MX2019000103A - Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc). - Google Patents

Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc).

Info

Publication number
MX2019000103A
MX2019000103A MX2019000103A MX2019000103A MX2019000103A MX 2019000103 A MX2019000103 A MX 2019000103A MX 2019000103 A MX2019000103 A MX 2019000103A MX 2019000103 A MX2019000103 A MX 2019000103A MX 2019000103 A MX2019000103 A MX 2019000103A
Authority
MX
Mexico
Prior art keywords
sgc stimulators
phosphorus prodrugs
prodrugs
phosphorus
sgc
Prior art date
Application number
MX2019000103A
Other languages
English (en)
Inventor
Mermerian Ara
Nakai Takashi
Robert Rennie Glen
Claude Barden Timothy
Edward Sheppeck James
R Iyengar Rajesh
Allan RENHOWE Paul
Original Assignee
Ironwood Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc
Publication of MX2019000103A publication Critical patent/MX2019000103A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
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  • Diabetes (AREA)
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  • Obesity (AREA)
  • Biochemistry (AREA)
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Abstract

La presente solicitud de patente describe los compuestos de acuerdo con la Fórmula (I) mostrados más abajo, o sales farmacéuticamente aceptables de estos, en donde JB, n, R1, R2, R3, R4, R5, m y X se definen en la presente descripción. (ver Fórmula).
MX2019000103A 2016-07-07 2017-07-06 Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc). MX2019000103A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662359419P 2016-07-07 2016-07-07
PCT/US2017/040809 WO2018009596A1 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sgc stimulators

Publications (1)

Publication Number Publication Date
MX2019000103A true MX2019000103A (es) 2019-04-22

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019000103A MX2019000103A (es) 2016-07-07 2017-07-06 Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc).
MX2022005024A MX2022005024A (es) 2016-07-07 2019-01-07 Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022005024A MX2022005024A (es) 2016-07-07 2019-01-07 Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc).

Country Status (13)

Country Link
US (1) US10927136B2 (es)
EP (1) EP3481837B1 (es)
JP (2) JP7016853B2 (es)
KR (1) KR102513343B1 (es)
CN (2) CN109476686B (es)
AU (2) AU2017291826B2 (es)
BR (1) BR112019000290B1 (es)
CA (1) CA3029374A1 (es)
EA (1) EA039683B1 (es)
IL (1) IL263993B2 (es)
MA (1) MA45592A (es)
MX (2) MX2019000103A (es)
WO (1) WO2018009596A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA45592A (fr) * 2016-07-07 2019-05-15 Ironwood Pharmaceuticals Inc Promédicaments à base de phosphore de stimulateurs de sgc
SG11202100092QA (en) 2018-07-11 2021-02-25 Cyclerion Therapeutics Inc USE OF sGC STIMULATORS FOR THE TREATMENT OF MITOCHONRIAL DISORDERS
CN114377149B (zh) * 2021-12-14 2023-11-10 西北工业大学 一种Mn基可降解MOF纳米反应器及其制备方法和应用
WO2024102304A1 (en) * 2022-11-07 2024-05-16 Virginia Commonwealth University Benzaldehyde compounds with direct polymer destabilizing effects to treat sickle cell disease
CN116478309B (zh) * 2023-05-19 2024-05-17 青海大学 锁阳精多糖、锁阳多糖化合物及制备方法和应用

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AU2017291826A1 (en) 2019-01-24
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CN114736240A (zh) 2022-07-12
BR112019000290B1 (pt) 2022-10-18
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JP7016853B2 (ja) 2022-02-07
BR112019000290A2 (pt) 2019-04-16
CA3029374A1 (en) 2018-01-11
AU2017291826B2 (en) 2021-10-21
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EP3481837B1 (en) 2023-12-06
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MA45592A (fr) 2019-05-15
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EA039683B1 (ru) 2022-02-28
AU2022200331A1 (en) 2022-02-17
US20240132528A1 (en) 2024-04-25
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