JP2019524710A - Sgc刺激剤の固体形態 - Google Patents
Sgc刺激剤の固体形態 Download PDFInfo
- Publication number
- JP2019524710A JP2019524710A JP2019500453A JP2019500453A JP2019524710A JP 2019524710 A JP2019524710 A JP 2019524710A JP 2019500453 A JP2019500453 A JP 2019500453A JP 2019500453 A JP2019500453 A JP 2019500453A JP 2019524710 A JP2019524710 A JP 2019524710A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- disease
- crystalline free
- free form
- pulmonary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007787 solid Substances 0.000 title claims abstract description 119
- 150000001875 compounds Chemical class 0.000 claims abstract description 272
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 192
- 201000010099 disease Diseases 0.000 claims abstract description 106
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims abstract description 87
- 208000035475 disorder Diseases 0.000 claims abstract description 80
- 238000000034 method Methods 0.000 claims abstract description 71
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 43
- 230000001965 increasing effect Effects 0.000 claims abstract description 29
- 239000002552 dosage form Substances 0.000 claims abstract description 19
- 230000000638 stimulation Effects 0.000 claims abstract description 16
- 230000008901 benefit Effects 0.000 claims abstract description 11
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 94
- 239000000203 mixture Substances 0.000 claims description 80
- 238000001228 spectrum Methods 0.000 claims description 75
- 239000003814 drug Substances 0.000 claims description 61
- 239000002002 slurry Substances 0.000 claims description 61
- 150000003839 salts Chemical class 0.000 claims description 55
- 239000000243 solution Substances 0.000 claims description 54
- 210000001519 tissue Anatomy 0.000 claims description 50
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 48
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 48
- -1 IPAC Chemical compound 0.000 claims description 46
- 238000011282 treatment Methods 0.000 claims description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 42
- 210000002216 heart Anatomy 0.000 claims description 41
- 206010019280 Heart failures Diseases 0.000 claims description 39
- 229940079593 drug Drugs 0.000 claims description 37
- 206010016654 Fibrosis Diseases 0.000 claims description 33
- 230000004054 inflammatory process Effects 0.000 claims description 31
- 208000002815 pulmonary hypertension Diseases 0.000 claims description 31
- 208000027418 Wounds and injury Diseases 0.000 claims description 30
- 210000004369 blood Anatomy 0.000 claims description 30
- 239000008280 blood Substances 0.000 claims description 30
- 206010020772 Hypertension Diseases 0.000 claims description 28
- 206010061218 Inflammation Diseases 0.000 claims description 28
- 206010012601 diabetes mellitus Diseases 0.000 claims description 27
- 230000004761 fibrosis Effects 0.000 claims description 27
- 238000001914 filtration Methods 0.000 claims description 27
- 239000002904 solvent Substances 0.000 claims description 27
- 230000001684 chronic effect Effects 0.000 claims description 26
- 230000006378 damage Effects 0.000 claims description 25
- 230000002685 pulmonary effect Effects 0.000 claims description 24
- 230000002829 reductive effect Effects 0.000 claims description 24
- 210000004185 liver Anatomy 0.000 claims description 23
- 230000001154 acute effect Effects 0.000 claims description 22
- 208000010125 myocardial infarction Diseases 0.000 claims description 22
- 208000007536 Thrombosis Diseases 0.000 claims description 21
- 208000014674 injury Diseases 0.000 claims description 21
- 208000017169 kidney disease Diseases 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 210000000056 organ Anatomy 0.000 claims description 20
- 210000004204 blood vessel Anatomy 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 19
- 239000000126 substance Substances 0.000 claims description 19
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 18
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 18
- 238000002329 infrared spectrum Methods 0.000 claims description 18
- 210000004072 lung Anatomy 0.000 claims description 18
- 208000011580 syndromic disease Diseases 0.000 claims description 18
- 208000034189 Sclerosis Diseases 0.000 claims description 17
- 208000006011 Stroke Diseases 0.000 claims description 17
- 239000000706 filtrate Substances 0.000 claims description 17
- 210000003734 kidney Anatomy 0.000 claims description 16
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 15
- 206010012289 Dementia Diseases 0.000 claims description 15
- 208000005189 Embolism Diseases 0.000 claims description 15
- 208000028867 ischemia Diseases 0.000 claims description 15
- 230000001568 sexual effect Effects 0.000 claims description 15
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 14
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 14
- 201000001320 Atherosclerosis Diseases 0.000 claims description 13
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 13
- 210000001367 artery Anatomy 0.000 claims description 13
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims description 12
- 206010052428 Wound Diseases 0.000 claims description 12
- 230000036772 blood pressure Effects 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 11
- 230000017531 blood circulation Effects 0.000 claims description 11
- 230000035876 healing Effects 0.000 claims description 11
- 201000006370 kidney failure Diseases 0.000 claims description 11
- 230000002265 prevention Effects 0.000 claims description 11
- 201000002793 renal fibrosis Diseases 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 208000031229 Cardiomyopathies Diseases 0.000 claims description 10
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims description 10
- 208000012322 Raynaud phenomenon Diseases 0.000 claims description 10
- 230000002159 abnormal effect Effects 0.000 claims description 10
- 230000035508 accumulation Effects 0.000 claims description 10
- 238000009825 accumulation Methods 0.000 claims description 10
- 230000004064 dysfunction Effects 0.000 claims description 10
- 210000003205 muscle Anatomy 0.000 claims description 10
- 230000008085 renal dysfunction Effects 0.000 claims description 10
- 231100000241 scar Toxicity 0.000 claims description 10
- 238000003860 storage Methods 0.000 claims description 10
- 238000005079 FT-Raman Methods 0.000 claims description 9
- 210000000988 bone and bone Anatomy 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 9
- 201000006417 multiple sclerosis Diseases 0.000 claims description 9
- 206010028537 myelofibrosis Diseases 0.000 claims description 9
- 208000004296 neuralgia Diseases 0.000 claims description 9
- 208000021722 neuropathic pain Diseases 0.000 claims description 9
- 230000002093 peripheral effect Effects 0.000 claims description 9
- 230000000750 progressive effect Effects 0.000 claims description 9
- 230000002861 ventricular Effects 0.000 claims description 9
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 8
- 102000008186 Collagen Human genes 0.000 claims description 8
- 108010035532 Collagen Proteins 0.000 claims description 8
- 206010011878 Deafness Diseases 0.000 claims description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 8
- 206010061216 Infarction Diseases 0.000 claims description 8
- 208000005615 Interstitial Cystitis Diseases 0.000 claims description 8
- 208000009525 Myocarditis Diseases 0.000 claims description 8
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 8
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 8
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 8
- 230000001746 atrial effect Effects 0.000 claims description 8
- 210000001736 capillary Anatomy 0.000 claims description 8
- 206010008118 cerebral infarction Diseases 0.000 claims description 8
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 8
- 229920001436 collagen Polymers 0.000 claims description 8
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 8
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims description 8
- 208000016354 hearing loss disease Diseases 0.000 claims description 8
- 201000001881 impotence Diseases 0.000 claims description 8
- 230000007574 infarction Effects 0.000 claims description 8
- 201000011461 pre-eclampsia Diseases 0.000 claims description 8
- 201000000306 sarcoidosis Diseases 0.000 claims description 8
- 208000007056 sickle cell anemia Diseases 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 208000019553 vascular disease Diseases 0.000 claims description 8
- 208000006029 Cardiomegaly Diseases 0.000 claims description 7
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 7
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 7
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 7
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims description 7
- 208000003782 Raynaud disease Diseases 0.000 claims description 7
- 201000004810 Vascular dementia Diseases 0.000 claims description 7
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 7
- 230000004913 activation Effects 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 230000000747 cardiac effect Effects 0.000 claims description 7
- 208000020832 chronic kidney disease Diseases 0.000 claims description 7
- 230000007850 degeneration Effects 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 208000006454 hepatitis Diseases 0.000 claims description 7
- 230000015654 memory Effects 0.000 claims description 7
- 201000006938 muscular dystrophy Diseases 0.000 claims description 7
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 7
- 208000037803 restenosis Diseases 0.000 claims description 7
- 238000001356 surgical procedure Methods 0.000 claims description 7
- 230000002792 vascular Effects 0.000 claims description 7
- 208000024827 Alzheimer disease Diseases 0.000 claims description 6
- 201000006935 Becker muscular dystrophy Diseases 0.000 claims description 6
- 206010006482 Bronchospasm Diseases 0.000 claims description 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 6
- 206010014561 Emphysema Diseases 0.000 claims description 6
- 208000010228 Erectile Dysfunction Diseases 0.000 claims description 6
- 108010023302 HDL Cholesterol Proteins 0.000 claims description 6
- 206010019196 Head injury Diseases 0.000 claims description 6
- 206010021143 Hypoxia Diseases 0.000 claims description 6
- 208000024934 IgG4-related mediastinitis Diseases 0.000 claims description 6
- 108010028554 LDL Cholesterol Proteins 0.000 claims description 6
- 208000000185 Localized scleroderma Diseases 0.000 claims description 6
- 206010039710 Scleroderma Diseases 0.000 claims description 6
- 201000001880 Sexual dysfunction Diseases 0.000 claims description 6
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 6
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 6
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 6
- 208000007502 anemia Diseases 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 230000007885 bronchoconstriction Effects 0.000 claims description 6
- 230000007882 cirrhosis Effects 0.000 claims description 6
- 238000002648 combination therapy Methods 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 230000010370 hearing loss Effects 0.000 claims description 6
- 231100000888 hearing loss Toxicity 0.000 claims description 6
- 231100000283 hepatitis Toxicity 0.000 claims description 6
- 208000006575 hypertriglyceridemia Diseases 0.000 claims description 6
- 210000003141 lower extremity Anatomy 0.000 claims description 6
- 230000001575 pathological effect Effects 0.000 claims description 6
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 6
- 231100000872 sexual dysfunction Toxicity 0.000 claims description 6
- 238000002560 therapeutic procedure Methods 0.000 claims description 6
- 238000002054 transplantation Methods 0.000 claims description 6
- 200000000007 Arterial disease Diseases 0.000 claims description 5
- 206010003658 Atrial Fibrillation Diseases 0.000 claims description 5
- 201000006474 Brain Ischemia Diseases 0.000 claims description 5
- 206010008120 Cerebral ischaemia Diseases 0.000 claims description 5
- 208000011231 Crohn disease Diseases 0.000 claims description 5
- 206010048554 Endothelial dysfunction Diseases 0.000 claims description 5
- 208000007530 Essential hypertension Diseases 0.000 claims description 5
- 208000035150 Hypercholesterolemia Diseases 0.000 claims description 5
- 206010027727 Mitral valve incompetence Diseases 0.000 claims description 5
- 206010029164 Nephrotic syndrome Diseases 0.000 claims description 5
- 206010030113 Oedema Diseases 0.000 claims description 5
- 208000002193 Pain Diseases 0.000 claims description 5
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims description 5
- 206010036805 Progressive massive fibrosis Diseases 0.000 claims description 5
- 208000025865 Ulcer Diseases 0.000 claims description 5
- 206010047115 Vasculitis Diseases 0.000 claims description 5
- 230000005856 abnormality Effects 0.000 claims description 5
- 238000002399 angioplasty Methods 0.000 claims description 5
- 210000002565 arteriole Anatomy 0.000 claims description 5
- 208000006673 asthma Diseases 0.000 claims description 5
- 208000010643 digestive system disease Diseases 0.000 claims description 5
- 230000008694 endothelial dysfunction Effects 0.000 claims description 5
- 230000002496 gastric effect Effects 0.000 claims description 5
- 230000028709 inflammatory response Effects 0.000 claims description 5
- 230000000302 ischemic effect Effects 0.000 claims description 5
- 210000000265 leukocyte Anatomy 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 5
- 208000019423 liver disease Diseases 0.000 claims description 5
- 206010025135 lupus erythematosus Diseases 0.000 claims description 5
- 230000002107 myocardial effect Effects 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 230000036961 partial effect Effects 0.000 claims description 5
- 208000007232 portal hypertension Diseases 0.000 claims description 5
- 238000007634 remodeling Methods 0.000 claims description 5
- 230000000241 respiratory effect Effects 0.000 claims description 5
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 5
- 201000002859 sleep apnea Diseases 0.000 claims description 5
- 230000000391 smoking effect Effects 0.000 claims description 5
- 231100000397 ulcer Toxicity 0.000 claims description 5
- 210000002700 urine Anatomy 0.000 claims description 5
- 206010047302 ventricular tachycardia Diseases 0.000 claims description 5
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 4
- 201000004384 Alopecia Diseases 0.000 claims description 4
- 206010003671 Atrioventricular Block Diseases 0.000 claims description 4
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims description 4
- 208000002330 Congenital Heart Defects Diseases 0.000 claims description 4
- 206010011796 Cystitis interstitial Diseases 0.000 claims description 4
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims description 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 4
- 208000032928 Dyslipidaemia Diseases 0.000 claims description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 claims description 4
- 201000009273 Endometriosis Diseases 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 claims description 4
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 4
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 4
- 208000016621 Hearing disease Diseases 0.000 claims description 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 4
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 4
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 4
- 208000002805 Mediastinal fibrosis Diseases 0.000 claims description 4
- 206010027525 Microalbuminuria Diseases 0.000 claims description 4
- 208000034486 Multi-organ failure Diseases 0.000 claims description 4
- 206010063985 Phytosterolaemia Diseases 0.000 claims description 4
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims description 4
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 claims description 4
- 201000001068 Prinzmetal angina Diseases 0.000 claims description 4
- 208000010378 Pulmonary Embolism Diseases 0.000 claims description 4
- 208000033626 Renal failure acute Diseases 0.000 claims description 4
- 206010040047 Sepsis Diseases 0.000 claims description 4
- 208000002227 Sitosterolemia Diseases 0.000 claims description 4
- 208000032594 Vascular Remodeling Diseases 0.000 claims description 4
- 208000009729 Ventricular Premature Complexes Diseases 0.000 claims description 4
- 201000011040 acute kidney failure Diseases 0.000 claims description 4
- 208000026594 alcoholic fatty liver disease Diseases 0.000 claims description 4
- 239000003146 anticoagulant agent Substances 0.000 claims description 4
- 206010002906 aortic stenosis Diseases 0.000 claims description 4
- 206010003246 arthritis Diseases 0.000 claims description 4
- 230000003143 atherosclerotic effect Effects 0.000 claims description 4
- 230000002490 cerebral effect Effects 0.000 claims description 4
- 208000026106 cerebrovascular disease Diseases 0.000 claims description 4
- 238000002512 chemotherapy Methods 0.000 claims description 4
- 208000010877 cognitive disease Diseases 0.000 claims description 4
- 208000028831 congenital heart disease Diseases 0.000 claims description 4
- 208000018631 connective tissue disease Diseases 0.000 claims description 4
- 238000007887 coronary angioplasty Methods 0.000 claims description 4
- 229940109239 creatinine Drugs 0.000 claims description 4
- 230000008021 deposition Effects 0.000 claims description 4
- 208000033679 diabetic kidney disease Diseases 0.000 claims description 4
- 230000003205 diastolic effect Effects 0.000 claims description 4
- 208000030533 eye disease Diseases 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 4
- 230000003176 fibrotic effect Effects 0.000 claims description 4
- 208000018685 gastrointestinal system disease Diseases 0.000 claims description 4
- 208000019622 heart disease Diseases 0.000 claims description 4
- 230000001900 immune effect Effects 0.000 claims description 4
- 230000001976 improved effect Effects 0.000 claims description 4
- 208000027866 inflammatory disease Diseases 0.000 claims description 4
- 230000002757 inflammatory effect Effects 0.000 claims description 4
- 201000002818 limb ischemia Diseases 0.000 claims description 4
- 208000030159 metabolic disease Diseases 0.000 claims description 4
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims description 4
- 208000031225 myocardial ischemia Diseases 0.000 claims description 4
- 201000009925 nephrosclerosis Diseases 0.000 claims description 4
- 201000001119 neuropathy Diseases 0.000 claims description 4
- 230000007823 neuropathy Effects 0.000 claims description 4
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 4
- 244000045947 parasite Species 0.000 claims description 4
- 230000010412 perfusion Effects 0.000 claims description 4
- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 4
- 201000004240 prostatic hypertrophy Diseases 0.000 claims description 4
- 208000015658 resistant hypertension Diseases 0.000 claims description 4
- 201000004409 schistosomiasis Diseases 0.000 claims description 4
- 201000000980 schizophrenia Diseases 0.000 claims description 4
- 208000017520 skin disease Diseases 0.000 claims description 4
- 208000002320 spinal muscular atrophy Diseases 0.000 claims description 4
- 206010042772 syncope Diseases 0.000 claims description 4
- 230000001732 thrombotic effect Effects 0.000 claims description 4
- 239000003053 toxin Substances 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- 108700012359 toxins Proteins 0.000 claims description 4
- 210000003462 vein Anatomy 0.000 claims description 4
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims description 3
- 206010002388 Angina unstable Diseases 0.000 claims description 3
- 206010059245 Angiopathy Diseases 0.000 claims description 3
- 206010003694 Atrophy Diseases 0.000 claims description 3
- 206010061666 Autonomic neuropathy Diseases 0.000 claims description 3
- 208000014644 Brain disease Diseases 0.000 claims description 3
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims description 3
- 201000004624 Dermatitis Diseases 0.000 claims description 3
- 208000008960 Diabetic foot Diseases 0.000 claims description 3
- 206010056340 Diabetic ulcer Diseases 0.000 claims description 3
- 208000001708 Dupuytren contracture Diseases 0.000 claims description 3
- 208000032274 Encephalopathy Diseases 0.000 claims description 3
- 206010057671 Female sexual dysfunction Diseases 0.000 claims description 3
- 206010063629 Hippocampal sclerosis Diseases 0.000 claims description 3
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 3
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 claims description 3
- 206010022562 Intermittent claudication Diseases 0.000 claims description 3
- 208000002260 Keloid Diseases 0.000 claims description 3
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims description 3
- 206010024119 Left ventricular failure Diseases 0.000 claims description 3
- 208000019693 Lung disease Diseases 0.000 claims description 3
- 206010028594 Myocardial fibrosis Diseases 0.000 claims description 3
- 208000008589 Obesity Diseases 0.000 claims description 3
- 201000000023 Osteosclerosis Diseases 0.000 claims description 3
- 244000170916 Paeonia officinalis Species 0.000 claims description 3
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 3
- 206010065159 Polychondritis Diseases 0.000 claims description 3
- 208000032319 Primary lateral sclerosis Diseases 0.000 claims description 3
- 206010037423 Pulmonary oedema Diseases 0.000 claims description 3
- 206010063837 Reperfusion injury Diseases 0.000 claims description 3
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 claims description 3
- 206010039163 Right ventricular failure Diseases 0.000 claims description 3
- 201000004239 Secondary hypertension Diseases 0.000 claims description 3
- 208000005392 Spasm Diseases 0.000 claims description 3
- 208000001435 Thromboembolism Diseases 0.000 claims description 3
- 206010060872 Transplant failure Diseases 0.000 claims description 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 3
- 208000026911 Tuberous sclerosis complex Diseases 0.000 claims description 3
- 208000007814 Unstable Angina Diseases 0.000 claims description 3
- 206010046298 Upper motor neurone lesion Diseases 0.000 claims description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 230000002776 aggregation Effects 0.000 claims description 3
- 238000004220 aggregation Methods 0.000 claims description 3
- 206010003119 arrhythmia Diseases 0.000 claims description 3
- 230000006793 arrhythmia Effects 0.000 claims description 3
- 208000037849 arterial hypertension Diseases 0.000 claims description 3
- 230000037444 atrophy Effects 0.000 claims description 3
- 230000005784 autoimmunity Effects 0.000 claims description 3
- 208000015114 central nervous system disease Diseases 0.000 claims description 3
- 201000009101 diabetic angiopathy Diseases 0.000 claims description 3
- 230000003511 endothelial effect Effects 0.000 claims description 3
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 3
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims description 3
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims description 3
- 230000001969 hypertrophic effect Effects 0.000 claims description 3
- 208000018875 hypoxemia Diseases 0.000 claims description 3
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims description 3
- 208000021156 intermittent vascular claudication Diseases 0.000 claims description 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 3
- 210000001117 keloid Anatomy 0.000 claims description 3
- 201000010901 lateral sclerosis Diseases 0.000 claims description 3
- 230000013016 learning Effects 0.000 claims description 3
- 230000003902 lesion Effects 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 208000005264 motor neuron disease Diseases 0.000 claims description 3
- 210000000653 nervous system Anatomy 0.000 claims description 3
- 235000020824 obesity Nutrition 0.000 claims description 3
- 230000000414 obstructive effect Effects 0.000 claims description 3
- 230000035699 permeability Effects 0.000 claims description 3
- 208000005987 polymyositis Diseases 0.000 claims description 3
- 201000000742 primary sclerosing cholangitis Diseases 0.000 claims description 3
- 230000035755 proliferation Effects 0.000 claims description 3
- 210000001147 pulmonary artery Anatomy 0.000 claims description 3
- 208000005333 pulmonary edema Diseases 0.000 claims description 3
- 208000010157 sclerosing cholangitis Diseases 0.000 claims description 3
- 230000002784 sclerotic effect Effects 0.000 claims description 3
- 230000007958 sleep Effects 0.000 claims description 3
- 210000002460 smooth muscle Anatomy 0.000 claims description 3
- 230000007863 steatosis Effects 0.000 claims description 3
- 231100000240 steatosis hepatitis Toxicity 0.000 claims description 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 3
- 230000002537 thrombolytic effect Effects 0.000 claims description 3
- 208000037816 tissue injury Diseases 0.000 claims description 3
- 230000001052 transient effect Effects 0.000 claims description 3
- 230000008733 trauma Effects 0.000 claims description 3
- 230000009529 traumatic brain injury Effects 0.000 claims description 3
- 208000009999 tuberous sclerosis Diseases 0.000 claims description 3
- 208000014001 urinary system disease Diseases 0.000 claims description 3
- 208000003663 ventricular fibrillation Diseases 0.000 claims description 3
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 claims description 2
- 206010067092 AIDS cholangiopathy Diseases 0.000 claims description 2
- 208000019932 Aciduria Diseases 0.000 claims description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 2
- 206010001580 Albuminuria Diseases 0.000 claims description 2
- 201000010053 Alcoholic Cardiomyopathy Diseases 0.000 claims description 2
- 208000000044 Amnesia Diseases 0.000 claims description 2
- 206010002153 Anal fissure Diseases 0.000 claims description 2
- 206010002199 Anaphylactic shock Diseases 0.000 claims description 2
- 206010002329 Aneurysm Diseases 0.000 claims description 2
- 208000016583 Anus disease Diseases 0.000 claims description 2
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 206010002915 Aortic valve incompetence Diseases 0.000 claims description 2
- 206010003130 Arrhythmia supraventricular Diseases 0.000 claims description 2
- 206010058029 Arthrofibrosis Diseases 0.000 claims description 2
- 208000002102 Atrial Premature Complexes Diseases 0.000 claims description 2
- 206010003662 Atrial flutter Diseases 0.000 claims description 2
- 206010004593 Bile duct cancer Diseases 0.000 claims description 2
- 206010004637 Bile duct stone Diseases 0.000 claims description 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 2
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 2
- 208000020925 Bipolar disease Diseases 0.000 claims description 2
- 208000006386 Bone Resorption Diseases 0.000 claims description 2
- 208000020084 Bone disease Diseases 0.000 claims description 2
- 206010006458 Bronchitis chronic Diseases 0.000 claims description 2
- 241000282461 Canis lupus Species 0.000 claims description 2
- 206010007637 Cardiomyopathy alcoholic Diseases 0.000 claims description 2
- 208000004990 Cardiorenal syndrome Diseases 0.000 claims description 2
- 206010048610 Cardiotoxicity Diseases 0.000 claims description 2
- 206010008635 Cholestasis Diseases 0.000 claims description 2
- 208000026151 Chronic thromboembolic pulmonary hypertension Diseases 0.000 claims description 2
- 208000028698 Cognitive impairment Diseases 0.000 claims description 2
- 208000004117 Congenital Myasthenic Syndromes Diseases 0.000 claims description 2
- 206010010356 Congenital anomaly Diseases 0.000 claims description 2
