/IL249674B/en not_active IP Right Cessation
-
2017
- 2017-01-03 SV SV2017005354A patent/SV2017005354A/es unknown
- 2017-01-03 PH PH12017500007A patent/PH12017500007A1/en unknown
- 2017-01-03 CL CL2017000006A patent/CL2017000006A1/es unknown
- 2017-01-03 CO CONC2017/0000011A patent/CO2017000011A2/es unknown
- 2017-06-16 HK HK17106009.7A patent/HK1232227A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
BR112017000132A2 (pt) | 2018-01-09 |
HK1232227A1 (zh) | 2018-01-05 |
IL249674A0 (en) | 2017-02-28 |
EA201692557A1 (ru) | 2017-05-31 |
WO2016001855A1 (en) | 2016-01-07 |
CN106470996B (zh) | 2019-02-22 |
IL249674B (en) | 2019-06-30 |
GEP20186934B (en) | 2018-12-10 |
PH12017500007A1 (en) | 2017-05-15 |
CU20160195A7 (es) | 2017-05-10 |
CO2017000011A2 (es) | 2017-04-10 |
AU2015283671A1 (en) | 2017-02-02 |
CU24428B1 (es) | 2019-06-04 |
UA115296C2 (uk) | 2017-10-10 |
AU2015283671B2 (en) | 2018-07-05 |
CR20160600A (es) | 2017-03-07 |
KR20170082490A (ko) | 2017-07-14 |
CA2954231A1 (en) | 2016-01-07 |
JP6291601B2 (ja) | 2018-03-14 |
JP2017519786A (ja) | 2017-07-20 |
SV2017005354A (es) | 2018-10-05 |
AP2016009661A0 (en) | 2016-12-31 |
US20170137421A1 (en) | 2017-05-18 |
CN106470996A (zh) | 2017-03-01 |
SG11201610770PA (en) | 2017-01-27 |
PE20170640A1 (es) | 2017-05-26 |
CL2017000006A1 (es) | 2017-06-02 |
US9944639B2 (en) | 2018-04-17 |
MA40250A (fr) | 2017-05-10 |
EP3164400A1 (en) | 2017-05-10 |
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