BR112017005917A2 - processos e composições para indução de imunidade protetora contra infecção com o vírus da imunodeficiência humana - Google Patents

processos e composições para indução de imunidade protetora contra infecção com o vírus da imunodeficiência humana

Info

Publication number
BR112017005917A2
BR112017005917A2 BR112017005917A BR112017005917A BR112017005917A2 BR 112017005917 A2 BR112017005917 A2 BR 112017005917A2 BR 112017005917 A BR112017005917 A BR 112017005917A BR 112017005917 A BR112017005917 A BR 112017005917A BR 112017005917 A2 BR112017005917 A2 BR 112017005917A2
Authority
BR
Brazil
Prior art keywords
processes
compositions
immunodeficiency virus
virus infection
human immunodeficiency
Prior art date
Application number
BR112017005917A
Other languages
English (en)
Inventor
Barouch Dan
VAN MANEN Danielle
Tomaka Frank
Anne Hendriks Jennifer
Schuitemaker Johanna
Grazia Pau Maria
Original Assignee
Beth Israel Deaconess Medical Ct Inc
Janssen Vaccines & Prevention Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Ct Inc, Janssen Vaccines & Prevention Bv filed Critical Beth Israel Deaconess Medical Ct Inc
Publication of BR112017005917A2 publication Critical patent/BR112017005917A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

a presente invenção refere-se aos compostos da fórmula i: i e sais farmaceuticamente aceitáveis dos mesmos, em que r1 , r2 e r3, são como são definidos aqui. a invenção refere-se ainda a composições farmacêuticas que compreendem estes compostos, processos de utilização destes compostos no tratamento de várias doenças e distúrbios, processos para a preparação destes compostos e intermediários úteis nestes processos.
BR112017005917A 2014-09-26 2015-09-24 processos e composições para indução de imunidade protetora contra infecção com o vírus da imunodeficiência humana BR112017005917A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462056059P 2014-09-26 2014-09-26
PCT/US2015/051891 WO2016049287A1 (en) 2014-09-26 2015-09-24 Methods and compositions for inducing protective immunity against human immunodeficiency virus infection

Publications (1)

Publication Number Publication Date
BR112017005917A2 true BR112017005917A2 (pt) 2017-12-12

Family

ID=55581992

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017005917A BR112017005917A2 (pt) 2014-09-26 2015-09-24 processos e composições para indução de imunidade protetora contra infecção com o vírus da imunodeficiência humana

Country Status (28)

