DE69715448D1 - Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten - Google Patents

Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten

Info

Publication number
DE69715448D1
DE69715448D1 DE69715448T DE69715448T DE69715448D1 DE 69715448 D1 DE69715448 D1 DE 69715448D1 DE 69715448 T DE69715448 T DE 69715448T DE 69715448 T DE69715448 T DE 69715448T DE 69715448 D1 DE69715448 D1 DE 69715448D1
Authority
DE
Germany
Prior art keywords
antagonists containing
pgd2 antagonists
benzothiophenecarboxamide
derivatives
benzothiophenecarboxamide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69715448T
Other languages
English (en)
Other versions
DE69715448T2 (de
Inventor
Tsunetoshi Honma
Yoshiharu Hiramatsu
Akinori Arimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE69715448D1 publication Critical patent/DE69715448D1/de
Publication of DE69715448T2 publication Critical patent/DE69715448T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
DE69715448T 1996-12-13 1997-12-10 Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten Expired - Lifetime DE69715448T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33349596 1996-12-13
JP25400197 1997-09-19
PCT/JP1997/004527 WO1998025919A1 (en) 1996-12-13 1997-12-10 Benzothiophenecarboxamide derivatives and pgd2 antagonists comprising them

Publications (2)

Publication Number Publication Date
DE69715448D1 true DE69715448D1 (de) 2002-10-17
DE69715448T2 DE69715448T2 (de) 2003-08-07

Family

ID=26541496

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715448T Expired - Lifetime DE69715448T2 (de) 1996-12-13 1997-12-10 Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten

Country Status (26)

Country Link
US (1) US6083974A (de)
EP (1) EP0944614B1 (de)
JP (1) JP3215441B2 (de)
KR (1) KR100433568B1 (de)
CN (2) CN1105112C (de)
AR (1) AR008939A1 (de)
AT (1) ATE223911T1 (de)
AU (1) AU718958B2 (de)
BR (1) BR9714016A (de)
CA (1) CA2274591C (de)
CZ (1) CZ297324B6 (de)
DE (1) DE69715448T2 (de)
DK (1) DK0944614T3 (de)
ES (1) ES2181039T3 (de)
HK (1) HK1020045A1 (de)
HU (1) HU226458B1 (de)
ID (1) ID22753A (de)
IL (1) IL130660A (de)
NO (1) NO992838L (de)
NZ (1) NZ336143A (de)
PL (1) PL191760B1 (de)
PT (1) PT944614E (de)
RU (1) RU2161617C1 (de)
TR (1) TR199901280T2 (de)
TW (1) TW438790B (de)
WO (1) WO1998025919A1 (de)

Families Citing this family (38)

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Publication number Priority date Publication date Assignee Title
CA2326418A1 (en) 1998-03-31 1999-10-07 Shionogi & Co., Ltd. Process for preparing benzothiophenecarboxamide derivatives
ES2244179T3 (es) * 1998-03-31 2005-12-01 SHIONOGI & CO., LTD. Proceso para la preparacion de derivados de acido 5-hidroxibenzo(b)tiofen-3-carboxilico.
JP3857525B2 (ja) * 1998-06-03 2006-12-13 塩野義製薬株式会社 Ｐｇｄ２拮抗剤を含有する痒みの治療剤
JP3730170B2 (ja) 1999-07-02 2005-12-21 塩野義製薬株式会社 ビシクロ環系アミノアルコールの新規な製造法
CA2402174A1 (en) 2000-03-09 2001-09-13 Ono Pharmaceutical Co., Ltd. Indole derivatives, process for preparation of the same and use thereof
EP1274457B1 (de) * 2000-04-12 2005-11-30 Merck Frosst Canada & Co. Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7273883B2 (en) 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
DE60108515T2 (de) 2000-10-17 2006-01-12 Shionogi & Co., Ltd. Verfahren zur herstellung eines pgd2-antagonisten
AU2001296013A1 (en) * 2000-11-01 2002-05-15 Shionogi And Co., Ltd. Pgd2 receptor antagonistic pharmaceutical compositions
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
WO2003078409A1 (fr) 2002-03-19 2003-09-25 Ono Pharmaceutical Co., Ltd. Composes d'acide carboxylique et medicaments renfermant les composes comme principe actif
WO2004006956A1 (ja) * 2002-07-12 2004-01-22 Japan Science And Technology Agency 脳損傷の予後改善薬とそのスクリーニング方法
WO2004030674A1 (ja) * 2002-09-30 2004-04-15 Shionogi & Co., Ltd. プロスタグランジンｄ２、プロスタグランジンｄ２アゴニストおよびプロスタグランジンｄ２アンタゴニストの新規用途
JP4332151B2 (ja) 2002-10-30 2009-09-16 メルク フロスト カナダ リミテツド ピリドピロリジンおよびピリドインドリジン誘導体
DK1725553T3 (da) 2004-03-11 2008-08-18 Actelion Pharmaceuticals Ltd Tetrahydropyridoindolderivater
JPWO2006068162A1 (ja) * 2004-12-24 2008-06-12 塩野義製薬株式会社 慢性閉塞性肺疾患の治療剤
TW200716093A (en) * 2005-04-28 2007-05-01 Shionogi & Co An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh) 2007-08-10 2013-10-01 Ono Pharmaceutical Co Phenylacetic acid compounds
AR079492A1 (es) 2009-12-23 2012-02-01 Ironwood Pharmaceuticals Inc Moduladores de crth2
US20130178475A1 (en) 2010-03-17 2013-07-11 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
JP5860459B2 (ja) 2010-06-30 2016-02-16 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激薬
US20130216552A1 (en) 2010-07-12 2013-08-22 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012009134A1 (en) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Crth2 modulators
CN103402515B (zh) 2010-11-09 2017-05-17 铁木医药有限公司 sGC刺激剂
WO2013101830A1 (en) 2011-12-27 2013-07-04 Ironwood Pharmaceuticals, Inc. 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators
WO2014047111A1 (en) 2012-09-18 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EP2897953B8 (de) 2012-09-19 2019-06-26 Cyclerion Therapeutics, Inc. Sgc-stimulatoren
RS59981B1 (sr) 2013-03-15 2020-03-31 Cyclerion Therapeutics Inc Sgc stimulatori
JP2016540017A (ja) 2013-12-11 2016-12-22 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激物質
EP3094327A1 (de) 2014-01-13 2016-11-23 Ironwood Pharmaceuticals, Inc. Verwendung von sgc-stimulatoren zur behandlung von neuromuskulären störungen
WO2016044445A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
AU2015317824A1 (en) 2014-09-17 2017-03-23 Cyclerion Therapeutics, Inc. Pyrazole derivatives as sGC stimulators
CN107406421A (zh) 2014-09-17 2017-11-28 铁木医药有限公司 sGC刺激物
EP4420734A2 (de) 2015-02-13 2024-08-28 Institut National de la Santé et de la Recherche Médicale Ptgdr-1- und/oder ptgdr-2-antagonisten zur vorbeugung und/oder behandlung von systemischem lupus erythematodes
AU2017291826B2 (en) 2016-07-07 2021-10-21 Cyclerion Therapeutics, Inc. Phosphorus prodrugs of sGC stimulators
KR20230074840A (ko) 2016-07-07 2023-05-31 사이클리온 테라퓨틱스, 인크. sGC 자극제의 고체 형태

