JP2005506348A5 - - Google Patents
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- Publication number
- JP2005506348A5 JP2005506348A5 JP2003535727A JP2003535727A JP2005506348A5 JP 2005506348 A5 JP2005506348 A5 JP 2005506348A5 JP 2003535727 A JP2003535727 A JP 2003535727A JP 2003535727 A JP2003535727 A JP 2003535727A JP 2005506348 A5 JP2005506348 A5 JP 2005506348A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- composition
- histone deacetylase
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 173
- 150000001875 compounds Chemical class 0.000 claims 78
- 150000003839 salts Chemical class 0.000 claims 74
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 58
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 58
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 39
- 102000003964 Histone deacetylase Human genes 0.000 claims 26
- 108090000353 Histone deacetylase Proteins 0.000 claims 26
- 125000004104 aryloxy group Chemical group 0.000 claims 25
- 230000002401 inhibitory effect Effects 0.000 claims 25
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 24
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 23
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 15
- 125000003282 alkyl amino group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000003277 amino group Chemical group 0.000 claims 12
- 125000004663 dialkyl amino group Chemical group 0.000 claims 12
- -1 hydroxylamino group Chemical group 0.000 claims 12
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 12
- 125000004947 alkyl aryl amino group Chemical group 0.000 claims 9
- 125000001769 aryl amino group Chemical group 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 6
- 150000001408 amides Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- 229920000155 polyglutamine Polymers 0.000 claims 2
- 108010040003 polyglutamine Proteins 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 0 CC(C(**)=O)NC(*)=O Chemical compound CC(C(**)=O)NC(*)=O 0.000 description 7
- YOZRCCTXOPFCAM-UHFFFAOYSA-N CC(C(Nc1ccc2ncccc2c1)=O)C(Nc1cc2cccnc2cc1)=O Chemical compound CC(C(Nc1ccc2ncccc2c1)=O)C(Nc1cc2cccnc2cc1)=O YOZRCCTXOPFCAM-UHFFFAOYSA-N 0.000 description 1
- APBBTKKLSNPFDP-UHFFFAOYSA-N CC(CCC1)c2c1cccc2 Chemical compound CC(CCC1)c2c1cccc2 APBBTKKLSNPFDP-UHFFFAOYSA-N 0.000 description 1
- VRZWCYZJGUYTKU-UHFFFAOYSA-N C[n]1c2ncncc2nc1 Chemical compound C[n]1c2ncncc2nc1 VRZWCYZJGUYTKU-UHFFFAOYSA-N 0.000 description 1
- WESDBLALURHRDL-UHFFFAOYSA-N Cc1c2nccnc2ncn1 Chemical compound Cc1c2nccnc2ncn1 WESDBLALURHRDL-UHFFFAOYSA-N 0.000 description 1
- KDYVCOSVYOSHOL-UHFFFAOYSA-N Cc1cc(nccc2)c2cc1 Chemical compound Cc1cc(nccc2)c2cc1 KDYVCOSVYOSHOL-UHFFFAOYSA-N 0.000 description 1
- JRLTTZUODKEYDH-UHFFFAOYSA-N Cc1cccc2cccnc12 Chemical compound Cc1cccc2cccnc12 JRLTTZUODKEYDH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32970501P | 2001-10-16 | 2001-10-16 | |
| PCT/US2002/033246 WO2003032921A2 (en) | 2001-10-16 | 2002-10-16 | Treatment of neurodegenerative diseases and cancer of the brain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005506348A JP2005506348A (ja) | 2005-03-03 |
| JP2005506348A5 true JP2005506348A5 (enExample) | 2006-01-05 |
| JP4638148B2 JP4638148B2 (ja) | 2011-02-23 |
Family
ID=23286625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535727A Expired - Fee Related JP4638148B2 (ja) | 2001-10-16 | 2002-10-16 | 神経変性疾患および脳の癌の処置 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20040087657A1 (enExample) |
| EP (2) | EP1443928B1 (enExample) |
| JP (1) | JP4638148B2 (enExample) |
| AT (1) | ATE517624T1 (enExample) |
| AU (2) | AU2002340253C1 (enExample) |
| CA (1) | CA2463552C (enExample) |
| WO (1) | WO2003032921A2 (enExample) |
Families Citing this family (61)
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| CN1378450A (zh) * | 1999-09-08 | 2002-11-06 | 斯隆-凯特林癌症研究院 | 新型细胞分化剂和组蛋白脱乙酰基酶抑制剂及其使用方法 |
| EP1443928B1 (en) * | 2001-10-16 | 2011-07-27 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
| US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
