BR112012000915A2 - derivados de triazol e imidazol substituídos como moduladores de gama secretase. - Google Patents
derivados de triazol e imidazol substituídos como moduladores de gama secretase.Info
- Publication number
- BR112012000915A2 BR112012000915A2 BR112012000915A BR112012000915A BR112012000915A2 BR 112012000915 A2 BR112012000915 A2 BR 112012000915A2 BR 112012000915 A BR112012000915 A BR 112012000915A BR 112012000915 A BR112012000915 A BR 112012000915A BR 112012000915 A2 BR112012000915 A2 BR 112012000915A2
- Authority
- BR
- Brazil
- Prior art keywords
- imidazole derivatives
- gamma secretase
- substituted triazole
- secretase modulators
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09165585 | 2009-07-15 | ||
| EP10164625 | 2010-06-01 | ||
| PCT/EP2010/060083 WO2011006903A1 (en) | 2009-07-15 | 2010-07-13 | Substituted triazole and imidazole derivatives as gamma secretase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012000915A2 true BR112012000915A2 (pt) | 2019-09-24 |
Family
ID=42542935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012000915A BR112012000915A2 (pt) | 2009-07-15 | 2010-07-13 | derivados de triazol e imidazol substituídos como moduladores de gama secretase. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8946266B2 (pt) |
| EP (1) | EP2454239B1 (pt) |
| JP (2) | JP2012532912A (pt) |
| KR (1) | KR20120050450A (pt) |
| CN (1) | CN102482227A (pt) |
| AP (1) | AP2011006034A0 (pt) |
| AU (1) | AU2010272578B2 (pt) |
| BR (1) | BR112012000915A2 (pt) |
| CA (1) | CA2778517A1 (pt) |
| EA (1) | EA021047B1 (pt) |
| ES (1) | ES2519565T3 (pt) |
| IL (1) | IL217491A (pt) |
| MX (1) | MX2012000763A (pt) |
| NZ (1) | NZ597505A (pt) |
| SG (1) | SG177644A1 (pt) |
| TW (1) | TW201109316A (pt) |
| WO (1) | WO2011006903A1 (pt) |
| ZA (1) | ZA201200285B (pt) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009028588A1 (ja) * | 2007-08-31 | 2009-03-05 | Eisai R & D Management Co., Ltd. | 多環式化合物 |
| US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| AP2011005779A0 (en) | 2009-02-06 | 2011-08-31 | Ortho Mcneil Janssen Pharm | Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. |
| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| AU2010218667A1 (en) | 2009-02-26 | 2011-07-21 | Eisai R&D Management Co., Ltd. | Salt of tetrahydrotriazolopyridine derivative and crystal thereof |
| SG173710A1 (en) | 2009-02-26 | 2011-09-29 | Eisai R&D Man Co Ltd | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| ES2431619T3 (es) | 2009-05-07 | 2013-11-27 | Janssen Pharmaceuticals, Inc. | Derivados de indazol y aza-indazol sustituidos como moduladores de gamma-secretasa |
| ES2519565T3 (es) | 2009-07-15 | 2014-11-07 | Janssen Pharmaceuticals Inc. | Derivados de triazol e imidazol sustituidos como moduladores de gamma secretasa |
| US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
| TWI468402B (zh) | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β－類澱粉生成之化合物 |
| CN102803261A (zh) | 2010-01-15 | 2012-11-28 | 杨森制药公司 | 作为γ分泌酶调节剂的新的取代的双环三唑衍生物 |
| TW201213327A (en) | 2010-09-02 | 2012-04-01 | Takeda Pharmaceutical | Heterocyclic compound and use thereof |
| CN102617457A (zh) * | 2011-01-28 | 2012-08-01 | 天津药物研究院 | 一种制备罗氟司特的新方法 |
| CN102690194B (zh) * | 2011-03-24 | 2014-06-25 | 上海通远生物科技有限公司 | 3-环丙基甲氧基-4-二氟甲氧基苯甲酸的制备方法 |
| CN103502225B (zh) * | 2011-03-24 | 2015-11-25 | 杨森制药公司 | 作为γ分泌酶调节剂的经取代的三唑基哌嗪以及三唑基哌啶衍生物 |
