ATE458729T1 - Amorphe form einer zimtsäureamidverbindung - Google Patents
Amorphe form einer zimtsäureamidverbindungInfo
- Publication number
- ATE458729T1 ATE458729T1 AT05805284T AT05805284T ATE458729T1 AT E458729 T1 ATE458729 T1 AT E458729T1 AT 05805284 T AT05805284 T AT 05805284T AT 05805284 T AT05805284 T AT 05805284T AT E458729 T1 ATE458729 T1 AT E458729T1
- Authority
- AT
- Austria
- Prior art keywords
- acid amide
- cinnamic acid
- amide compound
- amorphous form
- amorphous object
- Prior art date
Links
- APEJMQOBVMLION-UHFFFAOYSA-N cinnamic acid amide Natural products NC(=O)C=CC1=CC=CC=C1 APEJMQOBVMLION-UHFFFAOYSA-N 0.000 title 1
- -1 cinnamic acid amide compound Chemical class 0.000 title 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Tires In General (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004310909 | 2004-10-26 | ||
| PCT/JP2005/019626 WO2006046575A1 (ja) | 2004-10-26 | 2005-10-25 | シンナミド化合物の非晶質体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE458729T1 true ATE458729T1 (de) | 2010-03-15 |
Family
ID=36227816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05805284T ATE458729T1 (de) | 2004-10-26 | 2005-10-25 | Amorphe form einer zimtsäureamidverbindung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7923563B2 (de) |
| EP (1) | EP1808432B1 (de) |
| JP (1) | JPWO2006046575A1 (de) |
| KR (1) | KR20070083781A (de) |
| CN (1) | CN100577657C (de) |
| AT (1) | ATE458729T1 (de) |
| AU (1) | AU2005297966B2 (de) |
| CA (1) | CA2580119A1 (de) |
| DE (1) | DE602005019602D1 (de) |
| ES (1) | ES2338904T3 (de) |
| IL (1) | IL182524A (de) |
| WO (1) | WO2006046575A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0511504A (pt) | 2004-05-26 | 2008-01-22 | Eisai R&D Man Co Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, e, agente preventivo ou terapêutico para uma doença resultante de beta-amilóides |
| ATE458729T1 (de) | 2004-10-26 | 2010-03-15 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
| US20090048448A1 (en) * | 2005-11-18 | 2009-02-19 | Ikuo Kushida | Salts of cynnamide compound or solvates thereof |
| KR20080076907A (ko) * | 2005-11-18 | 2008-08-20 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 유도체의 제조 방법 |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| MY144960A (en) * | 2005-11-24 | 2011-11-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| JPWO2007135970A1 (ja) * | 2006-05-19 | 2009-10-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環系−シンナミド誘導体 |
| KR20090018963A (ko) * | 2006-05-19 | 2009-02-24 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 우레아계 신나미드 유도체 |
| SA07280403B1 (ar) | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | ملح رباعي لمركب سيناميد |
| WO2008097538A1 (en) * | 2007-02-08 | 2008-08-14 | Merck & Co., Inc. | Therapeutic agents |
| US20080207900A1 (en) | 2007-02-28 | 2008-08-28 | Teiji Kimura | Two cyclic oxomorphorin derivatives |
| DE102007009810A1 (de) * | 2007-02-28 | 2008-09-04 | Man Roland Druckmaschinen Ag | Übertragungsform für einen Übertragungszylinder einer Druckmaschine |
| US20100130537A1 (en) * | 2007-04-26 | 2010-05-27 | Eisai R&D Management Co., Ltd | Cinnamide compounds for dementia |
| WO2008140111A1 (ja) | 2007-05-16 | 2008-11-20 | Eisai R & D Management Co., Ltd. | シンナミド誘導体のワンポット製造方法 |
| EP2166854A4 (de) | 2007-06-13 | 2012-05-16 | Merck Sharp & Dohme | Triazolderivate zur behandlung von morbus alzheimer und verwandten leiden |
| EP2181992B8 (de) | 2007-08-31 | 2013-06-26 | Eisai R&D Management Co., Ltd. | Polycyclische verbindung |
| US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| JP2011507909A (ja) | 2007-12-20 | 2011-03-10 | エンビボ ファーマシューティカルズ インコーポレイテッド | 四置換ベンゼン |
| BRPI0906688A2 (pt) * | 2008-01-28 | 2015-06-30 | Eisai R&D Man Co Ltd | Sal, e, cristal |
