ES2181039T3 - Derivados de benzotiofenocarboxamida y antagonistas de pgd2 que los comprenden. - Google Patents

Derivados de benzotiofenocarboxamida y antagonistas de pgd2 que los comprenden.

Info

Publication number
ES2181039T3
ES2181039T3 ES97947866T ES97947866T ES2181039T3 ES 2181039 T3 ES2181039 T3 ES 2181039T3 ES 97947866 T ES97947866 T ES 97947866T ES 97947866 T ES97947866 T ES 97947866T ES 2181039 T3 ES2181039 T3 ES 2181039T3
Authority
ES
Spain
Prior art keywords
benzotiofenocarboxamida
pgd2
antagonists
derivatives
understand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97947866T
Other languages
English (en)
Inventor
Tsunetoshi Honma
Yoshiharu Hiramatsu
Akinori Arimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2181039T3 publication Critical patent/ES2181039T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

SE DESCRIBE UN COMPUESTO, UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO O UN HIDRATO DEL COMPUESTO QUE TIENE ACTIVIDADES ANTAGONISTAS DE LA PGD 2 , ACTIVIDADES DE INHIBICION CONTRA LA INFILTRACION DE EOSINOFILOS, Y QUE ES UTIL COMO FARMACOS PARA EL TRATAMIENTO DE ENFERMEDADES, TALES COMO LA MASTOCITOSIS SISTEMICA Y TRASTORNOS DE LA ACTIVACION DE LOS MASTOCITOS SISTEMICOS, ASI COMO LA CONTRACCION TRAQUEAL, EL ASMA, LA RINITIS ALERGICA, LA CONJUNTIVITIS ALERGICA, LA URTICARIA, LA LESION POR REPERFUSION ISQUEMICA, LA DERMATITIS INFLAMATORIA Y ATOPICA, SIENDO EL COMPUESTO REPRESENTADO POR LA FORMULA (I).
ES97947866T 1996-12-13 1997-12-10 Derivados de benzotiofenocarboxamida y antagonistas de pgd2 que los comprenden. Expired - Lifetime ES2181039T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33349596 1996-12-13
JP25400197 1997-09-19

Publications (1)

Publication Number Publication Date
ES2181039T3 true ES2181039T3 (es) 2003-02-16

Family

ID=26541496

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97947866T Expired - Lifetime ES2181039T3 (es) 1996-12-13 1997-12-10 Derivados de benzotiofenocarboxamida y antagonistas de pgd2 que los comprenden.

Country Status (26)

Country Link
US (1) US6083974A (es)
EP (1) EP0944614B1 (es)
JP (1) JP3215441B2 (es)
KR (1) KR100433568B1 (es)
CN (2) CN1105112C (es)
AR (1) AR008939A1 (es)
AT (1) ATE223911T1 (es)
AU (1) AU718958B2 (es)
BR (1) BR9714016A (es)
CA (1) CA2274591C (es)
CZ (1) CZ297324B6 (es)
DE (1) DE69715448T2 (es)
DK (1) DK0944614T3 (es)
ES (1) ES2181039T3 (es)
HK (1) HK1020045A1 (es)
HU (1) HU226458B1 (es)
ID (1) ID22753A (es)
IL (1) IL130660A (es)
NO (1) NO992838L (es)
NZ (1) NZ336143A (es)
PL (1) PL191760B1 (es)
PT (1) PT944614E (es)
RU (1) RU2161617C1 (es)
TR (1) TR199901280T2 (es)
TW (1) TW438790B (es)
WO (1) WO1998025919A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1069123B1 (en) 1998-03-31 2004-11-10 Shionogi & Co., Ltd. Process for producing benzothiophenecarboxylic acid amide derivatives
KR100596284B1 (ko) * 1998-03-31 2006-07-03 시오노기 앤드 컴파니, 리미티드 5-히드록시벤조[비]티오펜-3-카복실산 유도체의 제조 방법
DE69925270T2 (de) * 1998-06-03 2006-02-23 Shionogi & Co., Ltd. Mittel zur linderung von juckreiz, enthaltend pgd2- antagonisten
EP1808427A3 (en) * 1999-07-02 2008-06-25 Shionogi & Co., Ltd. Novel processes for the preparation of bicyclic aminoalcohols
MXPA02008801A (es) 2000-03-09 2003-07-07 Ono Pharmaceutical Co Derivados de indol, proceso para la preparacion de los mismos y su uso.
WO2001078697A2 (en) * 2000-04-12 2001-10-25 Merck Frosst Canada & Co. Method and compositions for the treatment of allergic conditions using pgd2 receptor antagonists
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
US7273883B2 (en) 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
JP4017978B2 (ja) * 2000-10-17 2007-12-05 塩野義製薬株式会社 Ｐｇｄ２アンタゴニストの製造方法
JPWO2002036583A1 (ja) * 2000-11-01 2004-03-11 塩野義製薬株式会社 Ｐｇｄ２受容体拮抗性医薬組成物
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
ATE516277T1 (de) 2002-03-19 2011-07-15 Ono Pharmaceutical Co Carbonsäureverbindungen und arzneimittel, die diese verbindungen als wirkstoffe enthalten
AU2003252499B2 (en) * 2002-07-12 2007-11-08 Japan Science And Technology Agency Drugs for improving the prognosis of brain injury and a method of screening the same
WO2004030674A1 (ja) * 2002-09-30 2004-04-15 Shionogi & Co., Ltd. プロスタグランジンｄ２、プロスタグランジンｄ２アゴニストおよびプロスタグランジンｄ２アンタゴニストの新規用途
KR20050084890A (ko) 2002-10-30 2005-08-29 머크 프로스트 캐나다 앤드 캄파니 피리도피롤리진 및 피리도인돌리진 유도체
PT1725553E (pt) 2004-03-11 2008-07-16 Actelion Pharmaceuticals Ltd Derivados de tetra-hidropiridoindole
JPWO2006068162A1 (ja) * 2004-12-24 2008-06-12 塩野義製薬株式会社 慢性閉塞性肺疾患の治療剤
TW200716093A (en) * 2005-04-28 2007-05-01 Shionogi & Co An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh) 2007-08-10 2013-10-01 Ono Pharmaceutical Co Phenylacetic acid compounds
EA201200855A1 (ru) 2009-12-23 2013-04-30 Айронвуд Фармасьютикелз, Инк. Модуляторы crth2
WO2011115804A1 (en) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
KR101813931B1 (ko) 2010-06-30 2018-01-02 아이언우드 파마슈티컬스, 인코포레이티드 Sgc 자극제
WO2012009137A1 (en) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Crth2 modulators
US20130259830A1 (en) 2010-07-12 2013-10-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012064559A1 (en) 2010-11-09 2012-05-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CA2861804C (en) 2011-12-27 2021-10-26 Ironwood Pharmaceuticals, Inc. 2-benzyl,3(pyrimidin-2-yl)substituted pyrazoles useful as sgc stimulators
US9309235B2 (en) 2012-09-18 2016-04-12 Ironwood Pharmaceuticals, Inc. SGC stimulators
US9487508B2 (en) 2012-09-19 2016-11-08 Ironwood Pharmaceuticals, Inc. SGC stimulators
CN110016020B (zh) 2013-03-15 2022-07-26 赛克里翁治疗有限公司 化合物或其药学上可接受的盐及其应用和药物组合物
JP2016540017A (ja) 2013-12-11 2016-12-22 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激物質
WO2015106268A1 (en) 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
US10844064B2 (en) 2014-09-17 2020-11-24 Cyclerion Therapeutics, Inc. sGC stimulators
WO2016044445A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
US20170291889A1 (en) 2014-09-17 2017-10-12 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators
BR112019000293A2 (pt) 2016-07-07 2019-04-16 Ironwood Pharmaceuticals, Inc. formas sólidas de um estimulador de sgc
CN114736240A (zh) 2016-07-07 2022-07-12 赛克里翁治疗有限公司 sGC刺激剂的磷前药

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560343A (en) * 1984-06-11 1985-12-24 Honeywell Inc. Functional check for a hot surface ignitor element
JPS6149A (ja) * 1984-06-12 1986-01-06 Ono Pharmaceut Co Ltd 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
NZ218115A (en) * 1985-11-18 1990-02-26 Shionogi & Co Bicyclic sulphonamides and pharmaceutical compositions
CA1294974C (en) * 1987-05-08 1992-01-28 Sanji Hagishita Bicyclic sulfonamide derivatives and process therefor
US5356926A (en) * 1992-02-24 1994-10-18 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
CA2113787A1 (en) * 1993-01-29 1994-07-30 Nobuyuki Hamanaka Carbocyclic sulfonamides
DE4317076A1 (de) * 1993-05-21 1994-11-24 Bayer Ag Benzthiophencarbonsäureamid-S-oxide
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
CN1134411C (zh) * 1995-06-21 2004-01-14 盐野义制药株式会社 双环氨基衍生物及含有此类化合物的前列腺素d2拮抗剂
JP2001501946A (ja) * 1996-10-08 2001-02-13 イーライ・リリー・アンド・カンパニー 新規セロトニン５―ｈｔ▲下１ｆ▼アゴニスト

Also Published As

Publication number Publication date
NO992838D0 (no) 1999-06-10
CN1240438A (zh) 2000-01-05
HU226458B1 (en) 2008-12-29
JP2000514824A (ja) 2000-11-07
DE69715448T2 (de) 2003-08-07
HUP0002869A3 (en) 2003-01-28
JP3215441B2 (ja) 2001-10-09
RU2161617C1 (ru) 2001-01-10
EP0944614A1 (en) 1999-09-29
EP0944614B1 (en) 2002-09-11
CN1445225A (zh) 2003-10-01
PT944614E (pt) 2003-01-31
CA2274591A1 (en) 1998-06-18
DK0944614T3 (da) 2003-01-13
BR9714016A (pt) 2000-02-29
NO992838L (no) 1999-07-20
TR199901280T2 (xx) 1999-10-21
AR008939A1 (es) 2000-02-23
NZ336143A (en) 2002-05-31
HK1020045A1 (en) 2000-03-10
DE69715448D1 (de) 2002-10-17
KR20000069402A (ko) 2000-11-25
HUP0002869A2 (hu) 2001-06-28
ID22753A (id) 1999-12-09
CA2274591C (en) 2005-06-14
AU5409798A (en) 1998-07-03
CN1185226C (zh) 2005-01-19
CZ206599A3 (cs) 1999-11-17
WO1998025919A1 (en) 1998-06-18
TW438790B (en) 2001-06-07
IL130660A (en) 2002-03-10
ATE223911T1 (de) 2002-09-15
CZ297324B6 (cs) 2006-11-15
US6083974A (en) 2000-07-04
IL130660A0 (en) 2000-06-01
CN1105112C (zh) 2003-04-09
KR100433568B1 (ko) 2004-05-31
PL191760B1 (pl) 2006-06-30
PL334072A1 (en) 2000-01-31
AU718958B2 (en) 2000-05-04

Similar Documents

Publication Publication Date Title
ES2181039T3 (es) Derivados de benzotiofenocarboxamida y antagonistas de pgd2 que los comprenden.
CO5690131A1 (es) Derivados de eter biarilico que presentan actividad como inhibidores de la recaptacion de monoaminas para el tratamiento de transtornos del snc
HRP941000B9 (hr) Morfolin i tiomorfolin antagonisti receptora tahikinina
BRPI0411699A (pt) compostos para uso como substáncia terapeuticamente ativa; método para o tratamento e/ou profilaxia de doenças que estão associadas à modulação de receptores cb1 e uso destes compostos
MXPA02001764A (es) Compuestos heteropoliciclicos y su uso como antagonistas de receptor de glutamato metabotropico.
BR0112756A (pt) Composto, composição farmacêutica, métodos para o tratamento de doenças mediadas por prostaglandina, de congestão nasal, asma alérgica, e rinite alérgica, e, uso de um composto
DE69732868D1 (de) Mittel gegen Juckreiz
DK1230243T3 (da) Polycycloalkylpuriner som adenosinreceptorantagonister
ES2156287T3 (es) Derivados de difenilmetilen piperidina.
MX9307062A (es) Derivado de quinuclidina para el tratamiento de los trastornos inflamatorios y del sistema nervioso central.
ECSP055745A (es) Derivados de 1-(4-bencil-piperazin-1-il)-3-fenil-propenona
DK0682664T3 (da) Forbindelser med både potent calciumantagonist og antioxiderende aktivitet og anvendelse deraf som cytobeskyttende midler
RS53428B (en) COMPOSITIONS AND ANTI-VIRUS ACTIVITY OF SUBSTITUTED AZAINDOLOXOSCETER PIPERAZINE DERIVATIVES
BR0316296A (pt) Compostos lapacone e seus métodos de uso
FI965021A (fi) Bentsimidatsolijohdannaisia, joilla on dopaminergistä vaikutusta keskushermostossa
CR6824A (es) Derivados de arilmetilamina para uso como inhibidores de triptasa
UY27232A1 (es) Nuevos compuestos de dihidropirimidina ciano substituidos y su uso para tratar padecimientos
BR0114697A (pt) Derivados em ponte de piperazina
DK0775118T3 (da) Benzimidazolderivater, der har dopaminerg aktivitet
NO20002655D0 (no) 5-(2-imidazolinylamino) -benzimidazol derivater, fremstilling og anvendelse derav som <alfa>-adrenoceptoragonister med forbedret metabolisk stabilitet
DE69819742D1 (de) Indolderivate als 5-ht1b und 5-ht1d agonisten
BG103553A (en) Benzopyranopyrol and benzopyranopyridine alpha-1 adrenergic compounds
ES2196349T3 (es) Uso de galanina para reparar lesiones en los nervios.
ECSP014079A (es) Derivados de sulfonamida
ES2149984T3 (es) Derivados imidazolilalquilos de imidazol(5,1-c)(1,4)benzoxazin-1-ona y su utilizacion como agentes terapeuticos.