AR008939A1 - Compuestos de benzotiofencarboxamidas, composiciones farmaceuticas y antagonistas de la pgd2 que los contienen, y compuestos intermediarios de aplicacion en la preparacion de dichos compuestos. - Google Patents

Compuestos de benzotiofencarboxamidas, composiciones farmaceuticas y antagonistas de la pgd2 que los contienen, y compuestos intermediarios de aplicacion en la preparacion de dichos compuestos.

Info

Publication number
AR008939A1
AR008939A1 ARP970105862A ARP970105862A AR008939A1 AR 008939 A1 AR008939 A1 AR 008939A1 AR P970105862 A ARP970105862 A AR P970105862A AR P970105862 A ARP970105862 A AR P970105862A AR 008939 A1 AR008939 A1 AR 008939A1
Authority
AR
Argentina
Prior art keywords
compounds
pgd2
pharmaceutical
benzotiofencarboxamides
preparation
Prior art date
Application number
ARP970105862A
Other languages
English (en)
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of AR008939A1 publication Critical patent/AR008939A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se propoircionan derivados y sales farmacéuticamente aceptable e hidratos de los mismos que tienen actividad antagonista de PGD2, actividad inhibitoriade la infiltracion de eosinofilos y utiles para preparar composiciones para el tratamiento ded plencias tales como mastocitosis sistémica e irregularidadesde la activacion sistémica de células mastoides (mast cells), contracciones traqueales, asma, rinitis alérgica, conjuntivitis alérgica, urticaria, danosisquémicos de la reperfusion,infl amacion y dermatitis atopicas, que tienen la formula (I); Se proponen composiciones farmacéuticas y antagonistas de la PGD2formuladas con dichos derivados y compuestos intermediarios para la síntesis de los mismos.
ARP970105862A 1996-12-13 1997-12-12 Compuestos de benzotiofencarboxamidas, composiciones farmaceuticas y antagonistas de la pgd2 que los contienen, y compuestos intermediarios de aplicacion en la preparacion de dichos compuestos. AR008939A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33349596 1996-12-13
JP25400197 1997-09-19

Publications (1)

Publication Number Publication Date
AR008939A1 true AR008939A1 (es) 2000-02-23

Family

ID=26541496

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105862A AR008939A1 (es) 1996-12-13 1997-12-12 Compuestos de benzotiofencarboxamidas, composiciones farmaceuticas y antagonistas de la pgd2 que los contienen, y compuestos intermediarios de aplicacion en la preparacion de dichos compuestos.

Country Status (26)

