JP2004520292A5 - - Google Patents

Download PDF

Info

Publication number
JP2004520292A5
JP2004520292A5 JP2002547905A JP2002547905A JP2004520292A5 JP 2004520292 A5 JP2004520292 A5 JP 2004520292A5 JP 2002547905 A JP2002547905 A JP 2002547905A JP 2002547905 A JP2002547905 A JP 2002547905A JP 2004520292 A5 JP2004520292 A5 JP 2004520292A5
Authority
JP
Japan
Prior art keywords
imidazole
alkyl
phenylethynyl
methyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002547905A
Other languages
English (en)
Japanese (ja)
Other versions
JP4077317B2 (ja
JP2004520292A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2001/013714 external-priority patent/WO2002046166A1/en
Publication of JP2004520292A publication Critical patent/JP2004520292A/ja
Publication of JP2004520292A5 publication Critical patent/JP2004520292A5/ja
Application granted granted Critical
Publication of JP4077317B2 publication Critical patent/JP4077317B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2002547905A 2000-12-04 2001-11-26 グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体 Expired - Fee Related JP4077317B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00126615 2000-12-04
PCT/EP2001/013714 WO2002046166A1 (en) 2000-12-04 2001-11-26 Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007325072A Division JP2008169206A (ja) 2000-12-04 2007-12-17 グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体

Publications (3)

Publication Number Publication Date
JP2004520292A JP2004520292A (ja) 2004-07-08
JP2004520292A5 true JP2004520292A5 (enExample) 2005-05-26
JP4077317B2 JP4077317B2 (ja) 2008-04-16

Family

ID=8170567

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002547905A Expired - Fee Related JP4077317B2 (ja) 2000-12-04 2001-11-26 グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体
JP2007325072A Pending JP2008169206A (ja) 2000-12-04 2007-12-17 グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007325072A Pending JP2008169206A (ja) 2000-12-04 2007-12-17 グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体

Country Status (31)

