JP2005533835A5 - - Google Patents
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- Publication number
- JP2005533835A5 JP2005533835A5 JP2004520132A JP2004520132A JP2005533835A5 JP 2005533835 A5 JP2005533835 A5 JP 2005533835A5 JP 2004520132 A JP2004520132 A JP 2004520132A JP 2004520132 A JP2004520132 A JP 2004520132A JP 2005533835 A5 JP2005533835 A5 JP 2005533835A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- aryl
- pharmaceutical composition
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 39
- 125000000217 alkyl group Chemical group 0.000 claims 28
- 125000003118 aryl group Chemical group 0.000 claims 24
- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 238000000034 method Methods 0.000 claims 23
- 125000003342 alkenyl group Chemical group 0.000 claims 20
- 125000002877 alkyl aryl group Chemical group 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 20
- 125000003710 aryl alkyl group Chemical group 0.000 claims 18
- 241001465754 Metazoa Species 0.000 claims 12
- 125000005843 halogen group Chemical group 0.000 claims 10
- 239000008024 pharmaceutical diluent Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 101100240529 Caenorhabditis elegans nhr-25 gene Proteins 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 1
- 101100240523 Caenorhabditis elegans nhr-19 gene Proteins 0.000 claims 1
- 101150073133 Cpt1a gene Proteins 0.000 claims 1
- 102000015303 Fatty Acid Synthases Human genes 0.000 claims 1
- 108010039731 Fatty Acid Synthases Proteins 0.000 claims 1
- 101710151321 Melanostatin Proteins 0.000 claims 1
- 102400000064 Neuropeptide Y Human genes 0.000 claims 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 claims 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000002350 geranyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 claims 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
- 0 CCCCC=CC=C[C@@](C)(*1)C(O)=CC1=O Chemical compound CCCCC=CC=C[C@@](C)(*1)C(O)=CC1=O 0.000 description 14
- JSGMQNCACRMGPO-UHFFFAOYSA-N CCCCCCOC(C(CC)C1)=CC1=O Chemical compound CCCCCCOC(C(CC)C1)=CC1=O JSGMQNCACRMGPO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39458502P | 2002-07-09 | 2002-07-09 | |
| PCT/US2003/021700 WO2004005277A1 (en) | 2002-07-09 | 2003-07-09 | Novel compunds, pharmaceutical compositions containing same, and methods of use for same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010228956A Division JP2011037881A (ja) | 2002-07-09 | 2010-10-08 | 新規の化合物、それを含有する医薬組成物、およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533835A JP2005533835A (ja) | 2005-11-10 |
| JP2005533835A5 true JP2005533835A5 (enExample) | 2007-10-04 |
Family
ID=30115739
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520132A Pending JP2005533835A (ja) | 2002-07-09 | 2003-07-09 | 新規の化合物、それを含有する医薬組成物、およびその使用方法 |
| JP2010228956A Pending JP2011037881A (ja) | 2002-07-09 | 2010-10-08 | 新規の化合物、それを含有する医薬組成物、およびその使用方法 |
| JP2013117677A Pending JP2013189464A (ja) | 2002-07-09 | 2013-06-04 | 新規の化合物、それを含有する医薬組成物、およびその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010228956A Pending JP2011037881A (ja) | 2002-07-09 | 2010-10-08 | 新規の化合物、それを含有する医薬組成物、およびその使用方法 |
| JP2013117677A Pending JP2013189464A (ja) | 2002-07-09 | 2013-06-04 | 新規の化合物、それを含有する医薬組成物、およびその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7649012B2 (enExample) |
| EP (3) | EP1539730A4 (enExample) |
| JP (3) | JP2005533835A (enExample) |
| KR (1) | KR101087559B1 (enExample) |
| CN (2) | CN101602756B (enExample) |
| AU (1) | AU2003265267B2 (enExample) |
| BR (1) | BRPI0312649A2 (enExample) |
| CA (2) | CA2491802C (enExample) |
| EA (1) | EA013371B1 (enExample) |
| IL (2) | IL166108A0 (enExample) |
| MX (1) | MXPA05000365A (enExample) |
| SG (1) | SG169236A1 (enExample) |
| WO (1) | WO2004005277A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2474884A1 (en) | 2002-02-08 | 2003-08-14 | John Hopkins University School Of Medicine | Stimulation of cpt-1 as a means to reduce weight |
| AU2003265267B2 (en) * | 2002-07-09 | 2010-03-11 | Fasgen, Llc | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
| CN101721412A (zh) * | 2002-07-09 | 2010-06-09 | 法斯根有限责任公司 | 治疗人和动物中微生物感染的方法 |
| MXPA06013687A (es) * | 2004-05-26 | 2007-10-18 | Fasgen Llc | Compuestos novedosos, composiciones farmaceuticas que los contienen y metodos para utilizar los mismos. |
| AU2007283113A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
| CA2668840A1 (en) * | 2006-11-08 | 2008-05-15 | Fasgen Llc | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
| WO2008059214A1 (en) * | 2006-11-13 | 2008-05-22 | Astrazeneca Ab | Bisamlde derivatives and use thereof as fatty acid synthase inhibitors |
| EP2285215A4 (en) * | 2008-06-02 | 2012-04-04 | Fasgen Inc | NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREFOR AND METHOD OF USE THEREOF |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2010118324A2 (en) | 2009-04-09 | 2010-10-14 | Nuclea Biotechnologies, LLC | Antibodies against fatty acid synthase |
| US9149445B2 (en) | 2009-07-27 | 2015-10-06 | The Trustees Of Princeton University | Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections |
| JP2013503135A (ja) | 2009-08-26 | 2013-01-31 | サノフイ | 新規な結晶性複素芳香族フルオログリコシド水和物、その化合物を含んでなる医薬及びその使用 |
| WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| CA2798330A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| EP2683703B1 (de) | 2011-03-08 | 2015-05-27 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012135027A2 (en) * | 2011-03-25 | 2012-10-04 | The Research Foundation Of State University Of New York | Thiolactone antibiotics |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| JP6228198B2 (ja) * | 2012-06-25 | 2017-11-08 | トーマス・ジェファーソン・ユニバーシティＴｈｏｍａｓ Ｊｅｆｆｅｒｓｏｎ Ｕｎｉｖｅｒｓｉｔｙ | 異常な脂質生合成シグナル伝達を有するがんを処置するための組成物および方法 |
| CA2884355C (en) * | 2012-09-07 | 2022-05-17 | Janssen Pharmaceutica Nv | Imidazolin-5-one derivative useful as fasn inhobitors for the treatment of cancer |
| CN112521369A (zh) | 2013-03-13 | 2021-03-19 | 福马治疗股份有限公司 | 用于抑制fasn的化合物及组合物 |
| US11202795B2 (en) | 2014-11-20 | 2021-12-21 | Vib Vzw | Means and methods for treatment of early-onset Parkinson's disease |
| WO2020092395A1 (en) | 2018-10-29 | 2020-05-07 | Forma Therapeutics, Inc. | SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE |
| CN114480521B (zh) * | 2020-11-13 | 2024-07-26 | 中国科学院青岛生物能源与过程研究所 | 一种三氮菌素c的制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3496187A (en) * | 1967-03-20 | 1970-02-17 | American Home Prod | N-(heterocyclyl)aconamides |
| US3472878A (en) * | 1969-01-27 | 1969-10-14 | American Home Prod | N-(hydroxyaryl)aconamides |
| JPS5859920A (ja) * | 1981-10-05 | 1983-04-09 | Chugai Pharmaceut Co Ltd | 生体防禦能賦活剤 |
| US4565699A (en) * | 1983-07-18 | 1986-01-21 | The Upjohn Company | Composition of matter and process |
| US4720503A (en) * | 1985-08-02 | 1988-01-19 | Merck & Co., Inc. | N-substituted fused-heterocyclic carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors |
| CH667655A5 (de) * | 1986-09-24 | 1988-10-31 | Lonza Ag | Verfahren zur herstellung von 4-alkoxy-2(5h)-thiophenonen. |
| US4753871A (en) * | 1986-12-12 | 1988-06-28 | Eastman Kodak Company | Cyan dye-forming couplers and photographic materials containing same |
| WO1988004652A1 (fr) * | 1986-12-17 | 1988-06-30 | Nippon Soda Co., Ltd. | Composes heterocycliques possedant un squelette triketo |
| US5759837A (en) | 1989-01-17 | 1998-06-02 | John Hopkins University | Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway |
| US5759791A (en) * | 1989-01-17 | 1998-06-02 | The Johns Hopkins University | Cancer related antigen |
| US5665874A (en) * | 1989-01-17 | 1997-09-09 | John Hopkins University | Cancer related antigen |
| US5679801A (en) * | 1991-04-12 | 1997-10-21 | American Home Products Corporation | Tetronic and thiotetronic acid derivatives as phospholipase A2 inhibitors |
| US5614551A (en) | 1994-01-24 | 1997-03-25 | The Johns Hopkins University | Inhibitors of fatty acid synthesis as antimicrobial agents |
| CA2220440A1 (en) * | 1995-05-09 | 1996-11-14 | Bayer Aktiengesellschaft | Alkyl dihalogenated phenyl-substituted ketoenols useful as pesticides and herbicides |
| US5981575A (en) | 1996-11-15 | 1999-11-09 | Johns Hopkins University, The | Inhibition of fatty acid synthase as a means to reduce adipocyte mass |
| JPH10212284A (ja) * | 1996-11-27 | 1998-08-11 | Sagami Chem Res Center | テトロン酸−３−カルボン酸誘導体、その製造方法、製造中間体、抗がん剤、及び蛋白脱リン酸化酵素阻害剤 |
| US6391912B1 (en) * | 1996-12-12 | 2002-05-21 | Bayer Aktiengesellschaft | Substituted phenylketoenols |
| CO4970714A1 (es) * | 1997-09-05 | 2000-11-07 | Boehringer Mannheim Gmbh | Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales |
| HN2000000051A (es) * | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
| IT1315267B1 (it) * | 1999-12-23 | 2003-02-03 | Novuspharma Spa | Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale |
| GB0000131D0 (en) * | 2000-01-06 | 2000-02-23 | Univ Cardiff | Thiolactomycin analogues,compositions containing the same and uses thereof |
| US6376682B1 (en) * | 2000-02-01 | 2002-04-23 | Takama System, Ltd. | Compound with α-glucosidase inhibiting action and method for producing the same |
| EP1383493A4 (en) * | 2001-05-02 | 2005-09-21 | Univ New York | INHIBITION OF PIGMENTATION BY INHIBITION OF FATTY ACID SYNTHASE |
| CA2474884A1 (en) * | 2002-02-08 | 2003-08-14 | John Hopkins University School Of Medicine | Stimulation of cpt-1 as a means to reduce weight |
| AU2003265267B2 (en) * | 2002-07-09 | 2010-03-11 | Fasgen, Llc | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
| CN101721412A (zh) * | 2002-07-09 | 2010-06-09 | 法斯根有限责任公司 | 治疗人和动物中微生物感染的方法 |
| US9690894B1 (en) | 2015-11-02 | 2017-06-27 | Altera Corporation | Safety features for high level design |
-
2003
- 2003-07-09 AU AU2003265267A patent/AU2003265267B2/en not_active Ceased
- 2003-07-09 EA EA200500178A patent/EA013371B1/ru not_active IP Right Cessation
- 2003-07-09 US US10/520,505 patent/US7649012B2/en not_active Expired - Fee Related
- 2003-07-09 CN CN200910203849.8A patent/CN101602756B/zh not_active Expired - Fee Related
- 2003-07-09 BR BRPI0312649A patent/BRPI0312649A2/pt not_active IP Right Cessation
- 2003-07-09 MX MXPA05000365A patent/MXPA05000365A/es active IP Right Grant
- 2003-07-09 SG SG200806632-6A patent/SG169236A1/en unknown
- 2003-07-09 CN CNB038185563A patent/CN100513404C/zh not_active Expired - Fee Related
- 2003-07-09 CA CA2491802A patent/CA2491802C/en not_active Expired - Fee Related
- 2003-07-09 KR KR1020057000382A patent/KR101087559B1/ko not_active Expired - Fee Related
- 2003-07-09 EP EP03763470A patent/EP1539730A4/en not_active Withdrawn
- 2003-07-09 EP EP11164126A patent/EP2386551A1/en not_active Withdrawn
- 2003-07-09 JP JP2004520132A patent/JP2005533835A/ja active Pending
- 2003-07-09 WO PCT/US2003/021700 patent/WO2004005277A1/en not_active Ceased
- 2003-07-09 EP EP11164123A patent/EP2386550A1/en not_active Withdrawn
- 2003-07-09 CA CA2767092A patent/CA2767092C/en not_active Expired - Fee Related
-
2005
- 2005-01-03 IL IL16610805A patent/IL166108A0/xx unknown
-
2008
- 2008-03-17 IL IL190218A patent/IL190218A0/en unknown
-
2010
- 2010-01-13 US US12/686,691 patent/US20100120901A1/en not_active Abandoned
- 2010-10-08 JP JP2010228956A patent/JP2011037881A/ja active Pending
-
2013
- 2013-06-04 JP JP2013117677A patent/JP2013189464A/ja active Pending
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