Country Link
US (4) US10137191B2 (pt)
EP (2) EP3868398A1 (pt)
JP (2) JP6438575B2 (pt)
KR (2) KR102159626B1 (pt)
CN (2) CN106999571B (pt)
AP (1) AP2017009846A0 (pt)
AU (2) AU2015320574B2 (pt)
BR (1) BR112017005917A2 (pt)
CA (1) CA2961024A1 (pt)
CY (1) CY1124254T1 (pt)
DK (1) DK3197489T3 (pt)
EA (2) EA037583B1 (pt)
ES (1) ES2865150T3 (pt)
HR (1) HRP20210608T1 (pt)
HU (1) HUE053585T2 (pt)
IL (2) IL251114B (pt)
LT (1) LT3197489T (pt)
MA (1) MA40765B1 (pt)
MX (2) MX2017003946A (pt)
MY (1) MY175620A (pt)
PH (1) PH12017500449A1 (pt)
PL (1) PL3197489T3 (pt)
PT (1) PT3197489T (pt)
RS (1) RS61902B1 (pt)
SG (1) SG11201702110RA (pt)
SI (1) SI3197489T1 (pt)
WO (1) WO2016049287A1 (pt)
ZA (1) ZA201702053B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS61902B1 (sr) 2014-09-26 2021-06-30 Beth Israel Deaconess Medical Ct Inc Metodi i kompozicije za indukovanje zaštitnog imuniteta protiv infekcije virusom humane imunodeficijencije
MA40783A (fr) 2014-10-03 2017-08-08 Los Alamos Nat Security Llc Vaccins contre le vih comprenant un ou plusieurs antigènes episensus de population
MA44059B1 (fr) 2015-12-15 2019-11-29 Janssen Vaccines & Prevention Bv Antigènes du virus de l'immunodéficience humaine, vecteurs, compositions, et leurs procédés d'utilisation
EP3416978A4 (en) * 2016-02-16 2019-11-06 Geovax, Inc. MULTIVALENT VACCINE RECALL COMPOSITIONS AGAINST HIV AND METHODS OF USE
EP3471765B1 (en) 2016-06-16 2024-04-24 Janssen Vaccines & Prevention B.V. Hiv vaccine formulation
US10307477B2 (en) 2016-09-02 2019-06-04 Janssen Vaccines & Prevention B.V. Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
MX2019002938A (es) 2016-09-15 2019-10-15 Janssen Vaccines & Prevention Bv Mutaciones estebilizantes de trimeros de proteinas de la envoltura del vih.
AU2018283811B2 (en) * 2017-06-15 2022-10-20 Bavarian Nordic A/S Poxvirus vectors encoding HIV antigens, and methods of use thereof
SG11202000112XA (en) 2017-07-19 2020-02-27 Janssen Vaccines & Prevention Bv Trimer stabilizing hiv envelope protein mutations
WO2019018724A1 (en) 2017-07-21 2019-01-24 Janssen Vaccines & Prevention B.V. METHODS FOR SAFE INDUCTION OF MULTICLADED CROSS-IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN HUMAN BEINGS
WO2019055888A1 (en) * 2017-09-18 2019-03-21 Janssen Vaccines & Prevention B.V. METHODS OF INDUCING AN IMMUNE RESPONSE AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN SUBJECTS UNDER ANTIRETROVIRAL TREATMENT
AU2019345942A1 (en) * 2018-09-25 2021-03-18 Janssen Vaccines & Prevention B.V. Method of inducing an immune response against human immunodeficiency virus by co-localized administration of vaccine components
WO2020214203A1 (en) * 2019-04-17 2020-10-22 The Wistar Institute Replication deficient adenoviral vectors for hiv vaccine applications
EP3972642A1 (en) * 2019-05-22 2022-03-30 Aelix Therapeutics S.L. Dosage regimens for vaccines
TW202110476A (zh) * 2019-05-22 2021-03-16 荷蘭商傑森疫苗防護公司 於接受抗反轉錄病毒治療之個體中誘發抗人類免疫缺乏病毒感染之免疫反應的方法
CN114761041A (zh) 2019-07-16 2022-07-15 吉利德科学公司 Hiv疫苗及其制备和使用方法
US11857619B2 (en) 2019-11-07 2024-01-02 Janssen Vaccines & Prevention B.V. Multimodal chromatography method for the purification of HIV-1 envelope glycoprotein
KR20230131481A (ko) 2021-01-14 2023-09-13 길리애드 사이언시즈, 인코포레이티드 Hiv 백신 및 이의 사용 방법
WO2023198815A1 (en) 2022-04-14 2023-10-19 Janssen Vaccines & Prevention B.V. Sequential administration of adenoviruses

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
CA1341245C (en) 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Recombinant vaccinia virus mva
US5298416A (en) 1989-01-18 1994-03-29 British Technology Group Ltd. Attenuated polioviruses
US5505947A (en) 1994-05-27 1996-04-09 The University Of North Carolina At Chapel Hill Attenuating mutations in Venezuelan Equine Encephalitis virus
UA68327C2 (en) 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
US6479258B1 (en) 1995-12-07 2002-11-12 Diversa Corporation Non-stochastic generation of genetic vaccines
AU4255397A (en) 1996-09-06 1998-03-26 Trustees Of The University Of Pennsylvania, The Chimpanzee adenovirus vectors
GB0023203D0 (en) 2000-09-21 2000-11-01 Isis Innovation Vaccination method
NZ515582A (en) 1999-05-17 2003-11-28 Crucell Holland B Adenovirus derived gene delivery vehicles comprising at least one element of adenovirus type 35
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6710173B1 (en) 1999-06-25 2004-03-23 Progenics Pharmaceuticals, Inc. Stabilized viral envelope proteins and uses thereof
EP1214333A4 (en) 1999-09-17 2005-01-19 Dana Farber Cancer Inst Inc STABILIZED SOLUBLE GLYCOPROTEINTRIMERE
DE60116371T3 (de) 2000-11-23 2016-11-17 Bavarian Nordic A/S Variante des modifizierten vaccinia ankara virus
US20030198621A1 (en) 2001-07-05 2003-10-23 Megede Jan Zur Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof
CN102409063A (zh) 2001-12-04 2012-04-11 巴法里安诺迪克有限公司 黄病毒ns1亚单位疫苗
EP1497440B1 (en) 2002-04-25 2008-08-20 Crucell Holland B.V. Stable adenoviral vectors and methods for propagation thereof
SI1497438T1 (sl) 2002-04-25 2010-03-31 Crucell Holland Bv Sredstva in postopki za pripravo adenovirusnih vektorjev
WO2004044155A2 (en) 2002-11-07 2004-05-27 Beth Israel Deaconess Medical Center MIP-1α AND GM-CSF AS ADJUVANTS OF IMMUNE RESPONSE
JP2006509039A (ja) 2002-12-03 2006-03-16 ユニバーシティ オブ マサチューセッツ 多価初代ｈｉｖ−１糖タンパク質ｄｎａワクチンおよびワクチン接種方法
EP2363143A3 (en) 2003-03-28 2012-02-15 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services MVA expressing modified hiv envelope, gag, and pol genes
EP1667631A4 (en) * 2003-09-15 2010-04-14 Novartis Vaccines & Diagnostic COMBINED APPROACHES TO PRODUCE IMMUNE RESPONSES
US20070298051A1 (en) 2003-11-19 2007-12-27 Beth Israel Deaconess Medical Center Adjuvants Of Immune Response
CN102719478A (zh) 2004-01-23 2012-10-10 P.安杰莱蒂分子生物学研究所 黑猩猩腺病毒疫苗载运体
EP1766097A4 (en) 2004-06-15 2008-03-19 Progenics Pharm Inc HIV-1 NEUTRALIZATION ANTIBODIES ELICITED BY A TRIMERIC COMPLEX OF HIV-1 ENVELOPE GLYCOPROTEINS
EP2397490B1 (en) 2004-07-16 2013-09-04 THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Vaccine constructs and combinations of vaccines designed to improve the breadth of the immune response to diverse strains and clades of HIV
ES2539010T3 (es) 2004-08-27 2015-06-25 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Virus MVA recombinantes que expresan genes env, gag y pol modificados de VIH clado A/G, clado B, y clado C
EA010433B1 (ru) 2004-10-13 2008-08-29 Круселл Холланд Б.В. Усовершенствованные аденовирусные векторы и их применение
US20100015211A1 (en) * 2004-11-01 2010-01-21 Barnett Susan W Combination Approaches For Generating Immune Responses
WO2007005934A2 (en) 2005-07-06 2007-01-11 University Of Maryland Biotechnology Institute Constrained hiv envelope-based immunogen that simultaneously presents receptor and coreceptor binding sites
CN101969996A (zh) 2005-08-23 2011-02-09 加利福尼亚大学董事会 多价疫苗
US20100143302A1 (en) 2006-03-16 2010-06-10 Crucell Holland B.V. Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof
WO2007149491A2 (en) 2006-06-19 2007-12-27 Progenics Pharmaceuticals, Inc. Soluble stabilized trimeric hiv env proteins and uses thereof