| US8575150B2 (en) | 2008-12-16 | 2013-11-05 | Merck Sharp & Dohme Corp. | Triazole derivatives for treatment of Alzheimer's disease |
| PA8854101A1 (es) * | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| JP5576403B2 (ja) | 2009-02-06 | 2014-08-20 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | γ分泌酵素調節物質としての新規置換二環複素環化合物 |
| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| KR20120024555A (ko) | 2009-05-07 | 2012-03-14 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 신규 치환된 인다졸 및 아자-인다졸 유도체 |
| ES2519565T3 (es) | 2009-07-15 | 2014-11-07 | Janssen Pharmaceuticals Inc. | Derivados de triazol e imidazol sustituidos como moduladores de gamma secretasa |
| WO2011086098A1 (en) | 2010-01-15 | 2011-07-21 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Novel substituted bicyclic triazole derivatives as gamma secretase modulators |
| MX2013002511A (es) | 2010-09-02 | 2013-07-29 | Takeda Pharmaceutical | Triazoles fusionados para el tratamiento o profilaxis de daño cognitivo moderado. |
| WO2012126984A1 (en) | 2011-03-24 | 2012-09-27 | Janssen Pharmaceuticals, Inc. | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
| MX2014000626A (es) | 2011-07-15 | 2014-04-30 | Janssen Pharmaceuticals Inc | Nuevos derivados de indol sustituidos como moduladores de gamma secretasa. |
| SG11201407051XA (en) | 2012-05-16 | 2014-11-27 | Janssen Pharmaceuticals Inc | Substituted 3, 4 - dihydro - 2h - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) alzheimer's disease |
| CA2889249C (en) | 2012-12-20 | 2021-02-16 | Francois Paul Bischoff | Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
| EP2945944B1 (de) | 2013-01-17 | 2016-11-09 | Janssen Pharmaceutica, N.V. | Neuartige substituierte pyrido-piperazinon-derivate als gamma-sekretase-modulatoren |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1101156A (en) | 1965-09-22 | 1968-01-31 | Hickson & Welch Ltd | Triazole derivatives and their use as optical whitening agents |
| US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| FR2314731A1 (fr) | 1975-06-19 | 1977-01-14 | Nelson Res & Dev | Azacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients |
| ES2061432T3 (es) * | 1985-10-09 | 1994-12-16 | Shell Int Research | Nuevas amidas de acido acrilico. |
| DE3541716A1 (de) | 1985-11-26 | 1987-05-27 | Celamerck Gmbh & Co Kg | Neue acrylsaeureamide |
| IT1205834B (it) | 1987-04-22 | 1989-03-31 | Elbart | Derivati tiodiossolanici ad attivita' mucolitica a procedimento per la loro preparazione |
| JPH03206042A (ja) | 1990-01-06 | 1991-09-09 | Takeda Chem Ind Ltd | 降圧剤 |
| EP0468054B1 (de) * | 1990-02-08 | 1997-05-28 | Eisai Co., Ltd. | Benzensulfonamidderivat |
| JPH04101852A (ja) * | 1990-08-21 | 1992-04-03 | Kanzaki Paper Mfg Co Ltd | ラインヘッド型熱転写プリンタ |
| FR2678784B1 (fr) * | 1991-07-03 | 1993-10-22 | Logistel | Dispositif pour la realisation de derivations de cables blindes. |
| AU680870B2 (en) | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
| GB9402807D0 (en) | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| AU3577995A (en) | 1994-10-04 | 1996-04-26 | Fujisawa Pharmaceutical Co., Ltd. | Urea derivatives and their use as acat-inhibitors |
| JPH08283219A (ja) | 1995-04-07 | 1996-10-29 | Eisai Co Ltd | アラルキルアミノアルキルアミド誘導体 |
| US5804577A (en) | 1995-09-12 | 1998-09-08 | Hoffmann-La Roche Inc. | Cephalosporin derivatives |
| WO1997014417A1 (en) | 1995-10-19 | 1997-04-24 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| KR20000010918A (ko) | 1996-05-10 | 2000-02-25 | 게리 엘. 윌콕스 | 카르볼린 유도체 |
| CN1238688A (zh) | 1996-07-22 | 1999-12-15 | 孟山都公司 | 硫羟磺酰胺金属蛋白酶抑制剂 |
| US5672612A (en) * | 1996-09-09 | 1997-09-30 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
