MA39956A - Analogues du benzomorphane et leur utilisation - Google Patents
Analogues du benzomorphane et leur utilisationInfo
- Publication number
- MA39956A MA39956A MA039956A MA39956A MA39956A MA 39956 A MA39956 A MA 39956A MA 039956 A MA039956 A MA 039956A MA 39956 A MA39956 A MA 39956A MA 39956 A MA39956 A MA 39956A
- Authority
- MA
- Morocco
- Prior art keywords
- benzomorphan
- analogs
- benzomorphan analogs
- diastereomers
- solvates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne des composés tels que représentés par la formule i ou i' et des sels, solvates, et diastéréoisomères pharmaceutiquement acceptables de ceux-ci : dans laquelle r1, r2, r2a, r3, et r4 sont tels que définis dans la description. L'invention concerne également des composés de formules ii, iii, a a-h et des sels, solvates et diastéréoisomères pharmaceutiquement acceptables de ceux-ci. Dans certains modes de réalisation, les composés de l'invention sont utiles pour le traitement de la douleur, de la constipation, et d'autres pathologies comme le souligne la description. Sans souhaiter être lié par une quelconque théorie, on pense que les composés de l'invention sont efficaces dans le traitement de pathologies qui sont modulées par l'activité de récepteurs opioïdes et/ou orl-1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461989129P | 2014-05-06 | 2014-05-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA39956A true MA39956A (fr) | 2015-11-12 |
Family
ID=54392885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA039956A MA39956A (fr) | 2014-05-06 | 2015-05-05 | Analogues du benzomorphane et leur utilisation |
Country Status (6)
Country | Link |
---|---|
US (1) | US9975854B2 (fr) |
EP (1) | EP3139921A4 (fr) |
JP (1) | JP6386088B2 (fr) |
CA (1) | CA2948144A1 (fr) |
MA (1) | MA39956A (fr) |
WO (1) | WO2015171553A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201408645A (zh) * | 2012-05-11 | 2014-03-01 | Purdue Pharma Lp | 苯並嗎凡類似物及其用途 |
CA2890655A1 (fr) * | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Analogues de benzomorphane et leur utilisation |
EP3087079B1 (fr) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Morphinanes oxabicyclo[2.2.2]octane modulateurs des récepteurs aux opiacés |
US9994571B2 (en) | 2013-12-26 | 2018-06-12 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
CA2934913A1 (fr) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Morphinanes a cycle contracte et leur utilisation |
WO2015097548A1 (fr) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Analogues 7-bêta-alkyle d'orvinols |
WO2015099863A1 (fr) | 2013-12-27 | 2015-07-02 | Purdue Pharma L.P. | Analogues de la morphinane 6-substitués et 7-substitués, et leurs utilisations |
US9902726B2 (en) | 2013-12-30 | 2018-02-27 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
CA2950567A1 (fr) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Morphinanes spirocycliques et utilisation associee |
CA2951697A1 (fr) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Derives d'azamophinan et leur utilisation |
MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
WO2018125716A1 (fr) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Dérivés de morphinane et leur utilisation |
KR20190098253A (ko) * | 2017-01-05 | 2019-08-21 | 타이완제이 파마슈티컬스 컴퍼니 리미티드 | 모르피난 유도체, 및 자가면역, 염증 또는 감염 관련 질환을 치료하기 위한 이를 포함하는 조성물 |
Family Cites Families (63)
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US3138603A (en) * | 1958-10-31 | 1964-06-23 | Everette L May | New benzomorphans (methanobenzazocines) and preparation thereof |
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CA2310664C (fr) | 1997-11-21 | 2008-03-11 | Euro-Celtique S.A. | 2-aminoacetamides substitues et leur utilisation |
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US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
IL145508A0 (en) | 1999-03-26 | 2002-06-30 | Euro Celtique Sa | Aryl substituted pyrazole, imidazole, oxazole, thiazole and pyrrole derivatives and pharmaceutical compositions containing the same |
WO2000061188A1 (fr) | 1999-04-09 | 2000-10-19 | Euro-Celtique S.A. | Composition de blocage du canal sodique et leur utilisation |
AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
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ES2304477T3 (es) * | 2000-10-31 | 2008-10-16 | Rensselaer Polytechnic Institute | Procedimiento de preparacion de compuestos con afinidad a receptores opioides. |
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EP2593434A1 (fr) | 2010-07-16 | 2013-05-22 | Purdue Pharma LP | Composés pyridines comme bloqueurs des canaux sodiques |
KR20130056345A (ko) | 2010-09-17 | 2013-05-29 | 퍼듀 퍼머 엘피 | 피리딘 화합물 및 그의 용도 |
CA2813704A1 (fr) | 2010-10-05 | 2012-04-12 | Purdue Pharma L.P. | Composes de quinazoline en tant que bloqueurs de canaux sodiques |
EP2655330B1 (fr) | 2010-12-22 | 2016-02-10 | Purdue Pharma LP | Pyridines substituées en tant que bloqueurs de canaux sodiques |
US9447957B2 (en) | 2011-06-30 | 2016-09-20 | Seoul Semiconductor Co., Ltd. | LED lamp |
WO2013021276A1 (fr) | 2011-08-10 | 2013-02-14 | Purdue Pharma L.P. | Antagonistes du trpv1 comprenant un substituant dihydroxy et leurs utilisations |
EP2753606B1 (fr) | 2011-09-02 | 2017-07-05 | Purdue Pharma LP | Pyrimidines utilisées comme bloqueurs de canaux sodiques |
US9388137B2 (en) | 2011-10-31 | 2016-07-12 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
WO2013064883A1 (fr) | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Composés hétéroaryliques comme agents de blocage des canaux sodiques |
WO2013072758A1 (fr) | 2011-11-15 | 2013-05-23 | Purdue Pharma L.P. | Pyrimidine diol amides comme bloqueurs des canaux sodiques |
WO2013136170A1 (fr) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Pyridines substituées en tant que bloqueurs des canaux sodiques |
TW201408645A (zh) * | 2012-05-11 | 2014-03-01 | Purdue Pharma Lp | 苯並嗎凡類似物及其用途 |
CA2890655A1 (fr) * | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Analogues de benzomorphane et leur utilisation |
WO2014091298A2 (fr) | 2012-12-14 | 2014-06-19 | Purdue Pharma L.P. | Dérivés de morphinane contenant de l'azote et leur utilisation |
EP2931724B1 (fr) | 2012-12-14 | 2017-01-25 | Purdue Pharma LP | Analogues de pyridonemorphinane et activité biologique sur des récepteurs des opioïdes |
WO2014096941A1 (fr) | 2012-12-20 | 2014-06-26 | Purdue Pharma L.P. | Sulfonamides cycliques en tant que bloquants des canaux sodiques |
EP2951160B1 (fr) * | 2013-01-31 | 2019-04-24 | Purdue Pharma LP | Analogues de benzomorphane et leur utilisation |
US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
CA2941171C (fr) | 2013-03-04 | 2020-07-07 | Purdue Pharma L.P. | Pyrimidine carboxamides a titre de bloqueurs des canaux sodiques |
JP6186494B2 (ja) | 2013-03-15 | 2017-08-23 | パーデュー、ファーマ、リミテッド、パートナーシップ | カルボキサミド誘導体及びその使用 |
US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
JP6161801B2 (ja) | 2013-05-24 | 2017-07-12 | ローズ テクノロジーズ | オピオイドケタール化合物及びその使用 |
US9359330B2 (en) | 2013-08-26 | 2016-06-07 | Purdue Pharma L.P. | Substituted piperidines as sodium channel blockers |
US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
US9994571B2 (en) | 2013-12-26 | 2018-06-12 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
US9902726B2 (en) | 2013-12-30 | 2018-02-27 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
JP6526023B2 (ja) | 2014-01-24 | 2019-06-05 | パーデュー、ファーマ、リミテッド、パートナーシップ | ピリジン類及びピリミジン類並びにその使用 |
US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
-
2015
- 2015-05-05 MA MA039956A patent/MA39956A/fr unknown
- 2015-05-05 JP JP2016566717A patent/JP6386088B2/ja active Active
- 2015-05-05 CA CA2948144A patent/CA2948144A1/fr not_active Abandoned
- 2015-05-05 EP EP15789868.5A patent/EP3139921A4/fr not_active Withdrawn
- 2015-05-05 US US15/308,987 patent/US9975854B2/en active Active
- 2015-05-05 WO PCT/US2015/029161 patent/WO2015171553A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20170073313A1 (en) | 2017-03-16 |
JP6386088B2 (ja) | 2018-09-05 |
CA2948144A1 (fr) | 2015-11-12 |
EP3139921A4 (fr) | 2018-02-14 |
US9975854B2 (en) | 2018-05-22 |
JP2017514863A (ja) | 2017-06-08 |
EP3139921A1 (fr) | 2017-03-15 |
WO2015171553A1 (fr) | 2015-11-12 |
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