- 206010056370 Congestive cardiomyopathy Diseases 0.000 claims description 2
- 208000026292 Cystic Kidney disease Diseases 0.000 claims description 2
- 208000016192 Demyelinating disease Diseases 0.000 claims description 2
- 206010012305 Demyelination Diseases 0.000 claims description 2
- 208000002249 Diabetes Complications Diseases 0.000 claims description 2
- 206010012655 Diabetic complications Diseases 0.000 claims description 2
- 206010054044 Diabetic microangiopathy Diseases 0.000 claims description 2
- 206010052337 Diastolic dysfunction Diseases 0.000 claims description 2
- 201000010046 Dilated cardiomyopathy Diseases 0.000 claims description 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 2
- 206010013774 Dry eye Diseases 0.000 claims description 2
- 208000030814 Eating disease Diseases 0.000 claims description 2
- 206010014418 Electrolyte imbalance Diseases 0.000 claims description 2
- 206010014954 Eosinophilic fasciitis Diseases 0.000 claims description 2
- 208000000289 Esophageal Achalasia Diseases 0.000 claims description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 108010049003 Fibrinogen Proteins 0.000 claims description 2
- 102000008946 Fibrinogen Human genes 0.000 claims description 2
- 208000009531 Fissure in Ano Diseases 0.000 claims description 2
- 206010070538 Gestational hypertension Diseases 0.000 claims description 2
- 208000010412 Glaucoma Diseases 0.000 claims description 2
- 208000022461 Glomerular disease Diseases 0.000 claims description 2
- 206010018366 Glomerulonephritis acute Diseases 0.000 claims description 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 2
- 206010018691 Granuloma Diseases 0.000 claims description 2
- 208000024815 Granulomatous liver disease Diseases 0.000 claims description 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 206010020575 Hyperammonaemia Diseases 0.000 claims description 2
- 206010020852 Hypertonia Diseases 0.000 claims description 2
- 206010020853 Hypertonic bladder Diseases 0.000 claims description 2
- 206010021036 Hyponatraemia Diseases 0.000 claims description 2
- 206010058558 Hypoperfusion Diseases 0.000 claims description 2
- 206010021133 Hypoventilation Diseases 0.000 claims description 2
- 206010021639 Incontinence Diseases 0.000 claims description 2
- 208000029523 Interstitial Lung disease Diseases 0.000 claims description 2
- 206010048858 Ischaemic cardiomyopathy Diseases 0.000 claims description 2
- 206010023330 Keloid scar Diseases 0.000 claims description 2
- 206010023439 Kidney transplant rejection Diseases 0.000 claims description 2
- 201000002832 Lewy body dementia Diseases 0.000 claims description 2
- 201000009342 Limb-girdle muscular dystrophy Diseases 0.000 claims description 2
- 208000008771 Lymphadenopathy Diseases 0.000 claims description 2
- 206010025219 Lymphangioma Diseases 0.000 claims description 2
- 208000026139 Memory disease Diseases 0.000 claims description 2
- 206010027476 Metastases Diseases 0.000 claims description 2
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 208000020128 Mitral stenosis Diseases 0.000 claims description 2
- 208000011682 Mitral valve disease Diseases 0.000 claims description 2
- 206010027982 Morphoea Diseases 0.000 claims description 2
- 208000001089 Multiple system atrophy Diseases 0.000 claims description 2
- 206010068871 Myotonic dystrophy Diseases 0.000 claims description 2
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims description 2
- 206010029279 Neurogenic bladder Diseases 0.000 claims description 2
- 208000007256 Nevus Diseases 0.000 claims description 2
- 206010030136 Oesophageal achalasia Diseases 0.000 claims description 2
- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 208000027089 Parkinsonian disease Diseases 0.000 claims description 2
- 206010034010 Parkinsonism Diseases 0.000 claims description 2
- 208000000450 Pelvic Pain Diseases 0.000 claims description 2
- 206010034487 Pericarditis constrictive Diseases 0.000 claims description 2
- 206010061340 Peripheral embolism Diseases 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 208000000418 Premature Cardiac Complexes Diseases 0.000 claims description 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 2
- 206010062300 Procedural hypotension Diseases 0.000 claims description 2
- 206010037457 Pulmonary vasculitis Diseases 0.000 claims description 2
- 206010037596 Pyelonephritis Diseases 0.000 claims description 2
- 206010038423 Renal cyst Diseases 0.000 claims description 2
- 208000017442 Retinal disease Diseases 0.000 claims description 2
- 206010038923 Retinopathy Diseases 0.000 claims description 2
- 201000007981 Reye syndrome Diseases 0.000 claims description 2
- 206010040070 Septic Shock Diseases 0.000 claims description 2
- 206010040642 Sickle cell anaemia with crisis Diseases 0.000 claims description 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 2
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims description 2
- 206010065342 Supraventricular tachyarrhythmia Diseases 0.000 claims description 2
- 206010071436 Systolic dysfunction Diseases 0.000 claims description 2
- 208000001871 Tachycardia Diseases 0.000 claims description 2
- 208000001163 Tangier disease Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 201000001943 Tricuspid Valve Insufficiency Diseases 0.000 claims description 2
- 206010044640 Tricuspid valve incompetence Diseases 0.000 claims description 2
- 206010044642 Tricuspid valve stenosis Diseases 0.000 claims description 2
- 208000026723 Urinary tract disease Diseases 0.000 claims description 2
- 208000012931 Urologic disease Diseases 0.000 claims description 2
- 206010046798 Uterine leiomyoma Diseases 0.000 claims description 2
- 208000009325 Variant Angina Pectoris Diseases 0.000 claims description 2
- 206010058990 Venous occlusion Diseases 0.000 claims description 2
- 208000008131 Ventricular Flutter Diseases 0.000 claims description 2
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims description 2
- 206010065341 Ventricular tachyarrhythmia Diseases 0.000 claims description 2
- 206010048215 Xanthomatosis Diseases 0.000 claims description 2
- 201000000621 achalasia Diseases 0.000 claims description 2
- 231100000851 acute glomerulonephritis Toxicity 0.000 claims description 2
- 206010069351 acute lung injury Diseases 0.000 claims description 2
- 201000005180 acute myocarditis Diseases 0.000 claims description 2
- 208000012998 acute renal failure Diseases 0.000 claims description 2
- 208000013228 adenopathy Diseases 0.000 claims description 2
- 210000000577 adipose tissue Anatomy 0.000 claims description 2
- 231100000360 alopecia Toxicity 0.000 claims description 2
- 208000006682 alpha 1-Antitrypsin Deficiency Diseases 0.000 claims description 2
- 208000033571 alveolar capillary dysplasia with misalignment of pulmonary veins Diseases 0.000 claims description 2
- 208000003455 anaphylaxis Diseases 0.000 claims description 2
- 230000036506 anxiety Effects 0.000 claims description 2
- 201000002064 aortic valve insufficiency Diseases 0.000 claims description 2
- 210000004227 basal ganglia Anatomy 0.000 claims description 2
- 210000000941 bile Anatomy 0.000 claims description 2
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 2
- 208000010217 blepharitis Diseases 0.000 claims description 2
- 208000015294 blood coagulation disease Diseases 0.000 claims description 2
- 230000004097 bone metabolism Effects 0.000 claims description 2
- 230000024279 bone resorption Effects 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 230000023852 carbohydrate metabolic process Effects 0.000 claims description 2
- 235000021256 carbohydrate metabolism Nutrition 0.000 claims description 2
- 206010007625 cardiogenic shock Diseases 0.000 claims description 2
- 231100000259 cardiotoxicity Toxicity 0.000 claims description 2
- 230000020411 cell activation Effects 0.000 claims description 2
- 230000003788 cerebral perfusion Effects 0.000 claims description 2
- 208000007451 chronic bronchitis Diseases 0.000 claims description 2
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 2
- 208000000839 constrictive pericarditis Diseases 0.000 claims description 2
- 231100000895 deafness Toxicity 0.000 claims description 2
- 230000002542 deteriorative effect Effects 0.000 claims description 2
- 238000000502 dialysis Methods 0.000 claims description 2
- 208000016097 disease of metabolism Diseases 0.000 claims description 2
- 230000005750 disease progression Effects 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 201000009338 distal myopathy Diseases 0.000 claims description 2
- 201000006549 dyspepsia Diseases 0.000 claims description 2
- 230000002500 effect on skin Effects 0.000 claims description 2
- 230000029142 excretion Effects 0.000 claims description 2
- 230000001815 facial effect Effects 0.000 claims description 2
- 208000010706 fatty liver disease Diseases 0.000 claims description 2
- 229940012952 fibrinogen Drugs 0.000 claims description 2
- 235000013305 food Nutrition 0.000 claims description 2
- 210000001652 frontal lobe Anatomy 0.000 claims description 2
- 230000001434 glomerular Effects 0.000 claims description 2
- 206010061989 glomerulosclerosis Diseases 0.000 claims description 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims description 2
- 208000024908 graft versus host disease Diseases 0.000 claims description 2
- 208000024963 hair loss Diseases 0.000 claims description 2
- 230000003676 hair loss Effects 0.000 claims description 2
- 210000003709 heart valve Anatomy 0.000 claims description 2
- 208000007386 hepatic encephalopathy Diseases 0.000 claims description 2
- 210000004024 hepatic stellate cell Anatomy 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 201000005991 hyperphosphatemia Diseases 0.000 claims description 2
- 230000001631 hypertensive effect Effects 0.000 claims description 2
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims description 2
- 208000001286 intracranial vasospasm Diseases 0.000 claims description 2
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims description 2
- 230000028252 learning or memory Effects 0.000 claims description 2
- 201000010260 leiomyoma Diseases 0.000 claims description 2
- 230000006372 lipid accumulation Effects 0.000 claims description 2
- 206010025005 lumbar spinal stenosis Diseases 0.000 claims description 2
- 230000036244 malformation Effects 0.000 claims description 2
- 230000003211 malignant effect Effects 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 201000001231 mediastinitis Diseases 0.000 claims description 2
- 230000006984 memory degeneration Effects 0.000 claims description 2
- 206010027175 memory impairment Diseases 0.000 claims description 2
- 208000023060 memory loss Diseases 0.000 claims description 2
- 230000009401 metastasis Effects 0.000 claims description 2
- 230000004089 microcirculation Effects 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- 230000005012 migration Effects 0.000 claims description 2
- 238000013508 migration Methods 0.000 claims description 2
- 208000006887 mitral valve stenosis Diseases 0.000 claims description 2
- 210000001616 monocyte Anatomy 0.000 claims description 2
- 230000001338 necrotic effect Effects 0.000 claims description 2
- 201000008383 nephritis Diseases 0.000 claims description 2
- 208000018360 neuromuscular disease Diseases 0.000 claims description 2
- 230000004112 neuroprotection Effects 0.000 claims description 2
- 230000008816 organ damage Effects 0.000 claims description 2
- 230000011164 ossification Effects 0.000 claims description 2
- 206010033103 otosclerosis Diseases 0.000 claims description 2
- 208000020629 overactive bladder Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 230000008447 perception Effects 0.000 claims description 2
- 206010034674 peritonitis Diseases 0.000 claims description 2
- 208000014321 polymorphic ventricular tachycardia Diseases 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 230000035935 pregnancy Effects 0.000 claims description 2
- 230000036316 preload Effects 0.000 claims description 2
- 206010036596 premature ejaculation Diseases 0.000 claims description 2
- 208000003476 primary myelofibrosis Diseases 0.000 claims description 2
- 201000008312 primary pulmonary hypertension Diseases 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 201000010298 pulmonary valve insufficiency Diseases 0.000 claims description 2
- 208000009138 pulmonary valve stenosis Diseases 0.000 claims description 2
- 208000030390 pulmonic stenosis Diseases 0.000 claims description 2
- 230000010451 regulation of platelet aggregation Effects 0.000 claims description 2
- 230000036303 septic shock Effects 0.000 claims description 2
- 230000035939 shock Effects 0.000 claims description 2
- 208000019116 sleep disease Diseases 0.000 claims description 2
- 208000005198 spinal stenosis Diseases 0.000 claims description 2
- 210000004003 subcutaneous fat Anatomy 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 230000001629 suppression Effects 0.000 claims description 2
- 230000006794 tachycardia Effects 0.000 claims description 2
- 230000000542 thalamic effect Effects 0.000 claims description 2
- 230000002885 thrombogenetic effect Effects 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 230000000472 traumatic effect Effects 0.000 claims description 2
- 210000005239 tubule Anatomy 0.000 claims description 2
- 206010046459 urethral obstruction Diseases 0.000 claims description 2
- 210000001635 urinary tract Anatomy 0.000 claims description 2
- 210000002229 urogenital system Anatomy 0.000 claims description 2
- 208000037820 vascular cognitive impairment Diseases 0.000 claims description 2
- 206010047470 viral myocarditis Diseases 0.000 claims description 2
- 230000001747 exhibiting effect Effects 0.000 claims 3
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 claims 1
- 208000025408 Autosomal Emery-Dreifuss Muscular Dystrophy Diseases 0.000 claims 1
- 208000037157 Azotemia Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 201000009110 Oculopharyngeal muscular dystrophy Diseases 0.000 claims 1
- 208000002158 Proliferative Vitreoretinopathy Diseases 0.000 claims 1
- 206010038934 Retinopathy proliferative Diseases 0.000 claims 1
- 201000008485 Wernicke-Korsakoff syndrome Diseases 0.000 claims 1
- 208000015953 X-linked Emery-Dreifuss muscular dystrophy Diseases 0.000 claims 1
- 230000010072 bone remodeling Effects 0.000 claims 1
- 230000001054 cortical effect Effects 0.000 claims 1
- 206010025482 malaise Diseases 0.000 claims 1
- 208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 claims 1
- 210000002997 osteoclast Anatomy 0.000 claims 1
- 230000006785 proliferative vitreoretinopathy Effects 0.000 claims 1
- 230000009424 thromboembolic effect Effects 0.000 claims 1
- 208000009852 uremia Diseases 0.000 claims 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 abstract description 26
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 abstract description 26
- ZOOGRGPOEVQQDX-KHLHZJAASA-N cyclic guanosine monophosphate Chemical compound C([C@H]1O2)O[P@](O)(=O)O[C@@H]1[C@H](O)[C@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-KHLHZJAASA-N 0.000 abstract description 20
- 239000003795 chemical substances by application Substances 0.000 abstract description 18
- 238000006243 chemical reaction Methods 0.000 description 49
- 238000009472 formulation Methods 0.000 description 26
- 239000000543 intermediate Substances 0.000 description 26
- 208000024891 symptom Diseases 0.000 description 24
- 230000008569 process Effects 0.000 description 22
- 239000003826 tablet Substances 0.000 description 22
- 238000004128 high performance liquid chromatography Methods 0.000 description 21
- 239000012065 filter cake Substances 0.000 description 19
- 229940124597 therapeutic agent Drugs 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 17
- 239000002775 capsule Substances 0.000 description 16
- 239000013078 crystal Substances 0.000 description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 239000003925 fat Substances 0.000 description 15
- 239000003921 oil Substances 0.000 description 15
- 235000019198 oils Nutrition 0.000 description 15
- 210000003491 skin Anatomy 0.000 description 15
- 238000005160 1H NMR spectroscopy Methods 0.000 description 14
- 235000019197 fats Nutrition 0.000 description 14
- 239000000725 suspension Substances 0.000 description 14
- 239000000463 material Substances 0.000 description 13
- 239000011541 reaction mixture Substances 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 210000001772 blood platelet Anatomy 0.000 description 12
- 210000004556 brain Anatomy 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 11
- 239000011149 active material Substances 0.000 description 11
- 230000015572 biosynthetic process Effects 0.000 description 11
- 210000002808 connective tissue Anatomy 0.000 description 11
- 239000003085 diluting agent Substances 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 11
- 239000010410 layer Substances 0.000 description 11
- 239000012071 phase Substances 0.000 description 11
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- 230000006870 function Effects 0.000 description 10
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 125000004429 atom Chemical group 0.000 description 9
- 230000036770 blood supply Effects 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 9
- 239000012458 free base Substances 0.000 description 9
- 210000004165 myocardium Anatomy 0.000 description 9
- 230000004044 response Effects 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 239000002202 Polyethylene glycol Substances 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 230000037396 body weight Effects 0.000 description 8
- 239000006071 cream Substances 0.000 description 8
- 238000011161 development Methods 0.000 description 8
- 230000018109 developmental process Effects 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 229920001223 polyethylene glycol Polymers 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 239000012453 solvate Substances 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 7
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 7
- 239000013543 active substance Substances 0.000 description 7
- 238000002425 crystallisation Methods 0.000 description 7
- 230000008025 crystallization Effects 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- 150000002500 ions Chemical class 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 239000012044 organic layer Substances 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 239000003755 preservative agent Substances 0.000 description 7
- 229940127296 soluble guanylate cyclase stimulator Drugs 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- 208000024172 Cardiovascular disease Diseases 0.000 description 6
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 6
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 239000000969 carrier Substances 0.000 description 6
- 208000029078 coronary artery disease Diseases 0.000 description 6
- 230000001419 dependent effect Effects 0.000 description 6
- 239000003623 enhancer Substances 0.000 description 6
- 239000011888 foil Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 210000004379 membrane Anatomy 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 239000002674 ointment Substances 0.000 description 6
- 239000004033 plastic Substances 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 230000008439 repair process Effects 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 239000003381 stabilizer Substances 0.000 description 6
- 239000003765 sweetening agent Substances 0.000 description 6
- 230000000699 topical effect Effects 0.000 description 6
- 206010002383 Angina Pectoris Diseases 0.000 description 5
- 206010007559 Cardiac failure congestive Diseases 0.000 description 5
- 208000021663 Female sexual arousal disease Diseases 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 5
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 5
- 208000031481 Pathologic Constriction Diseases 0.000 description 5
- 229930006000 Sucrose Natural products 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 206010047139 Vasoconstriction Diseases 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 239000000556 agonist Substances 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 239000007900 aqueous suspension Substances 0.000 description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 5
- 210000004351 coronary vessel Anatomy 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000003599 food sweetener Nutrition 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 229960003711 glyceryl trinitrate Drugs 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 5
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 230000002503 metabolic effect Effects 0.000 description 5
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 5
- 238000004806 packaging method and process Methods 0.000 description 5
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 5
- 230000000069 prophylactic effect Effects 0.000 description 5
- 229960004063 propylene glycol Drugs 0.000 description 5
- 230000036262 stenosis Effects 0.000 description 5
- 208000037804 stenosis Diseases 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- 239000000375 suspending agent Substances 0.000 description 5
- 230000025033 vasoconstriction Effects 0.000 description 5
- 239000000080 wetting agent Substances 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- BDGNHZONGFMQDB-UHFFFAOYSA-N 2-(aminomethyl)-3,3,3-trifluoro-2-hydroxypropanamide Chemical compound NCC(O)(C(N)=O)C(F)(F)F BDGNHZONGFMQDB-UHFFFAOYSA-N 0.000 description 4
- PBEIICCZAIHQEP-UHFFFAOYSA-N 2-(bromomethyl)-3,3,3-trifluoro-2-hydroxypropanamide Chemical compound NC(=O)C(O)(CBr)C(F)(F)F PBEIICCZAIHQEP-UHFFFAOYSA-N 0.000 description 4
- FBIFZOPWVOFVFW-UHFFFAOYSA-N 2-(bromomethyl)-3,3,3-trifluoro-2-trimethylsilyloxypropanenitrile Chemical compound BrCC(C#N)(C(F)(F)F)O[Si](C)(C)C FBIFZOPWVOFVFW-UHFFFAOYSA-N 0.000 description 4
- 239000005541 ACE inhibitor Substances 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 4
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 206010007558 Cardiac failure chronic Diseases 0.000 description 4
- 208000003417 Central Sleep Apnea Diseases 0.000 description 4
- 208000000059 Dyspnea Diseases 0.000 description 4
- 206010013975 Dyspnoeas Diseases 0.000 description 4
- 206010017076 Fracture Diseases 0.000 description 4
- 208000032612 Glial tumor Diseases 0.000 description 4
- 206010018338 Glioma Diseases 0.000 description 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 description 4
- 102100028452 Nitric oxide synthase, endothelial Human genes 0.000 description 4
- 101710090055 Nitric oxide synthase, endothelial Proteins 0.000 description 4
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 4
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 4
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 description 4
- ZIIQCSMRQKCOCT-YFKPBYRVSA-N S-nitroso-N-acetyl-D-penicillamine Chemical compound CC(=O)N[C@@H](C(O)=O)C(C)(C)SN=O ZIIQCSMRQKCOCT-YFKPBYRVSA-N 0.000 description 4
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 4
- 239000012472 biological sample Substances 0.000 description 4
- 229940045348 brown mixture Drugs 0.000 description 4
- NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000002270 dispersing agent Substances 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 150000003278 haem Chemical class 0.000 description 4
- 208000038002 heart failure with reduced ejection fraction Diseases 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 4
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 description 4
- 239000004530 micro-emulsion Substances 0.000 description 4
- 210000005036 nerve Anatomy 0.000 description 4
- 231100000252 nontoxic Toxicity 0.000 description 4
- 230000003000 nontoxic effect Effects 0.000 description 4
- 210000003899 penis Anatomy 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 4
- 229960004017 salmeterol Drugs 0.000 description 4
- 208000013220 shortness of breath Diseases 0.000 description 4
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 4
- 239000000829 suppository Substances 0.000 description 4
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
- 239000003981 vehicle Substances 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 3
- 208000010392 Bone Fractures Diseases 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- KJEBULYHNRNJTE-DHZHZOJOSA-N Cinalong Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC\C=C\C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 KJEBULYHNRNJTE-DHZHZOJOSA-N 0.000 description 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 3
- 108010036949 Cyclosporine Proteins 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- 229940118365 Endothelin receptor antagonist Drugs 0.000 description 3
- LMHIPJMTZHDKEW-XQYLJSSYSA-M Epoprostenol sodium Chemical compound [Na+].O1\C(=C/CCCC([O-])=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 LMHIPJMTZHDKEW-XQYLJSSYSA-M 0.000 description 3
- 241000282326 Felis catus Species 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 3
- 108010007859 Lisinopril Proteins 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 3
- HYHSBSXUHZOYLX-WDSKDSINSA-N S-nitrosoglutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O HYHSBSXUHZOYLX-WDSKDSINSA-N 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- 208000032109 Transient ischaemic attack Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 3
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 3
- 229960000711 alprostadil Drugs 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 239000003125 aqueous solvent Substances 0.000 description 3
- 229960003121 arginine Drugs 0.000 description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
- 235000009697 arginine Nutrition 0.000 description 3
- 230000001363 autoimmune Effects 0.000 description 3
- 235000019445 benzyl alcohol Nutrition 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 229940124630 bronchodilator Drugs 0.000 description 3
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 230000004663 cell proliferation Effects 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 229940046374 chromium picolinate Drugs 0.000 description 3
- GJYSUGXFENSLOO-UHFFFAOYSA-N chromium;pyridine-2-carboxylic acid Chemical compound [Cr].OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1 GJYSUGXFENSLOO-UHFFFAOYSA-N 0.000 description 3
- 238000011260 co-administration Methods 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 description 3
- 239000003246 corticosteroid Substances 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 3
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 3
- 229960002768 dipyridamole Drugs 0.000 description 3
- 239000002934 diuretic Substances 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 239000002308 endothelin receptor antagonist Substances 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 229960001123 epoprostenol Drugs 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 3
- 229960002240 iloprost Drugs 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 210000005240 left ventricle Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 3
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 3
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 description 3
- 239000003094 microcapsule Substances 0.000 description 3
- 239000002480 mineral oil Substances 0.000 description 3
- 235000010446 mineral oil Nutrition 0.000 description 3
- 208000005907 mitral valve insufficiency Diseases 0.000 description 3
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 3
- 239000004090 neuroprotective agent Substances 0.000 description 3
- 239000004006 olive oil Substances 0.000 description 3
- 235000008390 olive oil Nutrition 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- DHHVAGZRUROJKS-UHFFFAOYSA-N phentermine Chemical compound CC(C)(N)CC1=CC=CC=C1 DHHVAGZRUROJKS-UHFFFAOYSA-N 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 3
