WO2016125191A3 - Processes for the preparation of vortioxetine hydrobromide - Google Patents

Processes for the preparation of vortioxetine hydrobromide Download PDF

Info

Publication number
WO2016125191A3
WO2016125191A3 PCT/IN2016/050042 IN2016050042W WO2016125191A3 WO 2016125191 A3 WO2016125191 A3 WO 2016125191A3 IN 2016050042 W IN2016050042 W IN 2016050042W WO 2016125191 A3 WO2016125191 A3 WO 2016125191A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
processes
vortioxetine hydrobromide
vortioxetine
hydrobromide
Prior art date
Application number
PCT/IN2016/050042
Other languages
French (fr)
Other versions
WO2016125191A2 (en
Inventor
Sureshbabu JAYACHANDRA
Rathinapandian JEBARAJ
Shivakumar CHANDUPATLA
Sudarshan Rao Kothakonda
Attanti Veera Venkata SRINIVASARAO
Nagaraji GHANTA
Original Assignee
Mylan Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Limited filed Critical Mylan Laboratories Limited
Publication of WO2016125191A2 publication Critical patent/WO2016125191A2/en
Publication of WO2016125191A3 publication Critical patent/WO2016125191A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

The present invention relates to a process for the preparation of vortioxetine and its pharmaceutically acceptable salts.
PCT/IN2016/050042 2015-02-04 2016-02-04 Processes for the preparation of vortioxetine hydrobromide WO2016125191A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN552/CHE/2015 2015-02-04
IN552CH2015 2015-02-04
IN3789/CHE/2015 2015-07-22
IN3789CH2015 2015-07-22

Publications (2)

Publication Number Publication Date
WO2016125191A2 WO2016125191A2 (en) 2016-08-11
WO2016125191A3 true WO2016125191A3 (en) 2016-09-29

Family

ID=55806570

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2016/050042 WO2016125191A2 (en) 2015-02-04 2016-02-04 Processes for the preparation of vortioxetine hydrobromide

Country Status (1)

Country Link
WO (1) WO2016125191A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017162536A1 (en) * 2016-03-21 2017-09-28 H. Lundbeck A/S Vortioxetine prodrugs
CN106397446B (en) * 2016-08-31 2019-04-26 上海天慈生物谷生物工程有限公司 A method of preparing 2- (piperazine -1- base) -8- flutamine ketone
CN107915694A (en) * 2016-10-09 2018-04-17 北京阜康仁生物制药科技有限公司 1 [2 (2,4 3,5-dimethylphenyl sulfydryl) phenyl] piperazine hydrochloride and preparation method thereof
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
JP7389761B2 (en) 2018-06-20 2023-11-30 バイオ アーゲー ファーマシューティカルズ エス．エー． One-pot organo-pseudocatalytic C-H activation method for preparing vortioxetine and vortioxetine intermediates
CN111100112B (en) * 2018-10-29 2021-05-04 浙江京新药业股份有限公司 Benzothiophene derivative and process for producing the same
CN109912538B (en) * 2019-01-22 2021-03-12 安徽赛乐普制药有限公司 Preparation method of antidepressant vortioxetine
CN115073311B (en) * 2022-03-23 2023-05-23 河南大学 Efficient preparation of N, N ′ Synthesis method of-di (2-hydroxyethyl) aniline

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014161976A1 (en) * 2013-04-04 2014-10-09 Lek Pharmaceuticals D.D. New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (en) 2001-10-04 2008-02-11 Х. Луннбек А/С Derivated of phenylpiperazine as serotonin reuptake inhibitorS
ES2379200T5 (en) 2006-06-16 2021-10-20 H Lundbeck As 1- [2- (2,4-Dimethylphenylsulfanyl) phenyl] piperazine hydrobromide as a serotonin reuptake compound combined with 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
US9133144B2 (en) 2012-01-03 2015-09-15 H. Lundbeck A/S Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine
SG11201506651SA (en) 2013-02-22 2015-09-29 Lundbeck & Co As H Vortioxetine manufacturing process
CN105339361A (en) 2013-05-31 2016-02-17 斯洛文尼亚莱柯制药股份有限公司 New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014161976A1 (en) * 2013-04-04 2014-10-09 Lek Pharmaceuticals D.D. New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ULDAM H K ET AL: "Biosynthesis and identification of an N-oxide/N-glucuronide metabolite and first synthesis of an N-O-Glucuronide metabolite of Lu AA21004", DRUG METABOLISM AND DISPOSITION, PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 39, no. 12, 1 December 2011 (2011-12-01), pages 2264 - 2274, XP002714028, ISSN: 0090-9556, [retrieved on 20110906], DOI: 10.1124/DMD.111.040428 *

Also Published As

Publication number Publication date
WO2016125191A2 (en) 2016-08-11

Similar Documents

Publication Publication Date Title
WO2016079751A3 (en) A process for preparation of vortioxetine and polymorphs thereof
WO2015110897A3 (en) Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
WO2016125191A3 (en) Processes for the preparation of vortioxetine hydrobromide
WO2015166379A3 (en) Novel polymorphic forms of vortioxetine and its pharmaceutically acceptable salts
EP3297678A4 (en) An improved processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof
WO2016125192A3 (en) Processes for the preparation of dolute-gravir
WO2014125506A3 (en) A process for the preparation of ivacaftor and its intermediates
WO2015191945A3 (en) Solid state forms of sofosbuvir
IL267508B (en) Process for the preparation of a 2-pyridylethylcarboxamide derivative
HUE046278T2 (en) A method for the preparation, isolation and purification of pharmaceutically applicable forms of ahu-377
WO2016009401A3 (en) Preparation of tedizolid phosphate
WO2015068175A3 (en) An improved process for the preparation of pazopanib or a pharmaceutically acceptable salt thereof
WO2015121877A3 (en) Polymorphs of lomitapide and its salts
MX2017015137A (en) Once daily oral pharmaceutical composition of isotretinoin.
WO2016108206A3 (en) Processes for preparation of idelalisib and intermediates thereof
EP3405456A4 (en) Process for the preparation of 4-alkoxy-3-acetoxypicolinic acids
WO2015181802A3 (en) Oral pharmaceutical composition of isotretinoin
WO2017098533A3 (en) Process for preparation of lisdexamphetamine
WO2015104718A3 (en) A novel process for preparation of indacaterol or its pharmaceutically acceptable salts
WO2014155389A3 (en) Process for preparation of ticagrelor
EP3422855A4 (en) Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids
WO2015087343A3 (en) An improved process for the preparation of nilotinib and pharmaceutically acceptable salts thereof
EP3436439A4 (en) Process for the preparation of diphenylpyrazine derivatives
PT3394069T (en) Process for the preparation of hiv integrase inhibitors
EP3405034A4 (en) Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16718026

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16718026

Country of ref document: EP

Kind code of ref document: A2