BR112019000290A2 - pró-fármacos de fósforo dos estimuladores da scg - Google Patents
pró-fármacos de fósforo dos estimuladores da scgInfo
- Publication number
- BR112019000290A2 BR112019000290A2 BR112019000290-1A BR112019000290A BR112019000290A2 BR 112019000290 A2 BR112019000290 A2 BR 112019000290A2 BR 112019000290 A BR112019000290 A BR 112019000290A BR 112019000290 A2 BR112019000290 A2 BR 112019000290A2
- Authority
- BR
- Brazil
- Prior art keywords
- scg
- stimulators
- phosphorus prodrugs
- prodrugs
- phosphorus
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
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Abstract
o presente pedido de patente revela os compostos de acordo com fórmula (i) mostrada abaixo, ou os sais farmaceuticamente aceitáveis dos mesmos, sendo que jb, n, r1, r2, r3, r4, r5, m e x são conforme definidos na presente invenção. fórmula i
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662359419P | 2016-07-07 | 2016-07-07 | |
US62/359,419 | 2016-07-07 | ||
PCT/US2017/040809 WO2018009596A1 (en) | 2016-07-07 | 2017-07-06 | Phosphorus prodrugs of sgc stimulators |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112019000290A2 true BR112019000290A2 (pt) | 2019-04-16 |
BR112019000290B1 BR112019000290B1 (pt) | 2022-10-18 |
Family
ID=59351139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019000290-1A BR112019000290B1 (pt) | 2016-07-07 | 2017-07-06 | Prófármacos de fósforo dos estimuladores da sgc |
Country Status (13)
Country | Link |
---|---|
US (1) | US10927136B2 (pt) |
EP (1) | EP3481837B1 (pt) |
JP (2) | JP7016853B2 (pt) |
KR (1) | KR102513343B1 (pt) |
CN (2) | CN114736240A (pt) |
AU (2) | AU2017291826B2 (pt) |
BR (1) | BR112019000290B1 (pt) |
CA (1) | CA3029374A1 (pt) |
EA (1) | EA039683B1 (pt) |
IL (1) | IL263993B2 (pt) |
MA (1) | MA45592A (pt) |
MX (2) | MX2019000103A (pt) |
WO (1) | WO2018009596A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2017291826B2 (en) * | 2016-07-07 | 2021-10-21 | Cyclerion Therapeutics, Inc. | Phosphorus prodrugs of sGC stimulators |
US20210177846A1 (en) | 2018-07-11 | 2021-06-17 | Cyclerion Therapeutics, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF MITOCHONDRIAL DISORDERS |
CN114377149B (zh) * | 2021-12-14 | 2023-11-10 | 西北工业大学 | 一种Mn基可降解MOF纳米反应器及其制备方法和应用 |
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- 2017-07-06 CN CN202111570967.XA patent/CN114736240A/zh active Pending
- 2017-07-06 CN CN201780045937.2A patent/CN109476686B/zh active Active
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- 2017-07-06 EP EP17740237.7A patent/EP3481837B1/en active Active
- 2017-07-06 JP JP2019500509A patent/JP7016853B2/ja active Active
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EP3481837B1 (en) | 2023-12-06 |
IL263993B2 (en) | 2023-06-01 |
EP3481837A1 (en) | 2019-05-15 |
US10927136B2 (en) | 2021-02-23 |
JP2019525915A (ja) | 2019-09-12 |
US20190300555A1 (en) | 2019-10-03 |
IL263993A (en) | 2019-02-28 |
AU2017291826B2 (en) | 2021-10-21 |
MX2022005024A (es) | 2022-05-16 |
EA201990238A1 (ru) | 2019-07-31 |
CN114736240A (zh) | 2022-07-12 |
AU2022200331A1 (en) | 2022-02-17 |
AU2022200331B2 (en) | 2023-12-07 |
AU2017291826A1 (en) | 2019-01-24 |
JP2022062115A (ja) | 2022-04-19 |
CA3029374A1 (en) | 2018-01-11 |
EA039683B1 (ru) | 2022-02-28 |
JP7016853B2 (ja) | 2022-02-07 |
CN109476686B (zh) | 2022-01-18 |
JP7368516B2 (ja) | 2023-10-24 |
BR112019000290B1 (pt) | 2022-10-18 |
KR20190026841A (ko) | 2019-03-13 |
KR102513343B1 (ko) | 2023-03-22 |
MX2019000103A (es) | 2019-04-22 |
CN109476686A (zh) | 2019-03-15 |
WO2018009596A1 (en) | 2018-01-11 |
MA45592A (fr) | 2019-05-15 |
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