JP2004520292A5 - - Google Patents
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- Publication number
- JP2004520292A5 JP2004520292A5 JP2002547905A JP2002547905A JP2004520292A5 JP 2004520292 A5 JP2004520292 A5 JP 2004520292A5 JP 2002547905 A JP2002547905 A JP 2002547905A JP 2002547905 A JP2002547905 A JP 2002547905A JP 2004520292 A5 JP2004520292 A5 JP 2004520292A5
- Authority
- JP
- Japan
- Prior art keywords
- imidazole
- alkyl
- phenylethynyl
- methyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00126615 | 2000-12-04 | ||
| PCT/EP2001/013714 WO2002046166A1 (en) | 2000-12-04 | 2001-11-26 | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007325072A Division JP2008169206A (ja) | 2000-12-04 | 2007-12-17 | グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004520292A JP2004520292A (ja) | 2004-07-08 |
| JP2004520292A5 true JP2004520292A5 (enExample) | 2005-05-26 |
| JP4077317B2 JP4077317B2 (ja) | 2008-04-16 |
Family
ID=8170567
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002547905A Expired - Fee Related JP4077317B2 (ja) | 2000-12-04 | 2001-11-26 | グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体 |
| JP2007325072A Pending JP2008169206A (ja) | 2000-12-04 | 2007-12-17 | グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007325072A Pending JP2008169206A (ja) | 2000-12-04 | 2007-12-17 | グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US6706707B2 (enExample) |
| EP (1) | EP1349839B8 (enExample) |
| JP (2) | JP4077317B2 (enExample) |
| KR (1) | KR100515549B1 (enExample) |
| CN (1) | CN1257894C (enExample) |
| AR (1) | AR035401A1 (enExample) |
| AT (1) | ATE288898T1 (enExample) |
| AU (2) | AU2002229567B2 (enExample) |
| BG (1) | BG107877A (enExample) |
| BR (1) | BR0115871A (enExample) |
| CA (1) | CA2430696C (enExample) |
| CZ (1) | CZ20031795A3 (enExample) |
| DE (1) | DE60108900T2 (enExample) |
| DK (1) | DK1349839T3 (enExample) |
| EC (1) | ECSP034640A (enExample) |
| ES (1) | ES2248410T3 (enExample) |
| HR (1) | HRP20030429A2 (enExample) |
| HU (1) | HUP0400570A3 (enExample) |
| IL (2) | IL155999A0 (enExample) |
| MA (1) | MA26971A1 (enExample) |
| MX (1) | MXPA03004862A (enExample) |
| NO (1) | NO324326B1 (enExample) |
| NZ (1) | NZ525917A (enExample) |
| PL (1) | PL366222A1 (enExample) |
| PT (1) | PT1349839E (enExample) |
| RS (1) | RS43903A (enExample) |
| RU (1) | RU2284323C9 (enExample) |
| SI (1) | SI1349839T1 (enExample) |
| SK (1) | SK8402003A3 (enExample) |
| WO (1) | WO2002046166A1 (enExample) |
| ZA (1) | ZA200303870B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0128996D0 (en) * | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| WO2004014881A2 (en) | 2002-08-09 | 2004-02-19 | Astra Zeneca Ab | '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| CN1691944A (zh) * | 2002-08-09 | 2005-11-02 | 阿斯利康(瑞典)有限公司 | 作为代谢型谷氨酸受体－5调节剂的噁二唑 |
| AU2003264018A1 (en) | 2002-08-09 | 2004-02-25 | Astrazeneca Ab | Compounds having an activity at metabotropic glutamate receptors |
| ITMI20030151A1 (it) * | 2003-01-30 | 2004-07-31 | Recordati Ind Chimica E Farma Ceutica S P A | Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore. |
| JP2006519251A (ja) | 2003-03-04 | 2006-08-24 | アデックス ファーマシューティカルズ ソシエテ アノニム | ｍＧｌｕＲ５アンタゴニストとしての新規アミノピリジン誘導体 |
| CN100516040C (zh) | 2003-03-07 | 2009-07-22 | 安斯泰来制药有限公司 | 具有2,6-二取代苯乙烯基的含氮杂环衍生物 |
| TWI292318B (en) | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
| AU2004226450A1 (en) | 2003-03-26 | 2004-10-14 | Merck & Co. Inc. | Benzamide modulators of metabotropic glutamate receptors |
| UA80888C2 (en) | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US7531529B2 (en) | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
| MXPA05013233A (es) * | 2003-06-12 | 2006-03-09 | Hoffmann La Roche | Derivados de imidazol heteroaril-substituidos como antagonistas del receptor de glutamato. |
| ES2332184T3 (es) * | 2004-03-22 | 2010-01-28 | ELI LILLY & COMPANY | Derivados de piridilo y su uso como antagonistas del receptor mglu5. |