| WO1998024785A1 (en) | 1996-12-02 | 1998-06-11 | Fujisawa Pharmaceutical Co., Ltd. | Indole-urea derivatives with 5-ht antagonist properties |
| AU6520098A (en) | 1997-03-31 | 1998-10-22 | Takeda Chemical Industries Ltd. | Azole compounds, their production and their use |
| JP3108997B2 (ja) | 1997-03-31 | 2000-11-13 | 武田薬品工業株式会社 | アゾール化合物、その製造法および用途 |
| TW379224B (en) | 1997-12-02 | 2000-01-11 | Fujisawa Pharmaceutical Co | Urea derivatives |
| CA2317008C (en) | 1997-12-31 | 2009-01-20 | The University Of Kansas | Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof |
| GB9816984D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
| US6235728B1 (en) * | 1999-02-19 | 2001-05-22 | Bristol-Myers Squibb Company | Water-soluble prodrugs of azole compounds |
| WO2000050391A1 (en) | 1999-02-26 | 2000-08-31 | Merck & Co., Inc. | Novel sulfonamide compounds and uses thereof |
| AU2899400A (en) | 1999-03-04 | 2000-09-21 | Nortran Pharmaceuticals Inc. | Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics |
| AU2001241128A1 (en) * | 2000-03-14 | 2001-09-24 | Fujisawa Pharmaceutical Co. Ltd. | Novel amide compounds |
| US20010051642A1 (en) * | 2000-04-17 | 2001-12-13 | Kyunghye Ahn | Method for treating Alzheimer's disease |
| WO2001081312A2 (en) | 2000-04-24 | 2001-11-01 | Merck Frosst Canada & Co. | Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| KR100515549B1 (ko) * | 2000-12-04 | 2005-09-20 | 에프. 호프만-라 로슈 아게 | 글루타메이트 수용체 길항제로서의 페닐에테닐 또는페닐에티닐 유도체 |
| GB0108770D0 (en) | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| MXPA04002404A (es) | 2001-09-14 | 2004-05-31 | Novo Nordisk As | Ligandos novedosos para los sitios hisb10zn2+ del hexamero de insulina en estado r. |
| MXPA04005427A (es) * | 2001-12-10 | 2005-04-19 | Amgen Inc | Ligandos de receptor vainilloide y su uso en tratamientos. |
| HUP0500173A3 (en) * | 2001-12-20 | 2009-03-30 | Bristol Myers Squibb Co | Alpha-sulphonamido-acetamide derivatives as beta-amyloid inhibitors and pharmaceutical compositions containing them |
| JP2003206280A (ja) * | 2001-12-28 | 2003-07-22 | Takeda Chem Ind Ltd | ビアリール化合物およびその用途 |
| AU2003225668A1 (en) | 2002-03-01 | 2003-09-16 | Pintex Pharmaceutical, Inc. | Pin1-modulating compounds and methods of use thereof |
| GB0207436D0 (en) | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| PL375552A1 (en) * | 2002-05-22 | 2005-11-28 | Amgen Inc. | Vanilloid receptor ligands and their medical applications |
| PT1511710E (pt) | 2002-05-31 | 2014-02-26 | Proteotech Inc | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson |
| US7459476B2 (en) | 2002-06-27 | 2008-12-02 | Elan Pharmaceuticals, Inc. | Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere |
| WO2004007455A1 (de) | 2002-07-12 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Heterozyklisch substituierte benzoylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US6900354B2 (en) * | 2002-07-15 | 2005-05-31 | Hoffman-La Roche Inc. | 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives |
| EP1594847A2 (de) | 2003-02-12 | 2005-11-16 | Transtech Pharma, Inc. | Substituierte azolderivate zur therapeutischen verwendung |
| CA2521095A1 (en) * | 2003-04-01 | 2004-10-21 | Plus Chemicals, B.V. | Amorphous simvastatin calcium and methods for the preparation thereof |
| MXPA05012281A (es) | 2003-05-14 | 2006-05-19 | Torreypines Therapeutics Inc | Compuestos y uso de los mismos en la modulacion beta amiloide. |
| JP2005072731A (ja) | 2003-08-20 | 2005-03-17 | Matsushita Electric Ind Co Ltd | 双方向光送受信装置及び双方向光伝送システム |
| JP5010917B2 (ja) * | 2003-08-29 | 2012-08-29 | エグゼリクシス, インコーポレイテッド | c−Kit調節因子および使用方法 |
| CA2551038C (en) | 2003-12-22 | 2010-04-27 | Pfizer Inc. | Triazole derivatives as vasopressin antagonists |