| WO2013005354A1 (ja) * | 2011-07-01 | 2013-01-10 | 武田薬品工業株式会社 | 複素環化合物 |
| IN2014MN00258A (pt) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc | |
| EA201490286A1 (ru) | 2011-07-15 | 2014-04-30 | Янссен Фармацевтика Нв | Моноклональные антитела, специфичные в отношении x-37 бета-амилоида, и пути их применения |
| JP6479476B2 (ja) * | 2012-02-21 | 2019-03-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ＳｙｋチロシンキナーゼインヒビターおよびＧＣＮ２セリンキナーゼインヒビターとしての８−置換２−アミノー［１，２，４］トリアゾロ［１，５−Ａ］ピラジン類 |
| KR102096625B1 (ko) | 2012-05-16 | 2020-04-03 | 얀센 파마슈티칼즈, 인코포레이티드 | (무엇보다도) 알츠하이머병의 치료에 유용한 치환 3,4-디하이드로-2h-피리도[1,2-a]피라진-1,6-디온 유도체 |
| JP6453218B2 (ja) * | 2012-08-24 | 2019-01-16 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 疾患を治療するためのｈｉｆ活性の複素環式修飾物質 |
| JP6275161B2 (ja) * | 2012-12-20 | 2018-02-07 | ヤンセン ファーマシューティカ エヌ．ベー． | γセクレターゼ調節剤としての新規な三環式３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体 |
| CA2891755C (en) | 2013-01-17 | 2021-10-26 | Janssen Pharmaceutica Nv | Substituted pyrido-piperazinone derivatives as gamma secretase modulators |
| JP6368777B2 (ja) | 2013-06-04 | 2018-08-01 | アクチュラム・ライフ・サイエンス・アクチエボラーグ | ピリミジン化合物およびガンマセクレターゼモジュレーターとしてのその使用 |
| CN105263922B (zh) | 2013-06-04 | 2018-08-17 | 阿克图拉姆生命科学股份公司 | 三唑化合物及其作为γ分泌酶调节剂的用途 |
| US9611254B2 (en) | 2013-06-04 | 2017-04-04 | Acturum Life Science AB | Triazole compounds and their use as gamma secretase modulators |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| EP3110420B8 (en) | 2014-02-25 | 2019-07-10 | Board of Regents, The University of Texas System | Salts of heterocyclic modulators of hif activity for treatment of disease |
| AU2015338946B2 (en) * | 2014-10-31 | 2020-06-11 | The General Hospital Corporation | Potent gamma-secretase modulators |
| ES2796276T3 (es) * | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| EP3484884B1 (en) * | 2016-07-14 | 2021-01-27 | Hoffmann-La Roche AG | Fused pyrimidine derivatives |
| JP7132218B2 (ja) * | 2016-11-08 | 2022-09-06 | エフ．ホフマン－ラ ロシュ アーゲー | フェノキシトリアゾール |
| RU2020114670A (ru) | 2017-10-11 | 2021-11-12 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения для применения в качестве ингибиторов rip1 киназы |
| CA3147858A1 (en) | 2019-07-22 | 2021-01-28 | Bayer Aktiengesellschaft | 5-amino substituted pyrazoles and triazoles as pest control agents |
| CN110759902B (zh) * | 2019-11-01 | 2022-04-22 | 海南一龄医疗产业发展有限公司 | Set8赖氨酸甲基转移酶抑制剂及其制备方法和用途 |
| WO2022033991A1 (de) | 2020-08-13 | 2022-02-17 | Bayer Aktiengesellschaft | 5-amino substituierte triazole als schädlingsbekämpfungsmittel |
| CN112480073B (zh) * | 2020-12-02 | 2022-03-22 | 武汉药明康德新药开发有限公司 | 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法 |
| WO2023238065A1 (en) | 2022-06-09 | 2023-12-14 | Glaxosmithkline Intellectual Property Development Limited | Nitrogen containing condensed 2,3-dihydroquinazolinone compounds as nav1.8 inhibitors |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5767144A (en) | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
| AU6517196A (en) | 1995-07-13 | 1997-02-10 | Knoll Aktiengesellschaft | Piperazine derivatives as therapeutic agents |
| ATE284392T1 (de) * | 1998-11-03 | 2004-12-15 | Abbott Gmbh & Co Kg | Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung |
| CN1156445C (zh) | 1999-06-10 | 2004-07-07 | 沃尼尔·朗伯公司 | 采用二氢异吲哚衍生物抑制淀粉样蛋白聚集和使淀粉样蛋白沉积成像的方法 |
