JP2011524896A5 - - Google Patents
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- Publication number
- JP2011524896A5 JP2011524896A5 JP2011514537A JP2011514537A JP2011524896A5 JP 2011524896 A5 JP2011524896 A5 JP 2011524896A5 JP 2011514537 A JP2011514537 A JP 2011514537A JP 2011514537 A JP2011514537 A JP 2011514537A JP 2011524896 A5 JP2011524896 A5 JP 2011524896A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- acceptable salt
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 8
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 4
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 4
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010014561 Emphysema Diseases 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000009286 beneficial effect Effects 0.000 claims 2
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 2
- 201000009267 bronchiectasis Diseases 0.000 claims 2
- 206010006451 bronchitis Diseases 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 206010039083 rhinitis Diseases 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 1
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 1
- -1 2- (2- (5-hydroxy-3-oxo-3,4-dihydro-2H-benzo [b] [1,4] oxazin-8-yl) ethylamino) ethyl Chemical group 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000003149 muscarinic antagonist Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7342008P | 2008-06-18 | 2008-06-18 | |
| US61/073,420 | 2008-06-18 | ||
| PCT/SE2009/050749 WO2009154557A1 (en) | 2008-06-18 | 2009-06-17 | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011524896A JP2011524896A (ja) | 2011-09-08 |
| JP2011524896A5 true JP2011524896A5 (enExample) | 2013-08-15 |
Family
ID=41434296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514537A Pending JP2011524896A (ja) | 2008-06-18 | 2009-06-17 | 呼吸器障害の処置用のベータ２−アドレナリン受容体アゴニストとして作用するベンズオキサジノン誘導体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8017602B2 (enExample) |
| EP (1) | EP2303873A4 (enExample) |
| JP (1) | JP2011524896A (enExample) |
| KR (1) | KR20110017456A (enExample) |
| CN (1) | CN102124003A (enExample) |
| AR (1) | AR072189A1 (enExample) |
| AU (1) | AU2009260899B2 (enExample) |
| BR (1) | BRPI0915428A2 (enExample) |
| CA (1) | CA2726746A1 (enExample) |
| CL (1) | CL2010001459A1 (enExample) |
| CO (1) | CO6321269A2 (enExample) |
| CR (1) | CR11856A (enExample) |
| DO (1) | DOP2010000389A (enExample) |
| EA (1) | EA201001747A1 (enExample) |
| EC (1) | ECSP10010694A (enExample) |
| IL (1) | IL209731A0 (enExample) |
| MX (1) | MX2010013477A (enExample) |
| TW (1) | TW201002696A (enExample) |
| UY (1) | UY31905A (enExample) |
| WO (1) | WO2009154557A1 (enExample) |
| ZA (1) | ZA201008886B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110017456A (ko) | 2008-06-18 | 2011-02-21 | 아스트라제네카 아베 | 호흡기 장애의 치료를 위한 베타2-아드레날린성 수용체 효능제로서 작용하는 벤족사지논 유도체 |
| WO2011048409A1 (en) | 2009-10-20 | 2011-04-28 | Astrazeneca Ab | Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| WO2011073662A1 (en) | 2009-12-17 | 2011-06-23 | Astrazeneca Ab | Combination of a benzoxazinone and a further agent for treating respiratory diseases |
| CN102993116A (zh) * | 2012-12-04 | 2013-03-27 | 常州大学 | 一种苯并噁嗪类激动剂的制备方法 |
| TR201900659T4 (tr) * | 2014-06-30 | 2019-02-21 | Astrazeneca Ab | Mineralokortikoid reseptör modülatörleri olarak benzoksazinon amidleri. |
| CN104496920A (zh) * | 2014-12-04 | 2015-04-08 | 北京理工大学 | 一种n-烯丙基-二取代四唑及其制备方法和检测方法 |
| CN107188865B (zh) * | 2016-03-14 | 2019-08-27 | 益方生物科技（上海）有限公司 | 苯并噁嗪化合物及其制备方法和用途 |
| PL424609A1 (pl) * | 2018-02-16 | 2019-08-26 | Uniwersytet Przyrodniczy we Wrocławiu | Zastosowanie 6-(tert-butylo)-3-dodecylo-3,4-dihydro-2H-benzo[e][1,3]oxazyny |
| CN110028521B (zh) * | 2019-05-27 | 2020-07-14 | 湖南科技大学 | 11-芳基-1,4-苯并恶嗪酮并咪唑啉类化合物及其制备方法和用途 |
| WO2023104564A1 (en) | 2021-12-08 | 2023-06-15 | Basf Se | Pyrazine compounds for the control of invertebrate pests |