Country Link
US (4) US6706707B2 (enExample)
EP (1) EP1349839B8 (enExample)
JP (2) JP4077317B2 (enExample)
KR (1) KR100515549B1 (enExample)
CN (1) CN1257894C (enExample)
AR (1) AR035401A1 (enExample)
AT (1) ATE288898T1 (enExample)
AU (2) AU2002229567B2 (enExample)
BG (1) BG107877A (enExample)
BR (1) BR0115871A (enExample)
CA (1) CA2430696C (enExample)
CZ (1) CZ20031795A3 (enExample)
DE (1) DE60108900T2 (enExample)
DK (1) DK1349839T3 (enExample)
EC (1) ECSP034640A (enExample)
ES (1) ES2248410T3 (enExample)
HR (1) HRP20030429A2 (enExample)
HU (1) HUP0400570A3 (enExample)
IL (2) IL155999A0 (enExample)
MA (1) MA26971A1 (enExample)
MX (1) MXPA03004862A (enExample)
NO (1) NO324326B1 (enExample)
NZ (1) NZ525917A (enExample)
PL (1) PL366222A1 (enExample)
PT (1) PT1349839E (enExample)
RS (1) RS43903A (enExample)
RU (1) RU2284323C9 (enExample)
SI (1) SI1349839T1 (enExample)
SK (1) SK8402003A3 (enExample)
WO (1) WO2002046166A1 (enExample)
ZA (1) ZA200303870B (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
KR20050033070A (ko) 2002-08-09 2005-04-08 아스트라제네카 에이비이 메타보트로픽 글루타메이트 수용체-5의 조절제로서[1,2,4]옥사디아졸
AU2003268064A1 (en) * 2002-08-09 2004-02-25 Astrazeneca Ab Oxadiazoles as modulators of metabotropic glutamate receptor-5
AU2003264018A1 (en) * 2002-08-09 2004-02-25 Astrazeneca Ab Compounds having an activity at metabotropic glutamate receptors
ITMI20030151A1 (it) * 2003-01-30 2004-07-31 Recordati Ind Chimica E Farma Ceutica S P A Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore.
DE602004017966D1 (de) 2003-03-04 2009-01-08 Addex Pharma Sa Neue aminopyridinderivate als mglur5-antagonisten
WO2004078715A1 (ja) 2003-03-07 2004-09-16 Astellas Pharma Inc. ２，６－ジ置換スチリルを有する含窒素へテロ環誘導体
TWI292318B (en) 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
US7507836B2 (en) 2003-03-26 2009-03-24 Merck & Co. Inc. Benzamide modulators of metabotropic glutamate receptors
US7531529B2 (en) 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
NZ543638A (en) * 2003-06-12 2008-05-30 Hoffmann La Roche Heteroaryl-substituted imidazole derivatives as glutamate receptor antagonists
DE602005017129D1 (de) * 2004-03-22 2009-11-26 Lilly Co Eli Pyridyl-derivate und ihre verwendung als mglu5-rezeptorantagonisten
CA2566094A1 (en) * 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Cinnamide compound
KR101057032B1 (ko) * 2004-06-01 2011-08-16 에프. 호프만-라 로슈 아게 Ｍｇｌｕ5 수용체 길항제로서 피리딘-4-일-에틴일-이미다졸및 피라졸
AU2005250101B2 (en) * 2004-06-01 2011-08-25 F. Hoffmann-La Roche Ag Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mGlu5 receptor antagonists
GB0413605D0 (en) 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
DE102004044884A1 (de) 2004-09-14 2006-05-24 Grünenthal GmbH Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen
AU2005297966B2 (en) 2004-10-26 2010-12-23 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
MX2007007220A (es) * 2004-12-27 2007-08-20 Astrazeneca Ab Compuestos de pirazolona como agonistas de receptor de glutamato metabotropico para el tratamiento de trastornos neurologicos y psiquiatricos.
CN101171235B (zh) * 2005-03-16 2011-03-02 安万特药物公司 作为中枢神经系统活性剂的联吡唑类
ATE460417T1 (de) 2005-03-23 2010-03-15 Hoffmann La Roche Acetylenylpyrazolopyrimidinderivate als mglur2- antagonsten
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
CN101309916A (zh) * 2005-11-18 2008-11-19 卫材R&D管理有限公司 制备肉桂酰胺衍生物的方法
EP1953151A4 (en) * 2005-11-18 2010-06-02 Eisai R&D Man Co Ltd SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
BRPI0618814A2 (pt) * 2005-11-24 2014-04-29 Eisai R&D Man Co Ltd Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico
CA2632561C (en) * 2005-12-19 2015-01-27 The University Of Liverpool Substituted propofol derivatives as analgesics
DE102005062985A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln
PL1992618T3 (pl) * 2006-03-09 2012-06-29 Eisai R&D Man Co Ltd Policykliczna pochodna cynamidowa
TWI378091B (en) * 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
DE102006011574A1 (de) * 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
US7737141B2 (en) * 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
JP5405311B2 (ja) 2006-12-21 2014-02-05 エフ．ホフマン−ラ ロシュ アーゲー ｍＧｌｕＲ５受容体アンタゴニストの多形
CL2008000582A1 (es) 2007-02-28 2008-06-27 Eisai R&D Man Co Ltd Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis.
WO2008140111A1 (ja) * 2007-05-16 2008-11-20 Eisai R & D Management Co., Ltd. シンナミド誘導体のワンポット製造方法
CA2694401C (en) * 2007-08-31 2012-12-04 Eisai R&D Management Co., Ltd. Polycyclic compound
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
WO2009096349A1 (ja) * 2008-01-28 2009-08-06 Eisai R & D Management Co., Ltd. 結晶性のシンナミド化合物またはその塩
US8323805B2 (en) 2009-06-04 2012-12-04 Nitto Denko Corporation Emissive aryl-heteroaryl acetylenes
US8334287B2 (en) 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US8642626B2 (en) 2010-07-29 2014-02-04 Taisho Pharmaceutical Co., Ltd. Ethinyl-pyrazole derivative
CA3006745C (en) * 2010-11-05 2021-03-30 Oat Agrio Co., Ltd. Ethynylphenylamidine compound or salt thereof, method for producing same, and fungicide for agricultural and horticultural use
WO2012172093A1 (en) * 2011-06-17 2012-12-20 Merz Pharma Gmbh & Co. Kgaa Dihydroindolizine derivate as metabotropic glutamate receptor modulators
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
EP3400220B1 (en) * 2016-01-05 2021-03-24 Hua Medicine (Shanghai) Ltd. Pyrazole derivatives
US10669255B2 (en) 2016-04-06 2020-06-02 Hua Medicine (Shanghai) Ltd. Pyrrole derivatives
MX2019008230A (es) 2017-01-10 2019-10-24 Bayer Ag Derivados heterociclicos como agentes de control de plagas.
KR20200035035A (ko) 2017-07-31 2020-04-01 노파르티스 아게 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
EP4069685A1 (en) 2019-12-02 2022-10-12 F. Hoffmann-La Roche AG Alkynyl-(heteroaryl)-carboxamide hcn1 inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303199A (en) 1963-07-15 1967-02-07 Geigy Chem Corp Certain imidazolone derivatives and process for making same
US3341548A (en) 1964-04-29 1967-09-12 Hoffmann La Roche Nitroimidazoles and their preparation
DE2035905A1 (de) * 1970-07-20 1972-02-03 Chemische Fabrik Stockhausen & Cie.,4150Krefeld Imidazolverbindungen und deren Herstellungsverfahren
CA1174673A (en) 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
US4711962A (en) 1984-10-18 1987-12-08 Stauffer Chemical Company Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
KR0163595B1 (ko) 1989-06-30 1998-12-01 미리암디, 메코너헤이 치환된 이미다졸
US5821937A (en) * 1996-02-23 1998-10-13 Netsuite Development, L.P. Computer method for updating a network design
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
HRP20000079A2 (en) * 1997-08-14 2000-12-31 Hoffmann La Roche Heterocyclic vinylethers against neurological disorders
US6377987B1 (en) * 1999-04-30 2002-04-23 Cisco Technology, Inc. Mechanism for determining actual physical topology of network based on gathered configuration information representing true neighboring devices
JP4815083B2 (ja) * 1999-08-31 2011-11-16 メルク・シャープ・エンド・ドーム・コーポレイション 複素環化合物およびそれの使用方法