| JP2003530437A (ja) | 2000-04-13 | 2003-10-14 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | Ａβ４２低下物質 |
| US20030176454A1 (en) | 2000-05-15 | 2003-09-18 | Akira Yamada | N-coating heterocyclic compounds |
| DE10109867A1 (de) | 2001-03-01 | 2002-09-05 | Abbott Gmbh & Co Kg | Verwendung von Triazolverbindungen zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie |
| DE10238002A1 (de) | 2002-08-20 | 2004-03-04 | Merck Patent Gmbh | Benzimidazolderivate |
| BRPI0407913A (pt) | 2003-02-27 | 2006-03-01 | Hoffmann La Roche | antagonistas receptores de ccr-3 |
| CA2525547C (en) | 2003-05-14 | 2012-07-03 | Torreypines Therapeutics, Inc. | Compounds and uses thereof in modulating amyloid beta |
| KR100742014B1 (ko) | 2003-08-14 | 2007-07-23 | 에프. 호프만-라 로슈 아게 | Ｇａｂａ계 조절제 |
| ES2353309T3 (es) | 2004-03-08 | 2011-03-01 | Prosidion Ltd. | Hidrazidas del ácido pirrolopiridin-2-carboxílico como inhibidores de glucógeno fosforilasa. |
| US7880009B2 (en) | 2004-05-26 | 2011-02-01 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
| DE602005019602D1 (de) | 2004-10-26 | 2010-04-08 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
| US7572807B2 (en) | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| RU2008115499A (ru) | 2005-09-22 | 2009-10-27 | Санофи-Авентис (Fr) | Новые производные аминокиламидов в качестве антагонистов лигандов рецепторов ccr3 |
| WO2007043786A1 (en) | 2005-10-10 | 2007-04-19 | Seiyang Yang | Dynamic-based verification apparatus for verification from electronic system level to gate level, and verification method using the same |
| US8017805B2 (en) | 2005-10-11 | 2011-09-13 | Chemtura Corporation | Diaromatic amines |
| WO2007105053A2 (en) | 2006-03-13 | 2007-09-20 | Pfizer Products Inc. | Tetralines antagonists of the h-3 receptor |
| GB0606774D0 (en) | 2006-04-03 | 2006-05-10 | Novartis Ag | Organic compounds |
| US7893058B2 (en) | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| US20080090834A1 (en) * | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
| EP2099798A1 (en) | 2006-12-01 | 2009-09-16 | Galapagos N.V. | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2008082490A2 (en) | 2006-12-20 | 2008-07-10 | Schering Corporation | Novel jnk inhibitors |
| JP2010518080A (ja) | 2007-02-08 | 2010-05-27 | メルク・シャープ・エンド・ドーム・コーポレイション | 治療薬 |
| US8252803B2 (en) | 2007-02-12 | 2012-08-28 | Merck Sharp & Dohme Corp. | Piperidine derivatives |
| US20100204230A1 (en) | 2007-02-12 | 2010-08-12 | Peter Blurton | Piperazine derivatives for treatment of ad and related conditions |
| KR20100017573A (ko) | 2007-05-07 | 2010-02-16 | 쉐링 코포레이션 | 감마 세크레타제 조정인자 |
| AU2008250436B2 (en) | 2007-05-11 | 2013-03-28 | F. Hoffmann-La Roche Ag | Hetarylanilines as modulators for amyloid beta |
| EP2166854A4 (en) | 2007-06-13 | 2012-05-16 | Merck Sharp & Dohme | TRIAZOLE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND ASSOCIATED STATES |
| CA2692253A1 (en) | 2007-06-29 | 2009-01-08 | Schering Corporation | Gamma secretase modulators |
| EP2170875A1 (en) * | 2007-07-16 | 2010-04-07 | Wyeth LLC | Aminoalkylazole derivatives as histamine-3 antagonists |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| EP2200990A1 (en) | 2007-09-06 | 2010-06-30 | Schering Corporation | Gamma secretase modulators |
| GB0720444D0 (en) | 2007-10-18 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
| EP2229381A1 (en) | 2007-12-06 | 2010-09-22 | Schering Corporation | Gamma secretase modulators |
