MX2017003517A - Estimuladores de guanilato ciclasa soluble (sgc). - Google Patents

Estimuladores de guanilato ciclasa soluble (sgc).

Info

Publication number
MX2017003517A
MX2017003517A MX2017003517A MX2017003517A MX2017003517A MX 2017003517 A MX2017003517 A MX 2017003517A MX 2017003517 A MX2017003517 A MX 2017003517A MX 2017003517 A MX2017003517 A MX 2017003517A MX 2017003517 A MX2017003517 A MX 2017003517A
Authority
MX
Mexico
Prior art keywords
ring
sgc stimulators
formula
sgc
stimulators
Prior art date
Application number
MX2017003517A
Other languages
English (en)
Inventor
Wai-Ho Lee Thomas
Nakai Takashi
Robert Rennie Glen
Allan RENHOWE Paul
Perl Nicholas
R Iyengar Rajesh
Original Assignee
Ironwood Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc
Publication of MX2017003517A publication Critical patent/MX2017003517A/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)

Abstract

La presente solicitud de patente describe al menos los compuesto de conformidad con la Formula I´ que se muestran más abajo, o las sales farmacéuticamente aceptables de estos, (ver formula) en donde el anillo D, el anillo A, anillo E, anillo F JB , n, JD , J, o, RC1, RC2, W, JE, r , JF, s, Z1, Z2, Y Z3 son como se definen en la presente descripción.
MX2017003517A 2014-09-17 2015-09-16 Estimuladores de guanilato ciclasa soluble (sgc). MX2017003517A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051620P 2014-09-17 2014-09-17
US201562204672P 2015-08-13 2015-08-13
PCT/US2015/050458 WO2016044441A1 (en) 2014-09-17 2015-09-16 Sgc stimulators

Publications (1)

Publication Number Publication Date
MX2017003517A true MX2017003517A (es) 2017-07-28

Family

ID=54293334

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017003517A MX2017003517A (es) 2014-09-17 2015-09-16 Estimuladores de guanilato ciclasa soluble (sgc).

Country Status (12)

Country Link
US (1) US10047095B2 (es)
EP (1) EP3194395B1 (es)
JP (1) JP2017527605A (es)
KR (1) KR20170055531A (es)
CN (1) CN107223125B (es)
AU (1) AU2015317818A1 (es)
BR (1) BR112017005248A2 (es)
CA (1) CA2961531A1 (es)
EA (1) EA201790627A1 (es)
IL (1) IL251115A0 (es)
MX (1) MX2017003517A (es)
WO (1) WO2016044441A1 (es)

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JP2017527604A (ja) * 2014-09-17 2017-09-21 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激剤
KR20180094965A (ko) 2015-12-14 2018-08-24 아이언우드 파마슈티컬스, 인코포레이티드 위장 괄약근 기능장애의 치료를 위한 sGC 자극제의 용도
SG11201900096QA (en) 2016-07-07 2019-02-27 Ironwood Pharmaceuticals Inc Novel processes for preparation of soluble guanylate cyclase stimulators
US10918639B2 (en) 2016-10-11 2021-02-16 Bayer Pharma Aktiengesellschaft Combination containing SGC stimulators and mineralocorticoid receptor antagonists
CA3039735A1 (en) 2016-10-11 2018-04-19 Bayer Pharma Aktiengesellschaft Combination containing sgc activators and mineralocorticoid receptor antagonists
TW201822637A (zh) 2016-11-07 2018-07-01 德商拜耳廠股份有限公司 用於控制動物害蟲的經取代磺醯胺類
WO2018111795A2 (en) 2016-12-13 2018-06-21 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
CN110869041A (zh) * 2017-11-08 2020-03-06 奥尼佩普学会 在糖尿病足的情况下增强组织氧合的医药制剂及其用途
IL314714A (en) * 2018-01-10 2024-10-01 Cyclerion Therapeutics Inc PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF SOLUBLE GIONLIGHT CYCLAS FANS
EP3793553A1 (en) 2018-05-15 2021-03-24 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
JP7542518B2 (ja) 2018-07-11 2024-08-30 ティセント セラピューティクス インコーポレーテッド ミトコンドリア（ｍｉｔｏｃｈｏｎｒｉａｌ）障害の処置のためのｓＧＣ刺激剤の使用
EP4171562A1 (en) * 2020-06-25 2023-05-03 Tolremo Therapeutics AG Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of fibrotic disease

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CA2507509A1 (en) * 2002-11-25 2004-06-10 Mochida Pharmaceutical Co., Ltd. Therapeutic agent for respiratory disease containing 4-hydroxypiperidine derivative as active ingredient
WO2008070661A1 (en) * 2006-12-04 2008-06-12 Neurocrine Biosciences, Inc. Substituted pyrimidines as adenosine receptor antagonists
AR088020A1 (es) * 2010-06-30 2014-05-07 Ironwood Pharmaceuticals Inc Compuestos heterociclicos como estimuladores de sgc
CA2817319A1 (en) * 2010-11-09 2012-05-18 Ironwood Pharmaceuticals, Inc. Triazole derivatives as sgc stimulators
DE102012200360A1 (de) * 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte Triazine und ihre Verwendung
CA2885645A1 (en) * 2012-09-19 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
KR102362835B1 (ko) * 2013-03-15 2022-02-14 사이클리온 테라퓨틱스, 인크. ｓＧＣ 자극인자
EP3094327A1 (en) * 2014-01-13 2016-11-23 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS

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AU2015317818A1 (en) 2017-03-23
CA2961531A1 (en) 2016-03-24
KR20170055531A (ko) 2017-05-19
EA201790627A1 (ru) 2017-09-29
CN107223125B (zh) 2019-09-27
EP3194395B1 (en) 2019-12-04
BR112017005248A2 (pt) 2017-12-12
WO2016044441A1 (en) 2016-03-24
EP3194395A1 (en) 2017-07-26
US20170291902A1 (en) 2017-10-12
JP2017527605A (ja) 2017-09-21
CN107223125A (zh) 2017-09-29
US10047095B2 (en) 2018-08-14
IL251115A0 (en) 2017-04-30

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