JOP20180127A1 - صيغ صلبة من منشط محلقة غوانيليل قابل للذوبان (sGC) - Google Patents

صيغ صلبة من منشط محلقة غوانيليل قابل للذوبان (sGC)

Info

Publication number
JOP20180127A1
JOP20180127A1 JOP/2018/0127A JOP20180127A JOP20180127A1 JO P20180127 A1 JOP20180127 A1 JO P20180127A1 JO P20180127 A JOP20180127 A JO P20180127A JO P20180127 A1 JOP20180127 A1 JO P20180127A1
Authority
JO
Jordan
Prior art keywords
solid forms
sgc
disorders
sgc stimulator
stimulator
Prior art date
Application number
JOP/2018/0127A
Other languages
English (en)
Inventor
Vasu Sethuraman
Song Xue
Robert C Livingston
Kwame Wiredu Nti-Addae
Ahmad Hashash
Original Assignee
Ironwood Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc
Publication of JOP20180127A1 publication Critical patent/JOP20180127A1/ar

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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

يتعلق الاختراع الحالي بصور بلورية صلبة من محفز جوانيلات سيكلاز القابل للذوبان (sGC)، للمركب I. كما يتم في الوثيقة الحالية توفير طرق لتحضير هذه الصور الصلبة.كما يتعلق الاختراع بصيغ صيدلانية و صور جرعات تشتمل على هذه الصور الصلبة و استخداماتها، بمفردها أو بالاشتراك مع واحد أو أكثر من العوامل الإضافية، لعلاج و / أو الوقاية من أمراض أو اضطرابات مختلفة؛ هذه الأمراض أو الاضطرابات هي التي قد تستفيد من تحفيز sGC أو من الزيادة في تركيز حمض نيتريك (NO) و / أو جوانوسين مونو فوسفات الحلقي (cGMP).
JOP/2018/0127A 2016-07-07 2018-12-24 صيغ صلبة من منشط محلقة غوانيليل قابل للذوبان (sGC) JOP20180127A1 (ar)

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