ID22753A - Turunan-turunan benzotiofenkarboksamida dan antagonis pgd2 yang mengandung turunan benzotiofenkarboksamida tersebut - Google Patents
Turunan-turunan benzotiofenkarboksamida dan antagonis pgd2 yang mengandung turunan benzotiofenkarboksamida tersebutInfo
- Publication number
- ID22753A ID22753A IDW990472A ID990472A ID22753A ID 22753 A ID22753 A ID 22753A ID W990472 A IDW990472 A ID W990472A ID 990472 A ID990472 A ID 990472A ID 22753 A ID22753 A ID 22753A
- Authority
- ID
- Indonesia
- Prior art keywords
- benzotiofencarcoxamide
- benzotiofencarcox
- carboxamide
- characters
- distribution
- Prior art date
Links
- 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 title 1
- 101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000003857 carboxamides Chemical class 0.000 title 1
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 title 1
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33349596 | 1996-12-13 | ||
| JP25400197 | 1997-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID22753A true ID22753A (id) | 1999-12-09 |
Family
ID=26541496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW990472A ID22753A (id) | 1996-12-13 | 1997-12-10 | Turunan-turunan benzotiofenkarboksamida dan antagonis pgd2 yang mengandung turunan benzotiofenkarboksamida tersebut |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6083974A (de) |
| EP (1) | EP0944614B1 (de) |
| JP (1) | JP3215441B2 (de) |
| KR (1) | KR100433568B1 (de) |
| CN (2) | CN1105112C (de) |
| AR (1) | AR008939A1 (de) |
| AT (1) | ATE223911T1 (de) |
| AU (1) | AU718958B2 (de) |
| BR (1) | BR9714016A (de) |
| CA (1) | CA2274591C (de) |
| CZ (1) | CZ297324B6 (de) |
| DE (1) | DE69715448T2 (de) |
| DK (1) | DK0944614T3 (de) |
| ES (1) | ES2181039T3 (de) |
| HU (1) | HU226458B1 (de) |
| ID (1) | ID22753A (de) |
| IL (1) | IL130660A (de) |
| NO (1) | NO992838L (de) |
| NZ (1) | NZ336143A (de) |
| PL (1) | PL191760B1 (de) |
| PT (1) | PT944614E (de) |
| RU (1) | RU2161617C1 (de) |
| TR (1) | TR199901280T2 (de) |
| TW (1) | TW438790B (de) |
| WO (1) | WO1998025919A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID26346A (id) | 1998-03-31 | 2000-12-14 | Shionogi & Co | PROSES PEMBUATAN TURUNAN ASAM 5-HIDROKSIBENZO (b)TIOFEN-3-KARBOKSILAT |
| RU2185380C1 (ru) | 1998-03-31 | 2002-07-20 | Сионоги Энд Ко., Лтд. | Способ получения производных бензотиофенкарбоксамида и аминоспиртов (варианты) |
| CN1198649C (zh) * | 1998-06-03 | 2005-04-27 | 盐野义制药株式会社 | 用于治疗瘙痒的含pgd2受体拮抗剂的药物组合物 |
| AU5430100A (en) | 1999-07-02 | 2001-01-22 | Shionogi & Co., Ltd. | Novel process for producing bicyclic amino alcohol |
| EP1262475A4 (de) | 2000-03-09 | 2005-01-05 | Ono Pharmaceutical Co | Indolderivate, verfahren zu ihrer herstellung und deren verwendung |
| ATE311200T1 (de) * | 2000-04-12 | 2005-12-15 | Merck Frosst Canada Inc | Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten |
| US6410583B1 (en) * | 2000-07-25 | 2002-06-25 | Merck Frosst Canada & Co. | Cyclopentanoindoles, compositions containing such compounds and methods of treatment |
| US7273883B2 (en) | 2000-09-14 | 2007-09-25 | Allergan, Inc. | Prostaglandin EP4 antagonist |
| US7217725B2 (en) | 2000-09-14 | 2007-05-15 | Allergan, Inc. | Prostaglandin D2 antagonist |
| US6693203B2 (en) | 2000-10-17 | 2004-02-17 | Shionogi & Co., Ltd | Process for the preparation of PGD2 antagonist |
| US6933317B2 (en) * | 2000-11-01 | 2005-08-23 | Shionogi & Co. Ltd. | PGD2 receptor antagonistic pharmaceutical compositions |
| AR038136A1 (es) | 2002-01-24 | 2004-12-29 | Merck Frosst Canada Inc | Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento |
| MXPA04009095A (es) | 2002-03-19 | 2004-12-06 | Ono Pharmaceutical Co | Compuesto de acido carboxilico y agente farmaceutico que comprende el compuesto como ingrediente activo. |
| AU2003252499B2 (en) * | 2002-07-12 | 2007-11-08 | Japan Science And Technology Agency | Drugs for improving the prognosis of brain injury and a method of screening the same |
| JPWO2004030674A1 (ja) * | 2002-09-30 | 2006-01-26 | 塩野義製薬株式会社 | プロスタグランジンｄ▲下２▼、プロスタグランジンｄ▲下２▼アゴニストおよびプロスタグランジンｄ▲下２▼アンタゴニストの新規用途 |
| WO2004039807A1 (en) | 2002-10-30 | 2004-05-13 | Merck Frosst Canada & Co. | Pyridopyrrolizine and pyridoindolizine derivatives |
| US7714132B2 (en) | 2004-03-11 | 2010-05-11 | Actelion Pharmaceuticals, Ltd. | Tetrahydropyridoindole derivatives |
| JPWO2006068162A1 (ja) * | 2004-12-24 | 2008-06-12 | 塩野義製薬株式会社 | 慢性閉塞性肺疾患の治療剤 |
| TW200716093A (en) * | 2005-04-28 | 2007-05-01 | Shionogi & Co | An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist |
| TWI410410B (zh) | 2007-08-10 | 2013-10-01 | Ono Pharmaceutical Co | Phenylacetic acid compounds |
| JP5731538B2 (ja) | 2009-12-23 | 2015-06-10 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | Ｃｒｔｈ２モジュレーター |
| WO2011115804A1 (en) | 2010-03-17 | 2011-09-22 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP2588465B1 (de) | 2010-06-30 | 2017-01-25 | Ironwood Pharmaceuticals, Inc. | Sgc-stimulatoren |
| US20130259830A1 (en) | 2010-07-12 | 2013-10-03 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| WO2012009137A1 (en) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| CN107266433A (zh) | 2010-11-09 | 2017-10-20 | 铁木医药有限公司 | sGC刺激剂 |
| CN106117194A (zh) | 2011-12-27 | 2016-11-16 | 铁木医药有限公司 | 可用作sgc刺激剂的2‑苄基、3‑(嘧啶‑2‑基)取代的吡唑类 |
| WO2014047111A1 (en) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP2897953B8 (de) | 2012-09-19 | 2019-06-26 | Cyclerion Therapeutics, Inc. | Sgc-stimulatoren |
| EA033168B1 (ru) | 2013-03-15 | 2019-09-30 | Сайклерион Терапьютикс, Инк. | СТИМУЛЯТОРЫ sGC |
| CA2933250A1 (en) | 2013-12-11 | 2015-06-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP3094327A1 (de) | 2014-01-13 | 2016-11-23 | Ironwood Pharmaceuticals, Inc. | Verwendung von sgc-stimulatoren zur behandlung von neuromuskulären störungen |
| EP3194382B1 (de) | 2014-09-17 | 2021-09-08 | Cyclerion Therapeutics, Inc. | Pyrazolderivate als sgc-stimulatoren |
| EP3194386A2 (de) | 2014-09-17 | 2017-07-26 | Ironwood Pharmaceuticals, Inc. | Sgc-stimulatoren |
| US20170298055A1 (en) | 2014-09-17 | 2017-10-19 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| JP6770522B2 (ja) | 2015-02-13 | 2020-10-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 全身性エリテマトーデスを予防し、及び／又は、治療するためのｐｔｇｄｒ−１及び／又はｐｔｇｄｒ−２アンタゴニスト |
| CN109563087A (zh) | 2016-07-07 | 2019-04-02 | 铁木医药有限公司 | sGC刺激剂的固体形式 |
| EA039683B1 (ru) | 2016-07-07 | 2022-02-28 | Сайклерион Терапьютикс, Инк. | ФОСФОРСОДЕРЖАЩИЕ ПРОЛЕКАРСТВА СТИМУЛЯТОРОВ sGC |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8406906D0 (en) * | 1984-03-16 | 1984-04-18 | Akzo Nv | Benzo-thiazole and benzothiophene derivatives |
| US4560343A (en) * | 1984-06-11 | 1985-12-24 | Honeywell Inc. | Functional check for a hot surface ignitor element |
| JPS6149A (ja) * | 1984-06-12 | 1986-01-06 | Ono Pharmaceut Co Ltd | 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤 |
| CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
| CA1294974C (en) * | 1987-05-08 | 1992-01-28 | Sanji Hagishita | Bicyclic sulfonamide derivatives and process therefor |
| US5356926A (en) * | 1992-02-24 | 1994-10-18 | Warner-Lambert Company | 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion |
| CA2113787A1 (en) * | 1993-01-29 | 1994-07-30 | Nobuyuki Hamanaka | Carbocyclic sulfonamides |
| DE4317076A1 (de) * | 1993-05-21 | 1994-11-24 | Bayer Ag | Benzthiophencarbonsäureamid-S-oxide |
| US5863936A (en) * | 1995-04-18 | 1999-01-26 | Geron Corporation | Telomerase inhibitors |
| CN1134411C (zh) * | 1995-06-21 | 2004-01-14 | 盐野义制药株式会社 | 双环氨基衍生物及含有此类化合物的前列腺素d2拮抗剂 |
| CA2268164A1 (en) * | 1996-10-08 | 1998-04-16 | Yao-Chang Xu | New serotonin 5-ht1f agonists |
-
1997
- 1997-12-10 PL PL334072A patent/PL191760B1/pl not_active IP Right Cessation
- 1997-12-10 AU AU54097/98A patent/AU718958B2/en not_active Ceased
- 1997-12-10 NZ NZ336143A patent/NZ336143A/en unknown
- 1997-12-10 EP EP97947866A patent/EP0944614B1/de not_active Expired - Lifetime
- 1997-12-10 TR TR1999/01280T patent/TR199901280T2/xx unknown
- 1997-12-10 CN CN97180628A patent/CN1105112C/zh not_active Expired - Fee Related
- 1997-12-10 CA CA002274591A patent/CA2274591C/en not_active Expired - Fee Related
- 1997-12-10 WO PCT/JP1997/004527 patent/WO1998025919A1/en not_active Ceased
- 1997-12-10 HU HU0002869A patent/HU226458B1/hu not_active IP Right Cessation
- 1997-12-10 ID IDW990472A patent/ID22753A/id unknown
- 1997-12-10 US US09/308,176 patent/US6083974A/en not_active Expired - Lifetime
- 1997-12-10 CZ CZ0206599A patent/CZ297324B6/cs not_active IP Right Cessation
- 1997-12-10 AT AT97947866T patent/ATE223911T1/de not_active IP Right Cessation
- 1997-12-10 JP JP52649298A patent/JP3215441B2/ja not_active Expired - Fee Related
- 1997-12-10 IL IL13066097A patent/IL130660A/en not_active IP Right Cessation
- 1997-12-10 ES ES97947866T patent/ES2181039T3/es not_active Expired - Lifetime
- 1997-12-10 DK DK97947866T patent/DK0944614T3/da active
- 1997-12-10 BR BR9714016-3A patent/BR9714016A/pt active Search and Examination
- 1997-12-10 DE DE69715448T patent/DE69715448T2/de not_active Expired - Lifetime
- 1997-12-10 RU RU99115766/04A patent/RU2161617C1/ru not_active IP Right Cessation
- 1997-12-10 KR KR10-1999-7005154A patent/KR100433568B1/ko not_active Expired - Fee Related
- 1997-12-10 PT PT97947866T patent/PT944614E/pt unknown
- 1997-12-11 TW TW086118667A patent/TW438790B/zh not_active IP Right Cessation
- 1997-12-12 AR ARP970105862A patent/AR008939A1/es active IP Right Grant
-
1999
- 1999-06-10 NO NO992838A patent/NO992838L/no unknown
-
2002
- 2002-06-11 CN CNB021227608A patent/CN1185226C/zh not_active Expired - Fee Related
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