ES2102994T3 - Derivados de benzisotiazolinona-1-dioxido como inhibidores de elastasa. - Google Patents
Derivados de benzisotiazolinona-1-dioxido como inhibidores de elastasa.Info
- Publication number
- ES2102994T3 ES2102994T3 ES91301895T ES91301895T ES2102994T3 ES 2102994 T3 ES2102994 T3 ES 2102994T3 ES 91301895 T ES91301895 T ES 91301895T ES 91301895 T ES91301895 T ES 91301895T ES 2102994 T3 ES2102994 T3 ES 2102994T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- compositions
- dioxide
- benzisotiazolinone
- saturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003602 elastase inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002537 cosmetic Substances 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 102000016387 Pancreatic elastase Human genes 0.000 abstract 1
- 108010067372 Pancreatic elastase Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPOSICIONES FARMACEUTICAS Y COSMETICAS COMPRENDIENDO AL MENOS UN DERIVADO DE DIOXIDO-1-BENCISOTIAZOLINONO CON LA FORMULA: DONDE R ELEVADO 1 PUEDE SER HIDROGENO, Y R ELEVADO 2 PUEDE SER CIERTOS GRUPOS GENERALMENTE ALIFATICOS HIDROFOBICOS C SUB 8-C SUB 20 O EL GRUPO: DONDE R ELEVADO 5 ES ALIFATICO U OTRO R (AL CUADRADO) ES UN GRUPO C SUB 2-C SUB 8 SATURADO O NO SATURADO ACABANDO EN UN NUCLEO AROMATICO. ESTAS COMPOSICIONES PUEDEN SER UTILIZADAS PARA INHIBIR ELASTASOS TALES COMO ELASTASO LEUCOCITICO HUMANO. DEBEN DE SER APLICADAS TOPICAMENTE COMO COSMETICO. MUCHOS DE LOS DERIVADOS DE DIOXIDO-2-BENZISOTIAZOLINONO ESPECIFICADO COMO UN INGREDIENTE ACTIVO EN DICHAS COMPOSICIONES SON COMPUESTOS NUEVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9002951A FR2659327A1 (fr) | 1990-03-08 | 1990-03-08 | Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2102994T3 true ES2102994T3 (es) | 1997-08-16 |
Family
ID=9394523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91301895T Expired - Lifetime ES2102994T3 (es) | 1990-03-08 | 1991-03-07 | Derivados de benzisotiazolinona-1-dioxido como inhibidores de elastasa. |
Country Status (16)
Country | Link |
---|---|
US (2) | US5338747A (es) |
EP (1) | EP0446047B1 (es) |
JP (1) | JPH04234863A (es) |
KR (1) | KR960014782B1 (es) |
AT (1) | ATE154347T1 (es) |
AU (1) | AU636013B2 (es) |
BR (1) | BR9100938A (es) |
CA (1) | CA2037665A1 (es) |
DE (1) | DE69126460T2 (es) |
ES (1) | ES2102994T3 (es) |
FR (1) | FR2659327A1 (es) |
ID (1) | ID820B (es) |
IN (1) | IN172035B (es) |
MY (1) | MY106067A (es) |
TW (1) | TW200472B (es) |
ZA (1) | ZA911728B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5306818A (en) * | 1990-11-01 | 1994-04-26 | Sterling Winthrop Inc. | Tetrahydro 2-saccharinylmerthyl aryl carboxylates |
US5512589A (en) * | 1990-11-01 | 1996-04-30 | Sterling Winthrop Inc. | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
US5250696A (en) * | 1990-11-01 | 1993-10-05 | Sterling Winthrop Inc. | 2-saccharinylmethyl aryl carboxylate |
TW226016B (es) * | 1991-12-30 | 1994-07-01 | Sterling Winthrop Inc | |
AU653279B2 (en) * | 1991-12-30 | 1994-09-22 | Sanofi | Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
US6375948B1 (en) * | 1999-07-12 | 2002-04-23 | Kao Corporation | Treating method for suppressing hair growth |
GB0129987D0 (en) * | 2001-12-14 | 2002-02-06 | Zylepsis Ltd | Skin compositions |
US7423155B2 (en) | 2003-11-14 | 2008-09-09 | 3M Innovative Properties Company | N-sulfonyldicarboximide containing tethering compounds |
US7361767B2 (en) | 2003-11-14 | 2008-04-22 | 3M Innovative Properties Company | N-sulfonyldicarboximide containing tethering compounds |
US7943388B2 (en) | 2003-11-14 | 2011-05-17 | 3M Innovative Properties Company | Acoustic sensors and methods |
WO2005049590A2 (en) * | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | N-sulfonylaminocarbonyl containing compounds |
US7169933B2 (en) * | 2003-11-14 | 2007-01-30 | 3M Innovative Properties Company | N-sulfonylaminocarbonyl containing compounds |
WO2005066121A2 (en) * | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Multifunctional amine capture agents |
US7342082B2 (en) | 2004-12-17 | 2008-03-11 | 3M Innovative Properties Company | Soluble polymers as amine capture agents and methods |
US7402678B2 (en) | 2004-12-17 | 2008-07-22 | 3M Innovative Properties Company | Multifunctional amine capture agents |
US7544755B2 (en) | 2005-09-30 | 2009-06-09 | 3M Innovative Properties Company | Crosslinked polymers with amine binding groups |
US7544754B2 (en) | 2005-09-30 | 2009-06-09 | 3M Innovative Properties Company | Crosslinked polymers with amine binding groups |
US7544756B2 (en) | 2005-09-30 | 2009-06-09 | 3M Innovative Properties Company | Crosslinked polymers with amine binding groups |
US8034448B2 (en) * | 2008-08-19 | 2011-10-11 | Los Alamos National Security, Llc | Fibrous composites comprising carbon nanotubes and silica |
US9187590B2 (en) | 2009-12-01 | 2015-11-17 | Lubrizol Advanced Materials, Inc. | Hydrolytically stable multi-purpose polymers |
WO2018049324A1 (en) * | 2016-09-12 | 2018-03-15 | Numerate, Inc. | Monocyclic compounds useful as gpr120 modulators |
JP7065081B2 (ja) | 2016-09-12 | 2022-05-11 | インテグラル ヘルス, インコーポレイテッド | Gpr120モジュレーターとして有用な二環式化合物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4195023A (en) * | 1975-08-20 | 1980-03-25 | Merck & Co., Inc. | 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin |
US4276298A (en) * | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
FR2546164B1 (fr) * | 1983-05-16 | 1987-07-17 | Centre Nat Rech Scient | Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase |
-
1990
- 1990-03-08 FR FR9002951A patent/FR2659327A1/fr active Pending
-
1991
- 1991-03-06 AU AU72635/91A patent/AU636013B2/en not_active Ceased
- 1991-03-06 CA CA002037665A patent/CA2037665A1/en not_active Abandoned
- 1991-03-07 US US07/666,093 patent/US5338747A/en not_active Expired - Fee Related
- 1991-03-07 AT AT91301895T patent/ATE154347T1/de not_active IP Right Cessation
- 1991-03-07 EP EP91301895A patent/EP0446047B1/en not_active Expired - Lifetime
- 1991-03-07 DE DE69126460T patent/DE69126460T2/de not_active Expired - Fee Related
- 1991-03-07 ES ES91301895T patent/ES2102994T3/es not_active Expired - Lifetime
- 1991-03-07 MY MYPI91000361A patent/MY106067A/en unknown
- 1991-03-08 KR KR91003708A patent/KR960014782B1/ko active IP Right Grant
- 1991-03-08 JP JP3125607A patent/JPH04234863A/ja active Pending
- 1991-03-08 BR BR919100938A patent/BR9100938A/pt not_active Application Discontinuation
- 1991-03-08 IN IN69/BOM/91A patent/IN172035B/en unknown
- 1991-03-08 ZA ZA911728A patent/ZA911728B/xx unknown
- 1991-04-13 TW TW080102851A patent/TW200472B/zh active
-
1992
- 1992-01-29 ID IDP185092A patent/ID820B/id unknown
-
1994
- 1994-04-19 US US08/230,048 patent/US5411978A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69126460D1 (de) | 1997-07-17 |
KR910016330A (ko) | 1991-11-05 |
FR2659327A1 (fr) | 1991-09-13 |
ZA911728B (en) | 1992-11-25 |
AU7263591A (en) | 1991-09-12 |
EP0446047B1 (en) | 1997-06-11 |
MY106067A (en) | 1995-03-31 |
AU636013B2 (en) | 1993-04-08 |
IN172035B (es) | 1993-03-20 |
EP0446047A1 (en) | 1991-09-11 |
KR960014782B1 (en) | 1996-10-19 |
US5411978A (en) | 1995-05-02 |
CA2037665A1 (en) | 1991-09-09 |
US5338747A (en) | 1994-08-16 |
BR9100938A (pt) | 1991-11-05 |
ID820B (id) | 1996-07-22 |
ATE154347T1 (de) | 1997-06-15 |
TW200472B (es) | 1993-02-21 |
JPH04234863A (ja) | 1992-08-24 |
DE69126460T2 (de) | 1997-12-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2102994T3 (es) | Derivados de benzisotiazolinona-1-dioxido como inhibidores de elastasa. | |
CY1120513T1 (el) | Υψηλης συμπυκνωσης συνθεση μινοξιδιλης | |
ES2161291T3 (es) | N-(indol-2-carbonil)amidas y derivados como inhibidores de la glucogeno fosforilasa. | |
ECSP941104A (es) | Derivados de 2,6 diaminopurina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
AR023939A1 (es) | COMPUESTOS DERIVADOS DE PIPERIDINA uTILES COMO ANTAGONISTAS DE CCR5, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN, EL USO DE LOS MISMOS SOLOS O EN COMBINACIoN CON OTRO AGENTE ANTIVIRAL PARA LA PREPARACIoN DE UN MEDICAMENTO Y UN KIT | |
NO951162D0 (no) | 1-(2-okso-acetyl)-piperidin-2-karboksylsyrederivater som multi-medikamentresistente sensitivisatorer for kreftceller | |
ES2179353T3 (es) | Antagonistas muscarinicos. | |
SE9402558D0 (sv) | Ny användning av azatricykloderivat och farmaceutiska kompositioner innehållande desamma | |
AR029383A1 (es) | Moleculas pequenas, los intermediarios para su sintesis, las composiciones farmaceuticas que las contienen y su uso para preparar un medicamento destinado al tratamiento o la profilaxis de enfermedades inflamatorias o mediadas por celulas inmunes | |
DE69818286D1 (de) | Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen | |
NO883229D0 (no) | Nye benzimidazolderivater, fremgangsmaate for deres fremstilling og farmasoeytisk preparat inneholdende slike derivater. | |
IT1223313B (it) | Derivati di acidi biliari loro preparazione e composizioni farmaceutiche che li contengono | |
AR007021A1 (es) | Derivados de 3-descladinosa-2,3-anhidroeritromicina, procedimientos para su preparacion, compuestos para su exclusivo uso en dichos procedimientosy procedimiento para su preparacion, una composicion farmaceutica para tratar infecciones bacterianas y el uso de estos compuestos para preparar medicamentos | |
NO301542B1 (no) | Nye pyrazin-derivater | |
MX9205123A (es) | Derivados de 5-hidroxi-2-pirimidinilmetileno utiles como agentes anti-inflamatorios. | |
AR001931A1 (es) | Compuesto de 7-acilamino-3-iminometil (sustituido)cefalosporinas un proceso para su producción intermediarios en su producción una composición farmacéutica que contiene tales compuestos su utilizacióncomo compuestos farmacéuticos y un método para tratar enfermedades microbianas mediante administración de tales compuestos | |
ES2090083T3 (es) | Derivados de cefalosporina, procedimiento para su preparacion y composicion antimicrobiana que contiene estos derivados. | |
ES2059534T3 (es) | Nuevos derivados benzopiranos antihipertensivos. | |
ES2045189T3 (es) | Nuevos agentes anti-arritmicos i. | |
FR2680172B1 (fr) | Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique. | |
MX9401080A (es) | Compuestos heteroaromaticos. | |
RU94038042A (ru) | Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент | |
PA8525801A1 (es) | Compuestos de pirazol, composiciones farmacéuticas, y métodos para modular y/o inhibir la actividad de erab/hadh2 | |
AR009251A1 (es) | Compuestos de ácido 4-oxo-butanoico y composiciones que los contienen | |
IT1286545B1 (it) | Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 446047 Country of ref document: ES |