Country Link
US (1) US6083974A (es)
EP (1) EP0944614B1 (es)
JP (1) JP3215441B2 (es)
KR (1) KR100433568B1 (es)
CN (2) CN1105112C (es)
AR (1) AR008939A1 (es)
AT (1) ATE223911T1 (es)
AU (1) AU718958B2 (es)
BR (1) BR9714016A (es)
CA (1) CA2274591C (es)
CZ (1) CZ297324B6 (es)
DE (1) DE69715448T2 (es)
DK (1) DK0944614T3 (es)
ES (1) ES2181039T3 (es)
HK (1) HK1020045A1 (es)
HU (1) HU226458B1 (es)
ID (1) ID22753A (es)
IL (1) IL130660A (es)
NO (1) NO992838L (es)
NZ (1) NZ336143A (es)
PL (1) PL191760B1 (es)
PT (1) PT944614E (es)
RU (1) RU2161617C1 (es)
TR (1) TR199901280T2 (es)
TW (1) TW438790B (es)
WO (1) WO1998025919A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6320060B1 (en) 1998-03-31 2001-11-20 Shionogi & Co., Ltd. Process for producing 5-hydroxybenzo[b] thiophene-3-carboxylic acid derivatives
US6399788B1 (en) 1998-03-31 2002-06-04 Shionogi & Co., Ltd. Process for producing benzothiophenecarboxylic acid amide derivatives
ATE295183T1 (de) * 1998-06-03 2005-05-15 Shionogi & Co Mittel zur linderung von juckreiz, enthaltend pgd2- antagonisten
DE60039876D1 (de) 1999-07-02 2008-09-25 Shionogi & Co Neuartiges verfahren zur herstellung bicyclischer amino-alkohole
RU2259998C2 (ru) 2000-03-09 2005-09-10 Оно Фармасьютикал Ко., Лтд. Производные индола, способ их получения и их применение
DE60115411D1 (de) * 2000-04-12 2006-01-05 Merck Frosst Canada & Co Kirkl Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
US7273883B2 (en) 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
JP4017978B2 (ja) * 2000-10-17 2007-12-05 塩野義製薬株式会社 Ｐｇｄ２アンタゴニストの製造方法
US6933317B2 (en) * 2000-11-01 2005-08-23 Shionogi & Co. Ltd. PGD2 receptor antagonistic pharmaceutical compositions
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
ATE516277T1 (de) 2002-03-19 2011-07-15 Ono Pharmaceutical Co Carbonsäureverbindungen und arzneimittel, die diese verbindungen als wirkstoffe enthalten
EP1598065A2 (en) * 2002-07-12 2005-11-23 Japan Science and Technology Agency Drugs for improving prognosis of brain injury
WO2004030674A1 (ja) * 2002-09-30 2004-04-15 Shionogi & Co., Ltd. プロスタグランジンｄ２、プロスタグランジンｄ２アゴニストおよびプロスタグランジンｄ２アンタゴニストの新規用途
WO2004039807A1 (en) 2002-10-30 2004-05-13 Merck Frosst Canada & Co. Pyridopyrrolizine and pyridoindolizine derivatives
DK1725553T3 (da) 2004-03-11 2008-08-18 Actelion Pharmaceuticals Ltd Tetrahydropyridoindolderivater
WO2006068162A1 (ja) * 2004-12-24 2006-06-29 Shionogi & Co., Ltd. 慢性閉塞性肺疾患の治療剤
TW200716093A (en) * 2005-04-28 2007-05-01 Shionogi & Co An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh) 2007-08-10 2013-10-01 Ono Pharmaceutical Co Phenylacetic acid compounds
JP5731538B2 (ja) 2009-12-23 2015-06-10 アイアンウッド ファーマシューティカルズ インコーポレイテッド Ｃｒｔｈ２モジュレーター
US20130178475A1 (en) 2010-03-17 2013-07-11 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
DK2588465T3 (en) 2010-06-30 2017-05-01 Ironwood Pharmaceuticals Inc SGC stimulators
US20130216552A1 (en) 2010-07-12 2013-08-22 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012009134A1 (en) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Crth2 modulators
CN107266433A (zh) 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
CA2861804C (en) 2011-12-27 2021-10-26 Ironwood Pharmaceuticals, Inc. 2-benzyl,3(pyrimidin-2-yl)substituted pyrazoles useful as sgc stimulators
WO2014047111A1 (en) 2012-09-18 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CA2885645A1 (en) 2012-09-19 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CN109369635B (zh) 2013-03-15 2023-06-30 赛克里翁治疗有限公司 化合物或其药学上可接受的盐及其应用和药物组合物
US20160311826A1 (en) 2013-12-11 2016-10-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
WO2015106268A1 (en) 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
EP3194386A2 (en) 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
US20170291889A1 (en) 2014-09-17 2017-10-12 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators
US10889577B2 (en) 2016-07-07 2021-01-12 Cyclerion Therapeutics, Inc. Solid forms of an sGC stimulator
CA3029374A1 (en) 2016-07-07 2018-01-11 Ironwood Pharmaceuticals, Inc. Phosphorus prodrugs of sgc stimulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560343A (en) * 1984-06-11 1985-12-24 Honeywell Inc. Functional check for a hot surface ignitor element
JPS6149A (ja) * 1984-06-12 1986-01-06 Ono Pharmaceut Co Ltd 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
CA1278577C (en) * 1985-11-18 1991-01-02 Tatsuo Tsuri Bicyclic sulfonamide derivatives
CA1294974C (en) * 1987-05-08 1992-01-28 Sanji Hagishita Bicyclic sulfonamide derivatives and process therefor
US5356926A (en) * 1992-02-24 1994-10-18 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
CA2113787A1 (en) * 1993-01-29 1994-07-30 Nobuyuki Hamanaka Carbocyclic sulfonamides
DE4317076A1 (de) * 1993-05-21 1994-11-24 Bayer Ag Benzthiophencarbonsäureamid-S-oxide
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
EP0837052B1 (en) * 1995-06-21 2006-08-23 Shionogi & Co., Ltd. Bicyclic amino derivatives and pgd 2 antagonist containing the same
CA2268164A1 (en) * 1996-10-08 1998-04-16 Yao-Chang Xu New serotonin 5-ht1f agonists

Also Published As

Publication number Publication date
DE69715448T2 (de) 2003-08-07
PT944614E (pt) 2003-01-31
IL130660A0 (en) 2000-06-01
CN1445225A (zh) 2003-10-01
CA2274591A1 (en) 1998-06-18
EP0944614A1 (en) 1999-09-29
CN1105112C (zh) 2003-04-09
JP2000514824A (ja) 2000-11-07
DE69715448D1 (de) 2002-10-17
KR20000069402A (ko) 2000-11-25
CZ297324B6 (cs) 2006-11-15
DK0944614T3 (da) 2003-01-13
NZ336143A (en) 2002-05-31
AU718958B2 (en) 2000-05-04
WO1998025919A1 (en) 1998-06-18
KR100433568B1 (ko) 2004-05-31
AU5409798A (en) 1998-07-03
RU2161617C1 (ru) 2001-01-10
HU226458B1 (en) 2008-12-29
US6083974A (en) 2000-07-04
ES2181039T3 (es) 2003-02-16
BR9714016A (pt) 2000-02-29
TW438790B (en) 2001-06-07
ATE223911T1 (de) 2002-09-15
JP3215441B2 (ja) 2001-10-09
CN1240438A (zh) 2000-01-05
NO992838L (no) 1999-07-20
CN1185226C (zh) 2005-01-19
CZ206599A3 (cs) 1999-11-17
HUP0002869A3 (en) 2003-01-28
NO992838D0 (no) 1999-06-10
IL130660A (en) 2002-03-10
HUP0002869A2 (hu) 2001-06-28
ID22753A (id) 1999-12-09
PL191760B1 (pl) 2006-06-30
HK1020045A1 (en) 2000-03-10
CA2274591C (en) 2005-06-14
PL334072A1 (en) 2000-01-31
EP0944614B1 (en) 2002-09-11
TR199901280T2 (xx) 1999-10-21

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