| WO2005072731A1 (en) | 2004-01-29 | 2005-08-11 | X-Ceptor Therapeutics, Inc. | 3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders |
| AU2005214349B2 (en) | 2004-02-12 | 2011-11-03 | Transtech Pharma, Inc. | Substituted azole derivatives, compositions, and methods of use |
| CA2558026C (en) | 2004-03-09 | 2010-12-14 | Merck & Co., Inc. | Hiv integrase inhibitors |
| BRPI0511504A (pt) * | 2004-05-26 | 2008-01-22 | Eisai R&D Man Co Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, e, agente preventivo ou terapêutico para uma doença resultante de beta-amilóides |
| ATE458729T1 (de) | 2004-10-26 | 2010-03-15 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
| US20060241038A1 (en) | 2005-04-20 | 2006-10-26 | Eisai Co., Ltd. | Therapeutic agent for Abeta related disorders |
| WO2007034282A2 (en) | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists |
| KR20080076907A (ko) | 2005-11-18 | 2008-08-20 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 유도체의 제조 방법 |
| US20090048448A1 (en) * | 2005-11-18 | 2009-02-19 | Ikuo Kushida | Salts of cynnamide compound or solvates thereof |
| US20070117839A1 (en) * | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
| MY144960A (en) | 2005-11-24 | 2011-11-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| TWI378091B (en) * | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| WO2007102580A1 (ja) | 2006-03-09 | 2007-09-13 | Eisai R & D Management Co., Ltd. | 多環式シンナミド誘導体 |
| SA07280403B1 (ar) * | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | ملح رباعي لمركب سيناميد |
| MX2009012177A (es) | 2007-05-07 | 2009-11-23 | Schering Corp | Moduladores de gamma-secretasa. |
| MX2009012163A (es) * | 2007-05-11 | 2009-12-01 | Hoffmann La Roche | Hetarilanilinas como moduladores para beta-amiloide. |
| EP2166854A4 (de) | 2007-06-13 | 2012-05-16 | Merck Sharp & Dohme | Triazolderivate zur behandlung von morbus alzheimer und verwandten leiden |
| WO2009005729A1 (en) | 2007-06-29 | 2009-01-08 | Schering Corporation | Gamma secretase modulators |
| WO2009020580A1 (en) | 2007-08-06 | 2009-02-12 | Schering Corporation | Gamma secretase modulators |
-
2005
- 2005-10-25 AT AT05805284T patent/ATE458729T1/de not_active IP Right Cessation
- 2005-10-25 WO PCT/JP2005/019626 patent/WO2006046575A1/ja not_active Ceased
- 2005-10-25 US US11/663,550 patent/US7923563B2/en not_active Expired - Fee Related
- 2005-10-25 CA CA002580119A patent/CA2580119A1/en not_active Abandoned
- 2005-10-25 KR KR1020077009298A patent/KR20070083781A/ko not_active Abandoned
- 2005-10-25 JP JP2006543181A patent/JPWO2006046575A1/ja active Pending
- 2005-10-25 DE DE602005019602T patent/DE602005019602D1/de not_active Expired - Lifetime
- 2005-10-25 ES ES05805284T patent/ES2338904T3/es not_active Expired - Lifetime
- 2005-10-25 AU AU2005297966A patent/AU2005297966B2/en not_active Ceased
- 2005-10-25 CN CN200580036889A patent/CN100577657C/zh not_active Expired - Fee Related
- 2005-10-25 EP EP05805284A patent/EP1808432B1/de not_active Expired - Lifetime
-
2007
- 2007-04-12 IL IL182524A patent/IL182524A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070083781A (ko) | 2007-08-24 |
| WO2006046575A1 (ja) | 2006-05-04 |
| US20090203916A1 (en) | 2009-08-13 |
| AU2005297966B2 (en) | 2010-12-23 |
| US7923563B2 (en) | 2011-04-12 |
| ES2338904T3 (es) | 2010-05-13 |
| JPWO2006046575A1 (ja) | 2008-05-22 |
| DE602005019602D1 (de) | 2010-04-08 |
| EP1808432A1 (de) | 2007-07-18 |
| CN101061107A (zh) | 2007-10-24 |
| CN100577657C (zh) | 2010-01-06 |
| IL182524A0 (en) | 2007-09-20 |
| EP1808432A4 (de) | 2009-05-27 |
| EP1808432B1 (de) | 2010-02-24 |
| IL182524A (en) | 2010-11-30 |
| CA2580119A1 (en) | 2006-05-04 |
| AU2005297966A1 (en) | 2006-05-04 |
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