| EP2227471A1 (en) * | 2007-12-11 | 2010-09-15 | Schering Corporation | Gamma secretase modulators |
| AU2009216851B2 (en) | 2008-02-22 | 2013-11-07 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| US20100137320A1 (en) | 2008-02-29 | 2010-06-03 | Schering Corporation | Gamma secretase modulators |
| WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
| EP2356115A1 (en) | 2008-11-06 | 2011-08-17 | Schering Corporation | Gamma secretase modulators |
| WO2010052199A1 (en) | 2008-11-10 | 2010-05-14 | F. Hoffmann-La Roche Ag | Heterocyclic gamma secretase modulators |
| JP2012510515A (ja) | 2008-12-03 | 2012-05-10 | ブイアイエイ・ファーマシューティカルズ・インコーポレーテッド | ジアシルグリセロールアシルトランスフェラーゼの阻害剤 |
| PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| AP2011005779A0 (en) | 2009-02-06 | 2011-08-31 | Ortho Mcneil Janssen Pharm | Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. |
| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| SG173710A1 (en) * | 2009-02-26 | 2011-09-29 | Eisai R&D Man Co Ltd | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| JP2012051806A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
| CA2751534A1 (en) | 2009-03-03 | 2010-09-10 | Pfizer Inc. | Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators |
| JPWO2010106745A1 (ja) | 2009-03-16 | 2012-09-20 | パナソニック株式会社 | アプリケーション実行装置 |
| AU2010241929A1 (en) | 2009-04-27 | 2011-10-06 | High Point Pharmaceuticals, Llc | Substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors |
| ES2431619T3 (es) | 2009-05-07 | 2013-11-27 | Janssen Pharmaceuticals, Inc. | Derivados de indazol y aza-indazol sustituidos como moduladores de gamma-secretasa |
| JP2010274429A (ja) | 2009-05-26 | 2010-12-09 | Ihi Corp | アライメントステージ |
| ES2519565T3 (es) | 2009-07-15 | 2014-11-07 | Janssen Pharmaceuticals Inc. | Derivados de triazol e imidazol sustituidos como moduladores de gamma secretasa |
| CN102803261A (zh) | 2010-01-15 | 2012-11-28 | 杨森制药公司 | 作为γ分泌酶调节剂的新的取代的双环三唑衍生物 |
| CN103502225B (zh) | 2011-03-24 | 2015-11-25 | 杨森制药公司 | 作为γ分泌酶调节剂的经取代的三唑基哌嗪以及三唑基哌啶衍生物 |
| WO2012131539A1 (en) | 2011-03-31 | 2012-10-04 | Pfizer Inc. | Novel bicyclic pyridinones |
| IN2014MN00258A (pt) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc |
-
2010
- 2010-07-13 ES ES10734963.1T patent/ES2519565T3/es active Active
- 2010-07-13 JP JP2012520010A patent/JP2012532912A/ja active Pending
- 2010-07-13 WO PCT/EP2010/060083 patent/WO2011006903A1/en active Application Filing
- 2010-07-13 BR BR112012000915A patent/BR112012000915A2/pt not_active IP Right Cessation
- 2010-07-13 KR KR1020127003902A patent/KR20120050450A/ko not_active Application Discontinuation
- 2010-07-13 US US13/382,659 patent/US8946266B2/en not_active Expired - Fee Related
- 2010-07-13 AU AU2010272578A patent/AU2010272578B2/en not_active Ceased
- 2010-07-13 NZ NZ597505A patent/NZ597505A/xx not_active IP Right Cessation
- 2010-07-13 CN CN2010800332416A patent/CN102482227A/zh active Pending
- 2010-07-13 CA CA2778517A patent/CA2778517A1/en not_active Abandoned
- 2010-07-13 AP AP2011006034A patent/AP2011006034A0/xx unknown
- 2010-07-13 SG SG2012002473A patent/SG177644A1/en unknown
- 2010-07-13 EA EA201270166A patent/EA021047B1/ru not_active IP Right Cessation
- 2010-07-13 EP EP10734963.1A patent/EP2454239B1/en active Active
- 2010-07-13 MX MX2012000763A patent/MX2012000763A/es active IP Right Grant