| MXPA04008577A (es) * | 2002-03-04 | 2005-07-13 | Aton Pharma Inc | Metodos para inducir diferenciacion terminal. |
| WO2003083067A2 (en) * | 2002-03-28 | 2003-10-09 | Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and alzheimer's disease |
| US20040018968A1 (en) * | 2002-04-15 | 2004-01-29 | George Sgouros | Use of histone deacetylase inhibitors in combination with radiation for the treatment of cancer |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| BR0316206A (pt) * | 2002-11-12 | 2005-09-27 | Alcon Inc | Uso inibidores de histona desacetilase para o tratamento de distúrbios e de doenças oculares neovasculares ou edematosos |
| GB0226855D0 (en) * | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
| US7375228B2 (en) * | 2003-03-17 | 2008-05-20 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CA2520611A1 (en) * | 2003-04-01 | 2004-10-21 | Memorial Sloan-Kettering Cancer Center | Hydroxamic acid compounds and methods of use thereof |
| US20050075282A1 (en) * | 2003-10-01 | 2005-04-07 | Douglas Coulter | Materials and methods for inhibiting the development of epilepsy |
| EP1677731A4 (en) * | 2003-10-09 | 2009-05-06 | Aton Pharma Inc | THIOPHENE AND BENZOTHIOPHENE DERIVATIVES OF HYDROXAMIC ACID |
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| WO2005051901A1 (en) * | 2003-11-28 | 2005-06-09 | The University Of Queensland | Anti-cancer agents |
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| US7901675B2 (en) | 2004-10-13 | 2011-03-08 | U.S. Department Of Veterans Affairs | Method of using coenzyme Q10 to treat Huntington's disease |
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| TWI365068B (en) | 2005-05-20 | 2012-06-01 | Merck Sharp & Dohme | Formulations of suberoylanilide hydroxamic acid and methods for producing same |
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| US20090325862A1 (en) * | 2006-05-04 | 2009-12-31 | Christian Steinkuhler | Histone Deacetylase Inhibitors for the Treatment of Neurodegeneration |
| US20100093867A1 (en) * | 2006-07-05 | 2010-04-15 | Ryoichi Matsuda | Method Of Treating Genetic Disease Caused By Nonsense Mutation |
| US8399452B2 (en) | 2006-10-28 | 2013-03-19 | Methylgene Inc. | Dibenzo[b,f][1,4]oxazepin-11-yl-N-hydroxybenzamides as HDAC inhibitors |
| US8088951B2 (en) | 2006-11-30 | 2012-01-03 | Massachusetts Institute Of Technology | Epigenetic mechanisms re-establish access to long-term memory after neuronal loss |
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| CA2679629A1 (en) * | 2007-02-27 | 2008-09-04 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Use of histone deacetylase inhibitors for the treatment of central nervous system metastases |
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| US20250120928A1 (en) * | 2021-07-14 | 2025-04-17 | University Of Maryland, Baltimore | Suberoylanilide hydroxamic acid (saha) drugs, conjugates, and nanoparticles, and methods of use thereof |
| KR102859315B1 (ko) * | 2024-02-27 | 2025-09-12 | 주식회사 아이피에스바이오 | 히스톤 탈아세틸효소 저해제를 포함하는 다중 글루타민 질병의 예방 또는 치료용 약학적 조성물 |
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-
2002
- 2002-10-16 EP EP02778601A patent/EP1443928B1/en not_active Expired - Lifetime
- 2002-10-16 CA CA2463552A patent/CA2463552C/en not_active Expired - Fee Related
- 2002-10-16 AU AU2002340253A patent/AU2002340253C1/en not_active Ceased
- 2002-10-16 JP JP2003535727A patent/JP4638148B2/ja not_active Expired - Fee Related
- 2002-10-16 EP EP10183856A patent/EP2269609A3/en not_active Withdrawn
- 2002-10-16 AT AT02778601T patent/ATE517624T1/de not_active IP Right Cessation
- 2002-10-16 WO PCT/US2002/033246 patent/WO2003032921A2/en not_active Ceased
- 2002-10-16 US US10/273,401 patent/US20040087657A1/en not_active Abandoned
-
2005
- 2005-11-18 US US11/282,420 patent/US7879865B2/en not_active Expired - Fee Related
-
2006
- 2006-01-25 AU AU2006200326A patent/AU2006200326B2/en not_active Ceased
-
2011
- 2011-01-31 US US13/017,447 patent/US20110124731A1/en not_active Abandoned
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