- 230000010410 reperfusion Effects 0.000 description 3
- 230000033764 rhythmic process Effects 0.000 description 3
- 229960000529 riociguat Drugs 0.000 description 3
- WXXSNCNJFUAIDG-UHFFFAOYSA-N riociguat Chemical compound N1=C(N)C(N(C)C(=O)OC)=C(N)N=C1C(C1=CC=CN=C11)=NN1CC1=CC=CC=C1F WXXSNCNJFUAIDG-UHFFFAOYSA-N 0.000 description 3
- 229960002052 salbutamol Drugs 0.000 description 3
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 3
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 3
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229940083542 sodium Drugs 0.000 description 3
- 235000015424 sodium Nutrition 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 235000010356 sorbitol Nutrition 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- 230000001839 systemic circulation Effects 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 229960001967 tacrolimus Drugs 0.000 description 3
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 201000010875 transient cerebral ischemia Diseases 0.000 description 3
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 description 3
- 210000005166 vasculature Anatomy 0.000 description 3
- 229940124549 vasodilator Drugs 0.000 description 3
- 239000003071 vasodilator agent Substances 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 description 3
- 229960002911 zonisamide Drugs 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 2
- HMJIYCCIJYRONP-UHFFFAOYSA-N (+-)-Isradipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC2=NON=C12 HMJIYCCIJYRONP-UHFFFAOYSA-N 0.000 description 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 2
- TWUSDDMONZULSC-HZMBPMFUSA-N (1r,2s)-2-(tert-butylamino)-1-(2,5-dimethoxyphenyl)propan-1-ol Chemical compound COC1=CC=C(OC)C([C@@H](O)[C@H](C)NC(C)(C)C)=C1 TWUSDDMONZULSC-HZMBPMFUSA-N 0.000 description 2
- VEPOHXYIFQMVHW-PVJVQHJQSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;(2s,3s)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.O1CCN(C)[C@@H](C)[C@@H]1C1=CC=CC=C1 VEPOHXYIFQMVHW-PVJVQHJQSA-N 0.000 description 2
- MZAGXDHQGXUDDX-JSRXJHBZSA-N (e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/C(N)=O MZAGXDHQGXUDDX-JSRXJHBZSA-N 0.000 description 2
- KFNNPQDSPLWLCX-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethylbutan-1-amine;hydron;chloride;hydrate Chemical compound O.Cl.C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 KFNNPQDSPLWLCX-UHFFFAOYSA-N 0.000 description 2
- VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 description 2
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 2
- YDSGGZZKDUDBMD-UHFFFAOYSA-N 2-[(2-chloro-3,4-dimethoxyphenyl)methylideneamino]-1-hydroxyguanidine Chemical compound COC1=CC=C(C=NNC(=N)NO)C(Cl)=C1OC YDSGGZZKDUDBMD-UHFFFAOYSA-N 0.000 description 2
- IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
- XTFPDGZNWTZCMF-DHZHZOJOSA-N 3-o-methyl 5-o-[(e)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC\C=C\C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 XTFPDGZNWTZCMF-DHZHZOJOSA-N 0.000 description 2
- 208000004611 Abdominal Obesity Diseases 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 206010003225 Arteriospasm coronary Diseases 0.000 description 2
- 102000002723 Atrial Natriuretic Factor Human genes 0.000 description 2
- 101800001288 Atrial natriuretic factor Proteins 0.000 description 2
- 101800001890 Atrial natriuretic peptide Proteins 0.000 description 2
- ZKFQEACEUNWPMT-UHFFFAOYSA-N Azelnidipine Chemical compound CC(C)OC(=O)C1=C(C)NC(N)=C(C(=O)OC2CN(C2)C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZKFQEACEUNWPMT-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 description 2
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 description 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 2
- 206010006895 Cachexia Diseases 0.000 description 2
- 108090000312 Calcium Channels Proteins 0.000 description 2
- 102000003922 Calcium Channels Human genes 0.000 description 2
- 229940127291 Calcium channel antagonist Drugs 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 241000700198 Cavia Species 0.000 description 2
- 206010065941 Central obesity Diseases 0.000 description 2
- 206010008479 Chest Pain Diseases 0.000 description 2
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 108010037462 Cyclooxygenase 2 Proteins 0.000 description 2
- 229930105110 Cyclosporin A Natural products 0.000 description 2
- HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 description 2
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 2
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 2
- 108010061435 Enalapril Proteins 0.000 description 2
- 241000792859 Enema Species 0.000 description 2
- 241000283086 Equidae Species 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- XKMLYUALXHKNFT-UUOKFMHZSA-N Guanosine-5'-triphosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XKMLYUALXHKNFT-UUOKFMHZSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000001953 Hypotension Diseases 0.000 description 2
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 2
- YSDQQAXHVYUZIW-QCIJIYAXSA-N Liraglutide Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 description 2
- 108010019598 Liraglutide Proteins 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- ZPXSCAKFGYXMGA-UHFFFAOYSA-N Mazindol Chemical compound N12CCN=C2C2=CC=CC=C2C1(O)C1=CC=C(Cl)C=C1 ZPXSCAKFGYXMGA-UHFFFAOYSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- WFBHRSAKANVBKH-UHFFFAOYSA-N N-hydroxyguanidine Chemical compound NC(=N)NO WFBHRSAKANVBKH-UHFFFAOYSA-N 0.000 description 2
- ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 description 2
- 108010076864 Nitric Oxide Synthase Type II Proteins 0.000 description 2
- 102100022397 Nitric oxide synthase, brain Human genes 0.000 description 2
- 101710111444 Nitric oxide synthase, brain Proteins 0.000 description 2
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 description 2
- 239000000006 Nitroglycerin Substances 0.000 description 2
- MITFXPHMIHQXPI-UHFFFAOYSA-N Oraflex Chemical compound N=1C2=CC(C(C(O)=O)C)=CC=C2OC=1C1=CC=C(Cl)C=C1 MITFXPHMIHQXPI-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 206010033799 Paralysis Diseases 0.000 description 2
- 235000019483 Peanut oil Nutrition 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 208000006735 Periostitis Diseases 0.000 description 2
- 239000004264 Petrolatum Substances 0.000 description 2
- 241000286209 Phasianidae Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 description 2
- 108010001742 S-Nitrosoglutathione Proteins 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 208000008253 Systolic Heart Failure Diseases 0.000 description 2
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 description 2
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 2
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 2
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 description 2
- 206010053648 Vascular occlusion Diseases 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- PWDLDBWXTVILPC-QGGVPXFVSA-N [(3as,5ar,8ar)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate;2-methyl-1-phenylpropan-2-amine Chemical compound CC(C)(N)CC1=CC=CC=C1.C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)OC2[C@@H]2OC(C)(C)O[C@@H]21 PWDLDBWXTVILPC-QGGVPXFVSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 208000038016 acute inflammation Diseases 0.000 description 2
- 230000006022 acute inflammation Effects 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- OUJTZYPIHDYQMC-LJQANCHMSA-N ambrisentan Chemical compound O([C@@H](C(OC)(C=1C=CC=CC=1)C=1C=CC=CC=1)C(O)=O)C1=NC(C)=CC(C)=N1 OUJTZYPIHDYQMC-LJQANCHMSA-N 0.000 description 2
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 2
- QWGDMFLQWFTERH-UHFFFAOYSA-N amoxapine Chemical compound C12=CC(Cl)=CC=C2OC2=CC=CC=C2N=C1N1CCNCC1 QWGDMFLQWFTERH-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 230000002424 anti-apoptotic effect Effects 0.000 description 2
- 230000001078 anti-cholinergic effect Effects 0.000 description 2
- 230000003276 anti-hypertensive effect Effects 0.000 description 2
- 239000000883 anti-obesity agent Substances 0.000 description 2
- 239000003416 antiarrhythmic agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 239000002220 antihypertensive agent Substances 0.000 description 2
- 239000003524 antilipemic agent Substances 0.000 description 2
- 229940127218 antiplatelet drug Drugs 0.000 description 2
- 210000000709 aorta Anatomy 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 230000037007 arousal Effects 0.000 description 2
- 229950004646 azelnidipine Drugs 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- ANFSNXAXVLRZCG-RSAXXLAASA-N benzphetamine hydrochloride Chemical compound [Cl-].C([C@H](C)[NH+](C)CC=1C=CC=CC=1)C1=CC=CC=C1 ANFSNXAXVLRZCG-RSAXXLAASA-N 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 229950004495 binifibrate Drugs 0.000 description 2
- BFYRHDVAEJIBON-UHFFFAOYSA-N binifibrate Chemical compound C=1C=CN=CC=1C(=O)OCC(COC(=O)C=1C=NC=CC=1)OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 BFYRHDVAEJIBON-UHFFFAOYSA-N 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 description 2
- 230000003925 brain function Effects 0.000 description 2
- FFHBJDQSGDNCIV-MFVUMRCOSA-N bremelanotide Chemical compound C([C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCNC(=O)C[C@@H](C(N[C@@H](CC=2NC=NC=2)C(=O)N1)=O)NC(=O)[C@@H](NC(C)=O)CCCC)C(O)=O)C1=CC=CC=C1 FFHBJDQSGDNCIV-MFVUMRCOSA-N 0.000 description 2
- 108010072543 bremelanotide Proteins 0.000 description 2
- 239000000168 bronchodilator agent Substances 0.000 description 2
- 229960004436 budesonide Drugs 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 229940012191 bupropion / naltrexone Drugs 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
- 239000000480 calcium channel blocker Substances 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 210000005242 cardiac chamber Anatomy 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 description 2
- 229960004195 carvedilol Drugs 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- KWGDNRLPXGPVGH-UHFFFAOYSA-N chloro hypochlorite phosphorous acid Chemical compound O(Cl)Cl.P(O)(O)O KWGDNRLPXGPVGH-UHFFFAOYSA-N 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000000812 cholinergic antagonist Substances 0.000 description 2
- 208000037976 chronic inflammation Diseases 0.000 description 2
- 230000006020 chronic inflammation Effects 0.000 description 2
- 229960001265 ciclosporin Drugs 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 235000017471 coenzyme Q10 Nutrition 0.000 description 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- GOWQBFVDZPZZFA-UHFFFAOYSA-N diethyl 2-fluoropropanedioate Chemical compound CCOC(=O)C(F)C(=O)OCC GOWQBFVDZPZZFA-UHFFFAOYSA-N 0.000 description 2
- 229960005156 digoxin Drugs 0.000 description 2
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 2
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 2
- 229960004166 diltiazem Drugs 0.000 description 2
- 208000037765 diseases and disorders Diseases 0.000 description 2
- XEYBHCRIKKKOSS-UHFFFAOYSA-N disodium;azanylidyneoxidanium;iron(2+);pentacyanide Chemical compound [Na+].[Na+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].[O+]#N XEYBHCRIKKKOSS-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000009429 distress Effects 0.000 description 2
- 229940030606 diuretics Drugs 0.000 description 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 description 2
- 229960004242 dronabinol Drugs 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 229940088679 drug related substance Drugs 0.000 description 2
- 239000003221 ear drop Substances 0.000 description 2
- 229940047652 ear drops Drugs 0.000 description 2
- 230000010102 embolization Effects 0.000 description 2
- 239000008387 emulsifying waxe Substances 0.000 description 2
- OYFJQPXVCSSHAI-QFPUQLAESA-N enalapril maleate Chemical compound OC(=O)\C=C/C(O)=O.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 OYFJQPXVCSSHAI-QFPUQLAESA-N 0.000 description 2
- 239000007920 enema Substances 0.000 description 2
- 229960001208 eplerenone Drugs 0.000 description 2
- JUKPWJGBANNWMW-VWBFHTRKSA-N eplerenone Chemical compound C([C@@H]1[C@]2(C)C[C@H]3O[C@]33[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)C(=O)OC)C[C@@]21CCC(=O)O1 JUKPWJGBANNWMW-VWBFHTRKSA-N 0.000 description 2
- 230000008029 eradication Effects 0.000 description 2
- FMVJYQGSRWVMQV-UHFFFAOYSA-N ethyl propiolate Chemical compound CCOC(=O)C#C FMVJYQGSRWVMQV-UHFFFAOYSA-N 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 229940012356 eye drops Drugs 0.000 description 2
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 description 2
- 210000003195 fascia Anatomy 0.000 description 2
- 229940125753 fibrate Drugs 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 229960000289 fluticasone propionate Drugs 0.000 description 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 210000002683 foot Anatomy 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 210000004392 genitalia Anatomy 0.000 description 2
- 229960004580 glibenclamide Drugs 0.000 description 2
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- 230000037313 granulation tissue formation Effects 0.000 description 2
- 230000009442 healing mechanism Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical class O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 230000036543 hypotension Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000003701 inert diluent Substances 0.000 description 2
- 239000007972 injectable composition Substances 0.000 description 2
- 229940124975 inotropic drug Drugs 0.000 description 2
- 238000007917 intracranial administration Methods 0.000 description 2
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 description 2
- 229960001888 ipratropium Drugs 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 2
- 229940011051 isopropyl acetate Drugs 0.000 description 2
- 229940093268 isordil Drugs 0.000 description 2
- 229960000201 isosorbide dinitrate Drugs 0.000 description 2
- 229960003827 isosorbide mononitrate Drugs 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 229960004340 lacidipine Drugs 0.000 description 2
- GKQPCPXONLDCMU-CCEZHUSRSA-N lacidipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1C1=CC=CC=C1\C=C\C(=O)OC(C)(C)C GKQPCPXONLDCMU-CCEZHUSRSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229960004294 lercanidipine Drugs 0.000 description 2
- ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 description 2
- 239000008297 liquid dosage form Substances 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 229960002701 liraglutide Drugs 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000005461 lubrication Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 229960004640 memantine Drugs 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229960003105 metformin Drugs 0.000 description 2
- 229960004329 metformin hydrochloride Drugs 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 2
- 229960000907 methylthioninium chloride Drugs 0.000 description 2
- 210000004088 microvessel Anatomy 0.000 description 2
- 210000004115 mitral valve Anatomy 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- KRKPYFLIYNGWTE-UHFFFAOYSA-N n,o-dimethylhydroxylamine Chemical compound CNOC KRKPYFLIYNGWTE-UHFFFAOYSA-N 0.000 description 2
- OKCJNSDIVCXYAL-UHFFFAOYSA-N n-(2,3-dihydro-1h-inden-2-yl)-2,2-difluoro-1,3-benzodioxole-5-carboxamide Chemical compound C1C2=CC=CC=C2CC1NC(=O)C1=CC=C2OC(F)(F)OC2=C1 OKCJNSDIVCXYAL-UHFFFAOYSA-N 0.000 description 2
- BOFMSBVSYVESTM-UHFFFAOYSA-N n-(2,3-dihydro-1h-inden-2-yl)-4-fluorobenzamide Chemical compound C1=CC(F)=CC=C1C(=O)NC1CC2=CC=CC=C2C1 BOFMSBVSYVESTM-UHFFFAOYSA-N 0.000 description 2
- HPNRHPKXQZSDFX-OAQDCNSJSA-N nesiritide Chemical compound C([C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 HPNRHPKXQZSDFX-OAQDCNSJSA-N 0.000 description 2
- 230000000926 neurological effect Effects 0.000 description 2
- LBHIOVVIQHSOQN-UHFFFAOYSA-N nicorandil Chemical compound [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1 LBHIOVVIQHSOQN-UHFFFAOYSA-N 0.000 description 2
- 229960002497 nicorandil Drugs 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 150000002823 nitrates Chemical class 0.000 description 2
- 229960005425 nitrendipine Drugs 0.000 description 2
- 239000002840 nitric oxide donor Substances 0.000 description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 239000000346 nonvolatile oil Substances 0.000 description 2
- 208000001797 obstructive sleep apnea Diseases 0.000 description 2
- 239000003883 ointment base Substances 0.000 description 2
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 2
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 description 2
- GSKDBLIBBOYOFU-UHFFFAOYSA-N oxadiazol-5-amine Chemical compound NC1=CN=NO1 GSKDBLIBBOYOFU-UHFFFAOYSA-N 0.000 description 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 2
- 230000036542 oxidative stress Effects 0.000 description 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 229960002296 paroxetine Drugs 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000000312 peanut oil Substances 0.000 description 2
- 230000018052 penile erection Effects 0.000 description 2
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 2
- 210000003516 pericardium Anatomy 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 210000003460 periosteum Anatomy 0.000 description 2
- 208000030613 peripheral artery disease Diseases 0.000 description 2
- 229940066842 petrolatum Drugs 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 229940000306 phentermine / topiramate Drugs 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 229960005095 pioglitazone Drugs 0.000 description 2
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 2
- 210000004224 pleura Anatomy 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000035752 proliferative phase Effects 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 235000013772 propylene glycol Nutrition 0.000 description 2
- KAQKFAOMNZTLHT-OZUDYXHBSA-N prostaglandin I2 Chemical compound O1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-OZUDYXHBSA-N 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 2
- XKMLYUALXHKNFT-UHFFFAOYSA-N rGTP Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O XKMLYUALXHKNFT-UHFFFAOYSA-N 0.000 description 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 230000004648 relaxation of smooth muscle Effects 0.000 description 2
- 229940118867 remodulin Drugs 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 210000005241 right ventricle Anatomy 0.000 description 2
- JZCPYUJPEARBJL-UHFFFAOYSA-N rimonabant Chemical compound CC=1C(C(=O)NN2CCCCC2)=NN(C=2C(=CC(Cl)=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 JZCPYUJPEARBJL-UHFFFAOYSA-N 0.000 description 2
- 229960003015 rimonabant Drugs 0.000 description 2
- 238000007363 ring formation reaction Methods 0.000 description 2
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 2
- 229960004586 rosiglitazone Drugs 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 2
- 239000008159 sesame oil Substances 0.000 description 2
- 235000011803 sesame oil Nutrition 0.000 description 2
- 230000035946 sexual desire Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229960002930 sirolimus Drugs 0.000 description 2
- 229960002578 sitaxentan Drugs 0.000 description 2
- PHWXUGHIIBDVKD-UHFFFAOYSA-N sitaxentan Chemical compound CC1=NOC(NS(=O)(=O)C2=C(SC=C2)C(=O)CC=2C(=CC=3OCOC=3C=2)C)=C1Cl PHWXUGHIIBDVKD-UHFFFAOYSA-N 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 229940083618 sodium nitroprusside Drugs 0.000 description 2
- 239000007909 solid dosage form Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 229960002370 sotalol Drugs 0.000 description 2
- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 2
- 229960002256 spironolactone Drugs 0.000 description 2
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000002889 sympathetic effect Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229960001685 tacrine Drugs 0.000 description 2
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 description 2
- 229960000195 terbutaline Drugs 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229960003604 testosterone Drugs 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 229960000278 theophylline Drugs 0.000 description 2
- 238000011287 therapeutic dose Methods 0.000 description 2
- 229940126585 therapeutic drug Drugs 0.000 description 2
- ICRHORQIUXBEPA-UHFFFAOYSA-N thionitrous acid Chemical compound SN=O ICRHORQIUXBEPA-UHFFFAOYSA-N 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 239000012049 topical pharmaceutical composition Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 2
- 229960001641 troglitazone Drugs 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 230000024883 vasodilation Effects 0.000 description 2
- QZFHIXARHDBPBY-UHFFFAOYSA-N vericiguat Chemical compound N1=C(N)C(NC(=O)OC)=C(N)N=C1C(C1=CC(F)=CN=C11)=NN1CC1=CC=CC=C1F QZFHIXARHDBPBY-UHFFFAOYSA-N 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 2
- 210000004885 white matter Anatomy 0.000 description 2
- 230000010388 wound contraction Effects 0.000 description 2
- 229960001522 ximelagatran Drugs 0.000 description 2
- ZXIBCJHYVWYIKI-PZJWPPBQSA-N ximelagatran Chemical compound C1([C@@H](NCC(=O)OCC)C(=O)N2[C@@H](CC2)C(=O)NCC=2C=CC(=CC=2)C(\N)=N\O)CCCCC1 ZXIBCJHYVWYIKI-PZJWPPBQSA-N 0.000 description 2
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
- CEMAWMOMDPGJMB-UHFFFAOYSA-N (+-)-Oxprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1OCC=C CEMAWMOMDPGJMB-UHFFFAOYSA-N 0.000 description 1
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- OOMBRKGIWITBLL-UHFFFAOYSA-N (2-fluorophenyl)methylhydrazine Chemical compound NNCC1=CC=CC=C1F OOMBRKGIWITBLL-UHFFFAOYSA-N 0.000 description 1
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 description 1
- NXWGWUVGUSFQJC-GFCCVEGCSA-N (2r)-1-[(2-methyl-1h-indol-4-yl)oxy]-3-(propan-2-ylamino)propan-2-ol Chemical compound CC(C)NC[C@@H](O)COC1=CC=CC2=C1C=C(C)N2 NXWGWUVGUSFQJC-GFCCVEGCSA-N 0.000 description 1
- RJMIEHBSYVWVIN-LLVKDONJSA-N (2r)-2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]propanoic acid Chemical compound C1=CC([C@H](C(O)=O)C)=CC=C1N1C(=O)C2=CC=CC=C2C1 RJMIEHBSYVWVIN-LLVKDONJSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 description 1
- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
- YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 description 1
- SUUWYOYAXFUOLX-ZBRNBAAYSA-N (2s)-2-aminobutanedioic acid;(2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O.OC(=O)[C@@H](N)CCCN=C(N)N SUUWYOYAXFUOLX-ZBRNBAAYSA-N 0.000 description 1
- GIANIJCPTPUNBA-QMMMGPOBSA-N (2s)-3-(4-hydroxyphenyl)-2-nitramidopropanoic acid Chemical compound [O-][N+](=O)N[C@H](C(=O)O)CC1=CC=C(O)C=C1 GIANIJCPTPUNBA-QMMMGPOBSA-N 0.000 description 1
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 description 1
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 description 1
- JDKLPDJLXHXHNV-MFVUMRCOSA-N (3s,6s,9r,12s,15s,23s)-15-[[(2s)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1h-imidazol-5-ylmethyl)-3-(1h-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide Chemical compound C([C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCNC(=O)C[C@@H](C(N[C@@H](CC=2NC=NC=2)C(=O)N1)=O)NC(=O)[C@@H](NC(C)=O)CCCC)C(N)=O)C1=CC=CC=C1 JDKLPDJLXHXHNV-MFVUMRCOSA-N 0.000 description 1
- SLKURXRZHJOZOD-RUZDIDTESA-N (4ar)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline Chemical compound C([C@]1(C2)COCC)N(S(=O)(=O)C=3C=CC(=CC=3)C(F)(F)F)CCC1=CC1=C2C=NN1C1=CC=C(F)C=C1 SLKURXRZHJOZOD-RUZDIDTESA-N 0.000 description 1
- HDHDTKMUACZDAA-PHNIDTBTSA-N (4r,7s,10s,13r,16s,19r,22r)-22-[[(2s)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[3-(diaminomethylideneamino)propyl]-16-(1h-imidazol-5-ylmethyl)-7-(1h-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20 Chemical compound C([C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](C(N[C@@H](CC=2N=CNC=2)C(=O)N1)=O)C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(N)=O)C1=CC=CC=C1 HDHDTKMUACZDAA-PHNIDTBTSA-N 0.000 description 1
- HMLGSIZOMSVISS-ONJSNURVSA-N (7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2,2-dimethylpropanoyloxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound N([C@@H]1C(N2C(=C(C=C)CSC21)C(O)=O)=O)C(=O)\C(=N/OCOC(=O)C(C)(C)C)C1=CSC(N)=N1 HMLGSIZOMSVISS-ONJSNURVSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
- PVHUJELLJLJGLN-INIZCTEOSA-N (S)-nitrendipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC([N+]([O-])=O)=C1 PVHUJELLJLJGLN-INIZCTEOSA-N 0.000 description 1
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 description 1
- KQHAZGURWZYZJG-BENRWUELSA-N (Z)-hydroxyimino-[methyl-[6-(methylamino)hexyl]amino]-oxidoazanium Chemical compound C[NH2+]CCCCCCN(C)[N+](\[O-])=N\[O-] KQHAZGURWZYZJG-BENRWUELSA-N 0.000 description 1
- FHGWEHGZBUBQKL-UHFFFAOYSA-N 1,2-benzothiazepine Chemical compound S1N=CC=CC2=CC=CC=C12 FHGWEHGZBUBQKL-UHFFFAOYSA-N 0.000 description 1
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 description 1
- UXYRXGFUANQKTA-UHFFFAOYSA-N 1,2-oxazole-3-carboxylic acid Chemical compound OC(=O)C=1C=CON=1 UXYRXGFUANQKTA-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 150000005207 1,3-dihydroxybenzenes Chemical class 0.000 description 1
- YFVKHKCZBSGZPE-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-2-(propylamino)propan-1-one Chemical compound CCCNC(C)C(=O)C1=CC=C2OCOC2=C1 YFVKHKCZBSGZPE-UHFFFAOYSA-N 0.000 description 1
- DOJOOVGKNBZITK-UHFFFAOYSA-N 1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazole-3-carboximidamide;hydrochloride Chemical compound Cl.C=1C=CC=C(F)C=1CN1N=C(C(=N)N)C=C1C=1C=CON=1 DOJOOVGKNBZITK-UHFFFAOYSA-N 0.000 description 1
- BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 description 1
- WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 description 1
- IVVNZDGDKPTYHK-JTQLQIEISA-N 1-cyano-2-[(2s)-3,3-dimethylbutan-2-yl]-3-pyridin-4-ylguanidine Chemical compound CC(C)(C)[C@H](C)N=C(NC#N)NC1=CC=NC=C1 IVVNZDGDKPTYHK-JTQLQIEISA-N 0.000 description 1
- SJJCQDRGABAVBB-UHFFFAOYSA-N 1-hydroxy-2-naphthoic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC=C21 SJJCQDRGABAVBB-UHFFFAOYSA-N 0.000 description 1
- NPMOWVIHURUZDS-UHFFFAOYSA-N 1-hydroxy-2-phenylguanidine Chemical compound ONC(N)=NC1=CC=CC=C1 NPMOWVIHURUZDS-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- TXQAZWIBPGKHOX-UHFFFAOYSA-N 1H-indol-3-amine Chemical compound C1=CC=C2C(N)=CNC2=C1 TXQAZWIBPGKHOX-UHFFFAOYSA-N 0.000 description 1
- MYQXHLQMZLTSDB-UHFFFAOYSA-N 2-(2-ethyl-2,3-dihydro-1-benzofuran-5-yl)acetic acid Chemical compound OC(=O)CC1=CC=C2OC(CC)CC2=C1 MYQXHLQMZLTSDB-UHFFFAOYSA-N 0.000 description 1
- MUFJHYRCIHHATF-UHFFFAOYSA-N 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid Chemical compound O1C(CC(=O)O)CC(C=2C=CC=CC=2)=N1 MUFJHYRCIHHATF-UHFFFAOYSA-N 0.000 description 1
- YJBONAUXKNXNTQ-UHFFFAOYSA-N 2-(4,4,4-trifluorobutyl)guanidine Chemical compound NC(=N)NCCCC(F)(F)F YJBONAUXKNXNTQ-UHFFFAOYSA-N 0.000 description 1
- DEMLYXMVPJAVFU-UHFFFAOYSA-N 2-(chloromethyl)oxirane;2-methyl-1h-imidazole Chemical compound ClCC1CO1.CC1=NC=CN1 DEMLYXMVPJAVFU-UHFFFAOYSA-N 0.000 description 1
- VTAKZNRDSPNOAU-UHFFFAOYSA-M 2-(chloromethyl)oxirane;hydron;prop-2-en-1-amine;n-prop-2-enyldecan-1-amine;trimethyl-[6-(prop-2-enylamino)hexyl]azanium;dichloride Chemical compound Cl.[Cl-].NCC=C.ClCC1CO1.CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C VTAKZNRDSPNOAU-UHFFFAOYSA-M 0.000 description 1
- YFJKHTZXXMBJEW-UHFFFAOYSA-N 2-[(4-chlorophenyl)sulfonylamino]-4,5-dimethoxy-n-(4-thiomorpholin-4-ylsulfonylphenyl)benzamide Chemical compound C=1C=C(S(=O)(=O)N2CCSCC2)C=CC=1NC(=O)C=1C=C(OC)C(OC)=CC=1NS(=O)(=O)C1=CC=C(Cl)C=C1 YFJKHTZXXMBJEW-UHFFFAOYSA-N 0.000 description 1
- DCXHLPGLBYHNMU-UHFFFAOYSA-N 2-[1-(4-azidobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(N=[N+]=[N-])C=C1 DCXHLPGLBYHNMU-UHFFFAOYSA-N 0.000 description 1
- APBSKHYXXKHJFK-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid Chemical compound OC(=O)CC1=CSC(C=2C=CC(Cl)=CC=2)=N1 APBSKHYXXKHJFK-UHFFFAOYSA-N 0.000 description 1
- TYCOFFBAZNSQOJ-UHFFFAOYSA-N 2-[4-(3-fluorophenyl)phenyl]propanoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC(F)=C1 TYCOFFBAZNSQOJ-UHFFFAOYSA-N 0.000 description 1
- JWAZHODZSADEHB-UHFFFAOYSA-M 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate;2-hydroxyethyl(trimethyl)azanium Chemical compound C[N+](C)(C)CCO.C1=CC(OC(C)(C)C([O-])=O)=CC=C1C(=O)C1=CC=C(Cl)C=C1 JWAZHODZSADEHB-UHFFFAOYSA-M 0.000 description 1
- OFCLXUCSWLPMAY-UHFFFAOYSA-N 2-[4-(hydroxyamino)butyl]guanidine Chemical compound NC(=N)NCCCCNO OFCLXUCSWLPMAY-UHFFFAOYSA-N 0.000 description 1
- NSVFSAJIGAJDMR-UHFFFAOYSA-N 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate Chemical compound CC=1NC(C)=C(C(=O)OCCN(CC=2C=CC=CC=2)C=2C=CC=CC=2)C(C=2C=C(C=CC=2)[N+]([O-])=O)C=1P1(=O)OCC(C)(C)CO1 NSVFSAJIGAJDMR-UHFFFAOYSA-N 0.000 description 1
- XKSAJZSJKURQRX-UHFFFAOYSA-N 2-acetyloxy-5-(4-fluorophenyl)benzoic acid Chemical compound C1=C(C(O)=O)C(OC(=O)C)=CC=C1C1=CC=C(F)C=C1 XKSAJZSJKURQRX-UHFFFAOYSA-N 0.000 description 1
- IOJUJUOXKXMJNF-UHFFFAOYSA-N 2-acetyloxybenzoic acid [3-(nitrooxymethyl)phenyl] ester Chemical compound CC(=O)OC1=CC=CC=C1C(=O)OC1=CC=CC(CO[N+]([O-])=O)=C1 IOJUJUOXKXMJNF-UHFFFAOYSA-N 0.000 description 1
- JIVPVXMEBJLZRO-CQSZACIVSA-N 2-chloro-5-[(1r)-1-hydroxy-3-oxo-2h-isoindol-1-yl]benzenesulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC([C@@]2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-CQSZACIVSA-N 0.000 description 1
- IJMQWMFWLFIPIF-UHFFFAOYSA-N 2-cyclopropyl-1-hydroxyguanidine Chemical compound ONC(=N)NC1CC1 IJMQWMFWLFIPIF-UHFFFAOYSA-N 0.000 description 1
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- SGUAFYQXFOLMHL-UHFFFAOYSA-N 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide Chemical compound C=1C=C(O)C(C(N)=O)=CC=1C(O)CNC(C)CCC1=CC=CC=C1 SGUAFYQXFOLMHL-UHFFFAOYSA-N 0.000 description 1
- ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 description 1
- YZQLWPMZQVHJED-UHFFFAOYSA-N 2-methylpropanethioic acid S-[2-[[[1-(2-ethylbutyl)cyclohexyl]-oxomethyl]amino]phenyl] ester Chemical compound C=1C=CC=C(SC(=O)C(C)C)C=1NC(=O)C1(CC(CC)CC)CCCCC1 YZQLWPMZQVHJED-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- PPWLAQVKIFDULF-UHFFFAOYSA-N 2-phenyl-1h-pyrrolo[2,3-b]pyridine Chemical compound N1C2=NC=CC=C2C=C1C1=CC=CC=C1 PPWLAQVKIFDULF-UHFFFAOYSA-N 0.000 description 1
- ILYSAKHOYBPSPC-UHFFFAOYSA-N 2-phenylbenzoic acid Chemical class OC(=O)C1=CC=CC=C1C1=CC=CC=C1 ILYSAKHOYBPSPC-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- NMKSAYKQLCHXDK-UHFFFAOYSA-N 3,3-diphenyl-N-(1-phenylethyl)-1-propanamine Chemical compound C=1C=CC=CC=1C(C)NCCC(C=1C=CC=CC=1)C1=CC=CC=C1 NMKSAYKQLCHXDK-UHFFFAOYSA-N 0.000 description 1
- LHAMNQGGGDUVFZ-UHFFFAOYSA-N 3,4-dihydrodiazete Chemical compound C1CN=N1 LHAMNQGGGDUVFZ-UHFFFAOYSA-N 0.000 description 1
- JYAHXBWSCRHPMZ-UHFFFAOYSA-N 3-[5-(4,6-dichloro-5-fluoropyrimidin-2-yl)-2-[(2-fluorophenyl)methyl]pyrazol-3-yl]-1,2-oxazole Chemical compound FC1=CC=CC=C1CN1C(C2=NOC=C2)=CC(C=2N=C(Cl)C(F)=C(Cl)N=2)=N1 JYAHXBWSCRHPMZ-UHFFFAOYSA-N 0.000 description 1
- XDQRQLMGRLFVJW-UHFFFAOYSA-N 3-[5-(4-chloro-5-fluoro-6-methoxypyrimidin-2-yl)-2-[(2-fluorophenyl)methyl]pyrazol-3-yl]-1,2-oxazole Chemical compound ClC1=C(F)C(OC)=NC(C2=NN(CC=3C(=CC=CC=3)F)C(C3=NOC=C3)=C2)=N1 XDQRQLMGRLFVJW-UHFFFAOYSA-N 0.000 description 1
- GQGRIOSSVHQMPS-UHFFFAOYSA-N 3-[5-(4-chloro-5-fluoropyrimidin-2-yl)-2-[(2-fluorophenyl)methyl]pyrazol-3-yl]-1,2-oxazole Chemical compound FC1=CC=CC=C1CN1C(C2=NOC=C2)=CC(C=2N=C(Cl)C(F)=CN=2)=N1 GQGRIOSSVHQMPS-UHFFFAOYSA-N 0.000 description 1
- SGJXCKCBCGRUQQ-UHFFFAOYSA-N 3-[5-(5-fluoro-4-methoxypyrimidin-2-yl)-2-[(2-fluorophenyl)methyl]pyrazol-3-yl]-1,2-oxazole Chemical compound C1=C(F)C(OC)=NC(C2=NN(CC=3C(=CC=CC=3)F)C(C3=NOC=C3)=C2)=N1 SGJXCKCBCGRUQQ-UHFFFAOYSA-N 0.000 description 1
- OCNBSSLDAIWTKS-UHFFFAOYSA-N 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyltetrazol-5-yl)amino]methyl]-n,n-bis(cyclopropylmethyl)-8-methylquinolin-2-amine Chemical compound C1CC1CN(CC1CC1)C=1N=C2C(C)=CC=CC2=CC=1CN(C1=NN(C)N=N1)CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 OCNBSSLDAIWTKS-UHFFFAOYSA-N 0.000 description 1
- XSFVAQRSZSENGO-UHFFFAOYSA-N 3-benzyl-2h-indazole Chemical compound N1N=C2C=CC=CC2=C1CC1=CC=CC=C1 XSFVAQRSZSENGO-UHFFFAOYSA-N 0.000 description 1
- ONZQYZKCUHFORE-UHFFFAOYSA-N 3-bromo-1,1,1-trifluoropropan-2-one Chemical compound FC(F)(F)C(=O)CBr ONZQYZKCUHFORE-UHFFFAOYSA-N 0.000 description 1
- TYNLGDBUJLVSMA-UHFFFAOYSA-N 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid Chemical compound O=C1C2=CC(C(O)=O)=CC(OC(C)=O)=C2C(=O)C2=C1C=CC=C2OC(=O)C TYNLGDBUJLVSMA-UHFFFAOYSA-N 0.000 description 1
- VUUUHLIHQHVLLE-UHFFFAOYSA-N 4-[(5-fluoropyridin-2-yl)methoxy]-1-(5-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-7-yl)pyridin-2-one Chemical compound C1=C2N(C)C=3CCNCC=3C2=CC=C1N(C(C=1)=O)C=CC=1OCC1=CC=C(F)C=N1 VUUUHLIHQHVLLE-UHFFFAOYSA-N 0.000 description 1
- XWBXJBSVYVJAMZ-UHFFFAOYSA-N 4-[4-(2-adamantylcarbamoyl)-5-tert-butylpyrazol-1-yl]benzoic acid Chemical compound CC(C)(C)C1=C(C(=O)NC2C3CC4CC(C3)CC2C4)C=NN1C1=CC=C(C(O)=O)C=C1 XWBXJBSVYVJAMZ-UHFFFAOYSA-N 0.000 description 1
- PZSMUPGANZGPBF-UHFFFAOYSA-N 4-[5-(dithiolan-3-yl)pentanoylamino]butanoic acid Chemical compound OC(=O)CCCNC(=O)CCCCC1CCSS1 PZSMUPGANZGPBF-UHFFFAOYSA-N 0.000 description 1
- SYCHUQUJURZQMO-UHFFFAOYSA-N 4-hydroxy-2-methyl-1,1-dioxo-n-(1,3-thiazol-2-yl)-1$l^{6},2-benzothiazine-3-carboxamide Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=CS1 SYCHUQUJURZQMO-UHFFFAOYSA-N 0.000 description 1
- PJJGZPJJTHBVMX-UHFFFAOYSA-N 5,7-Dihydroxyisoflavone Chemical compound C=1C(O)=CC(O)=C(C2=O)C=1OC=C2C1=CC=CC=C1 PJJGZPJJTHBVMX-UHFFFAOYSA-N 0.000 description 1
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 1
- YZCSJBGQLATPMH-UHFFFAOYSA-N 5-[3-(dimethylamino)propoxy]-N-(4-methoxyphenyl)-2-(phenylmethyl)-3-pyrazolecarboxamide Chemical compound C1=CC(OC)=CC=C1NC(=O)C1=CC(OCCCN(C)C)=NN1CC1=CC=CC=C1 YZCSJBGQLATPMH-UHFFFAOYSA-N 0.000 description 1
- MVDXXGIBARMXSA-PYUWXLGESA-N 5-[[(2r)-2-benzyl-3,4-dihydro-2h-chromen-6-yl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1CC1=CC=C(O[C@@H](CC=2C=CC=CC=2)CC2)C2=C1 MVDXXGIBARMXSA-PYUWXLGESA-N 0.000 description 1
- PQHLRGARXNPFCF-UHFFFAOYSA-N 5-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]-n-(4-morpholin-4-ylsulfonylphenyl)benzamide Chemical compound S1C(Cl)=CC=C1S(=O)(=O)NC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(S(=O)(=O)N2CCOCC2)C=C1 PQHLRGARXNPFCF-UHFFFAOYSA-N 0.000 description 1
- YIEAVVIJPFEHCX-UHFFFAOYSA-N 5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-4a,7a-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-one Chemical compound CCCOC1=CC=C(C=C1C1=NC2C(N(CC)C=C2CCC)C(=O)N1)S(=O)(=O)N1CCN(CCO)CC1 YIEAVVIJPFEHCX-UHFFFAOYSA-N 0.000 description 1
- LIVYVCAUBHXIMI-UHFFFAOYSA-N 5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-1h-pyrimidin-6-one Chemical compound C1=C(F)C(O)=NC(C2=NN(CC=3C(=CC=CC=3)F)C(C3=NOC=C3)=C2)=N1 LIVYVCAUBHXIMI-UHFFFAOYSA-N 0.000 description 1
- ZPANOJAXKGHYBC-UHFFFAOYSA-N 5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-4-hydroxy-1h-pyrimidin-6-one Chemical compound N1C(=O)C(F)=C(O)N=C1C1=NN(CC=2C(=CC=CC=2)F)C(C2=NOC=C2)=C1 ZPANOJAXKGHYBC-UHFFFAOYSA-N 0.000 description 1
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
- RBSGUQYXRDKPAE-QFIPXVFZSA-N 6-[4-[2-[[(2s)-3-(9h-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]pyridine-3-carboxamide Chemical compound C([C@H](O)COC=1C=2C3=CC=CC=C3NC=2C=CC=1)NC(C)(C)CC(C=C1)=CC=C1OC1=CC=C(C(N)=O)C=N1 RBSGUQYXRDKPAE-QFIPXVFZSA-N 0.000 description 1
- BKYKPTRYDKTTJY-UHFFFAOYSA-N 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1CCCC1 BKYKPTRYDKTTJY-UHFFFAOYSA-N 0.000 description 1
- DHSSDEDRBUKTQY-UHFFFAOYSA-N 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine Chemical compound C1CN(CC=C)CCC2=C1N=C(N)S2 DHSSDEDRBUKTQY-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical class C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 1
- DJQOOSBJCLSSEY-UHFFFAOYSA-N Acipimox Chemical compound CC1=CN=C(C(O)=O)C=[N+]1[O-] DJQOOSBJCLSSEY-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- QYPPJABKJHAVHS-UHFFFAOYSA-N Agmatine Natural products NCCCCNC(N)=N QYPPJABKJHAVHS-UHFFFAOYSA-N 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 description 1
- ITPDYQOUSLNIHG-UHFFFAOYSA-N Amiodarone hydrochloride Chemical compound [Cl-].CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC[NH+](CC)CC)C(I)=C1 ITPDYQOUSLNIHG-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- NCUCGYYHUFIYNU-UHFFFAOYSA-N Aranidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)=O)C1C1=CC=CC=C1[N+]([O-])=O NCUCGYYHUFIYNU-UHFFFAOYSA-N 0.000 description 1
- 208000031104 Arterial Occlusive disease Diseases 0.000 description 1
- 208000036490 Arterial inflammations Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 description 1
- 208000004746 Atrophic Vaginitis Diseases 0.000 description 1
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 description 1
- 229930003347 Atropine Natural products 0.000 description 1
- 235000007319 Avena orientalis Nutrition 0.000 description 1
- 235000007558 Avena sp Nutrition 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 description 1
- 239000005528 B01AC05 - Ticlopidine Substances 0.000 description 1
- 229940127280 BAY 41-2272 Drugs 0.000 description 1
- ATOAHNRJAXSBOR-UHFFFAOYSA-N BAY 41-2272 Chemical compound NC1=NC(C=2C3=CC=CN=C3N(CC=3C(=CC=CC=3)F)N=2)=NC=C1C1CC1 ATOAHNRJAXSBOR-UHFFFAOYSA-N 0.000 description 1
- AQYFUZRYBJBAGZ-UHFFFAOYSA-N BAY-41-8543 Chemical compound NC1=NC(C=2C3=CC=CN=C3N(CC=3C(=CC=CC=3)F)N=2)=NC(N)=C1N1CCOCC1 AQYFUZRYBJBAGZ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 208000006274 Brain Stem Neoplasms Diseases 0.000 description 1
- 102400000667 Brain natriuretic peptide 32 Human genes 0.000 description 1
- 101800002247 Brain natriuretic peptide 45 Proteins 0.000 description 1
- PJFHZKIDENOSJB-UHFFFAOYSA-N Budesonide/formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1.C1CC2=CC(=O)C=CC2(C)C2C1C1CC3OC(CCC)OC3(C(=O)CO)C1(C)CC2O PJFHZKIDENOSJB-UHFFFAOYSA-N 0.000 description 1
- RHLJLALHBZGAFM-UHFFFAOYSA-N Bunazosinum Chemical compound C1CN(C(=O)CCC)CCCN1C1=NC(N)=C(C=C(OC)C(OC)=C2)C2=N1 RHLJLALHBZGAFM-UHFFFAOYSA-N 0.000 description 1
- 239000004358 Butane-1, 3-diol Substances 0.000 description 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 239000002083 C09CA01 - Losartan Substances 0.000 description 1
- 239000004072 C09CA03 - Valsartan Substances 0.000 description 1
- 239000002947 C09CA04 - Irbesartan Substances 0.000 description 1
- 239000005537 C09CA07 - Telmisartan Substances 0.000 description 1
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 1
- 108010002025 CER-001 Proteins 0.000 description 1
- 201000002829 CREST Syndrome Diseases 0.000 description 1
- KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 description 1
- QLTVVOATEHFXLT-UHFFFAOYSA-N Cadralazine Chemical compound CCOC(=O)NNC1=CC=C(N(CC)CC(C)O)N=N1 QLTVVOATEHFXLT-UHFFFAOYSA-N 0.000 description 1
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 1
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 1
- OKTJSMMVPCPJKN-NJFSPNSNSA-N Carbon-14 Chemical compound [14C] OKTJSMMVPCPJKN-NJFSPNSNSA-N 0.000 description 1
- 206010007513 Cardiac aneurysm Diseases 0.000 description 1
- 206010007556 Cardiac failure acute Diseases 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- RKWGIWYCVPQPMF-UHFFFAOYSA-N Chloropropamide Chemical compound CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1 RKWGIWYCVPQPMF-UHFFFAOYSA-N 0.000 description 1
- 229920001268 Cholestyramine Polymers 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- CVKNDPRBJVBDSS-UHFFFAOYSA-N Cicletanine Chemical compound O1CC2=C(O)C(C)=NC=C2C1C1=CC=C(Cl)C=C1 CVKNDPRBJVBDSS-UHFFFAOYSA-N 0.000 description 1
- KPSRODZRAIWAKH-JTQLQIEISA-N Ciprofibrate Natural products C1=CC(OC(C)(C)C(O)=O)=CC=C1[C@H]1C(Cl)(Cl)C1 KPSRODZRAIWAKH-JTQLQIEISA-N 0.000 description 1
- 206010009192 Circulatory collapse Diseases 0.000 description 1
- OIRAEJWYWSAQNG-UHFFFAOYSA-N Clidanac Chemical compound ClC=1C=C2C(C(=O)O)CCC2=CC=1C1CCCCC1 OIRAEJWYWSAQNG-UHFFFAOYSA-N 0.000 description 1
- BMOVQUBVGICXQN-UHFFFAOYSA-N Clinofibrate Chemical compound C1=CC(OC(C)(CC)C(O)=O)=CC=C1C1(C=2C=CC(OC(C)(CC)C(O)=O)=CC=2)CCCCC1 BMOVQUBVGICXQN-UHFFFAOYSA-N 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- 229920002905 Colesevelam Polymers 0.000 description 1
- 229920000230 Colestilan Polymers 0.000 description 1
- 229920002911 Colestipol Polymers 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 208000013600 Diabetic vascular disease Diseases 0.000 description 1
- 208000003037 Diastolic Heart Failure Diseases 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 description 1
- 229940123900 Direct thrombin inhibitor Drugs 0.000 description 1
- JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical class C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 description 1
- 102000015554 Dopamine receptor Human genes 0.000 description 1
- 108050004812 Dopamine receptor Proteins 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 206010014476 Elevated cholesterol Diseases 0.000 description 1
- 206010014486 Elevated triglycerides Diseases 0.000 description 1
- 206010014513 Embolism arterial Diseases 0.000 description 1
- 108010066671 Enalaprilat Proteins 0.000 description 1
- 108050009340 Endothelin Proteins 0.000 description 1
- 102000002045 Endothelin Human genes 0.000 description 1
- 102100036725 Epithelial discoidin domain-containing receptor 1 Human genes 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- HTQBXNHDCUEHJF-XWLPCZSASA-N Exenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 description 1
- 108010011459 Exenatide Proteins 0.000 description 1
- OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 description 1
- 206010016228 Fasciitis Diseases 0.000 description 1
- CVKUMNRCIJMVAR-UHFFFAOYSA-N Fenoldopam mesylate Chemical compound CS(O)(=O)=O.C1=CC(O)=CC=C1C1C2=CC(O)=C(O)C(Cl)=C2CCNC1 CVKUMNRCIJMVAR-UHFFFAOYSA-N 0.000 description 1
- RBBWCVQDXDFISW-UHFFFAOYSA-N Feprazone Chemical compound O=C1C(CC=C(C)C)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 RBBWCVQDXDFISW-UHFFFAOYSA-N 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 206010027677 Fractures and dislocations Diseases 0.000 description 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 241000699694 Gerbillinae Species 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 206010018341 Gliosis Diseases 0.000 description 1
- FAEKWTJYAYMJKF-QHCPKHFHSA-N GlucoNorm Chemical compound C1=C(C(O)=O)C(OCC)=CC(CC(=O)N[C@@H](CC(C)C)C=2C(=CC=CC=2)N2CCCCC2)=C1 FAEKWTJYAYMJKF-QHCPKHFHSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- INJOMKTZOLKMBF-UHFFFAOYSA-N Guanfacine Chemical compound NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl INJOMKTZOLKMBF-UHFFFAOYSA-N 0.000 description 1
- 108010010234 HDL Lipoproteins Proteins 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 208000016988 Hemorrhagic Stroke Diseases 0.000 description 1
- 208000028782 Hereditary disease Diseases 0.000 description 1
- 101000780028 Homo sapiens Natriuretic peptides A Proteins 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
- OMCPLEZZPVJJIS-UHFFFAOYSA-N Hypadil (TN) Chemical compound C1C(O[N+]([O-])=O)COC2=C1C=CC=C2OCC(O)CNC(C)C OMCPLEZZPVJJIS-UHFFFAOYSA-N 0.000 description 1
- 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 description 1
- 206010058359 Hypogonadism Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- FQYQMFCIJNWDQZ-CYDGBPFRSA-N Ile-Pro-Pro Chemical compound CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 FQYQMFCIJNWDQZ-CYDGBPFRSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 description 1
- 229940122199 Insulin secretagogue Drugs 0.000 description 1
- 238000012695 Interfacial polymerization Methods 0.000 description 1
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
- 108700021006 Interleukin-1 receptor antagonist Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- PJLVTVAIERNDEQ-BTJKTKAUSA-N Irsogladine maleate Chemical compound OC(=O)\C=C/C(O)=O.NC1=NC(N)=NC(C=2C(=CC=C(Cl)C=2)Cl)=N1 PJLVTVAIERNDEQ-BTJKTKAUSA-N 0.000 description 1
- 208000032382 Ischaemic stroke Diseases 0.000 description 1
- 108010041872 Islet Amyloid Polypeptide Chemical class 0.000 description 1
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 description 1
- HUYWAWARQUIQLE-UHFFFAOYSA-N Isoetharine Chemical compound CC(C)NC(CC)C(O)C1=CC=C(O)C(O)=C1 HUYWAWARQUIQLE-UHFFFAOYSA-N 0.000 description 1
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 description 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
- 208000011200 Kawasaki disease Diseases 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 125000002059 L-arginyl group Chemical class O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- FSBIGDSBMBYOPN-VKHMYHEASA-N L-canavanine Chemical compound OC(=O)[C@@H](N)CCONC(N)=N FSBIGDSBMBYOPN-VKHMYHEASA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- JXNRXNCCROJZFB-RYUDHWBXSA-O L-tyrosiniumyl-L-arginine(1+) Chemical compound NC(=[NH2+])NCCC[C@@H](C([O-])=O)NC(=O)[C@@H]([NH3+])CC1=CC=C(O)C=C1 JXNRXNCCROJZFB-RYUDHWBXSA-O 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 240000002605 Lactobacillus helveticus Species 0.000 description 1
- 235000013967 Lactobacillus helveticus Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000004552 Lacunar Stroke Diseases 0.000 description 1
- 240000000759 Lepidium meyenii Species 0.000 description 1
- 235000000421 Lepidium meyenii Nutrition 0.000 description 1
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- LTXREWYXXSTFRX-QGZVFWFLSA-N Linagliptin Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 LTXREWYXXSTFRX-QGZVFWFLSA-N 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 239000004907 Macro-emulsion Substances 0.000 description 1
- 206010057672 Male sexual dysfunction Diseases 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 description 1
- 208000024556 Mendelian disease Diseases 0.000 description 1
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 description 1
- HBNPJJILLOYFJU-VMPREFPWSA-N Mibefradil Chemical compound C1CC2=CC(F)=CC=C2[C@H](C(C)C)[C@@]1(OC(=O)COC)CCN(C)CCCC1=NC2=CC=CC=C2N1 HBNPJJILLOYFJU-VMPREFPWSA-N 0.000 description 1
- UWWDHYUMIORJTA-HSQYWUDLSA-N Moexipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC(OC)=C(OC)C=C2C1)C(O)=O)CC1=CC=CC=C1 UWWDHYUMIORJTA-HSQYWUDLSA-N 0.000 description 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 description 1
- WPNJAUFVNXKLIM-UHFFFAOYSA-N Moxonidine Chemical compound COC1=NC(C)=NC(Cl)=C1NC1=NCCN1 WPNJAUFVNXKLIM-UHFFFAOYSA-N 0.000 description 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
- 208000008238 Muscle Spasticity Diseases 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- RTGDFNSFWBGLEC-UHFFFAOYSA-N Mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1CC=C(C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-UHFFFAOYSA-N 0.000 description 1
- 108010083674 Myelin Proteins Proteins 0.000 description 1
- 102000006386 Myelin Proteins Human genes 0.000 description 1
- 206010028604 Myocardial rupture Diseases 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- FQWRAVYMZULPNK-BYPYZUCNSA-N N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NO FQWRAVYMZULPNK-BYPYZUCNSA-N 0.000 description 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 238000007126 N-alkylation reaction Methods 0.000 description 1
- RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- JZFPYUNJRRFVQU-UHFFFAOYSA-N Niflumic acid Chemical compound OC(=O)C1=CC=CN=C1NC1=CC=CC(C(F)(F)F)=C1 JZFPYUNJRRFVQU-UHFFFAOYSA-N 0.000 description 1
- FAIIFDPAEUKBEP-UHFFFAOYSA-N Nilvadipine Chemical compound COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC([N+]([O-])=O)=C1 FAIIFDPAEUKBEP-UHFFFAOYSA-N 0.000 description 1
- 102000011779 Nitric Oxide Synthase Type II Human genes 0.000 description 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- PHVGLTMQBUFIQQ-UHFFFAOYSA-N Nortryptiline Chemical compound C1CC2=CC=CC=C2C(=CCCNC)C2=CC=CC=C21 PHVGLTMQBUFIQQ-UHFFFAOYSA-N 0.000 description 1
- 229920003355 Novatec® Polymers 0.000 description 1
- FSBIGDSBMBYOPN-UHFFFAOYSA-N O-guanidino-DL-homoserine Natural products OC(=O)C(N)CCON=C(N)N FSBIGDSBMBYOPN-UHFFFAOYSA-N 0.000 description 1
- LSGIIWMOYDZCCN-VQHVLOKHSA-N O1N=C(C=C1)C(/C=C(\C(=O)OCC)/N(C)OC)=O Chemical compound O1N=C(C=C1)C(/C=C(\C(=O)OCC)/N(C)OC)=O LSGIIWMOYDZCCN-VQHVLOKHSA-N 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005480 Olmesartan Substances 0.000 description 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 description 1
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 description 1
- 229940076380 PDE9 inhibitor Drugs 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 240000001090 Papaver somniferum Species 0.000 description 1
- 235000008753 Papaver somniferum Nutrition 0.000 description 1
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 1
- 101800001672 Peptide YY(3-36) Proteins 0.000 description 1
- 208000005228 Pericardial Effusion Diseases 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- 229940123263 Phosphodiesterase 3 inhibitor Drugs 0.000 description 1
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 description 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- 208000002151 Pleural effusion Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- CYLWJCABXYDINA-UHFFFAOYSA-N Polythiazide Polymers ClC1=C(S(N)(=O)=O)C=C2S(=O)(=O)N(C)C(CSCC(F)(F)F)NC2=C1 CYLWJCABXYDINA-UHFFFAOYSA-N 0.000 description 1
- TVQZAMVBTVNYLA-UHFFFAOYSA-N Pranoprofen Chemical compound C1=CC=C2CC3=CC(C(C(O)=O)C)=CC=C3OC2=N1 TVQZAMVBTVNYLA-UHFFFAOYSA-N 0.000 description 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 description 1
- 206010037211 Psychomotor hyperactivity Diseases 0.000 description 1
- 241000340987 Ptychopetalum olacoides Species 0.000 description 1
- 208000011191 Pulmonary vascular disease Diseases 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 208000007718 Stable Angina Diseases 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- JLRGJRBPOGGCBT-UHFFFAOYSA-N Tolbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 JLRGJRBPOGGCBT-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 description 1
- 241001521901 Tribulus lanuginosus Species 0.000 description 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 description 1
- 206010067775 Upper airway obstruction Diseases 0.000 description 1
- ICMGLRUYEQNHPF-UHFFFAOYSA-N Uraprene Chemical compound COC1=CC=CC=C1N1CCN(CCCNC=2N(C(=O)N(C)C(=O)C=2)C)CC1 ICMGLRUYEQNHPF-UHFFFAOYSA-N 0.000 description 1
- 206010065584 Urethral stenosis Diseases 0.000 description 1
- DOFAQXCYFQKSHT-SRVKXCTJSA-N Val-Pro-Pro Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 DOFAQXCYFQKSHT-SRVKXCTJSA-N 0.000 description 1
- 208000030451 Vascular dementia disease Diseases 0.000 description 1
- 229940116211 Vasopressin antagonist Drugs 0.000 description 1
- 206010047163 Vasospasm Diseases 0.000 description 1
- ZVNYJIZDIRKMBF-UHFFFAOYSA-N Vesnarinone Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)N1CCN(C=2C=C3CCC(=O)NC3=CC=2)CC1 ZVNYJIZDIRKMBF-UHFFFAOYSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- PFRQBZFETXBLTP-UHFFFAOYSA-N Vitamin K2 Natural products C1=CC=C2C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-UHFFFAOYSA-N 0.000 description 1
- FZNCGRZWXLXZSZ-CIQUZCHMSA-N Voglibose Chemical compound OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O FZNCGRZWXLXZSZ-CIQUZCHMSA-N 0.000 description 1
- 206010047924 Wheezing Diseases 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- YDTUJCNTIMWHPJ-NRFANRHFSA-N [(1r)-2-[4-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3-yl]-2-methoxyphenoxy]-1-cyclopropylethyl] dihydrogen phosphate Chemical compound C1([C@@H](OP(O)(O)=O)COC2=CC=C(C=C2OC)N2C(C=3SC(=CC=3N=C2)C=2C=CC(Cl)=CC=2)=O)CC1 YDTUJCNTIMWHPJ-NRFANRHFSA-N 0.000 description 1
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 description 1
- ZKEMUPZLDSXZCX-CEVDDVLHSA-N [(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]prop-2-enoate oxalic acid Chemical compound OC(=O)C(O)=O.C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=2C=CC(OCCN(C)C)=CC=2)C[C@@]21CO2.C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=2C=CC(OCCN(C)C)=CC=2)C[C@@]21CO2 ZKEMUPZLDSXZCX-CEVDDVLHSA-N 0.000 description 1
- YYAZJTUGSQOFHG-IAVNQIGZSA-N [(6s,8s,10s,11s,13s,14s,16r,17r)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]eth Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)C1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O YYAZJTUGSQOFHG-IAVNQIGZSA-N 0.000 description 1
- MJHYBJOMJPGNMM-KGWLDMEJSA-N [2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 4-(nitrooxymethyl)benzoate Chemical compound O=C([C@@]1(O)CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)[C@@H](O)C[C@@]21C)COC(=O)C1=CC=C(CO[N+]([O-])=O)C=C1 MJHYBJOMJPGNMM-KGWLDMEJSA-N 0.000 description 1
- RISQVQFWBQSZQE-OBOLPPCUSA-N [2-methoxy-5-[(e)-3-(4-nitrooxybutoxy)-3-oxoprop-1-enyl]phenyl] (4r)-4-[(3r,5s,7s,8r,9s,10s,13r,14s,17r)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoate Chemical compound COC1=CC=C(\C=C\C(=O)OCCCCO[N+]([O-])=O)C=C1OC(=O)CC[C@@H](C)[C@@H]1[C@@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](O)C[C@H]4C[C@H](O)[C@H]3[C@@H]2CC1 RISQVQFWBQSZQE-OBOLPPCUSA-N 0.000 description 1
- CTHNKWFUDCMLIQ-UHFFFAOYSA-N [4-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate Chemical compound CC(=O)OC1=CC=CC=C1C(=O)OC1=CC=C(CO[N+]([O-])=O)C=C1 CTHNKWFUDCMLIQ-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 229960002632 acarbose Drugs 0.000 description 1
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 description 1
- 229960002122 acebutolol Drugs 0.000 description 1
- GOEMGAFJFRBGGG-UHFFFAOYSA-N acebutolol Chemical compound CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 GOEMGAFJFRBGGG-UHFFFAOYSA-N 0.000 description 1
- 229960004892 acemetacin Drugs 0.000 description 1
- FSQKKOOTNAMONP-UHFFFAOYSA-N acemetacin Chemical compound CC1=C(CC(=O)OCC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 FSQKKOOTNAMONP-UHFFFAOYSA-N 0.000 description 1
- 229940062352 aceon Drugs 0.000 description 1
- BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 description 1
- 229960000571 acetazolamide Drugs 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- VYMCYRPQICLHKC-WCCKRBBISA-N acetic acid;(2s)-2-amino-5-[[amino-(hydroxyamino)methylidene]amino]pentanoic acid Chemical compound CC(O)=O.OC(=O)[C@@H](N)CCCN=C(N)NO VYMCYRPQICLHKC-WCCKRBBISA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229960001466 acetohexamide Drugs 0.000 description 1
- VGZSUPCWNCWDAN-UHFFFAOYSA-N acetohexamide Chemical compound C1=CC(C(=O)C)=CC=C1S(=O)(=O)NC(=O)NC1CCCCC1 VGZSUPCWNCWDAN-UHFFFAOYSA-N 0.000 description 1
- 229960003526 acipimox Drugs 0.000 description 1
- 150000003926 acrylamides Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229940062328 actos Drugs 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000004721 adaptive immunity Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940099424 adenocard Drugs 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 108060000200 adenylate cyclase Proteins 0.000 description 1
- 102000030621 adenylate cyclase Human genes 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000000048 adrenergic agonist Substances 0.000 description 1
- 239000000695 adrenergic alpha-agonist Substances 0.000 description 1
- 239000000674 adrenergic antagonist Substances 0.000 description 1
- 210000002934 adrenergic neuron Anatomy 0.000 description 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229940090167 advair Drugs 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- QYPPJABKJHAVHS-UHFFFAOYSA-P agmatinium(2+) Chemical compound NC(=[NH2+])NCCCC[NH3+] QYPPJABKJHAVHS-UHFFFAOYSA-P 0.000 description 1
- 230000001270 agonistic effect Effects 0.000 description 1
- 229960005142 alclofenac Drugs 0.000 description 1
- ARHWPKZXBHOEEE-UHFFFAOYSA-N alclofenac Chemical compound OC(=O)CC1=CC=C(OCC=C)C(Cl)=C1 ARHWPKZXBHOEEE-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940083712 aldosterone antagonist Drugs 0.000 description 1
- 239000002170 aldosterone antagonist Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 229960004601 aliskiren Drugs 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229960001667 alogliptin Drugs 0.000 description 1
- ZSBOMTDTBDDKMP-OAHLLOKOSA-N alogliptin Chemical compound C=1C=CC=C(C#N)C=1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1 ZSBOMTDTBDDKMP-OAHLLOKOSA-N 0.000 description 1
- 239000002160 alpha blocker Substances 0.000 description 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 102000030619 alpha-1 Adrenergic Receptor Human genes 0.000 description 1
- 108020004102 alpha-1 Adrenergic Receptor Proteins 0.000 description 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 description 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 description 1
- 229940124308 alpha-adrenoreceptor antagonist Drugs 0.000 description 1
- 229960003318 alteplase Drugs 0.000 description 1
- 229960002414 ambrisentan Drugs 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 description 1
- 229960002576 amiloride Drugs 0.000 description 1
- 238000005576 amination reaction Methods 0.000 description 1
- 229960000959 amineptine Drugs 0.000 description 1
- VDPUXONTAVMIKZ-UHFFFAOYSA-N amineptine hydrochloride Chemical compound [Cl-].C1CC2=CC=CC=C2C([NH2+]CCCCCCC(=O)O)C2=CC=CC=C21 VDPUXONTAVMIKZ-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000005005 aminopyrimidines Chemical class 0.000 description 1
- 229960005260 amiodarone Drugs 0.000 description 1
- 229960000836 amitriptyline Drugs 0.000 description 1
- 229960000528 amlodipine Drugs 0.000 description 1
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 238000005280 amorphization Methods 0.000 description 1
- 229950010351 amosulalol Drugs 0.000 description 1
- LVEXHFZHOIWIIP-UHFFFAOYSA-N amosulalol Chemical compound COC1=CC=CC=C1OCCNCC(O)C1=CC=C(C)C(S(N)(=O)=O)=C1 LVEXHFZHOIWIIP-UHFFFAOYSA-N 0.000 description 1
- 229960002519 amoxapine Drugs 0.000 description 1
- 229960002105 amrinone Drugs 0.000 description 1
- RNLQIBCLLYYYFJ-UHFFFAOYSA-N amrinone Chemical compound N1C(=O)C(N)=CC(C=2C=CN=CC=2)=C1 RNLQIBCLLYYYFJ-UHFFFAOYSA-N 0.000 description 1
- 229960003116 amyl nitrite Drugs 0.000 description 1
- 206010002022 amyloidosis Diseases 0.000 description 1
- MZZLGJHLQGUVPN-HAWMADMCSA-N anacetrapib Chemical compound COC1=CC(F)=C(C(C)C)C=C1C1=CC=C(C(F)(F)F)C=C1CN1C(=O)O[C@H](C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)[C@@H]1C MZZLGJHLQGUVPN-HAWMADMCSA-N 0.000 description 1
- 229950000285 anacetrapib Drugs 0.000 description 1
- 229960004238 anakinra Drugs 0.000 description 1
- 229940051880 analgesics and antipyretics pyrazolones Drugs 0.000 description 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 1
- 229940125364 angiotensin receptor blocker Drugs 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 230000002300 anti-fibrosis Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000561 anti-psychotic effect Effects 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 229940125708 antidiabetic agent Drugs 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 229940127088 antihypertensive drug Drugs 0.000 description 1
- 229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000013176 antiplatelet therapy Methods 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 239000003698 antivitamin K Substances 0.000 description 1
- 210000002376 aorta thoracic Anatomy 0.000 description 1
- 210000001765 aortic valve Anatomy 0.000 description 1
- NETXMUIMUZJUTB-UHFFFAOYSA-N apabetalone Chemical compound C=1C(OC)=CC(OC)=C(C(N2)=O)C=1N=C2C1=CC(C)=C(OCCO)C(C)=C1 NETXMUIMUZJUTB-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229950007556 aranidipine Drugs 0.000 description 1
- KXNPVXPOPUZYGB-XYVMCAHJSA-N argatroban Chemical compound OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NC[C@H](C)C2 KXNPVXPOPUZYGB-XYVMCAHJSA-N 0.000 description 1
- 229960003856 argatroban Drugs 0.000 description 1
- BHIAIPWSVYSKJS-UHFFFAOYSA-N arotinolol Chemical compound S1C(SCC(O)CNC(C)(C)C)=NC(C=2SC(=CC=2)C(N)=O)=C1 BHIAIPWSVYSKJS-UHFFFAOYSA-N 0.000 description 1
- 229950010731 arotinolol Drugs 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 208000021328 arterial occlusion Diseases 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 206010003230 arteritis Diseases 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 229950007878 ataciguat Drugs 0.000 description 1
- METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 description 1
- 229960005370 atorvastatin Drugs 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- 229960000307 avanafil Drugs 0.000 description 1
- WEAJZXNPAWBCOA-INIZCTEOSA-N avanafil Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(N2[C@@H](CCC2)CO)=NC=C1C(=O)NCC1=NC=CC=N1 WEAJZXNPAWBCOA-INIZCTEOSA-N 0.000 description 1
- 229940062310 avandia Drugs 0.000 description 1
- 229950000586 aviptadil Drugs 0.000 description 1
- 108010006060 aviptadil Proteins 0.000 description 1
- 210000003050 axon Anatomy 0.000 description 1
- UEMCCCNXEVDMGD-UHFFFAOYSA-N azane 1-(2-chloropropan-2-yl)-2-octadecylbenzene Chemical compound N.CCCCCCCCCCCCCCCCCCC1=CC=CC=C1C(C)(C)Cl UEMCCCNXEVDMGD-UHFFFAOYSA-N 0.000 description 1
- 229960001671 azapropazone Drugs 0.000 description 1
- WOIIIUDZSOLAIW-NSHDSACASA-N azapropazone Chemical compound C1=C(C)C=C2N3C(=O)[C@H](CC=C)C(=O)N3C(N(C)C)=NC2=C1 WOIIIUDZSOLAIW-NSHDSACASA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 229960004530 benazepril Drugs 0.000 description 1
- 229960003515 bendroflumethiazide Drugs 0.000 description 1
- HDWIHXWEUNVBIY-UHFFFAOYSA-N bendroflumethiazidum Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1=CC=CC=C1 HDWIHXWEUNVBIY-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960004916 benidipine Drugs 0.000 description 1
- QZVNQOLPLYWLHQ-ZEQKJWHPSA-N benidipine Chemical compound C1([C@H]2C(=C(C)NC(C)=C2C(=O)OC)C(=O)O[C@H]2CN(CC=3C=CC=CC=3)CCC2)=CC=CC([N+]([O-])=O)=C1 QZVNQOLPLYWLHQ-ZEQKJWHPSA-N 0.000 description 1
- 229960005430 benoxaprofen Drugs 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960003228 benzphetamine hydrochloride Drugs 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229960003665 bepridil Drugs 0.000 description 1
- UIEATEWHFDRYRU-UHFFFAOYSA-N bepridil Chemical compound C1CCCN1C(COCC(C)C)CN(C=1C=CC=CC=1)CC1=CC=CC=C1 UIEATEWHFDRYRU-UHFFFAOYSA-N 0.000 description 1
- 229940124748 beta 2 agonist Drugs 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 229960002537 betamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 1
- 229960000516 bezafibrate Drugs 0.000 description 1
- IIBYAHWJQTYFKB-UHFFFAOYSA-N bezafibrate Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1CCNC(=O)C1=CC=C(Cl)C=C1 IIBYAHWJQTYFKB-UHFFFAOYSA-N 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- HUTDDBSSHVOYJR-UHFFFAOYSA-H bis[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphaplumbetan-2-yl)oxy]lead Chemical compound [Pb+2].[Pb+2].[Pb+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O HUTDDBSSHVOYJR-UHFFFAOYSA-H 0.000 description 1
- OIRCOABEOLEUMC-GEJPAHFPSA-N bivalirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 OIRCOABEOLEUMC-GEJPAHFPSA-N 0.000 description 1
- 108010055460 bivalirudin Proteins 0.000 description 1
- 229960001500 bivalirudin Drugs 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 229940046049 bontril Drugs 0.000 description 1
- 229960003065 bosentan Drugs 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 229950000740 bremelanotide Drugs 0.000 description 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 1
- 229960002802 bromocriptine Drugs 0.000 description 1
- IJTPQQVCKPZIMV-UHFFFAOYSA-N bucloxic acid Chemical compound ClC1=CC(C(=O)CCC(=O)O)=CC=C1C1CCCCC1 IJTPQQVCKPZIMV-UHFFFAOYSA-N 0.000 description 1
- 229950005608 bucloxic acid Drugs 0.000 description 1
- 239000012512 bulk drug substance Substances 0.000 description 1
- 229960002467 bunazosin Drugs 0.000 description 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 1
- 229960001736 buprenorphine Drugs 0.000 description 1
- 229960001058 bupropion Drugs 0.000 description 1
- 229950009770 butaxamine Drugs 0.000 description 1
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 description 1
- 229960001113 butorphanol Drugs 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N butyl alcohol Substances CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 230000003222 cGMP degradation Effects 0.000 description 1
- 229960004596 cabergoline Drugs 0.000 description 1
- 229960005211 cadralazine Drugs 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- OYPRJOBELJOOCE-AKLPVKDBSA-N calcium-43 atom Chemical compound [43Ca] OYPRJOBELJOOCE-AKLPVKDBSA-N 0.000 description 1
- 229960001713 canagliflozin Drugs 0.000 description 1
- VHOFTEAWFCUTOS-TUGBYPPCSA-N canagliflozin hydrate Chemical compound O.CC1=CC=C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C=C1CC(S1)=CC=C1C1=CC=C(F)C=C1.CC1=CC=C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C=C1CC(S1)=CC=C1C1=CC=C(F)C=C1 VHOFTEAWFCUTOS-TUGBYPPCSA-N 0.000 description 1
- 239000012830 cancer therapeutic Substances 0.000 description 1
- 229960004349 candesartan cilexetil Drugs 0.000 description 1
- 229940097633 capoten Drugs 0.000 description 1
- 229960000830 captopril Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000011111 cardboard Substances 0.000 description 1
- 229940097611 cardene Drugs 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 238000013172 carotid endarterectomy Methods 0.000 description 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 description 1
- 229950008486 carperitide Drugs 0.000 description 1
- 229960003184 carprofen Drugs 0.000 description 1
- IVUMCTKHWDRRMH-UHFFFAOYSA-N carprofen Chemical compound C1=CC(Cl)=C[C]2C3=CC=C(C(C(O)=O)C)C=C3N=C21 IVUMCTKHWDRRMH-UHFFFAOYSA-N 0.000 description 1
- FYBXRCFPOTXTJF-UHFFFAOYSA-N carteolol hydrochloride Chemical compound [Cl-].N1C(=O)CCC2=C1C=CC=C2OCC(O)C[NH2+]C(C)(C)C FYBXRCFPOTXTJF-UHFFFAOYSA-N 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940047495 celebrex Drugs 0.000 description 1
- 229960000590 celecoxib Drugs 0.000 description 1
- 229940047493 celexa Drugs 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 229940107810 cellcept Drugs 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 201000007455 central nervous system cancer Diseases 0.000 description 1
- 208000025997 central nervous system neoplasm Diseases 0.000 description 1
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 229910052729 chemical element Inorganic materials 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229960002155 chlorothiazide Drugs 0.000 description 1
- 229960001761 chlorpropamide Drugs 0.000 description 1
- 229960001523 chlortalidone Drugs 0.000 description 1
- 229960003653 choline fenofibrate Drugs 0.000 description 1
- 239000000544 cholinesterase inhibitor Substances 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 229940117229 cialis Drugs 0.000 description 1
- 229960001932 cicletanine Drugs 0.000 description 1
- YZFWTZACSRHJQD-UHFFFAOYSA-N ciglitazone Chemical compound C=1C=C(CC2C(NC(=O)S2)=O)C=CC=1OCC1(C)CCCCC1 YZFWTZACSRHJQD-UHFFFAOYSA-N 0.000 description 1
- 229950009226 ciglitazone Drugs 0.000 description 1
- 229960005025 cilazapril Drugs 0.000 description 1
- HHHKFGXWKKUNCY-FHWLQOOXSA-N cilazapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N2[C@@H](CCCN2CCC1)C(O)=O)=O)CC1=CC=CC=C1 HHHKFGXWKKUNCY-FHWLQOOXSA-N 0.000 description 1
- 229960003020 cilnidipine Drugs 0.000 description 1
- 229950002128 cinaciguat Drugs 0.000 description 1
- WPYWMXNXEZFMAK-UHFFFAOYSA-N cinaciguat Chemical compound C=1C=C(C(O)=O)C=CC=1CN(CCCCC(=O)O)CCC1=CC=CC=C1OCC(C=C1)=CC=C1CCC1=CC=CC=C1 WPYWMXNXEZFMAK-UHFFFAOYSA-N 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 229960002174 ciprofibrate Drugs 0.000 description 1
- KPSRODZRAIWAKH-UHFFFAOYSA-N ciprofibrate Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1C1C(Cl)(Cl)C1 KPSRODZRAIWAKH-UHFFFAOYSA-N 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229960001653 citalopram Drugs 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 229960002173 citrulline Drugs 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229960003597 clevidipine Drugs 0.000 description 1
- KPBZROQVTHLCDU-GOSISDBHSA-N clevidipine Chemical compound CCCC(=O)OCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@H]1C1=CC=CC(Cl)=C1Cl KPBZROQVTHLCDU-GOSISDBHSA-N 0.000 description 1
- 229950010886 clidanac Drugs 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 229950003072 clinofibrate Drugs 0.000 description 1
- 229960001214 clofibrate Drugs 0.000 description 1
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 description 1
- 229960002896 clonidine Drugs 0.000 description 1
- 229960003009 clopidogrel Drugs 0.000 description 1
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 229960001152 colesevelam Drugs 0.000 description 1
- 229960004095 colestilan Drugs 0.000 description 1
- GMRWGQCZJGVHKL-UHFFFAOYSA-N colestipol Chemical compound ClCC1CO1.NCCNCCNCCNCCN GMRWGQCZJGVHKL-UHFFFAOYSA-N 0.000 description 1
- 229960002604 colestipol Drugs 0.000 description 1
- 229950005210 colforsin Drugs 0.000 description 1
- OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 208000020020 complex sleep apnea Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229940126214 compound 3 Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229920002770 condensed tannin Polymers 0.000 description 1
- 208000016569 congenital mitral valve insufficiency Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229940108928 copper Drugs 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 229940072645 coumadin Drugs 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229960000265 cromoglicic acid Drugs 0.000 description 1
- 229940109248 cromoglycate Drugs 0.000 description 1
- 229960005168 croscarmellose Drugs 0.000 description 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 235000015140 cultured milk Nutrition 0.000 description 1
- 238000007333 cyanation reaction Methods 0.000 description 1
- 229940126513 cyclase activator Drugs 0.000 description 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical class OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
- 229960003206 cyclopenthiazide Drugs 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 229960003850 dabigatran Drugs 0.000 description 1
- YBSJFWOBGCMAKL-UHFFFAOYSA-N dabigatran Chemical compound N=1C2=CC(C(=O)N(CCC(O)=O)C=3N=CC=CC=3)=CC=C2N(C)C=1CNC1=CC=C(C(N)=N)C=C1 YBSJFWOBGCMAKL-UHFFFAOYSA-N 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 229950004181 dalcetrapib Drugs 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 229960005227 delapril Drugs 0.000 description 1
- WOUOLAUOZXOLJQ-MBSDFSHPSA-N delapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N(CC(O)=O)C1CC2=CC=CC=C2C1)CC1=CC=CC=C1 WOUOLAUOZXOLJQ-MBSDFSHPSA-N 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 231100000223 dermal penetration Toxicity 0.000 description 1
- 201000001981 dermatomyositis Diseases 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 229960003914 desipramine Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 description 1
- 229960004193 dextropropoxyphene Drugs 0.000 description 1
- VTMVHDZWSFQSQP-VBNZEHGJSA-N dezocine Chemical compound C1CCCC[C@H]2CC3=CC=C(O)C=C3[C@]1(C)[C@H]2N VTMVHDZWSFQSQP-VBNZEHGJSA-N 0.000 description 1
- 229960003461 dezocine Drugs 0.000 description 1
- 201000002249 diabetic peripheral angiopathy Diseases 0.000 description 1
- 229960004590 diacerein Drugs 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 229960004042 diazoxide Drugs 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229940120144 didrex Drugs 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- LBJLVZKEUWCGIA-UHFFFAOYSA-N diethylamine NONOate Chemical compound CCNCC.CCN(CC)N(O)N=O LBJLVZKEUWCGIA-UHFFFAOYSA-N 0.000 description 1
- ICFXZZFWRWNZMA-UHFFFAOYSA-N diethylpropion hydrochloride Chemical compound [Cl-].CC[NH+](CC)C(C)C(=O)C1=CC=CC=C1 ICFXZZFWRWNZMA-UHFFFAOYSA-N 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229960000616 diflunisal Drugs 0.000 description 1
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- 229940127292 dihydropyridine calcium channel blocker Drugs 0.000 description 1
- 239000002866 dihydropyridine calcium channel blocker Substances 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 229940064420 dilatrate Drugs 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- VFNGKCDDZUSWLR-UHFFFAOYSA-L disulfate(2-) Chemical compound [O-]S(=O)(=O)OS([O-])(=O)=O VFNGKCDDZUSWLR-UHFFFAOYSA-L 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- IXTMWRCNAAVVAI-UHFFFAOYSA-N dofetilide Chemical compound C=1C=C(NS(C)(=O)=O)C=CC=1CCN(C)CCOC1=CC=C(NS(C)(=O)=O)C=C1 IXTMWRCNAAVVAI-UHFFFAOYSA-N 0.000 description 1
- 229960002994 dofetilide Drugs 0.000 description 1
- 229960003530 donepezil Drugs 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 229940052760 dopamine agonists Drugs 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 229940052764 dopaminergic anti-parkinson drug mao b inhibitors Drugs 0.000 description 1
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 description 1
- 229960001389 doxazosin Drugs 0.000 description 1
- 229960005426 doxepin Drugs 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 229950003102 efonidipine Drugs 0.000 description 1
- IKBJGZQVVVXCEQ-UHFFFAOYSA-N efonidipine hydrochloride Chemical compound Cl.CCO.CC=1NC(C)=C(C(=O)OCCN(CC=2C=CC=CC=2)C=2C=CC=CC=2)C(C=2C=C(C=CC=2)[N+]([O-])=O)C=1P1(=O)OCC(C)(C)CO1 IKBJGZQVVVXCEQ-UHFFFAOYSA-N 0.000 description 1
- QBEPNUQJQWDYKU-BMGKTWPMSA-N egrifta Chemical compound C([C@H](NC(=O)C/C=C/CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O)C1=CC=C(O)C=C1 QBEPNUQJQWDYKU-BMGKTWPMSA-N 0.000 description 1
- 229940011681 elavil Drugs 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000003073 embolic effect Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 229960000873 enalapril Drugs 0.000 description 1
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 210000003989 endothelium vascular Anatomy 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 229940079360 enema for constipation Drugs 0.000 description 1
- 229950002375 englitazone Drugs 0.000 description 1
- 229960000972 enoximone Drugs 0.000 description 1
- ZJKNESGOIKRXQY-UHFFFAOYSA-N enoximone Chemical compound C1=CC(SC)=CC=C1C(=O)C1=C(C)NC(=O)N1 ZJKNESGOIKRXQY-UHFFFAOYSA-N 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 230000002327 eosinophilic effect Effects 0.000 description 1
- CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 description 1
- 229950010170 epalrestat Drugs 0.000 description 1
- CHNUOJQWGUIOLD-UHFFFAOYSA-N epalrestate Natural products C=1C=CC=CC=1C=C(C)C=C1SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-UHFFFAOYSA-N 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 235000018905 epimedium Nutrition 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 229960003745 esmolol Drugs 0.000 description 1
- AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- XNXAZXZVTDKDIL-UHFFFAOYSA-N ethyl 1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazole-3-carboxylate Chemical compound C=1C=CC=C(F)C=1CN1N=C(C(=O)OCC)C=C1C=1C=CON=1 XNXAZXZVTDKDIL-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229940043351 ethyl-p-hydroxybenzoate Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 229940108366 exelon Drugs 0.000 description 1
- 229960001519 exenatide Drugs 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000003885 eye ointment Substances 0.000 description 1
- 229960000815 ezetimibe Drugs 0.000 description 1
- 201000001386 familial hypercholesterolemia Diseases 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- RZTAMFZIAATZDJ-UHFFFAOYSA-N felodipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-UHFFFAOYSA-N 0.000 description 1
- ZWJINEZUASEZBH-UHFFFAOYSA-N fenamic acid Chemical class OC(=O)C1=CC=CC=C1NC1=CC=CC=C1 ZWJINEZUASEZBH-UHFFFAOYSA-N 0.000 description 1
- 229960001395 fenbufen Drugs 0.000 description 1
- ZPAKPRAICRBAOD-UHFFFAOYSA-N fenbufen Chemical compound C1=CC(C(=O)CCC(=O)O)=CC=C1C1=CC=CC=C1 ZPAKPRAICRBAOD-UHFFFAOYSA-N 0.000 description 1
- 229950006236 fenclofenac Drugs 0.000 description 1
- IDKAXRLETRCXKS-UHFFFAOYSA-N fenclofenac Chemical compound OC(=O)CC1=CC=CC=C1OC1=CC=C(Cl)C=C1Cl IDKAXRLETRCXKS-UHFFFAOYSA-N 0.000 description 1
- 229950011481 fenclozic acid Drugs 0.000 description 1
- 229960002602 fendiline Drugs 0.000 description 1
- 229960004009 fenoldopam mesylate Drugs 0.000 description 1
- 229960001419 fenoprofen Drugs 0.000 description 1
- 229960001022 fenoterol Drugs 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 1
- 229960000489 feprazone Drugs 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 206010016629 fibroma Diseases 0.000 description 1
- LPEPZBJOKDYZAD-UHFFFAOYSA-N flufenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 LPEPZBJOKDYZAD-UHFFFAOYSA-N 0.000 description 1
- 229960004369 flufenamic acid Drugs 0.000 description 1
- 229950007979 flufenisal Drugs 0.000 description 1
- 229960000676 flunisolide Drugs 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 229960002464 fluoxetine Drugs 0.000 description 1
- 229950001284 fluprofen Drugs 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 229960002714 fluticasone Drugs 0.000 description 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical class C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
- 229960003765 fluvastatin Drugs 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- KANJSNBRCNMZMV-ABRZTLGGSA-N fondaparinux Chemical compound O[C@@H]1[C@@H](NS(O)(=O)=O)[C@@H](OC)O[C@H](COS(O)(=O)=O)[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O4)NS(O)(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS(O)(=O)=O)O2)NS(O)(=O)=O)[C@H](C(O)=O)O1 KANJSNBRCNMZMV-ABRZTLGGSA-N 0.000 description 1
- 229960001318 fondaparinux Drugs 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 229960002490 fosinopril Drugs 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229950010931 furofenac Drugs 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229960003883 furosemide Drugs 0.000 description 1
- 229960003980 galantamine Drugs 0.000 description 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 1
- 201000010175 gallbladder cancer Diseases 0.000 description 1
- 229960003627 gemfibrozil Drugs 0.000 description 1
- 229940003380 geodon Drugs 0.000 description 1
- 229960000346 gliclazide Drugs 0.000 description 1
- 229960004346 glimepiride Drugs 0.000 description 1
- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 description 1
- 230000007387 gliosis Effects 0.000 description 1
- 229960001381 glipizide Drugs 0.000 description 1
- ZJJXGWJIGJFDTL-UHFFFAOYSA-N glipizide Chemical compound C1=NC(C)=CN=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZJJXGWJIGJFDTL-UHFFFAOYSA-N 0.000 description 1
- 229940095884 glucophage Drugs 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940074045 glyceryl distearate Drugs 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 210000004884 grey matter Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- SCMLRESZJCKCTC-KMYQRJGFSA-N gtpl8173 Chemical compound C12=CC=C(CSCC)C=C2C2=C(CNC3=O)C3=C3C4=CC(CSCC)=CC=C4N4C3=C2N1[C@]1(C)[C@@](O)(C(=O)OC)C[C@H]4O1 SCMLRESZJCKCTC-KMYQRJGFSA-N 0.000 description 1
- HPBNRIOWIXYZFK-UHFFFAOYSA-N guanadrel Chemical compound O1C(CNC(=N)N)COC11CCCCC1 HPBNRIOWIXYZFK-UHFFFAOYSA-N 0.000 description 1
- 229960003845 guanadrel Drugs 0.000 description 1
- ACGDKVXYNVEAGU-UHFFFAOYSA-N guanethidine Chemical compound NC(N)=NCCN1CCCCCCC1 ACGDKVXYNVEAGU-UHFFFAOYSA-N 0.000 description 1
- 229960003602 guanethidine Drugs 0.000 description 1
- 229960002048 guanfacine Drugs 0.000 description 1
- 150000002357 guanidines Chemical class 0.000 description 1
- 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 208000018578 heart valve disease Diseases 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 102000056614 human NPPA Human genes 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- ZUXNZUWOTSUBMN-UHFFFAOYSA-N hydralazine hydrochloride Chemical compound Cl.C1=CC=C2C(NN)=NN=CC2=C1 ZUXNZUWOTSUBMN-UHFFFAOYSA-N 0.000 description 1
- 229960005384 hydralazine hydrochloride Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 229960002003 hydrochlorothiazide Drugs 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 description 1
- 229960001410 hydromorphone Drugs 0.000 description 1
- ZUFVXZVXEJHHBN-UHFFFAOYSA-N hydron;1,2,3,4-tetrahydroacridin-9-amine;chloride Chemical compound [Cl-].C1=CC=C2C([NH3+])=C(CCCC3)C3=NC2=C1 ZUFVXZVXEJHHBN-UHFFFAOYSA-N 0.000 description 1
- USZLCYNVCCDPLQ-UHFFFAOYSA-N hydron;n-methoxymethanamine;chloride Chemical compound Cl.CNOC USZLCYNVCCDPLQ-UHFFFAOYSA-N 0.000 description 1
- 239000008309 hydrophilic cream Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229960001330 hydroxycarbamide Drugs 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- CYWFCPPBTWOZSF-UHFFFAOYSA-N ibufenac Chemical compound CC(C)CC1=CC=C(CC(O)=O)C=C1 CYWFCPPBTWOZSF-UHFFFAOYSA-N 0.000 description 1
- 229950009183 ibufenac Drugs 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- TZJALUIVHRYQQB-XLRXWWTNSA-N icariin Chemical compound C1=CC(OC)=CC=C1C1=C(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)C(=O)C2=C(O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-XLRXWWTNSA-N 0.000 description 1
- 229940093221 imdur Drugs 0.000 description 1
- 229960001195 imidapril Drugs 0.000 description 1
- KLZWOWYOHUKJIG-BPUTZDHNSA-N imidapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1C(N(C)C[C@H]1C(O)=O)=O)CC1=CC=CC=C1 KLZWOWYOHUKJIG-BPUTZDHNSA-N 0.000 description 1
- 108010070995 imidazoline I1 receptors Proteins 0.000 description 1
- 229960004801 imipramine Drugs 0.000 description 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 description 1
- XZZXIYZZBJDEEP-UHFFFAOYSA-N imipramine hydrochloride Chemical compound [Cl-].C1CC2=CC=CC=C2N(CCC[NH+](C)C)C2=CC=CC=C21 XZZXIYZZBJDEEP-UHFFFAOYSA-N 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229960004569 indapamide Drugs 0.000 description 1
- NDDAHWYSQHTHNT-UHFFFAOYSA-N indapamide Chemical compound CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NDDAHWYSQHTHNT-UHFFFAOYSA-N 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 229960004187 indoprofen Drugs 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000006749 inflammatory damage Effects 0.000 description 1
- 230000008798 inflammatory stress Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 229910001959 inorganic nitrate Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000002608 insulinlike Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007919 intrasynovial administration Methods 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229940036543 ionamin Drugs 0.000 description 1
- 229960001361 ipratropium bromide Drugs 0.000 description 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
- 229960002198 irbesartan Drugs 0.000 description 1
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 229950010984 irsogladine Drugs 0.000 description 1
- 229940072673 ismo Drugs 0.000 description 1
- 229960001268 isoetarine Drugs 0.000 description 1
- 108010031424 isoleucyl-prolyl-proline Proteins 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940088024 isoptin Drugs 0.000 description 1
- 229960002479 isosorbide Drugs 0.000 description 1
- 229950002252 isoxicam Drugs 0.000 description 1