- 2010-07-14 TW TW099123059A patent/TW201109316A/zh unknown
-
2012
- 2012-01-12 IL IL217491A patent/IL217491A/en not_active IP Right Cessation
- 2012-01-13 ZA ZA2012/00285A patent/ZA201200285B/en unknown
-
2015
- 2015-02-06 JP JP2015022061A patent/JP2015129147A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015129147A (ja) | 2015-07-16 |
| JP2012532912A (ja) | 2012-12-20 |
| ES2519565T3 (es) | 2014-11-07 |
| US8946266B2 (en) | 2015-02-03 |
| IL217491A (en) | 2015-08-31 |
| EP2454239B1 (en) | 2014-08-13 |
| AP2011006034A0 (en) | 2011-12-31 |
| MX2012000763A (es) | 2012-02-08 |
| WO2011006903A1 (en) | 2011-01-20 |
| EA201270166A1 (ru) | 2012-06-29 |
| TW201109316A (en) | 2011-03-16 |
| KR20120050450A (ko) | 2012-05-18 |
| IL217491A0 (en) | 2012-02-29 |
| NZ597505A (en) | 2013-05-31 |
| AU2010272578B2 (en) | 2015-03-05 |
| SG177644A1 (en) | 2012-03-29 |
| AU2010272578A1 (en) | 2012-01-19 |
| US20120135981A1 (en) | 2012-05-31 |
| CA2778517A1 (en) | 2011-01-20 |
| ZA201200285B (en) | 2014-06-25 |
| CN102482227A (zh) | 2012-05-30 |
| EA021047B1 (ru) | 2015-03-31 |
| EP2454239A1 (en) | 2012-05-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112012000915A2 (pt) | derivados de triazol e imidazol substituídos como moduladores de gama secretase. | |
| BRPI0922664A2 (pt) | derivados de imidazol bicílicos substituídos como moduladores de gama secretase | |
| BR112012010502A2 (pt) | derivados de benzimidazol-imidazol | |
| BRPI0817609A2 (pt) | Derivados de imidazol | |
| BRPI0921348A2 (pt) | moduladores heterocíclicos da gama secretase | |
| BRPI0815135A2 (pt) | Derivados de azepina como inibidores de gama secretase. | |
| IL220838A0 (en) | Novel substituted triazole derivatives as gamma secretase modulators | |
| CL2016002135A1 (es) | Compuestos de [1,2,4]triazol e imidazol sustituidos útiles como fungicidas. | |
| BRPI0813412A2 (pt) | Derivados de benzimidazol | |
| BRPI0818855A2 (pt) | Derivados de imidazol | |
| AP2011005779A0 (en) | Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. | |
| IL228798A0 (en) | Substances containing imidazole, pyrazole or triazole and use of preparations containing these substances to treat bacterial infections | |
| BRPI0915977A2 (pt) | imidazol carboxamidas | |
| BRPI1016120A2 (pt) | derivados de benzoxazol, benzimidazol, oxazolopiridina e imidazopiridina substituídos como moduladores de gama secretase. | |
| BRPI1015568A2 (pt) | derivados de imidazolidin-2-ona 1,3-dissubstituído como inibidores de cyp 17. | |
| ME02455B (me) | Derivati indazola supstituisanog sa benzodioksinilom | |
| ATE505461T1 (de) | Substituierte imidazole und ihre verwendung als pestizide | |
| IL209025A0 (en) | Urea compounds as gamma secretase modulators | |
| BRPI0922799A2 (pt) | lactamas como inibidores da beta secretase | |
| BRPI0915876A2 (pt) | composto azol | |
| ME02193B (me) | Derivati imidazola kao inhibitori enzima pde10a | |
| BRPI0821357A2 (pt) | derivados de oxadiazois de triazol | |
| BR112015012885A2 (pt) | composições triazol e imidazol substituídas | |
| BRPI1015206A2 (pt) | gerador de raios gama | |
| ZA201103254B (en) | Triazole and imidazole compounds,use thereof and agents containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: JANSSEN PHARMACEUTICALS, INC. (US) ; CELLZOME LIMI Owner name: JANSSEN PHARMACEUTICALS, INC. (US) ; CELLZOME LIMITED (GB) |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |