AP2011006034A0 - Substituted triazole and imidazole derivatives as gamma secretase modulators. - Google Patents
Substituted triazole and imidazole derivatives as gamma secretase modulators.Info
- Publication number
- AP2011006034A0 AP2011006034A0 AP2011006034A AP2011006034A AP2011006034A0 AP 2011006034 A0 AP2011006034 A0 AP 2011006034A0 AP 2011006034 A AP2011006034 A AP 2011006034A AP 2011006034 A AP2011006034 A AP 2011006034A AP 2011006034 A0 AP2011006034 A0 AP 2011006034A0
- Authority
- AP
- ARIPO
- Prior art keywords
- imidazole derivatives
- gamma secretase
- substituted triazole
- secretase modulators
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09165585 | 2009-07-15 | ||
| EP10164625 | 2010-06-01 | ||
| PCT/EP2010/060083 WO2011006903A1 (en) | 2009-07-15 | 2010-07-13 | Substituted triazole and imidazole derivatives as gamma secretase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2011006034A0 true AP2011006034A0 (en) | 2011-12-31 |
Family
ID=42542935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2011006034A AP2011006034A0 (en) | 2009-07-15 | 2010-07-13 | Substituted triazole and imidazole derivatives as gamma secretase modulators. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8946266B2 (xx) |
| EP (1) | EP2454239B1 (xx) |
| JP (2) | JP2012532912A (xx) |
| KR (1) | KR20120050450A (xx) |
| CN (1) | CN102482227A (xx) |
| AP (1) | AP2011006034A0 (xx) |
| AU (1) | AU2010272578B2 (xx) |
| BR (1) | BR112012000915A2 (xx) |
| CA (1) | CA2778517A1 (xx) |
| EA (1) | EA021047B1 (xx) |
| ES (1) | ES2519565T3 (xx) |
| IL (1) | IL217491A (xx) |
| MX (1) | MX2012000763A (xx) |
| NZ (1) | NZ597505A (xx) |
| SG (1) | SG177644A1 (xx) |
| TW (1) | TW201109316A (xx) |
| WO (1) | WO2011006903A1 (xx) |
| ZA (1) | ZA201200285B (xx) |
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| PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| MX2011008335A (es) | 2009-02-06 | 2011-09-06 | Ortho Mcneil Janssen Pharm | Novedosos compuestos heterociclicos biciclicos sustituidos como moduladores de la gamma secretasa. |
| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| US8754100B2 (en) | 2009-02-26 | 2014-06-17 | Eisai R&D Management Co., Ltd. | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| JP5580816B2 (ja) | 2009-02-26 | 2014-08-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | テトラヒドロトリアゾロピリジン誘導体の塩およびその結晶 |
| WO2010145883A1 (en) | 2009-05-07 | 2010-12-23 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
| CA2778517A1 (en) | 2009-07-15 | 2011-01-20 | Janssen Pharmaceuticals, Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
| TWI468402B (zh) | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β－類澱粉生成之化合物 |
| US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
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| CN102690194B (zh) * | 2011-03-24 | 2014-06-25 | 上海通远生物科技有限公司 | 3-环丙基甲氧基-4-二氟甲氧基苯甲酸的制备方法 |
| BR112013023984A2 (pt) * | 2011-03-24 | 2016-09-13 | Cellzome Ltd | derivados triazolil piperazina e triazolil piperidina substituidos como moduladores de gama secretase |
| WO2013005354A1 (ja) * | 2011-07-01 | 2013-01-10 | 武田薬品工業株式会社 | 複素環化合物 |
| TWI567079B (zh) | 2011-07-15 | 2017-01-21 | 健生醫藥公司 | 作為伽瑪分泌酶調節劑之新穎的經取代的吲哚衍生物 |
| EP2731968A1 (en) | 2011-07-15 | 2014-05-21 | Janssen Pharmaceutica NV | Monoclonal antibodies specific for beta-amyloid x-37 and uses thereof |
| EP2817310B1 (en) * | 2012-02-21 | 2018-03-21 | Merck Patent GmbH | 8-substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors |
| MX355164B (es) | 2012-05-16 | 2018-04-06 | Janssen Pharmaceuticals Inc | Derivados de 3,4-dihidro-2h-pirido[1,2-a]pirazin-1,6-diona sustituidos utiles para el tratamiento de la enfermedad de alzheimer (inter alia). |
| HUE040025T2 (hu) * | 2012-08-24 | 2019-02-28 | Univ Texas | A HIF aktivitás heterociklusos modulátorai betegség kezelésére |
| JP6275161B2 (ja) * | 2012-12-20 | 2018-02-07 | ヤンセン ファーマシューティカ エヌ．ベー． | γセクレターゼ調節剤としての新規な三環式３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体 |
| JP6283691B2 (ja) | 2013-01-17 | 2018-02-21 | ヤンセン ファーマシューティカ エヌ．ベー． | γセクレターゼ調節剤としての新規な置換ピリド−ピペラジノン誘導体 |
| WO2014195322A1 (en) | 2013-06-04 | 2014-12-11 | Acturum Life Science AB | Triazole compounds and their use as gamma secretase modulators |
| CN105308037B (zh) | 2013-06-04 | 2017-09-19 | 阿克图拉姆生命科学股份公司 | 三唑化合物及其作为γ分泌酶调节剂的用途 |
| EP3004079B1 (en) | 2013-06-04 | 2018-01-17 | Acturum Real Estate AB | Pyrimidine compounds and their use as gamma secretase modulators |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| EP3110420B8 (en) | 2014-02-25 | 2019-07-10 | Board of Regents, The University of Texas System | Salts of heterocyclic modulators of hif activity for treatment of disease |
| EP3212633B1 (en) | 2014-10-31 | 2019-12-04 | The General Hospital Corporation | Potent gamma-secretase modulators |
| ES2796276T3 (es) * | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| WO2018011164A1 (en) * | 2016-07-14 | 2018-01-18 | F. Hoffmann-La Roche Ag | Fused pyrimidine derivatives |
| JP7132218B2 (ja) * | 2016-11-08 | 2022-09-06 | エフ．ホフマン－ラ ロシュ アーゲー | フェノキシトリアゾール |
| PE20211246A1 (es) | 2017-10-11 | 2021-07-13 | Hoffmann La Roche | Compuestos biciclicos para su uso como inhibidores de rip1 quinasa |
| KR20220035939A (ko) | 2019-07-22 | 2022-03-22 | 바이엘 악티엔게젤샤프트 | 살충제로서의 5-아미노-치환된 피라졸 및 트리아졸 |
| CN110759902B (zh) * | 2019-11-01 | 2022-04-22 | 海南一龄医疗产业发展有限公司 | Set8赖氨酸甲基转移酶抑制剂及其制备方法和用途 |
| WO2022033991A1 (de) | 2020-08-13 | 2022-02-17 | Bayer Aktiengesellschaft | 5-amino substituierte triazole als schädlingsbekämpfungsmittel |
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| JP2012051806A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| CA2751534A1 (en) | 2009-03-03 | 2010-09-10 | Pfizer Inc. | Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators |
| US20110299830A1 (en) | 2009-03-16 | 2011-12-08 | Panasonic Corporation | Application running device |
| WO2010126745A1 (en) | 2009-04-27 | 2010-11-04 | High Point Pharmaceuticals, Llc | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS |
| WO2010145883A1 (en) | 2009-05-07 | 2010-12-23 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
| JP2010274429A (ja) | 2009-05-26 | 2010-12-09 | Ihi Corp | アライメントステージ |
| CA2778517A1 (en) | 2009-07-15 | 2011-01-20 | Janssen Pharmaceuticals, Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
| KR20120123677A (ko) | 2010-01-15 | 2012-11-09 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 신규 치환된 비사이클릭 트리아졸 유도체 |
| BR112013023984A2 (pt) | 2011-03-24 | 2016-09-13 | Cellzome Ltd | derivados triazolil piperazina e triazolil piperidina substituidos como moduladores de gama secretase |
| EP2691393B1 (en) | 2011-03-31 | 2016-09-14 | Pfizer Inc | Novel bicyclic pyridinones |
| TWI567079B (zh) | 2011-07-15 | 2017-01-21 | 健生醫藥公司 | 作為伽瑪分泌酶調節劑之新穎的經取代的吲哚衍生物 |
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2010
- 2010-07-13 CA CA2778517A patent/CA2778517A1/en not_active Abandoned
- 2010-07-13 BR BR112012000915A patent/BR112012000915A2/pt not_active IP Right Cessation
- 2010-07-13 WO PCT/EP2010/060083 patent/WO2011006903A1/en active Application Filing
- 2010-07-13 EA EA201270166A patent/EA021047B1/ru not_active IP Right Cessation
- 2010-07-13 CN CN2010800332416A patent/CN102482227A/zh active Pending
- 2010-07-13 MX MX2012000763A patent/MX2012000763A/es active IP Right Grant
- 2010-07-13 EP EP10734963.1A patent/EP2454239B1/en active Active
- 2010-07-13 KR KR1020127003902A patent/KR20120050450A/ko not_active Application Discontinuation
- 2010-07-13 US US13/382,659 patent/US8946266B2/en not_active Expired - Fee Related
- 2010-07-13 JP JP2012520010A patent/JP2012532912A/ja active Pending
- 2010-07-13 NZ NZ597505A patent/NZ597505A/xx not_active IP Right Cessation
- 2010-07-13 SG SG2012002473A patent/SG177644A1/en unknown
- 2010-07-13 AU AU2010272578A patent/AU2010272578B2/en not_active Ceased
- 2010-07-13 AP AP2011006034A patent/AP2011006034A0/xx unknown
- 2010-07-13 ES ES10734963.1T patent/ES2519565T3/es active Active
- 2010-07-14 TW TW099123059A patent/TW201109316A/zh unknown
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2012
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- 2012-01-13 ZA ZA2012/00285A patent/ZA201200285B/en unknown
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2015
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| Publication number | Publication date |
|---|---|
| AU2010272578A1 (en) | 2012-01-19 |
| ZA201200285B (en) | 2014-06-25 |
| MX2012000763A (es) | 2012-02-08 |
| TW201109316A (en) | 2011-03-16 |
| ES2519565T3 (es) | 2014-11-07 |
| NZ597505A (en) | 2013-05-31 |
| WO2011006903A1 (en) | 2011-01-20 |
| EA201270166A1 (ru) | 2012-06-29 |
| SG177644A1 (en) | 2012-03-29 |
| EA021047B1 (ru) | 2015-03-31 |
| EP2454239A1 (en) | 2012-05-23 |
| AU2010272578B2 (en) | 2015-03-05 |
| JP2012532912A (ja) | 2012-12-20 |
| IL217491A (en) | 2015-08-31 |
| EP2454239B1 (en) | 2014-08-13 |
| JP2015129147A (ja) | 2015-07-16 |
| CA2778517A1 (en) | 2011-01-20 |
| CN102482227A (zh) | 2012-05-30 |
| BR112012000915A2 (pt) | 2019-09-24 |
| KR20120050450A (ko) | 2012-05-18 |
| IL217491A0 (en) | 2012-02-29 |
| US8946266B2 (en) | 2015-02-03 |
| US20120135981A1 (en) | 2012-05-31 |
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