BR0315041A - Métodos para inibir crth2 em um indivìduo que necessita inibição de crth2; composto; e composição farmacêutica - Google Patents

Métodos para inibir crth2 em um indivìduo que necessita inibição de crth2; composto; e composição farmacêutica

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Publication number
BR0315041A
BR0315041A BR0315041-0A BR0315041A BR0315041A BR 0315041 A BR0315041 A BR 0315041A BR 0315041 A BR0315041 A BR 0315041A BR 0315041 A BR0315041 A BR 0315041A
Authority
BR
Brazil
Prior art keywords
crth2
compound
pharmaceutical composition
inhibiting
methods
Prior art date
Application number
BR0315041-0A
Other languages
English (en)
Inventor
Shomir Ghosh
Amy M Elder
Kennth G Carson
Kevin Sprott
Sean Harrison
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of BR0315041A publication Critical patent/BR0315041A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Abstract

"MéTODO PARA INIBIR CRTH2 EM UM INDIVìDUO QUE NECESSITA INIBIçãO DE CRTH2; COMPOSTO; E COMPOSIçãO FARMACêUTICA". Descreve-se nesta invenção compostos representados pela Fórmula Estrutural (I): (I), onde as variáveis estão aqui definidas. Descreve-se também o uso de tais compostos para inibir receptor acoplado à proteína G, referido como molécula homáloga a receptores quimioatratores, expressada em Th2 ('CRTH2'), para o tratamento de distúrbios inflamatórios.
BR0315041-0A 2002-10-04 2003-10-03 Métodos para inibir crth2 em um indivìduo que necessita inibição de crth2; composto; e composição farmacêutica BR0315041A (pt)

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KR20050055747A (ko) 2005-06-13
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CN1720047A (zh) 2006-01-11
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