NO992838D0 - Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse - Google Patents

Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse

Info

Publication number
NO992838D0
NO992838D0 NO992838A NO992838A NO992838D0 NO 992838 D0 NO992838 D0 NO 992838D0 NO 992838 A NO992838 A NO 992838A NO 992838 A NO992838 A NO 992838A NO 992838 D0 NO992838 D0 NO 992838D0
Authority
NO
Norway
Prior art keywords
pgd2 antagonists
benzothiophenecarboxamide
derivatives
benzothiophenecarboxamide derivatives
pgd2
Prior art date
Application number
NO992838A
Other languages
English (en)
Other versions
NO992838L (no
Inventor
Tsunetoshi Honma
Yoshiharu Hiramatsu
Akinori Arimura
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NO992838D0 publication Critical patent/NO992838D0/no
Publication of NO992838L publication Critical patent/NO992838L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO992838A 1996-12-13 1999-06-10 Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse NO992838L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33349596 1996-12-13
JP25400197 1997-09-19
PCT/JP1997/004527 WO1998025919A1 (en) 1996-12-13 1997-12-10 Benzothiophenecarboxamide derivatives and pgd2 antagonists comprising them

Publications (2)

Publication Number Publication Date
NO992838D0 true NO992838D0 (no) 1999-06-10
NO992838L NO992838L (no) 1999-07-20

Family

ID=26541496

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992838A NO992838L (no) 1996-12-13 1999-06-10 Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse

Country Status (26)

Country Link
US (1) US6083974A (no)
EP (1) EP0944614B1 (no)
JP (1) JP3215441B2 (no)
KR (1) KR100433568B1 (no)
CN (2) CN1105112C (no)
AR (1) AR008939A1 (no)
AT (1) ATE223911T1 (no)
AU (1) AU718958B2 (no)
BR (1) BR9714016A (no)
CA (1) CA2274591C (no)
CZ (1) CZ297324B6 (no)
DE (1) DE69715448T2 (no)
DK (1) DK0944614T3 (no)
ES (1) ES2181039T3 (no)
HK (1) HK1020045A1 (no)
HU (1) HU226458B1 (no)
ID (1) ID22753A (no)
IL (1) IL130660A (no)
NO (1) NO992838L (no)
NZ (1) NZ336143A (no)
PL (1) PL191760B1 (no)
PT (1) PT944614E (no)
RU (1) RU2161617C1 (no)
TR (1) TR199901280T2 (no)
TW (1) TW438790B (no)
WO (1) WO1998025919A1 (no)

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ATE298747T1 (de) 1998-03-31 2005-07-15 Shionogi & Co Verfahren zur herstellung von 5- hydroxybenzo(b)thiophen-3-carbonsäure
TW458975B (en) 1998-03-31 2001-10-11 Shionogi & Amp Co Method for preparing benzothiophenecarboxylic acid amide derivatives
CN1198649C (zh) * 1998-06-03 2005-04-27 盐野义制药株式会社 用于治疗瘙痒的含pgd2受体拮抗剂的药物组合物
ATE404524T1 (de) * 1999-07-02 2008-08-15 Shionogi & Co Neuartiges verfahren zur herstellung bicyclischer amino-alkohole
NZ521192A (en) 2000-03-09 2005-01-28 Ono Pharmaceutical Co Indole derivatives, process for preparation of the same and use thereof
EP1274457B1 (en) * 2000-04-12 2005-11-30 Merck Frosst Canada & Co. Method and compositions for the treatment of allergic conditions using pgd2 receptor antagonists
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
US7273883B2 (en) 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
AU2002213505A1 (en) 2000-10-17 2002-04-29 Shionogi & Co., Ltd Process for the preparation of pgd2 antagonist
JPWO2002036583A1 (ja) * 2000-11-01 2004-03-11 塩野義製薬株式会社 Ｐｇｄ２受容体拮抗性医薬組成物
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
AU2003221325A1 (en) * 2002-03-19 2003-09-29 Ono Pharmaceutical Co., Ltd. Carboxyoic acid compounds and drugs containing the compounds as the acive ingredient
CA2493883C (en) * 2002-07-12 2011-08-30 Japan Science And Technology Agency Drugs for improving the prognosis of brain injury and a method of screening the same
WO2004030674A1 (ja) * 2002-09-30 2004-04-15 Shionogi & Co., Ltd. プロスタグランジンｄ２、プロスタグランジンｄ２アゴニストおよびプロスタグランジンｄ２アンタゴニストの新規用途
ATE479686T1 (de) 2002-10-30 2010-09-15 Merck Frosst Canada Ltd Pyridopyrrolizin- und pyridoindolizinderivate
BRPI0508540B8 (pt) 2004-03-11 2021-05-25 Actelion Pharmaceuticals Ltd composto, composição farmacêutica, e, uso de um composto
JPWO2006068162A1 (ja) * 2004-12-24 2008-06-12 塩野義製薬株式会社 慢性閉塞性肺疾患の治療剤
TW200716093A (en) * 2005-04-28 2007-05-01 Shionogi & Co An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh) 2007-08-10 2013-10-01 Ono Pharmaceutical Co Phenylacetic acid compounds
EP2516416A1 (en) 2009-12-23 2012-10-31 Ironwood Pharmaceuticals, Inc. Crth2 modulators
US20130178475A1 (en) 2010-03-17 2013-07-11 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
AR088020A1 (es) 2010-06-30 2014-05-07 Ironwood Pharmaceuticals Inc Compuestos heterociclicos como estimuladores de sgc
US20130216552A1 (en) 2010-07-12 2013-08-22 Ironwood Pharmaceuticals, Inc. Crth2 modulators
US20130259830A1 (en) 2010-07-12 2013-10-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators
CA2817319A1 (en) 2010-11-09 2012-05-18 Ironwood Pharmaceuticals, Inc. Triazole derivatives as sgc stimulators
CN104066731B (zh) 2011-12-27 2016-06-15 铁木医药有限公司 可用作sgc刺激剂的2-苄基、3-(嘧啶-2-基)取代的吡唑类
US9309235B2 (en) 2012-09-18 2016-04-12 Ironwood Pharmaceuticals, Inc. SGC stimulators
CA2885645A1 (en) 2012-09-19 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
KR102362835B1 (ko) 2013-03-15 2022-02-14 사이클리온 테라퓨틱스, 인크. ｓＧＣ 자극인자
CA2933250A1 (en) 2013-12-11 2015-06-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EP3094327A1 (en) 2014-01-13 2016-11-23 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
MX2017003516A (es) 2014-09-17 2017-07-28 Ironwood Pharmaceuticals Inc Derivados de pirazol como estimuladores de guanilato ciclasa soluble (sgc).
JP2017527604A (ja) 2014-09-17 2017-09-21 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激剤
US20180021302A1 (en) 2015-02-13 2018-01-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
MX2019000103A (es) 2016-07-07 2019-04-22 Ironwood Pharmaceuticals Inc Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc).
US10889577B2 (en) 2016-07-07 2021-01-12 Cyclerion Therapeutics, Inc. Solid forms of an sGC stimulator

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US4560343A (en) * 1984-06-11 1985-12-24 Honeywell Inc. Functional check for a hot surface ignitor element
JPS6149A (ja) * 1984-06-12 1986-01-06 Ono Pharmaceut Co Ltd 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
CA1278577C (en) * 1985-11-18 1991-01-02 Tatsuo Tsuri Bicyclic sulfonamide derivatives
CA1294974C (en) * 1987-05-08 1992-01-28 Sanji Hagishita Bicyclic sulfonamide derivatives and process therefor
US5356926A (en) * 1992-02-24 1994-10-18 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
CA2113787A1 (en) * 1993-01-29 1994-07-30 Nobuyuki Hamanaka Carbocyclic sulfonamides
DE4317076A1 (de) * 1993-05-21 1994-11-24 Bayer Ag Benzthiophencarbonsäureamid-S-oxide
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
MX9710256A (es) * 1995-06-21 1998-03-31 Shionogi & Co Derivados de amino biciclicos y antagonistas pgd2 que contienen los mismos.
JP2001501946A (ja) * 1996-10-08 2001-02-13 イーライ・リリー・アンド・カンパニー 新規セロトニン５―ｈｔ▲下１ｆ▼アゴニスト

Also Published As

Publication number Publication date
US6083974A (en) 2000-07-04
AU718958B2 (en) 2000-05-04
IL130660A0 (en) 2000-06-01
ID22753A (id) 1999-12-09
HUP0002869A2 (hu) 2001-06-28
HK1020045A1 (en) 2000-03-10
EP0944614B1 (en) 2002-09-11
DE69715448D1 (de) 2002-10-17
HUP0002869A3 (en) 2003-01-28
KR100433568B1 (ko) 2004-05-31
KR20000069402A (ko) 2000-11-25
NO992838L (no) 1999-07-20
JP3215441B2 (ja) 2001-10-09
TR199901280T2 (xx) 1999-10-21
WO1998025919A1 (en) 1998-06-18
CN1105112C (zh) 2003-04-09
JP2000514824A (ja) 2000-11-07
PL191760B1 (pl) 2006-06-30
EP0944614A1 (en) 1999-09-29
CZ297324B6 (cs) 2006-11-15
PL334072A1 (en) 2000-01-31
RU2161617C1 (ru) 2001-01-10
PT944614E (pt) 2003-01-31
BR9714016A (pt) 2000-02-29
AU5409798A (en) 1998-07-03
CA2274591C (en) 2005-06-14
TW438790B (en) 2001-06-07
CN1240438A (zh) 2000-01-05
HU226458B1 (en) 2008-12-29
CN1445225A (zh) 2003-10-01
AR008939A1 (es) 2000-02-23
ATE223911T1 (de) 2002-09-15
IL130660A (en) 2002-03-10
CN1185226C (zh) 2005-01-19
CZ206599A3 (cs) 1999-11-17
NZ336143A (en) 2002-05-31
DE69715448T2 (de) 2003-08-07
ES2181039T3 (es) 2003-02-16
DK0944614T3 (da) 2003-01-13
CA2274591A1 (en) 1998-06-18

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