| EP4194453A1 (en) | 2021-12-08 | 2023-06-14 | Basf Se | Pyrazine compounds for the control of invertebrate pests |
| CN117143019B (zh) * | 2023-07-28 | 2025-11-25 | 常州大学 | 用作β2-肾上腺素受体别构拮抗剂的吡唑酰胺类衍生物 |
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| US4554287A (en) | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones |
| GB8525483D0 (en) | 1985-10-16 | 1985-11-20 | Glaxo Group Ltd | Chemical compounds |
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| GB9211172D0 (en) | 1992-05-27 | 1992-07-08 | Fisons Plc | Compounds |
| US5648370A (en) | 1990-11-20 | 1997-07-15 | Astra Pharmaceuticals Limited | 7-(2-aminoethyl) benzothiazolones |
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| TW356468B (en) | 1995-09-15 | 1999-04-21 | Astra Pharma Prod | Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same |
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| SE9700706D0 (sv) | 1997-02-27 | 1997-02-27 | Astra Pharma Prod | Process for the preparation of benzothiazoline compounds |
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| TW200740781A (en) * | 2005-08-29 | 2007-11-01 | Astrazeneca Ab | Novel compounds |
| TW200738659A (en) | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200745084A (en) * | 2006-03-08 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2008041914A1 (en) | 2006-10-06 | 2008-04-10 | Astrazeneca Ab | 5-(2-AMINO-L-HYDROXYETHYL)-8-HYDROXY-2-OXOQUINOLINE DERIVATIVES AND OTHER COMPOUNDS AS β2 -ADRENERGIC AGONISTS |
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| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702459D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 669 |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| GB0702457D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination 666 |
| GB0702456D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination |
| GB0704000D0 (en) | 2007-03-01 | 2007-04-11 | Astrazeneca Ab | Salts 670 |
| GB0703999D0 (en) | 2007-03-01 | 2007-04-11 | Astrazeneca Ab | New combination 667 |
| WO2009037503A2 (en) | 2007-09-18 | 2009-03-26 | Astrazeneca Ab | New combination - 012 for the treatment of respiratory diseases |
| KR20110017456A (ko) | 2008-06-18 | 2011-02-21 | 아스트라제네카 아베 | 호흡기 장애의 치료를 위한 베타2-아드레날린성 수용체 효능제로서 작용하는 벤족사지논 유도체 |
| CA2727908A1 (en) | 2008-06-20 | 2009-12-23 | Astrazeneca Ab | Pharmaceutical composition comprising a 4-hydroxy-2-oxo-2, 3- dihydro-1, 3-benzothiazol-7-yl compound for modulation of beta2-adrenoreceptor activity |
-
2009
- 2009-06-17 KR KR1020117001144A patent/KR20110017456A/ko not_active Withdrawn
- 2009-06-17 EA EA201001747A patent/EA201001747A1/ru unknown
- 2009-06-17 EP EP09766947A patent/EP2303873A4/en not_active Withdrawn
- 2009-06-17 TW TW098120291A patent/TW201002696A/zh unknown
- 2009-06-17 AU AU2009260899A patent/AU2009260899B2/en not_active Ceased
- 2009-06-17 BR BRPI0915428A patent/BRPI0915428A2/pt not_active IP Right Cessation
- 2009-06-17 JP JP2011514537A patent/JP2011524896A/ja active Pending
- 2009-06-17 WO PCT/SE2009/050749 patent/WO2009154557A1/en not_active Ceased
- 2009-06-17 CN CN2009801320729A patent/CN102124003A/zh active Pending
- 2009-06-17 MX MX2010013477A patent/MX2010013477A/es active IP Right Grant
- 2009-06-17 CA CA2726746A patent/CA2726746A1/en not_active Abandoned
- 2009-06-17 UY UY0001031905A patent/UY31905A/es unknown
- 2009-06-18 AR ARP090102225A patent/AR072189A1/es unknown
- 2009-06-18 US US12/486,854 patent/US8017602B2/en not_active Expired - Fee Related
-
2010
- 2010-11-29 CO CO10150418A patent/CO6321269A2/es not_active Application Discontinuation
- 2010-12-02 IL IL209731A patent/IL209731A0/en unknown
- 2010-12-09 ZA ZA2010/08886A patent/ZA201008886B/en unknown
- 2010-12-17 CR CR11856A patent/CR11856A/es not_active Application Discontinuation
- 2010-12-17 DO DO2010000389A patent/DOP2010000389A/es unknown
- 2010-12-17 CL CL2010001459A patent/CL2010001459A1/es unknown
- 2010-12-17 EC EC2010010694A patent/ECSP10010694A/es unknown