MA39956A - Analogues du benzomorphane et leur utilisation - Google Patents

Analogues du benzomorphane et leur utilisation

Info

Publication number
MA39956A
MA39956A MA039956A MA39956A MA39956A MA 39956 A MA39956 A MA 39956A MA 039956 A MA039956 A MA 039956A MA 39956 A MA39956 A MA 39956A MA 39956 A MA39956 A MA 39956A
Authority
MA
Morocco
Prior art keywords
benzomorphan
analogs
benzomorphan analogs
diastereomers
solvates
Prior art date
Application number
MA039956A
Other languages
English (en)
Inventor
R Richard Goehring
Laykea Tafesse
Jiangchao Yao
Jianming Yu
Original Assignee
Purdue Pharma Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Pharma Lp filed Critical Purdue Pharma Lp
Publication of MA39956A publication Critical patent/MA39956A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés tels que représentés par la formule i ou i' et des sels, solvates, et diastéréoisomères pharmaceutiquement acceptables de ceux-ci : dans laquelle r1, r2, r2a, r3, et r4 sont tels que définis dans la description. L'invention concerne également des composés de formules ii, iii, a a-h et des sels, solvates et diastéréoisomères pharmaceutiquement acceptables de ceux-ci. Dans certains modes de réalisation, les composés de l'invention sont utiles pour le traitement de la douleur, de la constipation, et d'autres pathologies comme le souligne la description. Sans souhaiter être lié par une quelconque théorie, on pense que les composés de l'invention sont efficaces dans le traitement de pathologies qui sont modulées par l'activité de récepteurs opioïdes et/ou orl-1.
MA039956A 2014-05-06 2015-05-05 Analogues du benzomorphane et leur utilisation MA39956A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461989129P 2014-05-06 2014-05-06

Publications (1)

Publication Number Publication Date
MA39956A true MA39956A (fr) 2015-11-12

Family

ID=54392885

Family Applications (1)

Application Number Title Priority Date Filing Date
MA039956A MA39956A (fr) 2014-05-06 2015-05-05 Analogues du benzomorphane et leur utilisation

Country Status (6)

Country Link
US (1) US9975854B2 (fr)
EP (1) EP3139921A4 (fr)
JP (1) JP6386088B2 (fr)
CA (1) CA2948144A1 (fr)
MA (1) MA39956A (fr)
WO (1) WO2015171553A1 (fr)

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* Cited by examiner, † Cited by third party
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TW201408645A (zh) * 2012-05-11 2014-03-01 Purdue Pharma Lp 苯並嗎凡類似物及其用途
CA2890655A1 (fr) * 2012-11-09 2014-05-15 Purdue Pharma L.P. Analogues de benzomorphane et leur utilisation
EP3087079B1 (fr) 2013-12-26 2019-04-03 Purdue Pharma LP Morphinanes oxabicyclo[2.2.2]octane modulateurs des récepteurs aux opiacés
US9994571B2 (en) 2013-12-26 2018-06-12 Purdue Pharma L.P. 10-substituted morphinan hydantoins
CA2934913A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Morphinanes a cycle contracte et leur utilisation
WO2015097548A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Analogues 7-bêta-alkyle d'orvinols
WO2015099863A1 (fr) 2013-12-27 2015-07-02 Purdue Pharma L.P. Analogues de la morphinane 6-substitués et 7-substitués, et leurs utilisations
US9902726B2 (en) 2013-12-30 2018-02-27 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands
CA2950567A1 (fr) 2014-05-27 2015-12-03 Purdue Pharma L.P. Morphinanes spirocycliques et utilisation associee
CA2951697A1 (fr) 2014-06-13 2015-12-17 Purdue Pharma L.P. Derives d'azamophinan et leur utilisation
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
WO2018125716A1 (fr) 2017-01-02 2018-07-05 Purdue Pharma L.P. Dérivés de morphinane et leur utilisation
KR20190098253A (ko) * 2017-01-05 2019-08-21 타이완제이 파마슈티컬스 컴퍼니 리미티드 모르피난 유도체, 및 자가면역, 염증 또는 감염 관련 질환을 치료하기 위한 이를 포함하는 조성물

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Also Published As

Publication number Publication date
US20170073313A1 (en) 2017-03-16
JP6386088B2 (ja) 2018-09-05
CA2948144A1 (fr) 2015-11-12
EP3139921A4 (fr) 2018-02-14
US9975854B2 (en) 2018-05-22
JP2017514863A (ja) 2017-06-08
EP3139921A1 (fr) 2017-03-15
WO2015171553A1 (fr) 2015-11-12

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