Similar Documents

Publication Publication Date Title
JP2004520292A5 (enExample)
RU2003119548A (ru) Фенилэтенил-или фенилэтенилпроизводные в качестве антагонистов глутаматного рецептора
JP2004523535A5 (enExample)
JP2003510359A5 (enExample)
US7629374B2 (en) Use of aminoindazole derivatives for the inhibition of tau phosphorylation
TWI268925B (en) 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them
JP2005509632A5 (enExample)
IL160945A (en) 4, 5 - diarylthiazole - 2 - carboxamides having cb1 - antagonistic, agonistic or partial agonistic activity and use thereof for the preparation of pharmaceutical compositions
JP2006501201A5 (enExample)
JP2005536475A5 (enExample)
RU2005131165A (ru) Производные имидазол-4-илэтинилпиридина
JP2009525340A5 (enExample)
JP2014502979A5 (enExample)
JP2005533835A5 (enExample)
JP2004525965A5 (enExample)
JP2006501306A5 (enExample)
JP2007502265A5 (enExample)
JP2011524896A5 (enExample)
JP2006524686A5 (enExample)
JP2002505286A5 (enExample)
CN102223882A (zh) 用于治疗肥厚型心肌病的III 型磷酸二酯酶(PPE III)抑制剂或Ca2+敏化剂
JP2004521150A5 (enExample)
JP2004524279A5 (enExample)
JP2004520424A5 (enExample)
JP2004525184A5 (enExample)