BR0314188A - Acetil 2-hidróxi-1,3-diaminoalcanos - Google Patents

Acetil 2-hidróxi-1,3-diaminoalcanos

Info

Publication number
BR0314188A
BR0314188A BR0314188-8A BR0314188A BR0314188A BR 0314188 A BR0314188 A BR 0314188A BR 0314188 A BR0314188 A BR 0314188A BR 0314188 A BR0314188 A BR 0314188A
Authority
BR
Brazil
Prior art keywords
diaminoalkanes
hydroxy
acetyl
beta
compounds
Prior art date
Application number
BR0314188-8A
Other languages
English (en)
Inventor
Michel Maillard
Eric T Baldwin
James P Beck
Robert Hughes
Varghese John
Shon R Pulley
Ruth Tenbrink
Original Assignee
Upjohn Co
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Elan Pharm Inc filed Critical Upjohn Co
Publication of BR0314188A publication Critical patent/BR0314188A/pt

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    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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Abstract

"ACETIL-2-HIDROXI-1,3- DIAMINOALCANOS". São descritos os compostos de fórmula: onde as variáveis Z, X, R~ 15~, R~ 2~, R~ 3~, e R~ c~ são definidas aqui. Os compostos aqui descritos são inibidores de enzima beta-secretase e são, assim, utilizáveis no tratamento de mal de Alzheimer e outras doenças caracterizadas pela deposição de peptídeo beta A em um mamífero.
BR0314188-8A 2002-09-10 2003-09-10 Acetil 2-hidróxi-1,3-diaminoalcanos BR0314188A (pt)

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PCT/US2003/028503 WO2004024081A2 (en) 2002-09-10 2003-09-10 Acetyl 2-hydroxy-1,3 diaminoalkanes

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PL376511A1 (pl) 2006-01-09
UA84407C2 (en) 2008-10-27
KR20060057520A (ko) 2006-05-26
NO20051239L (no) 2005-06-06
NZ539095A (en) 2007-04-27
US20100145056A1 (en) 2010-06-10
EA009196B1 (ru) 2007-12-28
PE20041079A1 (es) 2005-02-05
JP2011084568A (ja) 2011-04-28
GEP20074166B (en) 2007-07-25
ECSP055696A (es) 2005-07-06
AR043679A1 (es) 2005-08-10
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US7244725B2 (en) 2007-07-17
AU2003267132A1 (en) 2004-04-30
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