BR112019000293A2 - formas sólidas de um estimulador de sgc - Google Patents

formas sólidas de um estimulador de sgc

Info

Publication number
BR112019000293A2
BR112019000293A2 BR112019000293-6A BR112019000293A BR112019000293A2 BR 112019000293 A2 BR112019000293 A2 BR 112019000293A2 BR 112019000293 A BR112019000293 A BR 112019000293A BR 112019000293 A2 BR112019000293 A2 BR 112019000293A2
Authority
BR
Brazil
Prior art keywords
solid forms
sgc
disorders
sgc stimulator
diseases
Prior art date
Application number
BR112019000293-6A
Other languages
English (en)
Inventor
Vasu SETHURAMAN
Ahmad Hashash
Song Xue
Robert C. Livingston
Kwame Wiredu NTI-ADDAE
Original Assignee
Ironwood Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ironwood Pharmaceuticals, Inc. filed Critical Ironwood Pharmaceuticals, Inc.
Publication of BR112019000293A2 publication Critical patent/BR112019000293A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Gynecology & Obstetrics (AREA)

Abstract

a presente descrição refere-se a formas sólidas cristalinas de um estimulador da guanilato ciclase solúvel (sgc), o composto i. ela também fornece métodos para a preparação dessas formas sólidas. a invenção refere-se, também, às formulações farmacêuticas e formas de dosagem que compreendem essas formas sólidas e seus usos, sozinhos ou em combinação com um ou mais agentes adicionais, para tratamento e/ou prevenção de várias doenças ou distúrbios; essas doenças ou distúrbios são aqueles que podem se beneficiar da estimulação de sgc ou de um aumento na concentração de óxido nítrico (no) e/ou de monofosfato cíclico de guanosina (cgmp).
BR112019000293-6A 2016-07-07 2017-07-06 formas sólidas de um estimulador de sgc BR112019000293A2 (pt)

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US201662359466P 2016-07-07 2016-07-07
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PCT/US2017/040827 WO2018009609A1 (en) 2016-07-07 2017-07-06 Solid forms of an sgc stimulator

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AU2017292818B2 (en) 2021-10-21
JOP20180127A1 (ar) 2019-01-30
JP2022130689A (ja) 2022-09-06
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TW201805283A (zh) 2018-02-16
IL263996A (en) 2019-01-31
JP2019524710A (ja) 2019-09-05
CL2019000018A1 (es) 2019-05-03
KR20230074840A (ko) 2023-05-31
IL263996B2 (en) 2024-03-01
EP3481820A1 (en) 2019-05-15
CN109563087A (zh) 2019-04-02
US20240059683A1 (en) 2024-02-22
MA45588A (fr) 2019-05-15
US10889577B2 (en) 2021-01-12
US11572358B2 (en) 2023-02-07
EP3481820B1 (en) 2023-10-18
US20210188830A1 (en) 2021-06-24
TWI774683B (zh) 2022-08-21
WO2018009609A1 (en) 2018-01-11
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CA3029333A1 (en) 2018-01-11
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