- YYUAYBYLJSNDCX-UHFFFAOYSA-N isoxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC=1C=C(C)ON=1 YYUAYBYLJSNDCX-UHFFFAOYSA-N 0.000 description 1
- 229960004427 isradipine Drugs 0.000 description 1
- FPCCSQOGAWCVBH-UHFFFAOYSA-N ketanserin Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CCN2C(C3=CC=CC=C3NC2=O)=O)CC1 FPCCSQOGAWCVBH-UHFFFAOYSA-N 0.000 description 1
- 229960005417 ketanserin Drugs 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 108010053037 kyotorphin Proteins 0.000 description 1
- 229960001632 labetalol Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940054346 lactobacillus helveticus Drugs 0.000 description 1
- 108010058587 lactokinins Proteins 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000012902 lepidium meyenii Nutrition 0.000 description 1
- 229940090243 letairis Drugs 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 229940097443 levitra Drugs 0.000 description 1
- 229960003406 levorphanol Drugs 0.000 description 1
- WHXMKTBCFHIYNQ-SECBINFHSA-N levosimendan Chemical compound C[C@@H]1CC(=O)NN=C1C1=CC=C(NN=C(C#N)C#N)C=C1 WHXMKTBCFHIYNQ-SECBINFHSA-N 0.000 description 1
- 229960000692 levosimendan Drugs 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 229960002397 linagliptin Drugs 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 230000013190 lipid storage Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 229960002394 lisinopril Drugs 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 229940125389 long-acting beta agonist Drugs 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000027928 long-term synaptic potentiation Effects 0.000 description 1
- 239000002171 loop diuretic Substances 0.000 description 1
- 229960004773 losartan Drugs 0.000 description 1
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 description 1
- 229940080268 lotensin Drugs 0.000 description 1
- 229960004844 lovastatin Drugs 0.000 description 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 229960000994 lumiracoxib Drugs 0.000 description 1
- KHPKQFYUPIUARC-UHFFFAOYSA-N lumiracoxib Chemical compound OC(=O)CC1=CC(C)=CC=C1NC1=C(F)C=CC=C1Cl KHPKQFYUPIUARC-UHFFFAOYSA-N 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 150000002672 m-cresols Chemical class 0.000 description 1
- JGCMEBMXRHSZKX-UHFFFAOYSA-N macitentan Chemical compound C=1C=C(Br)C=CC=1C=1C(NS(=O)(=O)NCCC)=NC=NC=1OCCOC1=NC=C(Br)C=N1 JGCMEBMXRHSZKX-UHFFFAOYSA-N 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 229960003963 manidipine Drugs 0.000 description 1
- ANEBWFXPVPTEET-UHFFFAOYSA-N manidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ANEBWFXPVPTEET-UHFFFAOYSA-N 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 229960000299 mazindol Drugs 0.000 description 1
- 229960003803 meclofenamic acid Drugs 0.000 description 1
- 210000001370 mediastinum Anatomy 0.000 description 1
- 229960003464 mefenamic acid Drugs 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 description 1
- 229960003134 mepindolol Drugs 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
- 229960001797 methadone Drugs 0.000 description 1
- 229960002532 methamphetamine hydrochloride Drugs 0.000 description 1
- TWXDDNPPQUTEOV-FVGYRXGTSA-N methamphetamine hydrochloride Chemical compound Cl.CN[C@@H](C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-FVGYRXGTSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- NBTOZLQBSIZIKS-UHFFFAOYSA-N methoxide Chemical compound [O-]C NBTOZLQBSIZIKS-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- IYJMSDVSVHDVGT-PEQKVOOWSA-N metildigoxin Chemical compound O1[C@H](C)[C@@H](OC)[C@@H](O)C[C@@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O IYJMSDVSVHDVGT-PEQKVOOWSA-N 0.000 description 1
- 229960003746 metildigoxin Drugs 0.000 description 1
- 229960002817 metolazone Drugs 0.000 description 1
- AQCHWTWZEMGIFD-UHFFFAOYSA-N metolazone Chemical compound CC1NC2=CC(Cl)=C(S(N)(=O)=O)C=C2C(=O)N1C1=CC=CC=C1C AQCHWTWZEMGIFD-UHFFFAOYSA-N 0.000 description 1
- 229960002237 metoprolol Drugs 0.000 description 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 229960000668 metreleptin Drugs 0.000 description 1
- 108700008455 metreleptin Proteins 0.000 description 1
- 229960004438 mibefradil Drugs 0.000 description 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
- 208000027061 mild cognitive impairment Diseases 0.000 description 1
- PZRHRDRVRGEVNW-UHFFFAOYSA-N milrinone Chemical compound N1C(=O)C(C#N)=CC(C=2C=CN=CC=2)=C1C PZRHRDRVRGEVNW-UHFFFAOYSA-N 0.000 description 1
- 229960003574 milrinone Drugs 0.000 description 1
- 229940042472 mineral oil Drugs 0.000 description 1
- 229950002245 mirodenafil Drugs 0.000 description 1
- OJGQFYYLKNCIJD-UHFFFAOYSA-N miroprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C1=CN(C=CC=C2)C2=N1 OJGQFYYLKNCIJD-UHFFFAOYSA-N 0.000 description 1
- 229950006616 miroprofen Drugs 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 229960003365 mitiglinide Drugs 0.000 description 1
- WPGGHFDDFPHPOB-BBWFWOEESA-N mitiglinide Chemical compound C([C@@H](CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)C(=O)O)C1=CC=CC=C1 WPGGHFDDFPHPOB-BBWFWOEESA-N 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 201000006646 mixed sleep apnea Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229960005170 moexipril Drugs 0.000 description 1
- 229960005285 mofebutazone Drugs 0.000 description 1
- REOJLIXKJWXUGB-UHFFFAOYSA-N mofebutazone Chemical compound O=C1C(CCCC)C(=O)NN1C1=CC=CC=C1 REOJLIXKJWXUGB-UHFFFAOYSA-N 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 229940063181 monoket Drugs 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 description 1
- 229960004866 mycophenolate mofetil Drugs 0.000 description 1
- 210000005012 myelin Anatomy 0.000 description 1
- 210000000651 myofibroblast Anatomy 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 description 1
- WIEDUMBCZQRGSY-UHFFFAOYSA-N n-[[2,6-difluoro-4-[3-(1h-1,2,4-triazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1h-inden-2-amine Chemical compound C=1C(F)=C(CNC2CC3=CC=CC=C3C2)C(F)=CC=1C(C=1)=CC=CC=1C1=NC=NN1 WIEDUMBCZQRGSY-UHFFFAOYSA-N 0.000 description 1
- ULDDTFAPYWLDGF-UHFFFAOYSA-N n-butyl-n'-hydroxyguanidine Chemical compound CCCCNC(=N)NO ULDDTFAPYWLDGF-UHFFFAOYSA-N 0.000 description 1
- DLBKWJOHNPIHQO-UHFFFAOYSA-N n-hydroxy-n-[methyl-[6-(methylamino)hexyl]amino]nitrous amide Chemical compound CNCCCCCCN(C)N(O)N=O DLBKWJOHNPIHQO-UHFFFAOYSA-N 0.000 description 1
- DHEWMIAJHISOGS-UHFFFAOYSA-N n-methoxy-n-methyl-1,2-oxazole-3-carboxamide Chemical compound CON(C)C(=O)C=1C=CON=1 DHEWMIAJHISOGS-UHFFFAOYSA-N 0.000 description 1
- CSDTZUBPSYWZDX-UHFFFAOYSA-N n-pentyl nitrite Chemical compound CCCCCON=O CSDTZUBPSYWZDX-UHFFFAOYSA-N 0.000 description 1
- 229960004255 nadolol Drugs 0.000 description 1
- VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 description 1
- NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 description 1
- 229960000805 nalbuphine Drugs 0.000 description 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 1
- 229960003086 naltrexone Drugs 0.000 description 1
- 229940033872 namenda Drugs 0.000 description 1
- 239000002088 nanocapsule Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229960003759 naproxcinod Drugs 0.000 description 1
- AKFJWRDCWYYTIG-ZDUSSCGKSA-N naproxcinod Chemical compound C1=C([C@H](C)C(=O)OCCCCO[N+]([O-])=O)C=CC2=CC(OC)=CC=C21 AKFJWRDCWYYTIG-ZDUSSCGKSA-N 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229960000698 nateglinide Drugs 0.000 description 1
- OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
- 229960004398 nedocromil Drugs 0.000 description 1
- 230000004903 negative regulation of intestinal cholesterol absorption Effects 0.000 description 1
- FTQHGWIXJSSWOY-UHFFFAOYSA-N nelociguat Chemical compound N1=C(N)C(NC(=O)OC)=C(N)N=C1C(C1=CC=CN=C11)=NN1CC1=CC=CC=C1F FTQHGWIXJSSWOY-UHFFFAOYSA-N 0.000 description 1
- 229940063121 neoral Drugs 0.000 description 1
- 229960001267 nesiritide Drugs 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 230000002644 neurohormonal effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229960001783 nicardipine Drugs 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 229960000916 niflumic acid Drugs 0.000 description 1
- 229960005366 nilvadipine Drugs 0.000 description 1
- UIAGMCDKSXEBJQ-UHFFFAOYSA-N nimodipine Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-UHFFFAOYSA-N 0.000 description 1
- 229950000754 nipradilol Drugs 0.000 description 1
- 229960000227 nisoldipine Drugs 0.000 description 1
- PVHUJELLJLJGLN-UHFFFAOYSA-N nitrendipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC([N+]([O-])=O)=C1 PVHUJELLJLJGLN-UHFFFAOYSA-N 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 230000009935 nitrosation Effects 0.000 description 1
- 238000007034 nitrosation reaction Methods 0.000 description 1
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 229940124643 non-selective drug Drugs 0.000 description 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 229940087480 norpramin Drugs 0.000 description 1
- 229960001158 nortriptyline Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229960005017 olanzapine Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229960005117 olmesartan Drugs 0.000 description 1
- VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 description 1
- JPAWFIIYTJQOKW-UHFFFAOYSA-N olprinone Chemical compound N1C(=O)C(C#N)=CC(C2=CN3C=CN=C3C=C2)=C1C JPAWFIIYTJQOKW-UHFFFAOYSA-N 0.000 description 1
- 229950005421 olprinone Drugs 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000000014 opioid analgesic Substances 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 229940127294 oral prostanoid Drugs 0.000 description 1
- 229960002657 orciprenaline Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229940082615 organic nitrates used in cardiac disease Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229960001243 orlistat Drugs 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 230000001599 osteoclastic effect Effects 0.000 description 1
- 229940097271 other diuretics in atc Drugs 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 229960002739 oxaprozin Drugs 0.000 description 1
- OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 description 1
- QPTISOPQFLIZCY-UHFFFAOYSA-N oxatriazol-5-amine Chemical compound NC1=NN=NO1 QPTISOPQFLIZCY-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- 229960004570 oxprenolol Drugs 0.000 description 1
- 229960002085 oxycodone Drugs 0.000 description 1
- 229960005118 oxymorphone Drugs 0.000 description 1
- 229960000649 oxyphenbutazone Drugs 0.000 description 1
- HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N p-hydroxybenzoic acid methyl ester Natural products COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 238000012858 packaging process Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 229960001789 papaverine Drugs 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 239000011087 paperboard Substances 0.000 description 1
- 229960004662 parecoxib Drugs 0.000 description 1
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- AQIXEPGDORPWBJ-UHFFFAOYSA-N pentan-3-ol Chemical class CCC(O)CC AQIXEPGDORPWBJ-UHFFFAOYSA-N 0.000 description 1
- VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 description 1
- 229960005301 pentazocine Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 210000004912 pericardial fluid Anatomy 0.000 description 1
- 208000008494 pericarditis Diseases 0.000 description 1
- 229960002582 perindopril Drugs 0.000 description 1
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 description 1
- IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical compound CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 208000027232 peripheral nervous system disease Diseases 0.000 description 1
- 229960000482 pethidine Drugs 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 229960003725 phendimetrazine tartrate Drugs 0.000 description 1
- 229960003562 phentermine Drugs 0.000 description 1
- 229960003056 phentolamine mesylate Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229960002895 phenylbutazone Drugs 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- 150000004031 phenylhydrazines Chemical class 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000002570 phosphodiesterase III inhibitor Substances 0.000 description 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 210000003105 phrenic nerve Anatomy 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229960002164 pimobendan Drugs 0.000 description 1
- GLBJJMFZWDBELO-UHFFFAOYSA-N pimobendane Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC=C(C=3C(CC(=O)NN=3)C)C=C2N1 GLBJJMFZWDBELO-UHFFFAOYSA-N 0.000 description 1
- 229960002310 pinacidil Drugs 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
- 235000010204 pine bark Nutrition 0.000 description 1
- 235000018192 pine bark supplement Nutrition 0.000 description 1
- JSPCTNUQYWIIOT-UHFFFAOYSA-N piperidine-1-carboxamide Chemical compound NC(=O)N1CCCCC1 JSPCTNUQYWIIOT-UHFFFAOYSA-N 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 229960002797 pitavastatin Drugs 0.000 description 1
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229960005483 polythiazide Drugs 0.000 description 1
- 229920000046 polythiazide Polymers 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 238000002600 positron emission tomography Methods 0.000 description 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 229960000206 potassium canrenoate Drugs 0.000 description 1
- JTZQCHFUGHIPDF-RYVBEKKQSA-M potassium canrenoate Chemical compound [K+].O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)CCC([O-])=O)[C@@H]4[C@@H]3C=CC2=C1 JTZQCHFUGHIPDF-RYVBEKKQSA-M 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229940125422 potassium channel blocker Drugs 0.000 description 1
- 239000003450 potassium channel blocker Substances 0.000 description 1
- 239000004036 potassium channel stimulating agent Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 239000003286 potassium sparing diuretic agent Substances 0.000 description 1
- 229940097241 potassium-sparing diuretic Drugs 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 229960003089 pramipexole Drugs 0.000 description 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 description 1
- 229960003611 pramlintide Drugs 0.000 description 1
- 108010029667 pramlintide Proteins 0.000 description 1
- NRKVKVQDUCJPIZ-MKAGXXMWSA-N pramlintide acetate Chemical compound C([C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NRKVKVQDUCJPIZ-MKAGXXMWSA-N 0.000 description 1
- 229950004891 pranidipine Drugs 0.000 description 1
- 229960003101 pranoprofen Drugs 0.000 description 1
- 229960002965 pravastatin Drugs 0.000 description 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 description 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
- 229960001289 prazosin Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical class O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 239000009235 prelox Substances 0.000 description 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000009862 primary prevention Effects 0.000 description 1
- 229940088953 prinivil Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229940072288 prograf Drugs 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 description 1
- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- JWHAUXFOSRPERK-UHFFFAOYSA-N propafenone Chemical compound CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 JWHAUXFOSRPERK-UHFFFAOYSA-N 0.000 description 1
- 229960000203 propafenone Drugs 0.000 description 1
- 150000005599 propionic acid derivatives Chemical class 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003815 prostacyclins Chemical class 0.000 description 1
- 238000011471 prostatectomy Methods 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 229950003776 protoporphyrin Drugs 0.000 description 1
- 229940035613 prozac Drugs 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000003304 psychophysiological effect Effects 0.000 description 1
- 230000004088 pulmonary circulation Effects 0.000 description 1
- 210000003102 pulmonary valve Anatomy 0.000 description 1
- 210000003492 pulmonary vein Anatomy 0.000 description 1
- 239000003379 purinergic P1 receptor agonist Substances 0.000 description 1
- 229940106796 pycnogenol Drugs 0.000 description 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical class O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical class O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 229960001455 quinapril Drugs 0.000 description 1
- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 1
- 229960001404 quinidine Drugs 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 229960003401 ramipril Drugs 0.000 description 1
- 229940099538 rapamune Drugs 0.000 description 1
- 229960000245 rasagiline Drugs 0.000 description 1
- RUOKEQAAGRXIBM-GFCCVEGCSA-N rasagiline Chemical compound C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 description 1
- 229940051845 razadyne Drugs 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 229960003770 reboxetine Drugs 0.000 description 1
- CBQGYUDMJHNJBX-RTBURBONSA-N reboxetine Chemical compound CCOC1=CC=CC=C1O[C@H](C=1C=CC=CC=1)[C@@H]1OCCNC1 CBQGYUDMJHNJBX-RTBURBONSA-N 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229940100618 rectal suppository Drugs 0.000 description 1
- 239000006215 rectal suppository Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000002461 renin inhibitor Substances 0.000 description 1
- 229940086526 renin-inhibitors Drugs 0.000 description 1
- 229960002354 repaglinide Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 229940039245 revatio Drugs 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229960001534 risperidone Drugs 0.000 description 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 1
- 229960004136 rivastigmine Drugs 0.000 description 1
- 229960000371 rofecoxib Drugs 0.000 description 1
- 229960000804 ronifibrate Drugs 0.000 description 1
- AYJVGKWCGIYEAK-UHFFFAOYSA-N ronifibrate Chemical compound C=1C=CN=CC=1C(=O)OCCCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 AYJVGKWCGIYEAK-UHFFFAOYSA-N 0.000 description 1
- SUFUKZSWUHZXAV-BTJKTKAUSA-N rosiglitazone maleate Chemical compound [H+].[H+].[O-]C(=O)\C=C/C([O-])=O.C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O SUFUKZSWUHZXAV-BTJKTKAUSA-N 0.000 description 1
- 229960000672 rosuvastatin Drugs 0.000 description 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 description 1
- 229940125526 sGC activator Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229940127100 salmeterol-fluticasone Drugs 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000003752 saphenous vein Anatomy 0.000 description 1
- QGJUIPDUBHWZPV-SGTAVMJGSA-N saxagliptin Chemical compound C1C(C2)CC(C3)CC2(O)CC13[C@H](N)C(=O)N1[C@H](C#N)C[C@@H]2C[C@@H]21 QGJUIPDUBHWZPV-SGTAVMJGSA-N 0.000 description 1
- 229960004937 saxagliptin Drugs 0.000 description 1
- 108010033693 saxagliptin Proteins 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000009863 secondary prevention Effects 0.000 description 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
- 229960003946 selegiline Drugs 0.000 description 1
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003215 serotonin 5-HT2 receptor antagonist Substances 0.000 description 1
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 description 1
- 230000000697 serotonin reuptake Effects 0.000 description 1
- 229960002073 sertraline Drugs 0.000 description 1
- 230000036332 sexual response Effects 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 229960005303 sibutramine hydrochloride monohydrate Drugs 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229960003310 sildenafil Drugs 0.000 description 1
- 229960002639 sildenafil citrate Drugs 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 229960004034 sitagliptin Drugs 0.000 description 1
- MFFMDFFZMYYVKS-SECBINFHSA-N sitagliptin Chemical compound C([C@H](CC(=O)N1CC=2N(C(=NN=2)C(F)(F)F)CC1)N)C1=CC(F)=C(F)C=C1F MFFMDFFZMYYVKS-SECBINFHSA-N 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- OPLFZLANTJVJDX-UHFFFAOYSA-M sodium [4-chloro-2-[(4-morpholin-4-ylsulfonylphenyl)carbamoyl]phenyl]-(5-chlorothiophen-2-yl)sulfonylazanide Chemical compound [Na+].S1C(Cl)=CC=C1S(=O)(=O)[N-]C1=CC=C(Cl)C=C1C(=O)NC1=CC=C(S(=O)(=O)N2CCOCC2)C=C1 OPLFZLANTJVJDX-UHFFFAOYSA-M 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WRIKHQLVHPKCJU-UHFFFAOYSA-N sodium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([Na])[Si](C)(C)C WRIKHQLVHPKCJU-UHFFFAOYSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940125794 sodium channel blocker Drugs 0.000 description 1
- 239000003195 sodium channel blocking agent Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- XMVONEAAOPAGAO-UHFFFAOYSA-N sodium tungstate Chemical compound [Na+].[Na+].[O-][W]([O-])(=O)=O XMVONEAAOPAGAO-UHFFFAOYSA-N 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 229960004532 somatropin Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- 229960002909 spirapril Drugs 0.000 description 1
- 108700035424 spirapril Proteins 0.000 description 1
- HRWCVUIFMSZDJS-SZMVWBNQSA-N spirapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)CC1=CC=CC=C1 HRWCVUIFMSZDJS-SZMVWBNQSA-N 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000007847 structural defect Effects 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 230000002739 subcortical effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229950005175 sudoxicam Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229940035718 sular Drugs 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229960000894 sulindac Drugs 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229940035073 symbicort Drugs 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 208000037905 systemic hypertension Diseases 0.000 description 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 1
- 229960000835 tadalafil Drugs 0.000 description 1
- IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 description 1
- WOXKDUGGOYFFRN-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C(C4=CC=CC=C4N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 WOXKDUGGOYFFRN-IIBYNOLFSA-N 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229960003658 talinolol Drugs 0.000 description 1
- MXFWWQICDIZSOA-UHFFFAOYSA-N talinolol Chemical compound C1=CC(OCC(O)CNC(C)(C)C)=CC=C1NC(=O)NC1CCCCC1 MXFWWQICDIZSOA-UHFFFAOYSA-N 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 229960005187 telmisartan Drugs 0.000 description 1
- 229960004084 temocapril Drugs 0.000 description 1
- FIQOFIRCTOWDOW-BJLQDIEVSA-N temocapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C[C@H](SC1)C=1SC=CC=1)=O)CC1=CC=CC=C1 FIQOFIRCTOWDOW-BJLQDIEVSA-N 0.000 description 1
- 229960002871 tenoxicam Drugs 0.000 description 1
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 description 1
- 229940034887 tenuate Drugs 0.000 description 1
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 1
- 229960001693 terazosin Drugs 0.000 description 1
- 229960001874 tesamorelin Drugs 0.000 description 1
- 108700002800 tesamorelin Proteins 0.000 description 1
- VCVWXKKWDOJNIT-ZOMKSWQUSA-N tesofensine Chemical compound C1([C@H]2C[C@@H]3CC[C@@H](N3C)[C@@H]2COCC)=CC=C(Cl)C(Cl)=C1 VCVWXKKWDOJNIT-ZOMKSWQUSA-N 0.000 description 1
- 229950009970 tesofensine Drugs 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940125670 thienopyridine Drugs 0.000 description 1
- 239000002175 thienopyridine Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000003448 thoracic nerve Anatomy 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 208000021510 thyroid gland disease Diseases 0.000 description 1
- 229960005001 ticlopidine Drugs 0.000 description 1
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 description 1
- 229940110309 tiotropium Drugs 0.000 description 1
- 230000019432 tissue death Effects 0.000 description 1
- 238000003354 tissue distribution assay Methods 0.000 description 1
- 230000009092 tissue dysfunction Effects 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229940041597 tofranil Drugs 0.000 description 1
- 229960002277 tolazamide Drugs 0.000 description 1
- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
- 229960005371 tolbutamide Drugs 0.000 description 1
- YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
- 229960002905 tolfenamic acid Drugs 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
- GYHCTFXIZSNGJT-UHFFFAOYSA-N tolvaptan Chemical compound CC1=CC=CC=C1C(=O)NC(C=C1C)=CC=C1C(=O)N1C2=CC=C(Cl)C=C2C(O)CCC1 GYHCTFXIZSNGJT-UHFFFAOYSA-N 0.000 description 1
- 229960001256 tolvaptan Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 229940118436 tracleer Drugs 0.000 description 1
- 229960002051 trandolapril Drugs 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 229960003991 trazodone Drugs 0.000 description 1
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 1
- 229960005032 treprostinil Drugs 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical class O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960001288 triamterene Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
- LEIMLDGFXIOXMT-UHFFFAOYSA-N trimethylsilyl cyanide Chemical compound C[Si](C)(C)C#N LEIMLDGFXIOXMT-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 229960004747 ubidecarenone Drugs 0.000 description 1
- 229960000438 udenafil Drugs 0.000 description 1
- IYFNEFQTYQPVOC-UHFFFAOYSA-N udenafil Chemical compound C1=C(C=2NC=3C(CCC)=NN(C)C=3C(=O)N=2)C(OCCC)=CC=C1S(=O)(=O)NCCC1CCCN1C IYFNEFQTYQPVOC-UHFFFAOYSA-N 0.000 description 1
- 229960001130 urapidil Drugs 0.000 description 1
- 201000001988 urethral stricture Diseases 0.000 description 1
- 229940044953 vaginal ring Drugs 0.000 description 1
- 239000006213 vaginal ring Substances 0.000 description 1
- 229940044977 vaginal tablet Drugs 0.000 description 1
- 239000000003 vaginal tablet Substances 0.000 description 1
- 229960002004 valdecoxib Drugs 0.000 description 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
- 229960004699 valsartan Drugs 0.000 description 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
- 108010015385 valyl-prolyl-proline Proteins 0.000 description 1
- 229960002381 vardenafil Drugs 0.000 description 1
- 230000006496 vascular abnormality Effects 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 230000003639 vasoconstrictive effect Effects 0.000 description 1
- 239000003038 vasopressin antagonist Substances 0.000 description 1
- 229940099270 vasotec Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229960004688 venlafaxine Drugs 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- 208000037997 venous disease Diseases 0.000 description 1
- 229940105295 ventavis Drugs 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229950005018 vericiguat Drugs 0.000 description 1
- 229950005577 vesnarinone Drugs 0.000 description 1
- 229940094720 viagra Drugs 0.000 description 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
- 229960001254 vildagliptin Drugs 0.000 description 1
- 229940087652 vioxx Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019143 vitamin K2 Nutrition 0.000 description 1
- 239000011728 vitamin K2 Substances 0.000 description 1
- 229940019333 vitamin k antagonists Drugs 0.000 description 1
- 229960001729 voglibose Drugs 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229940002552 xenical Drugs 0.000 description 1
- 229950000339 xinafoate Drugs 0.000 description 1
- 229960000537 xipamide Drugs 0.000 description 1
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 1
- 229940072252 zestril Drugs 0.000 description 1
- 229950007802 zidometacin Drugs 0.000 description 1
- MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
- 229960005332 zileuton Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- 229960002769 zofenopril Drugs 0.000 description 1
- IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 description 1
- 229940020965 zoloft Drugs 0.000 description 1
- 229960003414 zomepirac Drugs 0.000 description 1
- ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
- 229940039925 zyprexa Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gynecology & Obstetrics (AREA)
Abstract
Description
[0009]本開示の目的上、「化合物I」は、特に明記されない限り、上に表示される構造の遊離塩基または塩酸塩を表す。化合物Iは、その結晶性遊離塩基として、高度に多形性であり、7種の結晶体(形態A、B、D、E、F、GおよびH)、同様に複数の溶媒和物を有することが公知である。化合物Iは、WO2014144100、実施例1に、淡オレンジ色固体として既に記載された。
[0012]別の態様では、本発明は、本明細書に開示される化合物Iの1つもしくは複数の多形体、または化合物Iの塩酸塩、および少なくとも1つの薬学的に許容される賦形剤または担体を含む医薬組成物に関する。別の実施形態では、本発明は、前記医薬組成物を含む医薬剤形に関する。
[0016]本開示の目的上、化学元素は、元素周期表、CASバージョン、およびHandbook of Chemistry and Physics、第75版、1994年に基づいて同定される。加えて、有機化学の一般原理は、「Organic Chemistry」、Thomas Sorrell、University Science Books、Sausalito:1999年、および「March’s Advanced Organic Chemistry」、第5版、Smith、M.B.およびMarch,J.,eds.John Wiley & Sons、New York:2001年に記載されており、これらはその全容が参照により本明細書に組み込まれる。
[0019]化合物Iなどの化合物は、その「他物質を含まない形態(neat form)」または「遊離塩基形態」で存在し得、遊離塩基形態は、結晶性または非晶質のいずれかであり得る。化合物の遊離塩基形態は、前記化合物の分子によってのみ形成される。
[0029]本開示は、塩(塩酸塩)である、化合物Iの1種の固体形態を記載する。
[0037]一態様では、本発明は、以下に示される、化合物Iの結晶性固体形態:
[0038]化合物Iは、前臨床モデルにおいて、多数のNO関連の障害の処置に関する実証された有効性を有するsGC刺激剤である。化合物Iは、様々な結晶形または多形体で存在し得る。これらの多形体のいくつかは、結晶性遊離塩基形態である。他の多形体は、溶媒和物である。いくつかの実施形態では、溶媒和物は水和物である。化合物Iはまた、その塩酸塩を含む、いくつかの薬学的に許容される塩も形成する。
[0052]いくつかの実施形態では、形態Aは、図10に示されるものと実質的に同様のFT−ラマンスペクトルにより特徴付けられる。
[0054]いくつかの実施形態では、形態Aは、図2または図3Aに示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる。
[0059]他の実施形態では、形態Aは、6.1(80.81%の相対強度またはrel int)、18.4(53.57%)、19.4(100.00%)、20.3(57.01%)および22.0(56.64)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる。
[0063]いくつかの実施形態では、形態Bは、図10に示されるものと実質的に同様のFT−ラマンスペクトルにより特徴付けられる。
[0065]いくつかの実施形態では、形態Bは、図2または図4Aに示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる。
[0067]別の実施形態では、形態Bは、8.8、16.4、17.2、18.8〜19.1、20.1および21.1〜21.6の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる。
[0070]他の実施形態では、形態Bは、8.9(76.55%の相対強度)、17.4(57.67%)、19.1(100.00%)、および25.5(52.26)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる。
[0074]いくつかの実施形態では、形態Dは、図10に示されるものと実質的に同様のFT−ラマンスペクトルにより特徴付けられる。
[0077]他の実施形態では、形態Dは、40℃および75%の相対湿度の安定性条件下で14か月間保管された時、本質的に変化しないXRPDトレースを示すことにより特徴付けられる。これらの条件下での保管の前後における形態Dに関するXRPDトレースは、図5Bに示される。
[0079]別の実施形態では、形態Dは、17.1、18.1、18.8および25.0の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる。
[0082]他の実施形態では、形態Dは、4.7(97.11%の相対強度)、18.1(80.97%)、18.6(100.00%)、および26.8(65.25)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる。
[0085]いくつかの実施形態では、形態Eは、図10に示されるものと実質的に同様のFT−ラマンスペクトルにより特徴付けられる。
[0088]他の実施形態では、形態Eは、7.4、18.8〜19.3、21.1、24.8および25.5の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる。
[0091]いくつかの実施形態では、形態Fは、図7に示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる。
[0095]いくつかの実施形態では、形態Gは、図8に示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる。
[0099]いくつかの実施形態では、形態Hは、図9に示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる。
本発明の薬学的に許容される塩。
[00106]化合物Iの塩酸塩は、上述のように調製されたその多形形態Dにおける化合物Iを、1MのHCl中で懸濁させ、それをi−PrOHと混合し、20〜40℃の間の温度サイクルで、40℃/時の加熱速度で、かつ5℃/時の冷却速度で撹拌することにより調製され得る。
[00108]化合物Iの塩酸塩は、pH1.4における0.5mg/mLの水溶解度により特徴付けられる。水溶解度は、飽和溶液のpHにおいて決定された。該塩を、水中で25℃で24時間振盪した。濾過後、その濃度は、HPLCにより、pH1.4において0.5mg/mLであると決定された。
医薬組成物および投与方法
[00110]本明細書に開示される結晶性固体形態は、医薬組成物または「製剤」として製剤化され得る。
[00127]経口使用に水性懸濁液が必要とされる時、活性材料は、乳化剤および懸濁化剤と組み合わせられる。所望ならば、特定の甘味剤および/または香味剤が添加されてもよい。シロップ剤およびエリキシル剤は、例えばグリセリン、プロピレングリコール、ソルビトールまたはスクロースのような甘味剤と共に製剤化され得る。そのような製剤はまた、粘滑薬、防腐剤、香味剤および着色剤ならびに抗酸化剤も含有し得る。
治療方法
[00144]別の態様では、本発明は、本明細書に開示される化合物Iの結晶性固体形態を、単独もしくは組み合わせのいずれかで、またはそれらを含む医薬組成物で、それを必要とする患者において使用することによる、特定の障害の処置に関する。
[00158]MI(心筋梗塞)は、2種類に分類され得る:「非ST部分上昇型」MIおよび「ST部分上昇型」MI。急性冠症候群の合併症は、どのくらいの大きさで、どのくらいの期間、かつどこで冠動脈が遮断されたかに依存する。遮断が、大量の心筋に影響を及ぼす場合、心臓は、効率的にポンピングしない。遮断が、心臓の電気系への血流を止めた場合、心リズムが影響され得る。心臓発作が起きた時、心筋層の一部が死滅する。死滅組織およびそれを置き換える瘢痕組織は、収縮しない。瘢痕組織は、心臓の残りの部分が収縮しようとする時、時々、膨張または膨隆さえする。結果的に、血液をポンピングする筋肉はより少ない。十分な筋肉が死滅した場合、心臓のポンピング能力は非常に低下し得るため、心臓は、酸素および血液に対する身体の需要に応えることができない。心不全、低血圧またはその両方が次に発生する。の半分を超える心筋層が損傷を受けるかまたは死滅した場合、心臓は、一般に機能することができず、重度の能力障害または死の可能性がある。
[00165]糖尿病は、心不全を有する患者に一般的な併存症であり、より乏しい転帰と同様に、処置の有効性を潜在的に損なうことに関連する。他の重要な併存症は、全身性高血圧、慢性気流閉塞、睡眠時無呼吸、認知機能障害、貧血、慢性腎臓疾患および関節炎を含む。慢性左心不全は、肺高血圧の発達に頻繁に関連する。特定の併存症の頻度は、男女差がある:女性の間では、高血圧および甲状腺疾患がより一般的である一方、男性は通常、慢性閉塞性肺疾患(COPD)、末梢血管疾患、冠動脈疾患および腎機能不全を患う。うつ病は、心不全の高頻度の併存症であり、2つの状態が、互いに併発し得、かつしばしば併発する。悪液質は、重篤な、かつ高頻度の心不全の合併症と長く認識されており、全ての心不全患者の15%までに影響を及ぼし、予後不良に関連する。心臓悪液質は、6か月間にわたる、非浮腫性の、体重の少なくとも6%の随意的でない損失と定義される。
・高血圧症および減少した冠血流に関連する障害;増加した急性および慢性の冠血圧;動脈性高血圧;心臓および腎臓の合併症に起因する血管障害;心臓疾患、脳卒中、大脳虚血または腎不全に起因する血管障害;抵抗性高血圧;糖尿病性高血圧;本態性高血圧;二次性高血圧;妊娠性高血圧;子癇前症;門脈圧亢進症;心筋梗塞;
・心不全、HFPEF、HFREF;急性および慢性のHF;より特異的な形態のHF:急性非代償性HF、右室不全、左室不全、総HF、虚血性心筋症、拡張型心筋症、先天性心欠損、心臓弁奇形を有するHF、僧帽弁狭窄、僧帽弁閉鎖不全、大動脈弁狭窄、大動脈弁閉鎖不全、三尖弁狭窄、三尖弁閉鎖不全、肺動脈弁狭窄、肺動脈弁閉鎖不全、複合心臓弁奇形;糖尿病性心不全;アルコール性心筋症または保管肥大型心筋症;拡張期HF、収縮期HF;急性期の既存の慢性HF(悪化HF);拡張期または収縮期の機能障害;冠機能不全;不整脈;心室前負荷の減少;心肥大;心不全/心腎症候群;門脈圧亢進症;内皮機能障害または傷害;心房および心室調律の妨害および伝導妨害:段階I〜III(AVB I〜III)の房室ブロック、上室性頻脈性不整脈、心房細動、心房粗動、心室細動、心室粗動、心室性頻脈性不整脈、多形性心室頻拍症、心房および心室性の期外収縮、AV接合部期外収縮、洞不全症候群、失神、AV結節リエントリー性頻拍;ウォルフ・パーキンソン・ホワイト症候群または急性冠症候群;ボクサー心筋症;心室性期外収縮;心筋症;がん誘発性心筋症;化学療法誘発性心毒性;
・血栓塞栓性障害および虚血;心筋虚血;梗塞;心筋梗塞;心臓発作;心筋機能不全;内皮機能障害;脳卒中;一過性脳虚血発作(TIA);閉塞性血栓性血管炎(thromboanginitis);安定または不安定な狭心症;冠攣縮または末梢動脈の攣縮;異型狭心症;プリンツメタル狭心症;心肥大;子癇前症;血栓形成性障害;虚血−再灌流傷害;臓器移植に関連する虚血−再灌流;肺移植(lung transplant)、肺移植(pulmonary transplant)、心臓移植、静脈グラフト不全症;外傷患者における保存血液置換に関連する虚血−再灌流;
・末梢血管疾患;末梢動脈疾患;末梢動脈閉塞性疾患;筋緊張亢進;レイノー症候群または現象(原発性および二次性);レイノー病;重症下肢虚血;末梢塞栓症;間欠性跛行;血管閉塞性クリーゼ;筋ジストロフィー、デュシェンヌ型筋ジストロフィー、ベッカー型筋ジストロフィー;微小循環異常;血管漏出または浸透性の制御;腰部脊柱管狭窄;閉塞性血栓性血管炎;血栓性血管炎;末梢灌流妨害;動脈および静脈の血栓症;微量アルブミン尿;末梢性および自律神経ニューロパチー;糖尿病性神経障害疼痛;糖尿病性細小血管症;肝臓血管閉塞性障害;鎌状赤血球症における血管閉塞性クリーゼ;高血圧クリーゼ;
・浮腫;心不全が原因の腎性浮腫;
・アルツハイマー病;パーキンソン病;血管性認知症;血管性認知障害;脳血管攣縮;先天性筋無力症症候群;くも膜下出血;外傷性脳損傷;軽度認知障害に起きるもの、加齢性の学習および記憶の障害、加齢性の記憶喪失、血管性認知症、頭部損傷、脳卒中、脳卒中後の認知症、外傷性頭部損傷後、集中の一般的妨害ならびに学習および記憶の問題を伴う小児における集中の妨害などの、認知障害後の知覚、集中能力、学習または記憶の履行の能力の改善;レビー小体型認知症;ピック症候群を含む前頭葉変性を伴う認知症;進行性核上性麻痺;皮質基底核変性を伴う認知症;筋萎縮性側索硬化症(ALS);ハンチントン病;脱髄;多発性硬化症;視床変性;クロイツフェルト・ヤコブ認知症;HIV認知症;認知症またはコルサコフ精神病を伴う統合失調症;多系統萎縮症および他の形態のパーキンソニズムプラス(Parkinsonism Plus);運動障害;神経保護;不安、緊張および抑うつまたは外傷後ストレス障害(PTSD);双極性障害;統合失調症;CNS関連の性機能障害および睡眠障害;病理学的摂食障害ならびに高級食糧および依存性薬物の使用;制御性脳灌流;片頭痛;脳梗塞(脳卒中(apoplexia cerebri))の予防および結果の制御;脳卒中、大脳虚血および頭部損傷の予防および結果の制御;CNS疾患に関連するニューロパチー;MSに関連する神経障害性疼痛;化学療法誘発性の神経障害性疼痛;帯状疱疹に関連する神経障害性疼痛;脊椎外科手術に関連する神経障害性疼痛;
・ショック;心原性ショック;敗血症;敗血症性ショック;アナフィラキシーショック;動脈瘤;白血球活性化の制御;血小板凝集の抑制または調節;多臓器機能障害症候群(MODS);多臓器不全(MOF);
・肺性/呼吸状態:肺高血圧(PH);肺動脈性高血圧(PAH)、および関連する肺血管性再構築;局在性血栓症および右心肥大の形態における血管性再構築;肺性筋緊張亢進;原発性肺高血圧;二次性肺高血圧;家族性肺高血圧;孤発性肺高血圧;前毛細血管肺高血圧;特発性肺高血圧;他の形態のPH;左室疾患、HIV、SCD、血栓塞栓症(CTEPH)、サルコイドーシス、COPD、肺線維症、急性呼吸促迫症候群(ARDS)、急性肺傷害、α1アンチトリプシン欠損症(AATD)、肺気腫、喫煙誘発性の気腫および嚢胞性線維症(CF)に関連するPH;血栓性肺動脈症;多因性肺動脈症;嚢胞性線維症;気管支収縮または肺性気管支収縮;急性呼吸器症候群;肺線維症、肺移植;喘息性疾患;
・左室機能障害、低酸素血症、WHO群I、II、III、IVおよびVの高血圧、僧帽弁疾患、収縮性心膜炎、大動脈弁狭窄、心筋症、縦隔線維症、肺線維症、肺静脈還流異常、肺静脈閉塞症、肺性血管炎、膠原病性血管疾患、先天性心疾患、肺静脈圧上昇、間質性肺疾患、睡眠呼吸障害、睡眠時無呼吸、肺胞低換気障害、高高度への慢性曝露、新生児肺疾患、肺胞毛細血管異形成、鎌状赤血球症、他の血液凝固障害、慢性血栓塞栓症、肺塞栓症に関連するかまたは関する肺高血圧;腫瘍、寄生虫または異物が原因の肺塞栓症;結合組織疾患、ループス、ループス腎炎、住血吸虫症、サルコイドーシス、慢性閉塞性肺疾患、喘息、気腫、慢性気管支炎、肺毛細血管腫症、組織球症X、リンパ管腫症、圧縮肺血管(compressed pulmonary vessels);腺症、腫瘍または線維化性縦隔炎が原因の圧縮肺血管;
・動脈硬化性(arterosclerotic)疾患または状態:アテローム性動脈硬化症;内皮傷害、血小板および単球の接着および凝集、平滑筋の増殖または遊走に関連するアテローム性動脈硬化症;再狭窄;血栓溶解療法、経皮経管血管形成術(PTA)、経管冠動脈形成術(PTCA)、心臓移植、バイパス手術または炎症過程後に発達した再狭窄;
・微小血管および大血管の損傷(血管炎);増加したレベルのフィブリノーゲンおよび低密度のDLD;増加した濃度のプラスミノーゲン活性化因子阻害剤1(PA−1);
・メタボリックシンドローム;代謝性疾患またはメタボリックシンドロームに関連する疾患:肥満;過剰皮下脂肪;過剰体脂肪蓄積;糖尿病;高血圧症;脂質関連障害、高脂血症、脂質異常症、高コレステロール血症、減少した高密度リポタンパク質コレステロール(HDL−コレステロール)、中程度に上昇した低密度リポタンパク質コレステロール(LDL−コレステロール)レベル、高トリグリセリド血症、高グリセリド血症、低リポタンパク質貧血、シトステロール血症、脂肪肝疾患、アルコール性脂肪肝疾患(AFLD)、非アルコール性脂肪肝疾患(NAFLD)、肝炎;子癇前症;多発性腎臓疾患進行;肝脂肪変性または肝臓中の異常な脂質蓄積、非アルコール性脂肪性肝炎(NASH);心臓、腎臓または筋肉の脂肪変性;アルファベータリポタンパク血症;シトステロール血症;黄色腫症;タンジール病;高アンモニア血症および関連疾患;肝性脳症;他の中毒性脳症;ライ症候群;
・性的、婦人科および泌尿器科の状態の障害:勃起機能障害;インポテンス;早漏;女性性機能障害;女性性的刺激機能障害;低機能性的刺激障害;膣萎縮;性交疼痛症(dyspaneuria);萎縮性腟炎;良性前立腺肥大(BPH)、前立腺肥大、前立腺腫大;膀胱下尿道閉塞;膀胱痛症候群(BPS);間質性膀胱炎(IC);過活動膀胱;神経因性膀胱および失禁;糖尿病性腎症;原発性および二次性の月経困難症;下部尿路症候群(LUTS);子宮内膜症;骨盤痛;男性および女性の泌尿生殖器系の臓器の良性および悪性の疾患;
・慢性腎臓疾患;急性および慢性の腎機能不全;急性および慢性の腎不全;ループス腎炎;根本的なまたは関連する腎臓疾患:低灌流、透析中の低血圧、閉塞性尿路疾患、糸球体症、糸球体腎炎、急性糸球体腎炎、糸球体硬化症、尿細管間質障害、腎障害疾患、原発性および先天性の腎臓疾患、腎炎;異常に減少したクレアチニンおよびまたは水分排出により特徴付けられる疾患;尿素、窒素、カリウムおよび/またはクレアチニンの異常に増加した血液濃度により特徴付けられる疾患;腎臓酵素の変化した活性により特徴付けられる疾患、グルタミル合成酵素の変化した活性により特徴付けられる疾患;変化した尿浸透圧または尿量により特徴付けられる疾患;増加した微量アルブミン尿により特徴付けられる疾患、顕性アルブミン尿により特徴付けられる疾患;糸球体および細動脈の病変、尿細管拡大、高リン血症および/または透析の必要により特徴付けられる疾患;腎機能不全の続発症;肺水腫(pulmonary enema)関連の腎機能不全;HF関連の腎機能不全;尿毒症または貧血関連の腎機能不全;電解質異常(ヘルカレミア、低ナトリウム血症);骨および炭水化物代謝の妨害;急性腎臓傷害;
・緑内障、網膜症および糖尿病性網膜症などの眼の疾患または障害。
・心筋炎症(心筋炎);慢性心筋炎;急性心筋炎;ウイルス性心筋炎;
・血管炎;膵炎;腹膜炎;リウマチ様疾患;
・腎臓の炎症性疾患;免疫学的腎臓疾患:腎臓移植拒絶反応、免疫複合体誘発性の腎臓疾患、毒素誘発性の腎症、造影剤誘発性の腎症;糖尿病性および非糖尿病性の腎症、腎盂腎炎、腎嚢胞、腎硬化症、高血圧性腎硬化症およびネフローゼ症候群;
・慢性間質性炎症、炎症性腸疾患(IBD)、クローン病、潰瘍性大腸炎(UC);
・炎症性皮膚疾患;
・眼の炎症性疾患、眼瞼炎、ドライアイ症候群、およびシェーグレン症候群;眼線維症。
・糖尿病性の創傷または潰瘍の治癒;微小血管灌流改良;傷害に続くかまたは周術期ケアにおける炎症性応答に対抗する微小血管灌流改良;裂肛;糖尿病性潰瘍;糖尿病性足部潰瘍;骨治癒機転;破骨細胞性骨吸収および再構築;ならびに新骨形成。
[00198]「自己免疫性障害」では、抗体または身体により生成される他の細胞が、身体自身の組織を攻撃する。多くの自己免疫性障害は、種々の臓器における結合組織に影響を及ぼす。自己免疫性障害では、炎症および免疫応答が、腎臓または消化管臓器などの、生命の維持に必要不可欠な重要臓器を含む、関節の周りおよび他の組織中の結合組織傷害も来たし得る。心臓を取り囲む嚢(心膜)、肺を覆う膜(胸膜)、縦隔(胸郭中の構造の正確に表現されていない群、疎性結合組織に取り囲まれ、心臓、心臓の大血管、食道、気管、横隔神経、心臓神経、胸管、胸腺、および中心胸部のリンパ節を含む)および脳でさえ、影響され得る。
[00201]肺線維症(特発性肺線維症、嚢胞性線維症)、肝臓の線維症(または「肝硬変”)、心内膜心筋線維症、陳旧性心筋梗塞、心房線維症、縦隔線維症、骨髄線維症(骨髄に影響を及ぼす)、後腹膜線維症、進行性塊状線維症(肺に影響を及ぼす)、腎性線維症(皮膚に影響を及ぼす)、クローン病、関節線維症、ペロニー病(陰茎に影響を及ぼす)、デュピュイトラン拘縮(手および指に影響を及ぼす)、いくつかの形態の癒着性関節包炎(肩部に影響を及ぼす)を含むが、これらに限定されない、多くの種類の線維症または線維性疾患がある。
[00205]用語「好酸球性筋膜炎(oesinophilic fasciitis)」は、好酸球性免疫細胞が放出され、皮膚の真下で、筋肉の上および間にある強靱な線維性組織の層である、「筋膜」の炎症および硬化をもたらすまれな障害を表す。筋膜は、腕および脚において、痛んで炎症を起こし、腫脹し、かつ徐々に硬化する。腕および脚の皮膚が進行性に硬化するため、腕および脚は動かすことが困難になる。最終的に、これらは通常の位置で動かなくなる。時に、腕が関与する場合は、患者は手根管症候群に発達し得る。
・泌尿生殖器系または腎臓障害:糖尿病性腎症;慢性腎臓疾患または腎機能不全に起因する腎線維症および腎不全;蓄積/沈着および組織傷害が原因の腎線維症および腎不全;腎硬化症;進行性硬化症;糸球体腎炎;巣状分節性糸球体硬化症;ネフローゼ症候群;前立腺肥大;腎臓線維症;間質性腎線維症;
・肺系統障害:肺線維症;特発性肺線維症;嚢胞性線維症;進行性塊状線維症;肺に影響を及ぼす進行性塊状線維症;
・心臓に影響を及ぼす障害:心内膜心筋線維症;陳旧性心筋梗塞;心房線維症;心臓間質性線維症;心臓再構築および線維症;心肥大;
・肝臓および関連する臓器の障害:肝臓硬化症または肝硬変;慢性肝臓疾患に関連する肝硬変;肝線維症;肝星細胞活性化;NASH;肝線維性コラーゲンおよび総コラーゲン蓄積;壊死性炎症性および/または免疫学的起源の肝臓疾患;原発性胆汁性肝硬変;原発性硬化性胆管炎;他の胆汁うっ滞性肝臓疾患:肉芽腫性肝臓疾患に関連するもの、肝悪性腫瘍、妊娠の肝内胆汁うっ滞、肝炎、敗血症、薬物または毒素、移植片対宿主病、肝臓移植後、総胆管結石、胆管腫瘍、膵癌、ミリッツィ症候群、AIDS胆管症または寄生虫;住血吸虫症;肝細胞癌;
・消化器系疾患または障害:クローン病;潰瘍性大腸炎;消化器の硬化症;アカラシア;
・皮膚または眼の疾患:腎性線維症;増殖性硝子体網膜症(vitroretinopathy);糖尿病性網膜症;眼線維症;
・線維性局所的または皮膚の障害もしくは状態;真皮性線維症;強皮症、皮膚線維症;モルフェア;肥厚性瘢痕;母斑;ケロイド;サルコイド;肉芽腫;
・神経系に影響を及ぼす疾患:筋萎縮性側索硬化症(ALS);海馬硬化症、多発性硬化症(MS);巣状硬化症;原発性側索硬化症;
・骨の疾患;骨硬化症;
・耳硬化症;他の聴覚疾患または障害;難聴、部分的または全体的な聴力損失;部分的または全体的な聴覚喪失;耳鳴;騒音性聴力損失;
・自己免疫、炎症または線維症を含む他の疾患:強皮症;局在性強皮症または限局性強皮症;縦隔線維症;線維症縦隔炎;骨髄線維症;後腹膜線維症;関節線維症;ペロニー病;デュピュイトラン拘縮;硬化性苔癬;いくつかの形態の癒着性関節包炎;アテローム性動脈硬化症;結節性硬化症;全身性硬化症;多発性筋炎;皮膚筋炎;多発性軟骨炎;好酸球性筋膜炎;全身性エリテマトーデスまたはループス;骨髄線維症(bone marrow fibrosis)、骨髄線維症(myelofibrosis)または骨骨髄線維症;サルコイドーシス;子宮筋腫;子宮内膜症。
[00226]本明細書に記載される固体形態および医薬組成物は、1つまたは複数のさらなる治療剤を用いる併用療法に使用され得る。1種より多い活性薬剤を用いる併用処置に関して、該活性薬剤が別々の投薬製剤である場合、該活性薬剤は、別々にまたは併せて投与され得る。加えて、1要素の投与は、他の薬剤の投与の前、同時に、または後であってもよい。
[00229]本発明の一実施形態では、化合物Iの多形体または薬学的に許容される塩、およびさらなる治療剤は、有効量(すなわち、それぞれ、単独で投与される場合の治療上有効である量)でそれぞれ投与される。別の実施形態では、化合物Iの多形体または薬学的に許容される塩、およびさらなる治療剤は、単独では治療効果を提供しない量(サブ治療用量)で、それぞれ投与される。さらに別の実施形態では、化合物Iの多形体または薬学的に許容される塩は有効量で投与され得、一方、さらなる治療剤はサブ治療用量で投与される。さらに別の実施形態では、化合物Iの多形体または薬学的に許容される塩はサブ治療用量で投与され得、一方、例えば、好適ながん治療剤のようなさらなる治療剤は有効量で投与される。
(1)血管内皮由来の放出因子(EDRF);
(2)NOドナーの、例えばニトロソチオール、ニトリル、シドノニミン、NONOate、N−ニトロソアミン、N−ヒドロキシルニトロソアミン、ニトロソイミン、ニトロチロシン、ジアゼチン二酸化物、オキサトリアゾール5−イミン、オキシム、ヒドロキシルアミン、N−ヒドロキシグアニジン、ヒドロキシ尿素またはアンチフロキサン(antifuroxan)など。これらの種類の化合物のいくつかの例は:三硝酸グリセリル(GTN、ニトログリセリン(nitroglycerin)、ニトログリセリン(nitroglycerine)、およびトリニトログリセリン(trinitrogylcerin)としても公知)、グリセロールの硝酸エステル;ニトロプルシドナトリウム(SNP)、鉄金属に1分子の一酸化窒素が配位して、両四角錐(square bipyramidal)錯体を形成する;3−モルホリノシドノンイミン(SIN−1)、モルホリンとシドノンイミンとの組み合わせにより形成される双性イオン性化合物;S−ニトロソ−N−アセチルペニシラミン(SNAP)、ニトロソチオール官能基を有するN−アセチルアミノ酸誘導体;ジエチレントリアミン/NO(DETA/NO)、ジエチレントリアミンに共有結合的に連結した一酸化窒素の化合物;およびNCX4016、アセチルサリチル酸のm−ニトロキシメチルフェニルエステルを含む。これらのクラスのNOドナーのいくつかのより特異的な例は:ニトログリセリン、亜硝酸アミル、二硝酸イソソルビド、5−一硝酸イソソルビドおよびニコランジルを含む有機ニトレートおよび亜硝酸エステルなどの古典的ニトロ血管拡張薬;イソソルビド(Dilatrate(登録商標)−SR、Imdur(登録商標)、Ismo(登録商標)、Isordil(登録商標)、Isordil(登録商標)、Titradose(登録商標)、Monoket(登録商標))、FK409(NOR−3);FR144420(NOR−4);3−モルホリノシドノンイミン;リンシドミンクロロ水和物(「SIN−1」);S−ニトロソ−N−アセチルペニシラミン(「SNAP」);AZD3582(CINOD リード化合物)、NCX4016、NCX701、NCX1022、HCT1026、NCX1015、NCX950、NCX1000、NCX1020、AZD4717、NCX1510/NCX1512、NCX2216,およびNCX4040(全てNicOx S.A.から入手可能)、S−ニトロソグルタチオン(GSNO)、ニトロプルシドナトリウム、S−ニトロソグルタチオンモノ−エチル−エステル(GSNO−エステル)、6−(2−ヒドロキシ−1−メチル−ニトロソヒドラジノ)−N−メチル−1−ヘキサンアミン(NOC−9)またはジエチルアミンNONOateを含む。一酸化窒素ドナーはまた、米国特許第5,155,137号、同5,366,997号、同5,405,919号、同5,650,442号、同5,700,830号、同5,632,981号、同6,290,981号、同5,691,423号、同5,721,365号、同5,714,511号、同6,511,911号、および同5,814,666号、Chrysselisら、(2002年)J Med Chem. 45:5406−9(NOドナー 14〜17など)、およびNitric Oxide Donors for Pharmaceutical and Biological Research、Eds:Peng George Wang、Tingwei Bill Cai、Naoyuki Taniguchi、Wiley、2005年にも開示されている;
(3)cGMP濃度を増加させる他の物質の、例えばプロトポルフィリンIX、アラキドン酸およびフェニルヒドラジン誘導体など;
(4)一酸化窒素合成酵素基質:例えば、N[G]−ヒドロキシ−L−アルギニン(NOHA)、1−(3,4−ジメトキシ−2−クロロベンジリデンアミノ)−3−ヒドロキシグアニジン、およびPR5(1−(3,4−ジメトキシ−2−クロロベンジリデンアミノ)−3−ヒドロキシグアニジン)などのn−ヒドロキシグアニジンをベースとする類似体;L−アルギニン誘導体(ホモ−Arg、ホモ−NOHA、N−tert−ブチルオキシ−およびN−(3−メチル−2−ブテニル)オキシ−L−アルギニン、カナバニン、イプシロングアニジン−カルポ酸、アグマチン、ヒドロキシル−アグマチン、およびL−チロシル−L−アルギニンなど);N−アルキル−N’−ヒドロキシグアニジン(N−シクロプロピル−N’−ヒドロキシグアニジンおよびN−ブチル−N’−ヒドロキシグアニジンなど)、N−アリール−N’−ヒドロキシグアニジン(N−フェニル−N’−ヒドロキシグアニジンおよびそれぞれ、−F、−Cl、−メチル、−OH置換基を持つ、そのパラ−置換誘導体など);3−(トリフルオロメチル)プロピルグアニジンなどのグアニジン誘導体;ならびにCaliら(2005年、Current Topics in Medicinal Chemistry 5:721−736)に概説される他のものおよびそこに引用される文献に開示される他のもの;
(5)eNOS転写を増強する化合物:例えば、WO 02/064146、WO 02/064545、WO 02/064546およびWO 02/064565、ならびにUS2003/0008915、US2003/0022935、US2003/0022939およびUS2003/0055093などの対応する特許文献に記載されるもの。US20050101599に記載されるものを含む他のeNOS転写促進薬(例えば、2,2−ジフルオロベンゾ[1,3]ジオキソール−5−カルボン酸インダン−2−イルアミド、および4−フルオロ−N−(インダン−2−イル)−ベンズアミド)、ならびにサノフィ・アベンティス化合物AVE3085およびAVE9488(CA Registry NO.916514−70−0;Schaferら、Journal of Thrombosis and Homeostasis 2005年;第3巻、Supplement 1:要約番号P1487);
(6)NO非依存性ヘム−依存性のsGC活性化因子:BAY 58−2667(特許刊行物DE19943635を参照のこと)
HMR−1069(サノフィ・アベンティス)
を含むが、これらに限定されない。
YC−1(特許刊行物EP667345およびDE19744026を参照のこと)
BAY 41−2272(DE19834047およびDE19942809に記載される)
を含むが、これらに限定されない。
PDE5阻害剤の、例えば、シルデナフィル(Viagra(登録商標))ならびに他の関連する薬剤の、例えばアバナフィル、ロデナフィル(Lodenafil)、ミロデナフィル(Mirodenafil)、シルデナフィルクエン酸塩(Revatio(登録商標))、タダラフィル(Cialis(登録商標)またはAdcirca(登録商標))、バルデナフィル(Levitra(登録商標))およびウデナフィルなど;アルプロスタジル;およびジピリダモール;PF−00489791など;
例えば、PF−04447943などのPDE9阻害剤;など
(9)カルシウムチャネル遮断薬:
ジヒドロピリジンカルシウムチャネル遮断薬:アムロジピン(ノルバスク)、アラニジピン(サプレスタ(Sapresta))、アゼルニジピン(カルブロック)、バルニジピン(ヒポカ)、ベニジピン(コニール)、シルニジピン(アテレック、シナロング、シスカード(Siscard))、クレビジピン(クレビプレックス(Cleviprex))、ジルチアゼム、エホニジピン(ランデル)、フェロジピン(プレンジル(Plendil))、ラシジピン(モテンス(Motens)、ラシピル(Lacipil))、レルカニジピン(ザニジップ(Zanidip))、マニジピン(カルスロット、マジピン(Madipine))、ニカルジピン(カルデン(Cardene)、カルデンSR(Carden Sr))、ニフェジピン(プロカジア、アダラート)、ニルバジピン(ニバジール)、ニモジピン(ニモトップ(Nimotop))、ニソルジピン(バイミカード、スラー(Sular)、シスコール(Syscor))、ニトレンジピン(カージフ(Cardif)、ニトレピン(Nitrepin)、バイロテンシン)、プラニジピン(Pranidipine)(アカラス(Acalas))、イスラジピン(ロミール(Lomir));など
フェニルアルキルアミンカルシウムチャネル遮断薬:ベラパミル(カラン、イソプチン)
ベンゾチアゼピン:ジルチアゼム(カルディゼム);
(10)エンドセリン受容体アンタゴニスト(ERA):例えば、2種の(ETAおよびETB)エンドセリン受容体アンタゴニスト、ボセンタン(Tracleer(登録商標)として市販);シタキセンタン(Sitaxentan)、Thelin(登録商標)の名称で市販;アンブリセンタンは米国でLetairis(登録商標)として市販;2008年に臨床試験に入った、2種の/非選択性エンドセリンアンタゴニスト、アクテリオン−1(Actelion−1);
(11)プロスタサイクリン誘導体または類似体:例えば、プロスタサイクリン(プロスタグランジンI2)、エポプロステノール(合成のプロスタサイクリン、Flolan(登録商標)として市販);トレプロスチニル(Remodulin(登録商標))、イロプロスト(Ilomedin(登録商標))、イロプロスト(Ventavis(登録商標)として市販);開発中の経口および吸入形態のRemodulin(登録商標);ベラプロスト、日本および韓国で入手可能な口プロスタノイド;
(12)抗脂質異常症薬:胆汁酸捕捉剤(例えば、コレスチラミン、コレスチポール、コレスチランおよびコレセベラム);アトルバスタチン、シンバスタチン、ロバスタチン、フルバスタチン、ピタバスタチン、ロスバスタチンおよびプラバスタチンなどのスタチン;エゼチミブなどのコレステロール吸収阻害剤;イコサペント酸エチルエステル、オメガ3脂肪酸エチルエステル、レデュコール(Reducol)などの他の抗高脂血症剤;クロフィブレート、ベザフィブレート、クリノフィブレート、ゲムフィブロジル、ロニフィブレート、ビニフェブレート(Binifibrate)、フェノフィレート(Fenofirate)、シプロフィブレート、コリンフェノフィブレートなどのフィブリン酸誘導体:アシピモックスおよびナイアシンなどのニコチン酸誘導体;また、スタチン、ナイアシン、腸コレステロール吸収−阻害サプリメント(エゼチミブなど)およびフィブレートの組み合わせ;クロピドグレル二硫酸塩などの抗血小板療法;など
(13)抗凝固薬、以下の種類など:
・クマリン(ビタミンKアンタゴニスト):Warfarin(登録商標)(クマジン)、主にUSおよびUKで使用される;Acenocoumaro(登録商標)およびPhenprocoumon(登録商標)、主に他の国々で使用される;Phenindione(登録商標);
・ヘパリンおよび誘導体物質:ヘパリン;低分子量ヘパリン、フォンダパリナックスおよびイドラパリナックス;など
・直接トロンビン阻害剤:アルガトロバン、レピルジン、ビバリルジンおよびダビガトラン;キシメラガトラン(Exanta(登録商標))、USでは承認されていない;など
・組織プラスミノーゲン活性化因子、血塊を溶解し、かつ動脈の閉塞を取り除くために使用される、アルテプラーゼなど;
(14)抗血小板薬:例えば、ロピドグレル(Lopidogrel)およびチクロピジンなどのチエノピリジン;ジピリダモール;アスピリン;
(15)ACE阻害剤、例えば、以下の種類:
・カプトプリル(商標名Capoten(登録商標))、最初のACE阻害剤およびゾフェノプリルなどのスルフヒドリル含有の薬剤;
・エナラプリル(バソテック(Vasotec)/Renitec(登録商標))などのジカルボキシレート含有の薬剤;ラミプリル(アルテース(Altace)/トリテース(Tritace)/ラメース(Ramace)/Ramiwin(登録商標));キナプリル(Accupril(登録商標))、ペリンドプリル(コバシル/Aceon(登録商標));リシノプリル(リソヅル(Lisodur)/ロプリル(Lopril)/ノバテック(Novatec)/プリニビル(Prinivil)/Zestril(登録商標))およびベナゼプリル(Lotensin(登録商標));
・ホシノプリルなどのホスホネート含有の薬剤;
・特に発酵乳のような乳製品の摂取後に自然発生する、カゼインおよびホエーの分解産物である、カソキニン(Casokinin)およびラクトキニン(lactokinin)などの自然起源のACE阻害剤;生菌ラクトバチルス・ヘルベティカスにより生成されるかまたはカゼイン由来のラクトトリペプチドVal−Pro−ProおよびIle−Pro−Proもまた、ACE−阻害および抗高血圧性機能を有する;
・アラセプリル、デラプリル、シラザプリル、イミダプリル、トランドラプリル、テモカプリル、モエキシプリル、スピラプリルなどの他のACE阻害剤、
(16)酸素補給療法;
(17)以下の種類などのベータ遮断薬:
・非選択的薬剤:Alprenolol(登録商標)、Bucindolol(登録商標)、Carteolol(登録商標)、Carvedilol(登録商標)(付加的なα−遮断作用を有する)、Labetalol(登録商標)(付加的なα−遮断作用を有する)、Nadolol(登録商標)、Penbutolol(登録商標)(内因性交感神経刺激作用を有する)、Pindolol(登録商標)(内因性交感神経刺激作用を有する)、オクスプレノロール(Oxprenonol)、アセブトロール、ソタロール、メピンドロール、セリプロロール、アロチノロール、テルタトロール、アモスラロール、ニプラジロール、Propranolol(登録商標)およびTimolol(登録商標);
・β1−選択的薬剤:Acebutolol(登録商標)(内因性交感神経刺激作用を有する)、Atenolol(登録商標)、Betaxolol(登録商標)、Bisoprolol(登録商標)、Celiprolol(登録商標)、ドブタミン塩酸塩、イルソグラジンマレイン酸塩、カルベジロール、タリノロール、Esmolol(登録商標)、Metoprolol(登録商標)およびNebivolol(登録商標);
・β2−選択的薬剤:Butaxamine(登録商標)(弱いα−アドレナリン作動性アゴニスト作用);
(18)抗不整脈剤:以下の種類など
・I型(ナトリウムチャネル遮断薬):キニジン、リドカイン、フェニトイン、プロパフェノン
・III型(カリウムチャネル遮断薬):アミオダロン、ドフェチリド、ソタロール
・V型:アデノシン、ジゴキシン
(19)利尿薬:例えば、クロロチアジド、クロルタリドン、およびヒドロクロロチアジド、ベンドロフルメチアジド、シクロペンチアジド、メチクロチアジド、ポリチアジド、キネタゾン、キシパミド、メトラゾン、インダパミド、シクレタニンのようなチアジド系利尿薬;フロセミドおよびトレサミド(Toresamide)などのループ利尿薬;アミロライド、スピロノラクトン、カンレノ酸カリウム、エプレレノンおよびトリアムテレンなどのカリウム保持性利尿薬;これらの薬剤の組み合わせ;アセタゾラミドおよびカルペリチドなどの他の利尿薬など
(20a)ヒドララジン塩酸塩、ジアゾキシド、ニトロプルシドナトリウム、カドララジンなどの直接作用性血管拡張薬;二硝酸イソソルビドおよび5−一硝酸イソソルビドなどの他の血管拡張薬;
(20b)外因性血管拡張薬:
・Adenocard(登録商標)、アデノシンアゴニスト、抗不整脈薬として主に使用される;
・アルファ遮断薬(アドレナリンの血管収縮性効果を遮断する):プラゾシン、インドラミン、ウラピジル、ブナゾシン、テラゾシン、ドキサゾシンなどのアルファ−1−アドレナリン受容体アンタゴニスト
・心房性ナトリウム利尿ペプチド(ANP);
・エタノール
・マスト細胞および好塩基性顆粒球からヒスタミン放出を誘発することにより、タンパク質C3a、C4aおよびC5aの働きを補完するヒスタミン誘導物質;
・テトラヒドロカンナビノール(THC)、少ない血管拡張薬効果を有するマリファナ中の主要な活性化学物質;
・パパベリン、ケシ属ケシの催眠薬に見出されるアルカロイド;など
(21)気管支拡張薬:以下に例示される主要な2種類の気管支拡張薬、β2アゴニストおよび抗コリン薬がある:
・β2アゴニスト:Salbutamol(登録商標)またはアルブテロール(一般的商品名:ベントリン)およびTerbutaline(登録商標)は、COPD症状の急速軽減用の短時間作用型β2アゴニストである。Salmeterol(登録商標)およびFormoterol(登録商標)などの長時間作用型β2アゴニスト(LABA);
・抗コリン薬:Ipratropium(登録商標)は、最も広く処方される短時間作用型抗コリン薬である。Tiotropium(登録商標)は、COPDにおいて最も一般的に処方される長時間作用型抗コリン薬である;
・Theophylline(登録商標)、気管支拡張薬およびホスホジエステラーゼ阻害薬;
(22)副腎皮質ステロイド薬:ベクロメタゾン、メチルプレドニゾロン、ベタメタゾン、プレドニゾン、プレニソロン(prenisolone)、トリアムシノロン、デキサメタゾン、フルチカゾン、フルニソリドおよびヒドロコルチゾン、ならびにブデソニドなどの副腎皮質ステロイド薬類似体など
(23)栄養補助食品:例えば、オメガ−3油脂;葉酸、ナイアシン、亜鉛、銅、朝鮮紅参、イチョウ、松樹皮、ハマビシ(Tribulus terrestris)、アルギニン、エンバク、碇草(horny goat weed)、マカ球根、ムイラプアマ(muira puama)、ノコギリヤシ、およびスウェーデンフラワー(Swedish flower)花粉;ビタミンC、ビタミンE、ビタミンK2;テストステロン補充剤、テストステロン経皮パッチ;ゾラキセル(Zoraxel)、ナルトレキソン、ブレメラノチド(Bremelanotide)(以前はPT−141)、メラノタンII(Melanotan II)、hMaxi−K;プレロックス(Prelox):自然起源材料の特許薬(Proprietary)の混合/組み合わせ、L−アルギニンアスパラギン酸塩およびピクノジェノール(Pycnogenol);など
(24)PGD2受容体アンタゴニスト:米国出願公開US20020022218、US20010051624、およびUS20030055077、PCT出願公開W09700853、W09825919、WO03066046、WO03066047、WO03101961、WO03101981、WO04007451、WO0178697、WO04032848、WO03097042、WO03097598、WO03022814、WO03022813、およびWO04058164、欧州特許出願EP945450およびEP944614に、PGD2拮抗性作用を有すると記載された化合物、ならびに:Torisuら、2004年、Bioorg Med Chem Lett 14:4557、Torisuら、2004年、Bioorg Med Chem Lett 2004 14:4891、およびTorisuら、2004年、Bioorg & Med Chem 2004 12:4685に収載されたものを含むが、これらに限定されない;
(25)免疫抑制剤:シクロスポリン(シクロスポリンA、Sandimmune(登録商標)Neoral(登録商標))、タクロリムス(FK−506、Prograf(登録商標))、ラパマイシン(シロリムス、Rapamune)および他のFK−506型免疫抑制剤、ならびにミコフェノレート、例えば、ミコフェノール酸モフェチル(CellCept(登録商標));など
(26)非ステロイド系抗喘息薬:β2−アゴニスト(例えば、テルブタリン、メタプロテレノール、フェノテロール、イソエタリン、アルブテロール、サルメテロール、ビトルテロールおよびピルブテロール)ならびにβ2−アゴニスト−副腎皮質ステロイド薬の組み合わせ(例えば、サルメテロール−フルチカゾン(Advair(登録商標))、ホルモテロール−ブデソニド(Symbicort(登録商標)))、テオフィリン、クロモリン、クロモグリク酸ナトリウム、ネドクロミル、アトロピン、イプラトロピウム、イプラトロピウム臭化物、ロイコトリエン生合成阻害剤(ジロートン、BAY1005);など
(27)非ステロイド系抗炎症剤(NSAID):プロピオン酸誘導体(例えば、アルミノプロフェン、ベノキサプロフェン、ブクロキス酸、カルプロフェン、フェンブフェン、フェノプロフェン、フルプロフェン(fluprofen)、フルルビプロフェン、イブプロフェン、インドプロフェン、ケトプロフェン、ミロプロフェン(miroprofen)、ナプロキセ、オキサプロジン、ピルプロフェン、プラノプロフェン、スプロフェン、チアプロフェン酸およびチオキサプロフェン(tioxaprofen))、酢酸誘導体(例えば、インドメタシン、アセメタシン、アルクロフェナク、クリダナク、ジクロフェナク、フェンクロフェナク、フェンクロズ酸、フェンチアザク、フロフェナク(furofenac)、イブフェナク、イソキセパク(isoxepac)、オキシピナク(oxpinac)、スリンダク、チオピナク(tiopinac)、トルメチン、ジドメタシン(zidometacin)およびゾメピラク)、フェナム酸誘導体(例えば、フルフェナム酸、メクロフェナム酸、メフェナム酸、ニフルミン酸およびトルフェナム酸)、ビフェニルカルボン酸誘導体(例えば、ジフルニサルおよびフルフェニサル(flufenisal))、オキシカム(oxicam)(例えば、イソキシカム、ピロキシカム、スドキシカムおよびテノキシカム(tenoxican))、サリチレート(例えば、アセチルサリチル酸およびスルファサラジン)ならびにピラゾロン(例えば、アパゾン、ベズピペリロン、フェプラゾン、モフェブタゾン、オキシフェンブタゾンおよびフェニルブタゾン)など;
(28)シクロオキシゲナーゼ−2(COX−2)阻害剤:セレコキシブ(Celebrex(登録商標))、ロフェコキシブ(Vioxx(登録商標))、バルデコキシブ、エトリコキシブ、パレコキシブおよびルミラコキシブなど;
コデイン、フェンタニル、ヒドロモルホン、レボルファノール、メペリジン、メタドン、モルヒネ、オキシコドン、オキシモルフォン、プロポキシフェン、ブプレノルフィン、ブトルファノール、デゾシン、ナルブフィンおよびペンタゾシンなどのオピオイド鎮痛薬;ならびに
(29)抗糖尿病剤:インスリンおよびインスリン様薬剤、スルホニル尿素(例えば、グリブリド、グリベンクラミド、グリピジド、グリクラジド、グリキドン、グリメピリド、メグリナチド(Meglinatide)、トルブタミド、クロルプロパミド、アセトヘキサミド、トラザミド)、ビグアナイド薬、例えば、メトホルミン(Glucophage(登録商標))、α−グルコシダーゼ阻害剤(アカルボース、エパルレスタット、ボグリボース、ミグリトールなど)、チアゾリジノン化合物、例えば、ロシグリタゾン(Avandia(登録商標))、トログリタゾン(Rezulin(登録商標))、シグリタゾン、ピオグリタゾン(Actos((登録商標))およびエングリタゾン;ピオグリタゾンおよびロシグリタゾンなどのインスリン増感剤;レパグリニド、ナテグリニドおよびミチグリニドなどのインスリン分泌促進剤;エキサナチド(Exanatide)およびリラグルチドなどのインクレチン様薬剤;プラムリンチドなどのアミリン類似体;ピコリン酸クロム(任意選択でビオチンと組み合わせる)などの血糖降下剤;シタグリプチン、ビルダグリプチン、サクサグリプチン、アログリプチンおよびリナグリプチンなどのジペプチジルペプチダーゼIV阻害剤;糖尿病の処置用に現在開発されているワクチン;AVE−0277、Alum−GAD、BHT−3021、IBC−VS01;アナキンラ、カナキヌマブ、ジアセレイン、ゲボキズマブ、LY−2189102、MABP−1、GIT−027などの糖尿病の処置用に開発中のサイトカイン標的療法など;
(30)HDLコレステロール上昇剤:アナセトラピブ、MK−524A、CER−001、DRL−17822、ダルセトラピブ、JTT−302、RVX−000222、TA−8995など;
(31)抗肥満薬:メタンフェタミン塩酸塩、アンフェプラモン塩酸塩(Tenuate(登録商標))、フェンテルミン(Ionamin(登録商標))、ベンズフェタミン塩酸塩(Didrex(登録商標))、フェンジメトラジンタルトレート(Bontril(登録商標)、Prelu−2(登録商標)、Plegine(登録商標))、マジンドール(Sanorex(登録商標))、オルリスタット(Xenical(登録商標))、シブトラミン塩酸塩一水和物(Meridia(登録商標)、Reductil(登録商標))、リモナバン(Acomplia(登録商標))、アンフェプラモン、ピコリン酸クロム、RM−493、TZP−301;フェンテルミン/トピラメート、ブプロピオン/ナルトレキソン、シブトラミン/メトホルミン、ブプロピオンSR/ゾニサミドSR、サルメテロール、キシナホエート/プロピオン酸フルチカソン;ロルカセリン塩酸塩、フェンテルミン/トピラメート、ブプロピオン/ナルトレキソン、セチリスタット、エキセナチド、KI−0803、リラグルチド、メトホルミン塩酸塩、シブトラミン/メトホルミン、876167、ALS−L−1023、ブプロピオンSR/ゾニサミドSR、CORT−108297、カナグリフロジン、ピコリン酸クロム、GSK−1521498、LY−377604、メトレレプチン、オビネピチド(Obinepitide)、P−57AS3、PSN−821、キシナホ酸サルメテロール/プロピオン酸フルチカゾン、タングステン酸ナトリウム、ソマトロピン(組換え型)、TM−30339、TTP−435、テサモレリン、テソフェンシン(Tesofensine)、ベルネペリト、ゾニサミド、BMS−830216、ALB−127158、AP−1030、ATHX−105、AZD−2820、AZD−8329、ベロラニブヘミオキサレート(Beloranib hemioxalate)、CP−404、HPP−404、ISIS−FGFR4Rx、インスリノトロピン(Insulinotropin)、KD−3010PF、05212389、PP−1420、PSN−842、ペプチドYY3−36、レスベラトロール、S−234462;S−234462、ソベチローム(Sobetirome)、TM−38837、テトラヒドロカンナビバリン(Tetrahydrocannabivarin)、ZYO−1、ベータ−ラパコンなどの組み合わせ;など
(32)アンジオテンシン受容体遮断薬:ロサルタン、バルサルタン、カンデサルタンシレキセチル、エプロサラン(Eprosaran)、イルベサルタン、テルミサルタン、オルメサルタンメドキソミル(Olmesartran medoxomil)、アジルサルタンメドキソミルなど;
(33)レニン阻害剤:アリスキレンヘミフミレートなど;
(34)中枢作用性のアルファ−2−アドレナリン受容体アゴニスト:メチルドパ、クロニジン、グアンファシンなど;
(35)アドレナリン作動性ニューロン遮断薬:グアネチジン、グアナドレルなど;
(36)イミダゾリンI−1受容体アゴニスト:リメニジン(Rimenidine)リン酸二水素およびモクソニジン塩酸塩水和物など;
(37)アルドステロンアンタゴニスト:スピロノラクトンおよびエプレレノンなど
(38)カリウムチャネル活性化因子:ピナシジルなど
(39)ドーパミンD1アゴニスト:フェノルドパムメシレートなど;イボパミン、ドペキサミンおよびドカルパミンなどの他のドーパミンアゴニスト;
(40)5−HT2アンタゴニスト:ケタンセリンなど;
(42)バソプレシンアンタゴニスト:トルバプタンなど;
(43)カルシウムチャネル増感剤:レボシメンダンなどまたはニコランジルなどの活性化因子;
(44)PDE−3阻害剤:アムリノン、ミルリノン、エノキシモン、ベスナリノン、ピモベンダン、オルプリノンなど;
(45)アデニル酸シクラーゼ活性化因子:コルホルシンダプロペート塩酸塩など;
(46)陽性変力薬:ジゴキシンおよびメチルジゴキシンなど;ユビデカレノンなどの代謝性強心薬;ネシリチドなどの脳性ナトリウム利尿ペプチド(naturetic peptide);
(47)勃起機能障害の処置に使用される薬物:アルプロスタジル、アビプタジル(Aviptadil)、フェントラミンメシル酸塩、ウェイゲ(Weige)、アルプロスタジルなど;
(48)抗肥満薬:
(54)メチレンブルー(MB)
を含むが、これらに限定されない。
[00234]本明細書に記載される固体形態および医薬製剤は、キット中に含まれ得る。キットは、それぞれ個々に包装されるかもしくは製剤化された、単回もしくは複数回の投与量の2種以上の薬剤を、または組み合わせて包装されるかもしくは製剤化された、単回もしくは複数回の投与量の2種以上の薬剤を含有し得る。したがって、1つまたは複数の薬剤は第1の容器中に存在し得、キットは、任意選択で、1つまたは複数の薬剤を第2の容器中に含み得る。容器または複数の容器はパッケージ内に入れられ、パッケージは、任意選択で、投与または投薬量の説明書を含んでもよい。キットは、シリンジまたは薬剤と同様に希釈剤を投与するための他の手段または製剤用の他の手段などのさらなる構成要素を備え得る。したがって、キットは:a)本明細書に記載される化合物および薬学的に許容される担体、ビヒクルまたは希釈剤を含む医薬組成物;ならびにb)容器または包装を備え得る。キットは、任意選択で、本明細書に記載される1つまたは複数の方法(例えば、本明細書に記載される1つまたは複数の疾患および障害を予防するかまたは処置する)の中の、該医薬組成物を使用する1つの方法を記載する説明書を備え得る。キットは、任意選択で、同時療法使用のための本明細書に記載される1つもしくは複数のさらなる薬剤を含む第2の医薬組成物、薬学的に許容される担体、ビヒクルまたは希釈剤を含んでもよい。キット中に含まれる、本明細書に記載される化合物を含む医薬組成物および第2の医薬組成物は、任意選択で、同一の医薬組成物中に組み合わせられてもよい。
粗製の化合物Iの調製
i):N−メトキシ−N−メチルイソオキサゾール−3−カルボキサミド(2’)を提供するための、化合物(1’)とN,O−ジメチルヒドロキシルアミンとのカップリング
実施例2
粗製の(R)−3,3,3−トリフルオロ−2−(((5−フルオロ−2−(1−(2−フルオロベンジル)−5−(イソオキサゾール−3−イル)−1H−ピラゾール−3−イル)ピリミジン−4−イル)アミノ)メチル)−2−ヒドロキシプロパンアミド(粗製の化合物I)の、多形形態Bへの再結晶
[00257]粗製の化合物I(0.68kg、1.33mol)およびアセトニトリル(20.4L)を、30Lのジャケット付き反応容器に投入した。反応混合物を、低速度で撹拌し、ほとんどの固体が溶解するまで、70〜75℃に加熱した。30Lのジャケット付き反応容器中の溶液を、ガス拡散管(粗いフリット)を介して、100Lのジャケット付き反応容器内にインライン濾過した。次に、反応混合物を70〜75℃に加熱し、バッチ温度を1時間にわたり>65℃に維持しながら、水(20.4L)を投入した。反応混合物を、52〜62℃まで冷却し、52〜62℃で最短で1時間にわたり撹拌して、反応種源を形成した。得られたスラリーを、0〜5℃まで最短で4時間にわたり冷却し、0〜5℃で最短で1時間にわたり保持した。該スラリーを濾過し、濾過ケーキを、事前混合したアセトニトリルおよび水(3.4L/3.4L)の溶液で洗浄した。次に、該濾過ケーキを、真空下で90〜100℃で最短で30時間にわたり乾燥し、化合物Iを多形形態Bとして、白色固体として得た(0.58kg、85%収率)。1H-NMR (500 MHz, DMSO-d6) δ ppm 9.10 (s, 1 H); 8.33 (d, J=2.90 Hz, 1 H); 7.93 (s, br, 1 H); 7.90 (s, 1 H); 7.78 (s, br, 1 H); 7.69 (s, br, 1 H); 7.52 (s, 1 H); 7.33 (q, J=7.02 Hz, 1 H); 7.17 - 7.25 (m, 1 H); 7.17 - 7.25 (m, 1 H); 7.10 (t, J=7.48 Hz,1 H); 6.98 (t, J=7.55 Hz, 1 H); 5.90 (s, 2 H); 3.92-4.05 (m, 2 H)。
粗製の(R)−3,3,3−トリフルオロ−2−(((5−フルオロ−2−(1−(2−フルオロベンジル)−5−(イソオキサゾール−3−イル)−1H−ピラゾール−3−イル)ピリミジン−4−イル)アミノ)メチル)−2−ヒドロキシプロパンアミド(化合物I)の、多形形態Eへの再結晶
[00258]機械式撹拌機、コンデンサ、滴下漏斗、窒素入出口、熱電対および加熱−冷却能力を装備した5Lの4つ口丸底フラスコに、粗製の化合物I(67.4g、132mmol)およびメタノール(2500mL)を投入した。この混合物を、>60℃まで(例えば、70℃より高く)加熱し、溶液を得た。該溶液を濾過し、濾液を>60℃に加熱した。水(1500mL)を、温度を>60℃に維持しながら、この混合物に添加した。該混合物を、室温まで1時間にわたり放冷し、この温度で1時間にわたり保持した。スラリーを濾過し、濾過ケーキをメタノール/水(600mL、1/1 v/v)ですすいだ。該濾過ケーキを収集し、真空下で80℃で72時間にわたり乾燥して、化合物Iを多形形態Eとして、白色固体として得た(59.5g、88%収率)。
(R)−3,3,3−トリフルオロ−2−(((5−フルオロ−2−(1−(2−フルオロベンジル)−5−(イソオキサゾール−3−イル)−1H−ピラゾール−3−イル)ピリミジン−4−イル)アミノ)メチル)−2−ヒドロキシプロパンアミドの多形形態Eの、多形形態Aへの再結晶
[00259]機械式撹拌機、コンデンサ、滴下漏斗、窒素入出口、熱電対および加熱−冷却能力を装備した1Lの4つ口丸底フラスコに、多形形態Eとしての化合物I(19.3g、38mmol)および酢酸エチル(600mL)を投入した。この混合物を、>70℃に加熱し、溶液を得た。該溶液を濾過し、濾液を20〜25℃で16時間にわたり撹拌して、スラリーを得た。該スラリーを、約150mLの最終体積まで真空下で濃縮した。ヘプタン(300mL)を、該スラリーに20分間にわたり添加し、この混合物を、約350mLの最終体積まで真空下で濃縮した。該スラリーを濾過し、濾過ケーキをヘプタン(50mL)ですすいだ。該濾過ケーキを収集し、真空下で100℃で3時間にわたり乾燥して、多形形態Aを白色固体として得た(19.1g、99%収率)。
粗製の(R)−3,3,3−トリフルオロ−2−(((5−フルオロ−2−(1−(2−フルオロベンジル)−5−(イソオキサゾール−3−イル)−1H−ピラゾール−3−イル)ピリミジン−4−イル)アミノ)メチル)−2−ヒドロキシプロパンアミド(化合物I)の、多形形態Aへの再結晶
[00260]多形形態Aはまた、形態Eの代わりに粗製の化合物Iを出発物質として使用して、実施例4Aに記載されるものと類似の方法により、酢酸エチルから単離することにより、粗製の化合物Iから直接得られた。
[00262]多形形態Aはまた、粗製の化合物Iを、溶媒であるヘプタン、(酢酸イソプロピル)IPAC、エタノール、酢酸エチルまたはデカンのうちの任意の溶媒中で、室温でスラリー化し、14〜30時間撹拌しておく時にも、単離された。この試料を濾過し、残留固体をXRPDにより分析した。
(R)−3,3,3−トリフルオロ−2−(((5−フルオロ−2−(1−(2−フルオロベンジル)−5−(イソオキサゾール−3−イル)−1H−ピラゾール−3−イル)ピリミジン−4−イル)アミノ)メチル)−2−ヒドロキシプロパンアミドの多形形態Eの、多形形態Dへの再結晶
[00263]機械式撹拌機、コンデンサ、滴下漏斗、窒素入出口、熱電対および加熱−冷却能力を装備した2Lの4つ口丸底フラスコに、多形形態Eとしての化合物I(14.0g、28mmol)およびn−デカン(560mL)を投入した。この混合物を、145〜155℃に加熱し、145〜155℃で45分間保持した。得られたスラリーを、20〜30℃まで1時間にわたり冷却し、次に濾過した。濾過ケーキをヘプタン(280mL)ですすいだ。該濾過ケーキを収集し、真空下で80℃で72時間にわたり乾燥して、化合物Iを形態Dとして、白色固体として得た(12.9g、92%収率)。
多形形態Dを得るための他の方法
[00264]多形形態Dはまた、その他の多くの多形性形態(他物質を含まず)を、180℃で、図12に要約され、かつ以下に記載されるように加熱することにより得られた。いくつかの実施形態では、化合物Iを加熱して多形形態Dを得た。いくつかの実施形態では、多形形態Fを加熱して多形形態Dを得た。いくつかの実施形態では、多形形態Bを加熱して多形形態Dを得た。いくつかの実施形態では、多形形態Eを加熱して多形形態Dを得た。いくつかの実施形態では、多形形態Gを加熱して多形形態Dを得た。いくつかの実施形態では、多形形態Hを加熱して多形形態Dを得た。
形態Fの調製
[00266]新しい多形形態Fを、形態Aを、他物質を含まず160℃で加熱する時に得た。この形態は、rtで不安定であると考えられ、純粋に単離されなかった。
粗製の(R)−3,3,3−トリフルオロ−2−(((5−フルオロ−2−(1−(2−フルオロベンジル)−5−(イソオキサゾール−3−イル)−1H−ピラゾール−3−イル)ピリミジン−4−イル)アミノ)メチル)−2−ヒドロキシプロパンアミド(化合物I)の、多形形態Gへの再結晶
[00267]撹拌機を装備したフラスコに、粗製の化合物I(2.0g)およびアセトン(15.0mL)を投入した。この混合物を室温(22〜25℃)で2時間撹拌した。次に、得られたスラリーを濾過した。濾過ケーキをアセトン(5mL)ですすいだ。該濾過ケーキを収集し、真空下で40℃で15時間にわたり乾燥して、多形形態Gを白色固体として得た。
粗製の(R)−3,3,3−トリフルオロ−2−(((5−フルオロ−2−(1−(2−フルオロベンジル)−5−(イソオキサゾール−3−イル)−1H−ピラゾール−3−イル)ピリミジン−4−イル)アミノ)メチル)−2−ヒドロキシプロパンアミドの、多形形態Hへの再結晶
[00269]撹拌機を装備したフラスコに、粗製の化合物I(2.0g)およびアセトン(15.0mL)を投入した。この混合物を45〜50℃に加熱し、溶液が形成されるまで撹拌した。次に、この熱溶液を濾過し、撹拌しながらゆっくりと室温まで冷却した。さらに15時間撹拌し、次に得られたスラリーを濾過した。濾過ケーキをアセトン(5mL)ですすいだ。該濾過ケーキを収集し、真空下で40℃で15時間にわたり乾燥して、多形形態Hを白色固体として得た。
多形体の特徴付け
粉末X線回折(XRPD):
粉末X線回折トレースを、D8 Advance、Bruker装置を使用して;2種の方法の1つを使用して得た:
5〜45°の2−シータ走査、0.02°のステップ幅、1ステップ当たり1秒;または
3〜40°の2−シータ走査、0.037°のステップ幅、1ステップ当たり1.5秒
フーリエ変換赤外分光法(FTIR):
FTIRトレースを、ThermoFisher ScientificからのNicolet iS10 FTIR装置を使用して得た。
実施例10
HCl塩の調製
プロトコル1:
50.5mgのその多形形態Dとしての化合物Iおよび98.2mLの1MのHClを、2mLのi−PrOH中で懸濁させた。この懸濁液を、20℃〜40℃の間の温度サイクルで撹拌した。40℃/時の加熱速度および5℃/時の冷却速度を使用した。8日後、該懸濁液を濾過し、固体を真空下で(およそ5mbar、1時間)乾燥した。
299.9mgのその多形形態Dとしての化合物Iおよび上記で得られた塩酸塩(プロトコル1から)の少ない結晶を、5mLのi−PrOH中で懸濁させた。次に、589mLの1MのHClおよび5mLのi−PrOHを添加し、懸濁液を20℃〜40℃の間の温度サイクルで撹拌した。40℃/時の加熱速度および5℃/時の冷却速度を使用した。6日後、該懸濁液を濾過し、固体を真空下で(およそ5mbar、1時間)乾燥した。
HCl塩の特徴付け
化合物IのHCl塩は、図11のXRPDパターンにより特徴付けられる。
[00275]本明細書の全体にわたり、1つまたは複数の範囲が示される場合、各範囲は、情報を与えるための簡潔な書式であることが目的とされ、これと同一のものは、離散点が本明細書に完全に明示されているかの如く、その範囲内にそれぞれの離散点を包含すると理解される。
Claims (70)
- 形態A、形態B、形態D、形態E、形態F、形態Hまたは形態Gから選択される結晶性遊離形態である、請求項1に記載の結晶性固体形態。
- 塩酸塩である、請求項1に記載の結晶性固体形態。
- 7.4、18.8〜19.3、21.1、24.8および25.5の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態E。
- 7.4、13.9、15.1、16.3、17.6、18.8〜19.3、21.1、22.3〜22.5、24.8、25.5および27.1の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項4に記載の化合物Iの結晶性遊離形態である形態E。
- 図2または図6に示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態E。
- 図10に示されるものと実質的に同様のFT−ラマンスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態E。
- 1690cm−1においてピーク最大値を示すIRスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態E。
- 1515cm−1においてピーク最大値を示すIRスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態E。
- 1690および1515cm−1においてバンド極大を示すIRスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態E。
- 6.0、18.3、19.3、20.2および22.0の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態A。
- 6.0、8.5、9.5、12.4〜12.9、13.4、17.1、18.3、19.3、20.2、22.0、30.1および34.1の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項11に記載の化合物Iの結晶性遊離形態である形態A。
- 6.0、6.7、8.5、9.5、10.9、12.4〜12.9、13.4、16.2、17.1、18.3、19.3、20.2、22.0、23.0、24.1〜24.8、25.8、30.1および34.1の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項12に記載の化合物Iの結晶性遊離形態である形態A。
- 図2または図3Aに示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態A。
- 6.1(80.81%の相対強度)、9.6(40.35%)、12.6(41.26%)、13.6(43.19%)、18.4(53.57%)、19.4(100.00%)、20.3(57.01%)および22.0(56.64)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態A。
- 図3Cに示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態A。
- 図10に示されるものと実質的に同様のFT−ラマンスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態A。
- 1730cm−1においてバンド極大を示すIRスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態A。
- 40℃および75%の相対湿度の安定性条件下で14か月間保管された時、本質的に変化しないXRPDトレースを示すことにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態A。
- 18.8のo2θにおける、XRPDスペクトル中のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 17.1、18.1、18.8、および25.0の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項20に記載の化合物Iの結晶性遊離形態である形態D。
- 8.8、17.1、18.1、18.8、および25.0の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項21に記載の化合物Iの結晶性遊離形態である形態D。
- 図2または図5Aに示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 4.7(97.11%の相対強度)、8.3(64.04%)、18.1(80.97%)、18.6(100.00%)、および26.8(65.25)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 図5Cに示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 図10に示されるものと実質的に同様のFT−ラマンスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 1665cm−1においてバンド極大を示すIRスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 1639cm−1においてバンド極大を示すIRスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 968cm−1においてバンド極大を示すIRスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 1665、1639および968cm−1においてバンド極大を示すIRスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 40℃および75%の相対湿度の安定性条件下で14か月間保管された時、本質的に変化しないXRPDトレースを示すことにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態D。
- 18.8〜19.1の°2θにおける、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態B。
- 8.8、16.4、17.2、18.8〜19.1、20.1、および21.1〜21.6の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項32に記載の化合物Iの結晶性遊離形態である形態B。
- 8.8、10.6、12.6〜13.0、14.6、16.4、17.2、18.8〜19.1、20.1、21.1〜21.6、24.5、25.3、27.0〜27.5、28.9、29.8および30.5の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項33に記載の化合物Iの結晶性遊離形態である形態B。
- 図2または図4Aに示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態B。
- 7.0(44.44%の相対強度)、8.9(76.55%)、17.4(57.67%)、19.1(100.00%)、20.3(49.78%)、21.8(36.16%)、および25.5(52.26)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態B。
- 図4Cに示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態B。
- 図10に示されるものと実質的に同様のFT−ラマンスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態B。
- 1200cm−1においてピーク最大値を示すIRスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態B。
- 40℃および75%の相対湿度の安定性条件下で14か月間保管された時、本質的に変化しないXRPDトレースを示すことにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態B。
- 5.3(100.00%の相対強度)、8.6(58.80%)、16.4(62.95%)、および19.0(48.51%)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態F。
- 図7に示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態F。
- 10.7(55.47%の相対強度)、13.9(42.47%)、18.33(100.00%%)、および21.6(40.73%)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態G。
- 図8に示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態G。
- 5.77(89.22%の相対強度)、6.39(100.00%%)、9.1(84.17%)、および18.5(67.04%)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態H。
- 5.77(89.22%の相対強度)、6.39(100.00%%)、9.1(84.17%)、18.5(67.04%)、および18.83(67.04%)の°2θから選択される、XRPDスペクトル中の1つまたは複数のピークにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態H。
- 図9に示されるものと実質的に同様のXRPDスペクトルにより特徴付けられる、請求項2に記載の化合物Iの結晶性遊離形態である形態H。
- 256℃の融点により特徴付けられる、請求項3に記載の塩酸塩。
- pH1.4における0.5mg/mLの水溶解度により特徴付けられる、請求項3に記載の塩酸塩。
- 図11に示されるものと実質的に同様のXRPDパターンにより特徴付けられる、請求項3に記載の塩酸塩。
- 化合物Iの結晶性遊離形態である形態Eを調製する方法であって、
a.粗製の化合物Iを、最低で60℃でMeOHに溶解して、溶液を得るステップと、
b.溶液を濾過し、最低で60℃で濾液を加熱するステップと;
c.濾液に水を添加して水溶液を形成し、水溶液を室温(rt)に冷却するステップと、
d.水溶液を濾過し、濾液を真空下で乾燥するステップと
を含む方法。 - 化合物Iの結晶性遊離形態である形態Aを調製する方法であって、
a.結晶性遊離形態である形態Eを、最低で70℃で酢酸エチルに溶解して、溶液を得るステップと、
b.溶液を濾過し、得られた濾液を20〜25℃で16時間にわたり撹拌して、スラリーを形成するステップと、
c.スラリーを、真空下で濃縮し、濾過し、乾燥するステップと
を含む方法。 - 化合物Iの結晶性遊離形態である形態Aを調製する方法であって、
a.粗製の化合物Iを、最低で70℃で酢酸エチルに溶解して、溶液を得るステップと、
b.溶液を濾過し、得られた濾液を20〜25℃で16時間にわたり撹拌して、スラリーを形成するステップと、
c.スラリーを、真空下で濃縮し、濾過し、乾燥するステップと
を含む方法。 - 化合物Iの結晶性遊離形態である形態Aを調製する方法であって、
a.DMSO中の粗製の化合物Iを、最低で60℃で加熱して、溶液を形成ステップと、
b.水を添加して、スラリーを形成するステップと、
c.スラリーを濾過して、結晶性遊離形態である形態Aを単離するステップと
を含む方法。 - 化合物Iの結晶性遊離形態である形態Aを調製する方法であって、
a.粗製の化合物Iを、ヘプタン、IPAC、エタノール、酢酸エチル、もしくはデカンまたはこれらの混合物から選択される溶媒中でスラリー化するステップと、
b.14〜30時間、rtで撹拌するステップと、
c.スラリーを濾過し、真空下で乾燥するステップと
を含む方法。 - 化合物Iの結晶性遊離形態である形態Dを調製する方法であって、
a.結晶性遊離形態である形態Eを、n−デカンと145〜155℃で混合して、スラリーを得るステップと、
b.スラリーを、20〜30℃まで1時間にわたり冷却するステップと、
c.スラリーを濾過し、真空下で乾燥するステップと
を含む方法。 - 化合物Iの結晶性遊離形態である形態Dを調製する方法であって、結晶性遊離形態である形態F、形態B、形態E、形態G、もしくは形態Hのいずれか1つ、またはこれらの混合物を、他物質を含まず、180℃で加熱するステップを含む方法。
- 化合物Iの結晶性遊離形態である形態Bを調製する方法であって、
a.粗製の化合物Iを、アセトニトリルと混合して、溶液を形成するステップと、
b.溶液を濾過し、濾液を形成して、濾液を70〜75℃で加熱するステップと、
c.加熱された濾液に水を添加するステップと、
d.52〜62℃に冷却して、スラリーを形成するステップと、
e.スラリーを、0〜5℃まで少なくとも4時間さらに冷却するステップと、
f.冷却されたスラリーを濾過し、得られた濾液を真空下で乾燥するステップと
を含む方法。 - 化合物Iの結晶性遊離形態である形態Fを調製する方法であって、形態Aを、他物質を含まず、160℃で加熱するステップを含む方法。
- 化合物Iの結晶性遊離形態である形態Gを調製する方法であって、
a.アセトン中の粗製の化合物Iを、室温で約2時間混合して、スラリーを形成するステップと、
b.スラリーを濾過し、真空下で乾燥するステップと
を含む方法。 - 化合物Iの結晶性遊離形態である形態Gを調製する方法であって、
a.アセトン中の形態Hを、室温で約2時間撹拌して、スラリーを形成するステップと;
b.スラリーを濾過し、真空下で乾燥するステップと
を含む方法。 - 化合物Iの結晶性遊離形態である形態Hを調製する方法であって、
a.粗製の化合物Iを、アセトンと45〜50℃で混合して、溶液を得るステップと、
b.濾過し、冷却して、スラリーを形成するステップと、
c.スラリーを撹拌し、濾過し、真空下で乾燥するステップと
を含む方法。 - 請求項2に記載の化合物のI結晶性遊離形態または請求項3に記載の塩酸塩、および少なくとも1つの薬学的に許容される賦形剤または担体を含む医薬組成物。
- 請求項1、2または3のいずれか一項に記載の化合物Iの結晶性固体形態を含む医薬剤形。
- 処置を必要とする対象における疾患、健康状態または障害を処置する方法であって、治療有効量の、請求項1〜50のいずれか一項に記載の化合物Iの結晶性固体形態、または請求項63に記載の医薬組成物、または請求項64に記載の医薬剤形を、処置を必要とする対象に投与することを含み、疾患、健康状態または障害が:
・高血圧症および減少した冠血流に関連する障害;増加した急性および慢性の冠血圧;動脈性高血圧;心臓および腎臓の合併症に起因する血管障害;心臓疾患、脳卒中、大脳虚血または腎不全に起因する血管障害;抵抗性高血圧;糖尿病性高血圧;本態性高血圧;二次性高血圧;妊娠性高血圧;子癇前症;門脈圧亢進症;心筋梗塞;
・心不全、HFPEF、HFREF;急性および慢性のHF;より特異的な形態のHF:急性非代償性HF、右室不全、左室不全、総HF、虚血性心筋症、拡張型心筋症、先天性心欠損、心臓弁奇形を有するHF、僧帽弁狭窄、僧帽弁閉鎖不全、大動脈弁狭窄、大動脈弁閉鎖不全、三尖弁狭窄、三尖弁閉鎖不全、肺動脈弁狭窄、肺動脈弁閉鎖不全、複合心臓弁奇形;糖尿病性心不全;アルコール性心筋症または保管肥大型心筋症;拡張期HF、収縮期HF;急性期の既存の慢性HF(悪化HF);拡張期または収縮期の機能障害;冠機能不全;不整脈;心室前負荷の減少;心肥大;心不全/心腎症候群;門脈圧亢進症;内皮機能障害または傷害;心房および心室調律の妨害および伝導妨害:段階I〜III(AVB I〜III)の房室ブロック、上室性頻脈性不整脈、心房細動、心房粗動、心室細動、心室粗動、心室性頻脈性不整脈、多形性心室頻拍症、心房および心室性の期外収縮、AV接合部期外収縮、洞不全症候群、失神、AV結節リエントリー性頻拍;ウォルフ・パーキンソン・ホワイト症候群または急性冠症候群;ボクサー心筋症;心室性期外収縮;心筋症;がん誘発性心筋症;化学療法誘発性心毒性;
・血栓塞栓性障害および虚血;心筋虚血;梗塞;心筋梗塞;心臓発作;心筋機能不全;内皮機能障害;脳卒中;一過性脳虚血発作(TIA);閉塞性血栓性血管炎;安定または不安定な狭心症;冠攣縮または末梢動脈の攣縮;異型狭心症;プリンツメタル狭心症;心肥大;子癇前症;血栓形成性障害;虚血−再灌流傷害;臓器移植に関連する虚血−再灌流;肺移植(lung transplant)、肺移植(pulmonary transplant)、心臓移植、静脈グラフト不全症;外傷患者における保存血液置換(conserving blood substituent)に関連する虚血−再灌流;
・末梢血管疾患;末梢動脈疾患;末梢動脈閉塞性疾患;筋緊張亢進;レイノー症候群または現象(原発性および二次性);レイノー病;重症下肢虚血;末梢塞栓症;間欠性跛行;血管閉塞性クリーゼ;筋ジストロフィー、デュシェンヌ型筋ジストロフィー、ベッカー型筋ジストロフィー;微小循環異常;血管漏出または浸透性の制御;腰部脊柱管狭窄;閉塞性血栓性血管炎;血栓性血管炎;末梢灌流妨害;動脈および静脈の血栓症;微量アルブミン尿;末梢性および自律神経ニューロパチー;糖尿病性神経障害疼痛;糖尿病性細小血管症;肝臓血管閉塞性障害;鎌状赤血球症における血管閉塞性クリーゼ;高血圧クリーゼ;
・浮腫;心不全が原因の腎性浮腫;
・アルツハイマー病;パーキンソン病;血管性認知症;血管性認知障害;脳血管攣縮;先天性筋無力症症候群;くも膜下出血;外傷性脳損傷;外傷性脳損傷;軽度認知障害に起きるもの、加齢性の学習および記憶の障害、加齢性の記憶喪失、血管性認知症、頭部損傷、脳卒中、脳卒中後の認知症、外傷性頭部損傷後、集中の一般的妨害ならびに学習および記憶の問題を伴う小児における集中の妨害などの、認知障害後の知覚、集中能力、学習または記憶の履行の能力の改善;レビー小体型認知症;ピック症候群を含む前頭葉変性を伴う認知症;進行性核上性麻痺;皮質基底核変性を伴う認知症;筋萎縮性側索硬化症(ALS);ハンチントン病;脱髄;多発性硬化症;視床変性;クロイツフェルト・ヤコブ認知症;HIV認知症;認知症またはコルサコフ精神病を伴う統合失調症;多系統萎縮症および他の形態のパーキンソニズムプラス;運動障害;神経保護;不安、緊張および抑うつまたは外傷後ストレス障害(PTSD);双極性障害;統合失調症;CNS関連の性機能障害および睡眠障害;病理学的摂食障害ならびに高級食糧および依存性薬物の使用;制御性脳灌流;片頭痛;脳梗塞(脳卒中(apoplexia cerebri))の予防および結果の制御;脳卒中、大脳虚血および頭部損傷の予防および結果の制御;CNS疾患に関連するニューロパチー;MSに関連する神経障害性疼痛;化学療法誘発性の神経障害性疼痛;帯状疱疹に関連する神経障害性疼痛;脊椎外科手術に関連する神経障害性疼痛;
・ショック;心原性ショック;敗血症;敗血症性ショック;アナフィラキシーショック;動脈瘤;白血球活性化の制御;血小板凝集の抑制または調節;多臓器機能障害症候群(MODS);多臓器不全(MOF);
・肺性/呼吸状態:肺高血圧(PH);肺動脈性高血圧(PAH)、および関連する肺血管性再構築;局在性血栓症および右心肥大の形態における血管性再構築;肺性筋緊張亢進;原発性肺高血圧;二次性肺高血圧;家族性肺高血圧;孤発性肺高血圧;前毛細血管肺高血圧;特発性肺高血圧;他の形態のPH;左室疾患、HIV、SCD、血栓塞栓症(CTEPH)、サルコイドーシス、COPD、肺線維症、急性呼吸促迫症候群(ARDS)、急性肺傷害、α1アンチトリプシン欠損症(AATD)、肺気腫、喫煙誘発性の気腫および嚢胞性線維症(CF)に関連するPH;血栓性肺動脈症;多因性肺動脈症;嚢胞性線維症;気管支収縮または肺性気管支収縮;急性呼吸器症候群;肺線維症、肺移植;喘息性疾患;
・左室機能障害、低酸素血症、WHO群I、II、III、IVおよびVの高血圧、僧帽弁疾患、収縮性心膜炎、大動脈弁狭窄、心筋症、縦隔線維症、肺線維症、肺静脈還流異常、肺静脈閉塞症、肺性血管炎、膠原病性血管疾患、先天性心疾患、肺静脈圧上昇、間質性肺疾患、睡眠呼吸障害、睡眠時無呼吸、肺胞低換気障害、高高度への慢性曝露、新生児肺疾患、肺胞毛細血管異形成、鎌状赤血球症、他の血液凝固障害、慢性血栓塞栓症、肺塞栓症に関連するかまたは関する肺高血圧;腫瘍、寄生虫または異物が原因の肺塞栓症;結合組織疾患、ループス、ループス腎炎、住血吸虫症、サルコイドーシス、慢性閉塞性肺疾患、喘息、気腫、慢性気管支炎、肺毛細血管腫症、組織球症X、リンパ管腫症、圧縮肺血管(compressed pulmonary vessels);腺症、腫瘍または線維化性縦隔炎が原因の圧縮肺血管;
・動脈硬化性疾患または状態:アテローム性動脈硬化症;内皮傷害、血小板および単球の接着および凝集、平滑筋の増殖または遊走に関連するアテローム性動脈硬化症;再狭窄;血栓溶解療法、経皮経管血管形成術(PTA)、経管冠動脈形成術(PTCA)、心臓移植、バイパス手術または炎症過程後に発達した再狭窄;
・微小血管および大血管の損傷(血管炎);増加したレベルのフィブリノーゲンおよび低密度のDLD;増加した濃度のプラスミノーゲン活性化因子阻害剤1(PA−1);
・メタボリックシンドローム;代謝性疾患またはメタボリックシンドロームに関連する疾患:肥満;過剰皮下脂肪;過剰体脂肪蓄積;糖尿病;高血圧症;脂質関連障害、高脂血症、脂質異常症、高コレステロール血症、減少した高密度リポタンパク質コレステロール(HDL−コレステロール)、中程度に上昇した低密度リポタンパク質コレステロール(LDL−コレステロール)レベル、高トリグリセリド血症、高グリセリド血症、低リポタンパク質貧血、シトステロール血症、脂肪肝疾患、アルコール性脂肪肝疾患(AFLD)、非アルコール性脂肪肝疾患(NAFLD)、肝炎;子癇前症;多発性腎臓疾患進行;肝脂肪変性または肝臓中の異常な脂質蓄積、非アルコール性脂肪性肝炎(NASH);心臓、腎臓または筋肉の脂肪変性;アルファベータリポタンパク血症;シトステロール血症;黄色腫症;タンジール病;高アンモニア血症および関連疾患;肝性脳症;他の中毒性脳症;ライ症候群;
・性的、婦人科および泌尿器科の状態の障害:勃起機能障害;インポテンス;早漏;女性性機能障害;女性性的刺激機能障害;低機能性的刺激障害;膣萎縮;性交疼痛症;萎縮性腟炎;良性前立腺肥大(BPH)、前立腺肥大、前立腺腫大;膀胱下尿道閉塞;膀胱痛症候群(BPS);間質性膀胱炎(IC);過活動膀胱;神経因性膀胱および失禁;糖尿病性腎症;原発性および二次性の月経困難症;下部尿路症候群(LUTS);子宮内膜症;骨盤痛;男性および女性の泌尿生殖器系の臓器の良性および悪性の疾患;
・慢性腎臓疾患;急性および慢性の腎機能不全;急性および慢性の腎不全;ループス腎炎;根本的なまたは関連する腎臓疾患:低灌流、透析中の低血圧、閉塞性尿路疾患、糸球体症、糸球体腎炎、急性糸球体腎炎、糸球体硬化症、尿細管間質障害、腎障害疾患、原発性および先天性の腎臓疾患、腎炎;異常に減少したクレアチニンおよびまたは水分排出により特徴付けられる疾患;尿素、窒素、カリウムおよび/またはクレアチニンの異常に増加した血液濃度により特徴付けられる疾患;腎臓酵素の変化した活性により特徴付けられる疾患、グルタミル合成酵素の変化した活性により特徴付けられる疾患;変化した尿浸透圧または尿量により特徴付けられる疾患;増加した微量アルブミン尿により特徴付けられる疾患、顕性アルブミン尿により特徴付けられる疾患;糸球体および細動脈の病変、尿細管拡大、高リン血症および/または透析の必要により特徴付けられる疾患;腎機能不全の続発症;肺水腫関連の腎機能不全;HF関連の腎機能不全;尿毒症または貧血関連の腎機能不全;電解質異常(ヘルカレミア、低ナトリウム血症);骨および炭水化物代謝の妨害;急性腎臓傷害;
・緑内障、網膜症および糖尿病性網膜症などの眼の疾患または障害
から選択される、方法。 - 処置を必要とする対象における疾患、健康状態または障害を処置する方法であって、治療有効量の、請求項1〜50のいずれか一項に記載の化合物Iの結晶性固体形態、または請求項63に記載の医薬組成物、または請求項64に記載の医薬剤形を、処置を必要とする対象に投与することを含み、疾患、健康状態または障害が:
・心筋炎症(心筋炎);慢性心筋炎;急性心筋炎;ウイルス性心筋炎;
・血管炎;膵炎;腹膜炎;リウマチ様疾患;
・腎臓の炎症性疾患;免疫学的腎臓疾患:腎臓移植拒絶反応、免疫複合体誘発性の腎臓疾患、毒素誘発性の腎症、造影剤誘発性の腎症;糖尿病性および非糖尿病性の腎症、腎盂腎炎、腎嚢胞、腎硬化症、高血圧性腎硬化症およびネフローゼ症候群;
・慢性間質性炎症、炎症性腸疾患(IBD)、クローン病、潰瘍性大腸炎(UC);
・炎症性皮膚疾患;
・眼の炎症性疾患、眼瞼炎、ドライアイ症候群、およびシェーグレン症候群;眼線維症
から選択される、方法。 - 処置を必要とする対象における疾患、健康状態または障害を処置する方法であって、治療有効量の、請求項1〜50のいずれか一項に記載の化合物Iの結晶性固体形態、または請求項63に記載の薬学的に許容されるその塩、医薬組成物、または請求項64に記載の医薬剤形を、処置を必要とする対象に投与することを含み、疾患、健康状態または障害が:糖尿病性の創傷または潰瘍の治癒;微小血管灌流改良;傷害に続くかまたは周術期ケアにおける炎症性応答に対抗する微小血管灌流改良;裂肛;糖尿病性潰瘍;糖尿病性足部潰瘍;骨治癒機転;破骨細胞性骨吸収および再構築;ならびに新骨形成から選択される、方法。
- 処置を必要とする対象における疾患、健康状態または障害を処置する方法であって、治療有効量の、請求項1〜50のいずれか一項に記載の化合物Iの結晶性固体形態、または請求項63に記載の医薬組成物、または請求項64に記載の医薬剤形を、処置を必要とする対象に投与することを含み、疾患、健康状態または障害が:
・泌尿生殖器系または腎臓障害:糖尿病性腎症;慢性腎臓疾患または腎機能不全に起因する腎線維症および腎不全;蓄積/沈着および組織傷害が原因の腎線維症および腎不全;腎硬化症;進行性硬化症;糸球体腎炎;巣状分節性糸球体硬化症;ネフローゼ症候群;前立腺肥大;腎臓線維症;間質性腎線維症;
・肺系統障害:肺線維症;特発性肺線維症;嚢胞性線維症;進行性塊状線維症;肺に影響を及ぼす進行性塊状線維症;
・心臓に影響を及ぼす障害:心内膜心筋線維症;陳旧性心筋梗塞;心房線維症;心臓間質性線維症;心臓再構築および線維症;心肥大;
・肝臓および関連する臓器の障害:肝臓硬化症または肝硬変;慢性肝臓疾患に関連する肝硬変;肝線維症;肝星細胞活性化;NASH;肝線維性コラーゲンおよび総コラーゲン蓄積;壊死性炎症性および/または免疫学的起源の肝臓疾患;原発性胆汁性肝硬変;原発性硬化性胆管炎;他の胆汁うっ滞性肝臓疾患:肉芽腫性肝臓疾患に関連するもの、肝悪性腫瘍、妊娠の肝内胆汁うっ滞、肝炎、敗血症、薬物または毒素、移植片対宿主病、肝臓移植後、総胆管結石、胆管腫瘍、膵癌、ミリッツィ症候群、AIDS胆管症または寄生虫;住血吸虫症;肝細胞癌;
・消化器系疾患または障害:クローン病;潰瘍性大腸炎;消化器の硬化症;アカラシア;
・皮膚または眼の疾患:腎性線維症;増殖性硝子体網膜症;糖尿病性網膜症;眼線維症;
・線維性局所的または皮膚の障害もしくは状態;真皮性線維症;強皮症、皮膚線維症;モルフェア;肥厚性瘢痕;母斑;ケロイド;サルコイド;肉芽腫;
・神経系に影響を及ぼす疾患:筋萎縮性側索硬化症(ALS);海馬硬化症、多発性硬化症(MS);巣状硬化症;原発性側索硬化症;
・骨の疾患;骨硬化症;
・耳硬化症;他の聴覚疾患または障害;難聴、部分的または全体的な聴力損失;部分的または全体的な聴覚喪失;耳鳴;騒音性聴力損失;
・自己免疫、炎症または線維症を含む他の疾患:強皮症;局在性強皮症または限局性強皮症;縦隔線維症;線維症縦隔炎;骨髄線維症;後腹膜線維症;関節線維症;ペロニー病;デュピュイトラン拘縮;硬化性苔癬;いくつかの形態の癒着性関節包炎;アテローム性動脈硬化症;結節性硬化症;全身性硬化症;多発性筋炎;皮膚筋炎;多発性軟骨炎;好酸球性筋膜炎;全身性エリテマトーデスまたはループス;骨髄線維症(bone marrow fibrosis)、骨髄線維症(myelofibrosis)または骨骨髄線維症;サルコイドーシス;子宮筋腫;子宮内膜症
から選択される、方法。 - 処置を必要とする対象における疾患、健康状態または障害を処置する方法であって、治療有効量の、請求項1〜50のいずれか一項に記載の化合物Iの結晶性固体形態、または請求項63に記載の医薬組成物、または請求項64に記載の医薬剤形を、処置を必要とする対象に投与することを含み、疾患、健康状態または障害が、特定の種類のがん;鎌状赤血球症;鎌状赤血球貧血;がん転移;骨粗鬆症;胃不全麻痺;機能性ディスペプシア;糖尿病性合併症;脱毛症または毛髪脱落;内皮機能障害に関連する疾患;減少した一酸化窒素産生に関連する神経障害;アルギノコハク酸尿症;神経筋疾患;デュシェンヌ型筋ジストロフィー(DMD)、ベッカー型筋ジストロフィー(BMD)、肢帯型筋ジストロフィー、遠位型ミオパチー、I型およびII型の筋緊張性ジストロフィー、顔面肩甲腓骨筋ジストロフィー、常染色体性およびX連鎖性エメリ−ドレフュス型筋ジストロフィー、眼咽頭型筋ジストロフィー、筋萎縮性側索硬化症および脊髄性筋萎縮症(SMA)
から選択される、方法。 - 処置または予防を必要とする対象における疾患、健康状態または障害を処置または予防する方法であって、単独または併用療法で、治療有効量の請求項1〜50のいずれか一項に記載の化合物Iの結晶性固体形態を、対象に投与することを含み、疾患または障害が、sGC刺激からまたはNOおよび/もしくはcGMPの濃度増加から恩恵を受け得る疾患または障害である、方法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022107994A JP2022130689A (ja) | 2016-07-07 | 2022-07-04 | Sgc刺激剤の固体形態 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662359466P | 2016-07-07 | 2016-07-07 | |
US62/359,466 | 2016-07-07 | ||
PCT/US2017/040827 WO2018009609A1 (en) | 2016-07-07 | 2017-07-06 | Solid forms of an sgc stimulator |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022107994A Division JP2022130689A (ja) | 2016-07-07 | 2022-07-04 | Sgc刺激剤の固体形態 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019524710A true JP2019524710A (ja) | 2019-09-05 |
JP2019524710A5 JP2019524710A5 (ja) | 2020-08-20 |
Family
ID=59337923
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019500453A Pending JP2019524710A (ja) | 2016-07-07 | 2017-07-06 | Sgc刺激剤の固体形態 |
JP2022107994A Pending JP2022130689A (ja) | 2016-07-07 | 2022-07-04 | Sgc刺激剤の固体形態 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022107994A Pending JP2022130689A (ja) | 2016-07-07 | 2022-07-04 | Sgc刺激剤の固体形態 |
Country Status (16)
Country | Link |
---|---|
US (3) | US10889577B2 (ja) |
EP (1) | EP3481820B1 (ja) |
JP (2) | JP2019524710A (ja) |
KR (2) | KR20190025989A (ja) |
CN (1) | CN109563087A (ja) |
AU (1) | AU2017292818B2 (ja) |
BR (1) | BR112019000293A2 (ja) |
CA (1) | CA3029333A1 (ja) |
CL (1) | CL2019000018A1 (ja) |
EA (1) | EA039753B1 (ja) |
IL (1) | IL263996B2 (ja) |
JO (1) | JOP20180127A1 (ja) |
MA (1) | MA45588A (ja) |
MX (2) | MX2019000115A (ja) |
TW (1) | TWI774683B (ja) |
WO (1) | WO2018009609A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019524712A (ja) * | 2016-07-07 | 2019-09-05 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
JP2019525913A (ja) * | 2016-07-07 | 2019-09-12 | サイクレリオン・セラピューティクス,インコーポレーテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018009609A1 (en) * | 2016-07-07 | 2018-01-11 | Ironwood Pharmaceuticals, Inc. | Solid forms of an sgc stimulator |
WO2019161534A1 (en) * | 2018-02-22 | 2019-08-29 | Ironwood Pharmaceuticals, Inc. | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
CN109503574B (zh) * | 2018-12-14 | 2021-07-06 | 中国人民解放军军事科学院军事医学研究院 | 抗肺动脉高压药物sgc-003的多晶型晶体变体及其制备方法 |
CN110862424A (zh) * | 2019-12-03 | 2020-03-06 | 海南顿斯医药科技有限公司 | 一种硫酸阿米卡星化合物 |
WO2023009710A1 (en) * | 2021-07-28 | 2023-02-02 | Cyclerion Therapeutics, Inc. | Treatment of hfpef in post-menopausal women with an sgc stimulator |
CN114199812A (zh) * | 2021-12-28 | 2022-03-18 | 南通联亚药业有限公司 | 一种盐酸美金刚缓释制剂中盐酸美金刚的检测方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016044447A1 (en) * | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
JP2016517432A (ja) * | 2013-03-15 | 2016-06-16 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC刺激薬 |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4432987A (en) * | 1982-04-23 | 1984-02-21 | Pfizer Inc. | Crystalline benzenesulfonate salts of sultamicillin |
US5721365A (en) | 1989-09-15 | 1998-02-24 | Us Health | N-substituted piperazine NONOates |
US5155137A (en) | 1990-09-20 | 1992-10-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Complexes of nitric oxide with polyamines |
JP3190340B2 (ja) | 1991-09-24 | 2001-07-23 | アメリカ合衆国 | 酸化窒素供与体プロドラッグとしての求核試薬−酸化窒素付加物の酸素置換誘導体 |
US5814666A (en) | 1992-04-13 | 1998-09-29 | The United States As Represented By The Department Of Health And Human Services | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
US5405919A (en) | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
US5910316A (en) | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
US5691423A (en) | 1992-08-24 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-bound nitric oxide-nucleophile adducts |
KR100296810B1 (ko) * | 1993-03-12 | 2001-10-24 | 로렌스 티. 마이젠헬더 | 결정성세프티오퍼유리산 |
AU685178B2 (en) | 1993-10-08 | 1998-01-15 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers |
JP2928079B2 (ja) | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | 1−(置換ベンジル)−3−(置換アリール)縮合ピラゾール類、その製造法及びその用途 |
US5700830A (en) | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
DK0837052T3 (da) | 1995-06-21 | 2007-01-02 | Shionogi & Co | Bicykliske aminoderivater og PGD2-antagonist indeholdende disse |
US5714511A (en) | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
AU5409698A (en) | 1996-12-12 | 1998-07-03 | Shionogi & Co., Ltd. | Fused heterocyclic benzenecarboxylic acid amide derivatives and pgd2 antagonists containing the same |
HU226458B1 (en) | 1996-12-13 | 2008-12-29 | Shionogi & Co | Benzothiophenecarboxamide derivatives, pharmaceutical compositions thereof and intermediates |
DE19744026A1 (de) | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
DE19830430A1 (de) | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
ATE309206T1 (de) | 1998-07-08 | 2005-11-15 | Sanofi Aventis Deutschland | Schwefel-substituierte sulfonylaminocarbonsäure n-arylamide, ihre herstellung, ihre anwendung und diese enthaltende pharmazeutische zusammensetzungen |
DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
GB9824310D0 (en) | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
DE19942809A1 (de) | 1999-09-08 | 2001-03-15 | Bayer Ag | Verfahren zur Herstellung substituierter Pyrimidinderivate |
DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
US20010051624A1 (en) | 2000-04-12 | 2001-12-13 | Jones Thomas R. | Method and compositions for the treatment of allergic conditions using PGD2 receptor antagonists |
ATE311200T1 (de) | 2000-04-12 | 2005-12-15 | Merck Frosst Canada Inc | Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten |
US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
TWI243164B (en) | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
MY136316A (en) | 2001-02-13 | 2008-09-30 | Sanofi Aventis Deutschland | Acylated 6,7,8,9-tetrahydro-5h-benzocycloheptenyl amines and their use as pharmaceutical. |
PE20020856A1 (es) | 2001-02-13 | 2002-11-11 | Aventis Pharma Gmbh | 1,2,3,4-tetrahidronaftil aminas aciladas |
TWI241190B (en) | 2001-02-13 | 2005-10-11 | Aventis Pharma Gmbh | 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical |
US6511911B1 (en) | 2001-04-03 | 2003-01-28 | Advanced Micro Devices, Inc. | Metal gate stack with etch stop layer |
EP1424325A4 (en) | 2001-09-07 | 2005-12-21 | Ono Pharmaceutical Co | INDOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE AGENT |
CA2459515A1 (en) | 2001-09-07 | 2003-03-20 | Kazuhiko Torisu | Indole derivatives |
US7145002B2 (en) * | 2001-09-26 | 2006-12-05 | Merck & Co. Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
DE10216145A1 (de) | 2002-04-12 | 2003-10-23 | Bayer Ag | Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom |
DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
US7534897B2 (en) | 2002-05-16 | 2009-05-19 | Shionogi & Co., Ltd. | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism |
AU2003231513A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Pgd2 receptor antagonist |
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
EP1556047A4 (en) | 2002-10-04 | 2009-09-30 | Millennium Pharm Inc | ANTAGONISTS AGAINST THE PGD2 RECEPTOR FOR THE TREATMENT OF INFLAMMATORY DISEASES |
US7321001B2 (en) | 2002-12-20 | 2008-01-22 | Amgen Inc. | Asthma and allergic inflammation modulators |
US8309608B2 (en) | 2003-11-06 | 2012-11-13 | Sanofi-Aventis Deutschland Gmbh | Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases |
WO2009032249A1 (en) | 2007-09-06 | 2009-03-12 | Merck & Co., Inc. | Soluble guanylate cyclase activators |
JP2011510082A (ja) | 2008-01-24 | 2011-03-31 | メルク・シャープ・エンド・ドーム・コーポレイション | アンジオテンシンii受容体拮抗薬 |
EP2373317B1 (en) | 2008-11-25 | 2016-12-14 | Merck Sharp & Dohme Corp. | 4-amino-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one or 4-amino-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one derivatives as activators of the soluble guanylat cyclase for the treatment of cardiovascular diseases |
CN102414194A (zh) | 2009-02-26 | 2012-04-11 | 默沙东公司 | 可溶性鸟苷酸环化酶激活剂 |
WO2011119518A1 (en) | 2010-03-25 | 2011-09-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
SG185777A1 (en) | 2010-05-27 | 2012-12-28 | Merck Sharp & Dohme | Soluble guanylate cyclase activators |
CN107021951B (zh) | 2010-06-30 | 2020-10-20 | 赛克里翁治疗有限公司 | sGC刺激物 |
WO2012058132A1 (en) | 2010-10-28 | 2012-05-03 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
WO2012064559A1 (en) | 2010-11-09 | 2012-05-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
US20160324856A1 (en) * | 2014-01-13 | 2016-11-10 | Ironwood Pharmaceuticals, Inc. | Use of sgc stimulators for the treatment of neuromuscular disorders |
WO2018009609A1 (en) | 2016-07-07 | 2018-01-11 | Ironwood Pharmaceuticals, Inc. | Solid forms of an sgc stimulator |
-
2017
- 2017-07-06 WO PCT/US2017/040827 patent/WO2018009609A1/en unknown
- 2017-07-06 CN CN201780048867.6A patent/CN109563087A/zh active Pending
- 2017-07-06 KR KR1020197003464A patent/KR20190025989A/ko not_active Application Discontinuation
- 2017-07-06 US US16/315,226 patent/US10889577B2/en active Active
- 2017-07-06 AU AU2017292818A patent/AU2017292818B2/en active Active
- 2017-07-06 IL IL263996A patent/IL263996B2/en unknown
- 2017-07-06 CA CA3029333A patent/CA3029333A1/en active Pending
- 2017-07-06 EP EP17739833.6A patent/EP3481820B1/en active Active
- 2017-07-06 EA EA201990235A patent/EA039753B1/ru unknown
- 2017-07-06 MA MA045588A patent/MA45588A/fr unknown
- 2017-07-06 MX MX2019000115A patent/MX2019000115A/es unknown
- 2017-07-06 KR KR1020237017060A patent/KR20230074840A/ko not_active Application Discontinuation
- 2017-07-06 BR BR112019000293-6A patent/BR112019000293A2/pt unknown
- 2017-07-06 JP JP2019500453A patent/JP2019524710A/ja active Pending
- 2017-07-07 TW TW106122962A patent/TWI774683B/zh active
-
2018
- 2018-12-24 JO JOP/2018/0127A patent/JOP20180127A1/ar unknown
-
2019
- 2019-01-04 CL CL2019000018A patent/CL2019000018A1/es unknown
- 2019-01-07 MX MX2022001565A patent/MX2022001565A/es unknown
-
2020
- 2020-12-29 US US17/136,473 patent/US11572358B2/en active Active
-
2022
- 2022-07-04 JP JP2022107994A patent/JP2022130689A/ja active Pending
-
2023
- 2023-06-02 US US18/204,997 patent/US20240059683A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016517432A (ja) * | 2013-03-15 | 2016-06-16 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC刺激薬 |
WO2016044447A1 (en) * | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
Non-Patent Citations (2)
Title |
---|
平山令明編, 有機化合物結晶作製ハンドブック −原理とノウハウ−, JPN6011053065, 25 July 2008 (2008-07-25), pages 57 - 84, ISSN: 0004904017 * |
高田則幸: "創薬段階における原薬Formスクリーニングと選択", PHARM STAGE, vol. 6, no. 10, JPN6009053755, 15 January 2007 (2007-01-15), pages 20 - 25, ISSN: 0004904018 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019524712A (ja) * | 2016-07-07 | 2019-09-05 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
JP2019525913A (ja) * | 2016-07-07 | 2019-09-12 | サイクレリオン・セラピューティクス,インコーポレーテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
JP7054395B2 (ja) | 2016-07-07 | 2022-04-13 | サイクレリオン・セラピューティクス,インコーポレーテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
US11319308B2 (en) | 2016-07-07 | 2022-05-03 | Cyclerion Therapeutics, Inc. | Processes for preparation of soluble guanylate cyclase stimulators |
JP7112384B2 (ja) | 2016-07-07 | 2022-08-03 | サイクレリオン・セラピューティクス,インコーポレーテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
US11773089B2 (en) | 2016-07-07 | 2023-10-03 | Cyclerion Therapeutics, Inc. | Process for preparation of soluble guanylate cyclase stimulators |
US11834444B2 (en) | 2016-07-07 | 2023-12-05 | Cyclerion Therapeutics, Inc. | Processes for preparation of soluble guanylate cyclase stimulators |
Also Published As
Publication number | Publication date |
---|---|
IL263996B1 (en) | 2023-11-01 |
JOP20180127A1 (ar) | 2019-01-30 |
KR20230074840A (ko) | 2023-05-31 |
TWI774683B (zh) | 2022-08-21 |
AU2017292818B2 (en) | 2021-10-21 |
IL263996A (en) | 2019-01-31 |
TW201805283A (zh) | 2018-02-16 |
US20240059683A1 (en) | 2024-02-22 |
JP2022130689A (ja) | 2022-09-06 |
CL2019000018A1 (es) | 2019-05-03 |
EA201990235A1 (ru) | 2019-07-31 |
EP3481820B1 (en) | 2023-10-18 |
WO2018009609A1 (en) | 2018-01-11 |
US20210188830A1 (en) | 2021-06-24 |
KR20190025989A (ko) | 2019-03-12 |
AU2017292818A1 (en) | 2019-01-31 |
US10889577B2 (en) | 2021-01-12 |
US11572358B2 (en) | 2023-02-07 |
CN109563087A (zh) | 2019-04-02 |
MA45588A (fr) | 2019-05-15 |
MX2019000115A (es) | 2019-04-22 |
BR112019000293A2 (pt) | 2019-04-16 |
EP3481820A1 (en) | 2019-05-15 |
EA039753B1 (ru) | 2022-03-10 |
US20190169179A1 (en) | 2019-06-06 |
MX2022001565A (es) | 2022-03-02 |
CA3029333A1 (en) | 2018-01-11 |
IL263996B2 (en) | 2024-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11572358B2 (en) | Solid forms of an sGC stimulator | |
JP7368516B2 (ja) | sGC刺激剤のリンプロドラッグ | |
US20230095799A1 (en) | CRYSTALLINE FORMS OF AN sGC STIMULATOR | |
OA19465A (en) | Solid forms of an SGC stimulator. | |
EA045683B1 (ru) | ТВЕРДЫЕ ФОРМЫ СТИМУЛЯТОРА sGC |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20190710 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200706 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200706 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20210527 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210604 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210906 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211104 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20211104 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20220304 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220704 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20220704 |
|
C11 | Written invitation by the commissioner to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C11 Effective date: 20220715 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20220902 |
|
C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20220905 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20221028 |
|
C211 | Notice of termination of reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C211 Effective date: 20221101 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20231109 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20240513 |