JP2005506348A5 - - Google Patents
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- JP2005506348A5 JP2005506348A5 JP2003535727A JP2003535727A JP2005506348A5 JP 2005506348 A5 JP2005506348 A5 JP 2005506348A5 JP 2003535727 A JP2003535727 A JP 2003535727A JP 2003535727 A JP2003535727 A JP 2003535727A JP 2005506348 A5 JP2005506348 A5 JP 2005506348A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- composition
- histone deacetylase
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C(**)=O)NC(*)=O Chemical compound CC(C(**)=O)NC(*)=O 0.000 description 7
- YOZRCCTXOPFCAM-UHFFFAOYSA-N CC(C(Nc1ccc2ncccc2c1)=O)C(Nc1cc2cccnc2cc1)=O Chemical compound CC(C(Nc1ccc2ncccc2c1)=O)C(Nc1cc2cccnc2cc1)=O YOZRCCTXOPFCAM-UHFFFAOYSA-N 0.000 description 1
- APBBTKKLSNPFDP-UHFFFAOYSA-N CC(CCC1)c2c1cccc2 Chemical compound CC(CCC1)c2c1cccc2 APBBTKKLSNPFDP-UHFFFAOYSA-N 0.000 description 1
- VRZWCYZJGUYTKU-UHFFFAOYSA-N C[n]1c2ncncc2nc1 Chemical compound C[n]1c2ncncc2nc1 VRZWCYZJGUYTKU-UHFFFAOYSA-N 0.000 description 1
- WESDBLALURHRDL-UHFFFAOYSA-N Cc1c2nccnc2ncn1 Chemical compound Cc1c2nccnc2ncn1 WESDBLALURHRDL-UHFFFAOYSA-N 0.000 description 1
- KDYVCOSVYOSHOL-UHFFFAOYSA-N Cc1cc(nccc2)c2cc1 Chemical compound Cc1cc(nccc2)c2cc1 KDYVCOSVYOSHOL-UHFFFAOYSA-N 0.000 description 1
- JRLTTZUODKEYDH-UHFFFAOYSA-N Cc1cccc2cccnc12 Chemical compound Cc1cccc2cccnc12 JRLTTZUODKEYDH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32970501P | 2001-10-16 | 2001-10-16 | |
| PCT/US2002/033246 WO2003032921A2 (en) | 2001-10-16 | 2002-10-16 | Treatment of neurodegenerative diseases and cancer of the brain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005506348A JP2005506348A (ja) | 2005-03-03 |
| JP2005506348A5 true JP2005506348A5 (enExample) | 2006-01-05 |
| JP4638148B2 JP4638148B2 (ja) | 2011-02-23 |
Family
ID=23286625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535727A Expired - Fee Related JP4638148B2 (ja) | 2001-10-16 | 2002-10-16 | 神経変性疾患および脳の癌の処置 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20040087657A1 (enExample) |
| EP (2) | EP1443928B1 (enExample) |
| JP (1) | JP4638148B2 (enExample) |
| AT (1) | ATE517624T1 (enExample) |
| AU (2) | AU2002340253C1 (enExample) |
| CA (1) | CA2463552C (enExample) |
| WO (1) | WO2003032921A2 (enExample) |
Families Citing this family (61)
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| EP1443928B1 (en) * | 2001-10-16 | 2011-07-27 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
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| WO2003083067A2 (en) * | 2002-03-28 | 2003-10-09 | Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and alzheimer's disease |
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| WO2013066836A1 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
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| CN114846012B (zh) | 2019-09-27 | 2024-01-26 | 武田药品工业株式会社 | 可用作hdac6抑制剂的2-异吲哚-1,3,4-噁二唑衍生物 |
| EP4370109A4 (en) * | 2021-07-14 | 2025-10-22 | Univ Maryland | SUBEROYLANILIDE HYDROXAMIC ACID (SAHA) DRUGS, CONJUGATES AND NANOPARTICLES, AND METHODS OF USE THEREOF |
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| KR102859315B1 (ko) * | 2024-02-27 | 2025-09-12 | 주식회사 아이피에스바이오 | 히스톤 탈아세틸효소 저해제를 포함하는 다중 글루타민 질병의 예방 또는 치료용 약학적 조성물 |
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| WO2003083067A2 (en) | 2002-03-28 | 2003-10-09 | Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and alzheimer's disease |
| JP2005530734A (ja) | 2002-04-15 | 2005-10-13 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | 癌の処置のための併用療法 |
| JP2006508986A (ja) | 2002-11-20 | 2006-03-16 | エルラント ゲネ セラペウチクス エルエルシー | ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法 |
| AU2004228011A1 (en) | 2003-04-01 | 2004-10-21 | Memorial Sloan-Kettering Cancer Center | Hydroxamic acid compounds and methods of use thereof |
| CN102349927A (zh) | 2003-08-29 | 2012-02-15 | Hdac默克研究有限责任公司 | 联合治疗癌症的方法 |
| WO2007136615A2 (en) * | 2006-05-16 | 2007-11-29 | Merck & Co., Inc. | Combination cancer therapy |
-
2002
- 2002-10-16 EP EP02778601A patent/EP1443928B1/en not_active Expired - Lifetime
- 2002-10-16 WO PCT/US2002/033246 patent/WO2003032921A2/en not_active Ceased
- 2002-10-16 AT AT02778601T patent/ATE517624T1/de not_active IP Right Cessation
- 2002-10-16 JP JP2003535727A patent/JP4638148B2/ja not_active Expired - Fee Related
- 2002-10-16 EP EP10183856A patent/EP2269609A3/en not_active Withdrawn
- 2002-10-16 AU AU2002340253A patent/AU2002340253C1/en not_active Ceased
- 2002-10-16 CA CA2463552A patent/CA2463552C/en not_active Expired - Fee Related
- 2002-10-16 US US10/273,401 patent/US20040087657A1/en not_active Abandoned
-
2005
- 2005-11-18 US US11/282,420 patent/US7879865B2/en not_active Expired - Fee Related
-
2006
- 2006-01-25 AU AU2006200326A patent/AU2006200326B2/en not_active Ceased
-
2011
- 2011-01-31 US US13/017,447 patent/US20110124731A1/en not_active Abandoned
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