WO2008063331A2 (en) 2006-10-23 2008-05-29 Progenics Pharmaceuticals, Inc. Modified gp140 envelope polypeptides of hiv-1 isolates, compositions, stabilized trimeric complexes, and uses thereof
WO2008140579A2 (en) 2006-11-17 2008-11-20 New York University Induction of broadly reactive neutralizing antibodies by focusing the immune response on v3 epitopes of the hiv-1 gp120 envelope
CA2896131C (en) 2007-03-02 2020-04-07 Glaxosmithkline Biologicals S.A. Novel method and compositions
PT2340038T (pt) * 2008-10-10 2018-02-21 Beth Israel Deaconess Medical Ct Inc Vacina de trímero de envelope para hiv-1 bioquimicamente estabilizada
SI2358757T1 (sl) 2008-11-18 2018-12-31 Beth Israel Deaconess Medical Center Antivirusna cepiva z izboljšano celularno imunogenostjo
WO2010086189A2 (en) 2009-02-02 2010-08-05 Okairòs Ag, Switzerland Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
WO2010085984A1 (en) 2009-02-02 2010-08-05 Okairos Ag Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
WO2010096561A1 (en) 2009-02-18 2010-08-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Synthetic hiv/siv gag proteins and uses thereof
CN105399833B (zh) 2010-01-04 2019-09-06 Kj 生物科学有限公司 用于疫苗和诊断学的Dps融合蛋白
JP5783642B2 (ja) 2010-01-28 2015-09-24 バヴァリアン・ノルディック・アクティーゼルスカブ Ｍｖａの主なゲノム欠失を含むワクシニアウイルス変異体
CN102762721B (zh) * 2010-02-15 2015-03-11 克鲁塞尔荷兰公司 用于生产Ad26腺病毒载体的方法
EP2926830B1 (en) 2010-08-31 2017-08-02 Theraclone Sciences, Inc. Human immunodeficiency virus (hiv)-neutralizing antibodies
US9173933B2 (en) 2010-10-15 2015-11-03 Bavarian Nordic A/S Recombinant modified vaccinia virus Ankara influenza vaccine
EP2655604B1 (en) * 2010-12-14 2018-05-09 The Government of The United States of America as represented by The Secretary of The Department of Health and Human Services Adenovirus serotype 26 and serotype 35 filovirus vaccines
US20140348791A1 (en) 2011-09-09 2014-11-27 Beth Israel Deaconess Medical Center, Inc. Modified adenoviral vectors and methods of treatment using same
US20130189754A1 (en) 2011-09-12 2013-07-25 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
EP2766037A4 (en) 2011-10-12 2015-08-05 Scripps Research Inst HIV-1 GP-120 MINI-V3 LOOP AND USES THEREOF
WO2014047261A1 (en) 2012-09-19 2014-03-27 Beth Israel Deaconess Medical Center, Inc. Viruses associated with immunodeficiency and enteropathy and methods using same
EP2920313B1 (en) 2012-11-16 2019-06-12 Beth Israel Deaconess Medical Center, Inc. Recombinant adenoviruses and use thereof
CA2897059C (en) 2013-01-07 2021-12-28 Beth Israel Deaconess Medical Center, Inc. Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using same
US10248758B2 (en) 2013-02-07 2019-04-02 University Of Washington Through Its Center For Commercialization Self-assembling protein nanostructures
US10376583B2 (en) 2013-09-30 2019-08-13 Beth Israel Deaconess Medical Center, Inc. Human immunodeficiency virus therapies utilizing N332-glycan-dependent antibodies and a reservoir activator
CN103992396B (zh) * 2014-04-17 2017-03-29 南开大学 一种潜在的高效重组HIV‑1 CRF07‑BC gp140免疫原的制备方法
EP3189067B1 (en) 2014-09-04 2021-05-19 The United States of America, as represented by The Secretary, Department of Health and Human Services Recombinant hiv-1 envelope proteins and their use
RS61902B1 (sr) * 2014-09-26 2021-06-30 Beth Israel Deaconess Medical Ct Inc Metodi i kompozicije za indukovanje zaštitnog imuniteta protiv infekcije virusom humane imunodeficijencije
US9630994B2 (en) 2014-11-03 2017-04-25 University Of Washington Polypeptides for use in self-assembling protein nanostructures
MA44059B1 (fr) 2015-12-15 2019-11-29 Janssen Vaccines & Prevention Bv Antigènes du virus de l'immunodéficience humaine, vecteurs, compositions, et leurs procédés d'utilisation
US10307477B2 (en) * 2016-09-02 2019-06-04 Janssen Vaccines & Prevention B.V. Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment

Also Published As

Publication number Publication date
US10137191B2 (en) 2018-11-27
KR20190042736A (ko) 2019-04-24
CN106999571A (zh) 2017-08-01
ZA201702053B (en) 2021-09-29
MX2017003946A (es) 2017-12-20
SG11201702110RA (en) 2017-04-27
SI3197489T1 (sl) 2021-08-31
CN106999571B (zh) 2020-10-02
EP3197489A1 (en) 2017-08-02
KR101971808B1 (ko) 2019-04-23
CY1124254T1 (el) 2022-07-22
RS61902B1 (sr) 2021-06-30
WO2016049287A1 (en) 2016-03-31
US10471137B2 (en) 2019-11-12
CA2961024A1 (en) 2016-03-31
US20160089432A1 (en) 2016-03-31
KR20170066454A (ko) 2017-06-14
US20200030437A1 (en) 2020-01-30
AP2017009846A0 (en) 2017-03-31
EA201790717A1 (ru) 2018-02-28
ES2865150T3 (es) 2021-10-15
PT3197489T (pt) 2021-04-30
HRP20210608T1 (hr) 2021-06-11
NZ730841A (en) 2021-08-27
HUE053585T2 (hu) 2021-07-28
MA40765A (fr) 2017-08-02
AU2015320574B2 (en) 2018-12-06
JP6438575B2 (ja) 2018-12-12
PH12017500449A1 (en) 2017-07-31
EP3868398A1 (en) 2021-08-25
MX2020013153A (es) 2021-02-18
MY175620A (en) 2020-07-02
IL251114A0 (en) 2017-04-30
JP2019038849A (ja) 2019-03-14
EP3197489A4 (en) 2018-03-14
IL265733B (en) 2021-05-31
IL265733A (en) 2019-05-30
LT3197489T (lt) 2021-07-26
AU2015320574A1 (en) 2017-04-06
EP3197489B1 (en) 2021-02-17
US20220096622A1 (en) 2022-03-31
US11207400B2 (en) 2021-12-28
PL3197489T3 (pl) 2021-11-08
IL251114B (en) 2019-05-30
US20180250385A1 (en) 2018-09-06
KR102159626B1 (ko) 2020-09-25
AU2018267669A1 (en) 2018-12-13
DK3197489T3 (da) 2021-04-19
AU2018267669B2 (en) 2020-03-05
JP6625716B2 (ja) 2019-12-25
EA037583B1 (ru) 2021-04-16
CN112121160A (zh) 2020-12-25
JP2017531627A (ja) 2017-10-26
EA202092521A1 (ru) 2021-05-31
MA40765B1 (fr) 2021-04-30

Similar Documents

Publication Publication Date Title
BR112017005917A2 (pt) processos e composições para indução de imunidade protetora contra infecção com o vírus da imunodeficiência humana
UY36465A (es) Compuestos policíclicos de carbamoilpiridona y su uso farmacéutico
PH12018500904A1 (en) Peptide macrocycles against acinetobacter baumannii
PH12018500065A1 (en) Oxysterols and methods of use thereof
BR112014018990A8 (pt) Derivados de ácido benzotiazol-6-il acético e seu uso para tratamento de uma infecção
EA202090486A3 (ru) Соединения для лечения спинальной мышечной атрофии
CU20170109A7 (es) Derivado de quinoleina para tratar y prevenir infecciones virales
BR112018070123A2 (pt) oxiesterós e métodos de uso dos mesmos
BR112017020837A2 (pt) compostos de carbamoilpiridona policíclicos e seu uso farmacêutico
BR112015003188A2 (pt) Composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente
UY36126A (es) ?compuestos de 6,8-dioxabiciclo[3.2.1]octano-2,3-diol sustituidos como agentes de direccionamiento al asgpr?.
NZ629996A (en) 2’- substituted carba-nucleoside analogs for antiviral treatment
UY35263A (es) Compuestos terapéuticos
BR112017009647A2 (pt) 2-amino-3,5-difluoro-3,6-dimetil-6-fenil-3,4,5,6-tetraidropiridinas como inibidoras da bace1 para tratar a doença de alzheimer
BR112018005861A2 (pt) derivados de ácido oleanólico modificado com c4 para a inibição de il-17 e outros usos
CR20150313A (es) Composiciones farmacéuticas
PH12015500713B1 (en) Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases
BR112017001334A2 (pt) compostos de imidazopiridazina, seu uso e composição farmacêutica que os compreende
BR112019025230A2 (pt) Anéis 5-5 fundidos como inibidores de c5a
BR112019003320A2 (pt) compostos de heteroaril carboxamida como inibidores de ripk2
DOP2017000086A (es) Composiciones farmacéuticas de acción prolongada
BR112017000584A2 (pt) inibidores da aldosterona sintase
BR112019000290A2 (pt) pró-fármacos de fósforo dos estimuladores da scg
UY36851A (es) Compuestos para uso en aplicaciones antibacterianas
CR20170157A (es) Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.