| EP2261218B1 (en) * | 2004-05-26 | 2013-04-03 | Eisai R&D Management Co., Ltd. | Imidazole compound for use as an intermediate in the production of cinnamide compounds |
| HRP20080363T3 (hr) | 2004-06-01 | 2008-09-30 | F. Hoffmann - La Roche Ag | Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora |
| EP1756086B1 (en) * | 2004-06-01 | 2008-06-04 | F.Hoffmann-La Roche Ag | Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists |
| GB0413605D0 (en) | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
| DE102004044884A1 (de) | 2004-09-14 | 2006-05-24 | Grünenthal GmbH | Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen |
| KR20070083781A (ko) | 2004-10-26 | 2007-08-24 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물의 비정질체 |
| BRPI0517423A (pt) * | 2004-12-27 | 2008-10-07 | Astrazeneca Ab | composto, composição farmacêutica, método para o tratamento ou prevenção de distúrbios neurológicos e psiquiátricos associados com disfunção do glutamato em um animal, e, uso em um composto |
| CA2601098C (en) * | 2005-03-16 | 2011-07-05 | Aventis Pharmaceuticals Inc. | Dipyrazoles as central nervous system agents |
| PT1863818E (pt) * | 2005-03-23 | 2010-04-09 | Hoffmann La Roche | Derivados de acetilenil-pirazolo-pirimidina como antagonistas de mglur2 |
| GB0508319D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| CA2628047A1 (en) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | Process for production of cinnamide derivative |
| EP1953151A4 (en) * | 2005-11-18 | 2010-06-02 | Eisai R&D Man Co Ltd | SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| TWI386207B (zh) * | 2005-11-24 | 2013-02-21 | Eisai R&D Man Co Ltd | 味啉類型之肉桂醯胺化合物 |
| JP5537033B2 (ja) * | 2005-12-19 | 2014-07-02 | ザ ユニヴァーシティー オブ リヴァプール | 無痛覚 |
| DE102005062985A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| GEP20115139B (en) * | 2006-03-09 | 2011-01-10 | Eisai R&D Man Co Ltd | Polycyclic cinnamide derivative |
| DE102006011574A1 (de) * | 2006-03-10 | 2007-10-31 | Grünenthal GmbH | Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln |
| SA07280403B1 (ar) * | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | ملح رباعي لمركب سيناميد |
| AU2007336369B2 (en) | 2006-12-21 | 2013-01-17 | F. Hoffmann-La Roche Ag | Polymorphs of a mGluR5 receptor antagonist |
| TW200848054A (en) | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
| CN101679360A (zh) * | 2007-05-16 | 2010-03-24 | 卫材R&D管理有限公司 | 一步生产肉桂酰胺衍生物的方法 |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| AR068121A1 (es) | 2007-08-31 | 2009-11-04 | Eisai R&D Man Co Ltd | Compuestos multiciclicos para tratar enfermedades neurodegenerativas |
| CA2712095A1 (en) * | 2008-01-28 | 2009-08-06 | Eisai R&D Management Co., Ltd. | Crystalline cinnamide compounds or salts thereof |
| US8323805B2 (en) | 2009-06-04 | 2012-12-04 | Nitto Denko Corporation | Emissive aryl-heteroaryl acetylenes |
| US8334287B2 (en) | 2009-07-17 | 2012-12-18 | Hoffmann-La Roche Inc. | Imidazoles |
| WO2012015024A1 (ja) * | 2010-07-29 | 2012-02-02 | 大正製薬株式会社 | エチニル－ピラゾール誘導体 |
| CA3006745C (en) | 2010-11-05 | 2021-03-30 | Oat Agrio Co., Ltd. | Ethynylphenylamidine compound or salt thereof, method for producing same, and fungicide for agricultural and horticultural use |
| WO2012172093A1 (en) * | 2011-06-17 | 2012-12-20 | Merz Pharma Gmbh & Co. Kgaa | Dihydroindolizine derivate as metabotropic glutamate receptor modulators |
| KR101291037B1 (ko) * | 2011-10-12 | 2013-08-01 | 사회복지법인 삼성생명공익재단 | 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도 |
| WO2017117708A1 (en) | 2016-01-05 | 2017-07-13 | Hua Medicine (Shanghai) Ltd. | Pyrazole derivatives |
| WO2017173604A1 (en) | 2016-04-06 | 2017-10-12 | Hua Medicine (Shanghai) Ltd. | Pyrrole derivatives |
| TW201837026A (zh) | 2017-01-10 | 2018-10-16 | 德商拜耳廠股份有限公司 | 作為除害劑之雜環衍生物（二） |
| KR20200035035A (ko) | 2017-07-31 | 2020-04-01 | 노파르티스 아게 | 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도 |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
| CN114746408B (zh) * | 2019-12-02 | 2025-02-14 | 豪夫迈·罗氏有限公司 | 炔基-(杂芳基)-甲酰胺hcn1抑制剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3303199A (en) | 1963-07-15 | 1967-02-07 | Geigy Chem Corp | Certain imidazolone derivatives and process for making same |
| US3341548A (en) | 1964-04-29 | 1967-09-12 | Hoffmann La Roche | Nitroimidazoles and their preparation |
| DE2035905A1 (de) * | 1970-07-20 | 1972-02-03 | Chemische Fabrik Stockhausen & Cie.,4150Krefeld | Imidazolverbindungen und deren Herstellungsverfahren |
| CA1174673A (en) | 1981-02-27 | 1984-09-18 | Walter Hunkeler | Imidazodiazepines |
| US4711962A (en) | 1984-10-18 | 1987-12-08 | Stauffer Chemical Company | Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles |
| KR0163595B1 (ko) | 1989-06-30 | 1998-12-01 | 미리암디, 메코너헤이 | 치환된 이미다졸 |
| US5821937A (en) * | 1996-02-23 | 1998-10-13 | Netsuite Development, L.P. | Computer method for updating a network design |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| ID28529A (id) * | 1997-08-14 | 2001-05-31 | Hoffmann La Roche | Vinileter heterosiklik untuk gangguan neurologi |
| US6377987B1 (en) * | 1999-04-30 | 2002-04-23 | Cisco Technology, Inc. | Mechanism for determining actual physical topology of network based on gathered configuration information representing true neighboring devices |
| JP4815083B2 (ja) * | 1999-08-31 | 2011-11-16 | メルク・シャープ・エンド・ドーム・コーポレイション | 複素環化合物およびそれの使用方法 |
-
2001
- 2001-11-26 NZ NZ525917A patent/NZ525917A/en unknown
- 2001-11-26 HU HU0400570A patent/HUP0400570A3/hu unknown
- 2001-11-26 DK DK01990437T patent/DK1349839T3/da active
- 2001-11-26 PT PT01990437T patent/PT1349839E/pt unknown
- 2001-11-26 DE DE60108900T patent/DE60108900T2/de not_active Expired - Lifetime
- 2001-11-26 HR HR20030429A patent/HRP20030429A2/hr not_active Application Discontinuation
- 2001-11-26 ES ES01990437T patent/ES2248410T3/es not_active Expired - Lifetime
- 2001-11-26 IL IL15599901A patent/IL155999A0/xx unknown
- 2001-11-26 AT AT01990437T patent/ATE288898T1/de active
- 2001-11-26 CN CNB018199933A patent/CN1257894C/zh not_active Expired - Fee Related
- 2001-11-26 WO PCT/EP2001/013714 patent/WO2002046166A1/en not_active Ceased
- 2001-11-26 SI SI200130304T patent/SI1349839T1/xx unknown
- 2001-11-26 BR BR0115871-6A patent/BR0115871A/pt not_active Application Discontinuation
- 2001-11-26 EP EP01990437A patent/EP1349839B8/en not_active Expired - Lifetime
- 2001-11-26 KR KR10-2003-7007421A patent/KR100515549B1/ko not_active Expired - Fee Related
- 2001-11-26 CA CA002430696A patent/CA2430696C/en not_active Expired - Fee Related
- 2001-11-26 AU AU2002229567A patent/AU2002229567B2/en not_active Ceased
- 2001-11-26 MX MXPA03004862A patent/MXPA03004862A/es active IP Right Grant
- 2001-11-26 AU AU2956702A patent/AU2956702A/xx active Pending
- 2001-11-26 SK SK840-2003A patent/SK8402003A3/sk unknown
- 2001-11-26 CZ CZ20031795A patent/CZ20031795A3/cs unknown
- 2001-11-26 RU RU2003119548/04A patent/RU2284323C9/ru not_active IP Right Cessation
- 2001-11-26 JP JP2002547905A patent/JP4077317B2/ja not_active Expired - Fee Related
- 2001-11-26 PL PL01366222A patent/PL366222A1/xx unknown
- 2001-11-26 RS YU43903A patent/RS43903A/sr unknown
- 2001-11-28 US US09/996,641 patent/US6706707B2/en not_active Expired - Fee Related
- 2001-12-03 AR ARP010105602A patent/AR035401A1/es unknown
-
2003
- 2003-03-25 US US10/396,172 patent/US6972299B2/en not_active Expired - Fee Related
- 2003-04-04 US US10/407,929 patent/US6927232B2/en not_active Expired - Fee Related
- 2003-05-19 ZA ZA200303870A patent/ZA200303870B/en unknown
- 2003-05-19 IL IL155999A patent/IL155999A/en not_active IP Right Cessation
- 2003-06-03 EC EC2003004640A patent/ECSP034640A/es unknown
- 2003-06-03 NO NO20032503A patent/NO324326B1/no not_active IP Right Cessation
- 2003-06-04 MA MA27192A patent/MA26971A1/fr unknown
- 2003-06-04 BG BG107877A patent/BG107877A/bg unknown
-
2005
- 2005-01-18 US US11/037,904 patent/US20050131043A1/en not_active Abandoned
-
2007
- 2007-12-17 JP JP2007325072A patent/JP2008169206A/ja active Pending