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Publication number Priority date Publication date Assignee Title
US4560343A (en) * 1984-06-11 1985-12-24 Honeywell Inc. Functional check for a hot surface ignitor element
JPS6149A (ja) * 1984-06-12 1986-01-06 Ono Pharmaceut Co Ltd 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
CA1278577C (en) * 1985-11-18 1991-01-02 Tatsuo Tsuri Bicyclic sulfonamide derivatives
CA1294974C (en) * 1987-05-08 1992-01-28 Sanji Hagishita Bicyclic sulfonamide derivatives and process therefor
US5356926A (en) * 1992-02-24 1994-10-18 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
CA2113787A1 (en) * 1993-01-29 1994-07-30 Nobuyuki Hamanaka Carbocyclic sulfonamides
DE4317076A1 (de) * 1993-05-21 1994-11-24 Bayer Ag Benzthiophencarbonsäureamid-S-oxide
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
CA2225250C (en) * 1995-06-21 2005-03-22 Shionogi & Co., Ltd. Bicyclic amino derivatives and pgd2 antagonist containing the same
CA2268164A1 (en) * 1996-10-08 1998-04-16 Yao-Chang Xu New serotonin 5-ht1f agonists

Also Published As

Publication number Publication date
IL130660A0 (en) 2000-06-01
ID22753A (id) 1999-12-09
NZ336143A (en) 2002-05-31
CA2274591C (en) 2005-06-14
DE69715448T2 (de) 2003-08-07
CN1240438A (zh) 2000-01-05
CA2274591A1 (en) 1998-06-18
HUP0002869A3 (en) 2003-01-28
PT944614E (pt) 2003-01-31
AU5409798A (en) 1998-07-03
CN1185226C (zh) 2005-01-19
CZ206599A3 (cs) 1999-11-17
US6083974A (en) 2000-07-04
HUP0002869A2 (hu) 2001-06-28
KR20000069402A (ko) 2000-11-25
JP2000514824A (ja) 2000-11-07
AR008939A1 (es) 2000-02-23
TR199901280T2 (xx) 1999-10-21
IL130660A (en) 2002-03-10
ES2181039T3 (es) 2003-02-16
PL191760B1 (pl) 2006-06-30
ATE223911T1 (de) 2002-09-15
JP3215441B2 (ja) 2001-10-09
DK0944614T3 (da) 2003-01-13
CN1445225A (zh) 2003-10-01
HK1020045A1 (en) 2000-03-10
PL334072A1 (en) 2000-01-31
BR9714016A (pt) 2000-02-29
KR100433568B1 (ko) 2004-05-31
EP0944614B1 (de) 2002-09-11
RU2161617C1 (ru) 2001-01-10
NO992838D0 (no) 1999-06-10
CN1105112C (zh) 2003-04-09
EP0944614A1 (de) 1999-09-29
TW438790B (en) 2001-06-07
AU718958B2 (en) 2000-05-04
CZ297324B6 (cs) 2006-11-15
WO1998025919A1 (en) 1998-06-18
NO992838L (no) 1999-07-20
HU226458B1 (en) 2008-12-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition