NO20071193L - Fluorsubstituerte sykloalkanoindoler og deres anvendelse som prostaglandin D2-reseptorantagonister - Google Patents

Fluorsubstituerte sykloalkanoindoler og deres anvendelse som prostaglandin D2-reseptorantagonister

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Publication number
NO20071193L
NO20071193L NO20071193A NO20071193A NO20071193L NO 20071193 L NO20071193 L NO 20071193L NO 20071193 A NO20071193 A NO 20071193A NO 20071193 A NO20071193 A NO 20071193A NO 20071193 L NO20071193 L NO 20071193L
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Prior art keywords
prostaglandin
fluoro
alkyl
receptor antagonists
tetrahydrocyclopenta
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NO20071193A
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English (en)
Inventor
Carl Berthelette
Nicolas Lachance
Lianhai Li
Claudio Sturino
Zhaoyin Wang
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Merck Frosst Canada Ltd
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Publication date
Publication of NO20071193L publication Critical patent/NO20071193L/no
Application filed by Merck Frosst Canada Ltd filed Critical Merck Frosst Canada Ltd

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    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D209/82Carbazoles; Hydrogenated carbazoles
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Abstract

Forbindelser av formel I: og farmasøytisk akseptable salter derav, hvor n er 0 eller 1; m er 1, 2 eller 3; R1 er H, C1-C3-alkyl, halogenert C1-C3-alkyl eller syklo-propyl; R2 er 4-klorfenyl eller 2,4,6-triklorfenyl, bortsett fra isomeren (-) -[4-(4-klorbenzyl)-7-fluor-5-(metansulfonyl)-1,2,3,4-tetrahydrosyklopenta[b]indol-3-yl]eddiksyre, er terapeutisk aktive og kan anvendes ved fremstilling av et medikament for behandling av en prostaglandin D2-mediert sykdom, fortrinnsvis nasal kongestion, rhinitt eller astma. Forbindelser av formel I: og farmasøytisk akseptable salter derav, hvor n er 0 eller 1; m er 1, 2 eller 3; R1 er H, C1-C3-alkyl, halogenert C1-C3-alkyl eller syklo-propyl; R2 er 4-klorfenyl eller 2,4,6-triklorfenyl, bortsett fra isomeren (-) -[4-(4-klorbenzyl)-7-fluor-5-(metansulfonyl)-1,2,3,4-tetrahydrosyklopenta[b]indol-3-yl]eddiksyre, er terapeutisk aktive og kan anvendes ved fremstilling av et medikament for behandling av en prostaglandin D2-mediert sykdom, fortrinnsvis nasal kongestion, rhinitt eller astma.
NO20071193A 2002-01-24 2007-03-02 Fluorsubstituerte sykloalkanoindoler og deres anvendelse som prostaglandin D2-reseptorantagonister NO20071193L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35138402P 2002-01-24 2002-01-24
PCT/CA2003/000084 WO2003062200A2 (en) 2002-01-24 2003-01-22 Fluoro substituted cycloalkanoindoles and their use as prostaglandin d2 receptor antagonists

Publications (1)

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NO20071193L true NO20071193L (no) 2004-08-24

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ID=27613492

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20043536A NO327322B1 (no) 2002-01-24 2004-08-24 Fluorsubstituert forbindelse og farmasoytisk preparat
NO20071193A NO20071193L (no) 2002-01-24 2007-03-02 Fluorsubstituerte sykloalkanoindoler og deres anvendelse som prostaglandin D2-reseptorantagonister
NO2009013C NO2009013I2 (no) 2002-01-24 2009-06-19 Laropiprant eller et farmasøytisk akseptabelt saltderav

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Application Number Title Priority Date Filing Date
NO20043536A NO327322B1 (no) 2002-01-24 2004-08-24 Fluorsubstituert forbindelse og farmasoytisk preparat

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2009013C NO2009013I2 (no) 2002-01-24 2009-06-19 Laropiprant eller et farmasøytisk akseptabelt saltderav

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US (6) US20030158246A1 (no)
EP (3) EP2295409B1 (no)
JP (2) JP4008885B2 (no)
KR (2) KR100859230B1 (no)
CN (3) CN101851191A (no)
AR (1) AR038136A1 (no)
AT (1) ATE414690T1 (no)
AU (1) AU2003202343B2 (no)
BR (1) BR0307050A (no)
CA (1) CA2471952C (no)
CY (3) CY1108841T1 (no)
DE (2) DE60324767D1 (no)
DK (2) DK1470107T3 (no)
DO (1) DOP2003000566A (no)
EA (1) EA006134B1 (no)
EC (1) ECSP045203A (no)
EG (1) EG24978A (no)
ES (2) ES2391747T3 (no)
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HR (1) HRP20040665B1 (no)
IL (3) IL162825A0 (no)
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NO (3) NO327322B1 (no)
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PE (1) PE20030982A1 (no)
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PT (2) PT2045241E (no)
RS (2) RS20100338A (no)
SI (2) SI1470107T1 (no)
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UA (1) UA75520C2 (no)
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ZA (1) ZA200404999B (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7217725B2 (en) * 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
US7273883B2 (en) * 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
AR038136A1 (es) * 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
AR041089A1 (es) * 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
WO2004104205A2 (en) * 2003-05-16 2004-12-02 Merck & Co., Inc. Enzymatic preparation of chiral indole esters
CN1791577A (zh) * 2003-05-20 2006-06-21 麦克弗罗斯特加拿大有限公司 氟-甲基磺酰取代的环烷并吲哚和它们作为前列腺素d2拮抗剂的用途
WO2005013985A1 (en) * 2003-08-07 2005-02-17 Merck Sharp & Dohme Limited Treatment for alzheimer's disease and related conditions
TWI258478B (en) 2003-10-31 2006-07-21 Arena Pharm Inc Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
US7019022B2 (en) * 2003-12-15 2006-03-28 Merck Frosst Canada & Co. Substituted tetrahydrocarbazole and cyclopentanoindole derivatives
BRPI0508540B8 (pt) 2004-03-11 2021-05-25 Actelion Pharmaceuticals Ltd composto, composição farmacêutica, e, uso de um composto
ATE384046T1 (de) * 2004-04-02 2008-02-15 Merck & Co Inc Verfahren zur asymmetrischen hydrierung, das sich für die herstellung von cycloalkanindolderivaten eignet
GT200500284A (es) 2004-10-15 2006-03-27 Aventis Pharma Inc Pirimidinas como antagonistas del receptor de prostaglandina d2
US20070299122A1 (en) * 2004-11-08 2007-12-27 Tobert Jonathan A Method of Treating Pathological Blushing
PE20060949A1 (es) 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
JPWO2006068162A1 (ja) * 2004-12-24 2008-06-12 塩野義製薬株式会社 慢性閉塞性肺疾患の治療剤
PL1833791T3 (pl) 2004-12-27 2011-12-30 Actelion Pharmaceuticals Ltd Pochodne 2,3,4,9-tetrahydro-1H-karbazolu jako antagonisty receptora CRTH2
US20080139604A1 (en) * 2005-02-17 2008-06-12 Shaun Fitzpatrick Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions
CA2603757A1 (en) * 2005-04-13 2006-10-26 Merck & Co., Inc. Niacin receptor agonists, compositions containing such compounds and methods of treatment
EP1911759A4 (en) 2005-07-22 2010-07-21 Shionogi & Co AZAINDOL DERIVATIVE ANTAGONISTIC EFFECT ON PGD2 RECEPTOR
EP2397476A3 (en) 2005-07-22 2011-12-28 Shionogi & Co., Ltd. Indole derivative having PGD2 receptor antagonist activity
JP5147401B2 (ja) 2005-09-06 2013-02-20 塩野義製薬株式会社 Pgd2受容体アンタゴニスト活性を有するインドールカルボン酸誘導体
PL2037967T3 (pl) 2006-06-16 2017-07-31 The Trustees Of The University Of Pennsylvania Antagoniści receptora prostaglandyny D2 w leczeniu łysienia androgenowego
JP5220013B2 (ja) 2006-08-07 2013-06-26 アクテリオン ファーマシューティカルズ リミテッド (3−アミノ−1,2,3,4−テトラヒドロ−9h−カルバゾール−9−イル)−酢酸誘導体
US20100260841A1 (en) * 2007-02-08 2010-10-14 Paolini John F Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions
US20090076117A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched laropiprant
WO2010008864A2 (en) 2008-06-24 2010-01-21 Amira Pharmaceuticals, Inc. Cycloalkane[b]indole angtagonists of prostaglandin d2 receptors
US8507473B2 (en) 2008-09-11 2013-08-13 Arena Pharmaceuticals, Inc. 3H-imidazo[4,5-b]pyridin-5-ol derivatives useful in the treatment of GPR81 receptor disorders
CN102224154A (zh) * 2008-09-25 2011-10-19 默克弗罗斯特加拿大有限公司 作为EP4受体拮抗剂的β-咔啉磺酰脲衍生物
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
GB2465062B (en) 2008-11-06 2011-04-13 Amira Pharmaceuticals Inc Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors
US9180114B2 (en) * 2008-11-26 2015-11-10 President And Fellows Of Harvard College Neurodegenerative diseases and methods of modeling
US8882678B2 (en) * 2009-03-13 2014-11-11 Atrium Medical Corporation Pleural drainage system and method of use
MA34094B1 (fr) 2010-03-22 2013-03-05 Actelion Pharmaceuticals Ltd Dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole et leur utilisation comme modulateurs du récepteur de la prostaglandine d2
MX338516B (es) 2011-04-14 2016-04-20 Actelion Pharmaceuticals Ltd Derivados de acido 7- (heteroaril-amino) -6, 7, 8, 9- tetrahidropirido[1,2-a] indol acetico y sus usos como modulador del receptor de prostaglandina.
JP5841361B2 (ja) * 2011-06-29 2016-01-13 壽製薬株式会社 三環性化合物及びそれを含有する医薬組成物
AR088377A1 (es) * 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102659664B (zh) * 2012-03-28 2015-01-21 中国计量学院 合成分离拉洛皮兰及其类似物的方法
FR3000395A1 (fr) * 2012-12-31 2014-07-04 Galderma Res & Dev Combinaison de laropiprant et d'oxymetazoline pour le traitement de la rosacee
FR3000399B1 (fr) * 2012-12-31 2015-03-27 Galderma Res & Dev Utilisation topique du laropiprant pour le traitement de la rosacee
MY179356A (en) 2014-03-17 2020-11-05 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
EP3119780B1 (en) 2014-03-18 2018-08-29 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
US20180021302A1 (en) 2015-02-13 2018-01-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
MX2018003202A (es) 2015-09-15 2018-06-08 Idorsia Pharmaceuticals Ltd Formas cristalinas.
KR102465211B1 (ko) 2018-03-19 2022-11-10 미쯔이가가꾸가부시끼가이샤 표시 소자용 밀봉재 및 그의 경화물, 유기 el 소자용 프레임 밀봉재, 그리고 유기 el 소자용 면 밀봉재

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3535326A (en) * 1967-03-06 1970-10-20 Sumitomo Chemical Co Certain tetrahydro carboline derivatives
BE787444A (fr) * 1971-08-13 1973-02-12 Hoffmann La Roche Composes polycycliques
US4009181A (en) * 1973-01-22 1977-02-22 Hoffmann-La Roche Inc. Cyclopenta[b]indole-2-carboxylic acids and derivatives thereof
US4057559A (en) * 1973-10-01 1977-11-08 American Home Products Corporation Carbazole acetic acid derivatives
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
DE3768097D1 (de) 1986-01-23 1991-04-04 Merck Frosst Canada Inc Tetrahydrocarbazol-1-alkansaeuren.
US5021447A (en) * 1986-01-23 1991-06-04 Merck Frosst Canada, Inc. Tetrahydrocarbazole 1-alkanoic acids and pharmaecutical compositions
US4808608A (en) 1986-01-23 1989-02-28 Merck & Co., Inc. Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
US4940719A (en) * 1986-03-27 1990-07-10 Merck Frosst Canada, Inc. Tetrahydrocarbazole esters, pharmaceutical compositions and use
US4775680A (en) * 1987-07-21 1988-10-04 Merck & Co., Inc. Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use
US5221678A (en) 1990-07-26 1993-06-22 Merck Frosst Canada, Inc. (quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
GB9101375D0 (en) 1991-01-22 1991-03-06 Erba Carlo Spa N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohepht(b)indole
WO1995015973A1 (en) 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
US5510332A (en) 1994-07-07 1996-04-23 Texas Biotechnology Corporation Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor
DE69530392D1 (de) 1994-07-11 2003-05-22 Athena Neurosciences Inc Inhibitoren der leukozytenadhäsion
US5811391A (en) 1994-08-25 1998-09-22 Cytel Corporation Cyclic CS-1 peptidomimetics, compositions and methods of using same
GB9524630D0 (en) 1994-12-24 1996-01-31 Zeneca Ltd Chemical compounds
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
AU5259296A (en) 1995-04-07 1996-10-23 Warner-Lambert Company Flavones and coumarins as agents for the treatment of athero sclerosis
WO1996040781A1 (en) 1995-06-07 1996-12-19 Tanabe Seiyaku Co., Ltd. CYCLIC PEPTIDE INHIBITORS OF β1 AND β2 INTEGRIN-MEDIATED ADHESION
MX9710256A (es) 1995-06-21 1998-03-31 Shionogi & Co Derivados de amino biciclicos y antagonistas pgd2 que contienen los mismos.
AU6311996A (en) 1995-07-06 1997-02-05 Zeneca Limited Peptide inhibitors of fibronectine
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
ES2181039T3 (es) 1996-12-13 2003-02-16 Shionogi & Co Derivados de benzotiofenocarboxamida y antagonistas de pgd2 que los comprenden.
CN1198649C (zh) 1998-06-03 2005-04-27 盐野义制药株式会社 用于治疗瘙痒的含pgd2受体拮抗剂的药物组合物
US20010047027A1 (en) 2000-04-12 2001-11-29 Marc Labelle Prostaglandin D2 receptor antagonists
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
AR038136A1 (es) * 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
US7019022B2 (en) * 2003-12-15 2006-03-28 Merck Frosst Canada & Co. Substituted tetrahydrocarbazole and cyclopentanoindole derivatives

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