PE20041079A1 - Acetil-2-hidroxi-1,3-diaminoalcanos - Google Patents

Acetil-2-hidroxi-1,3-diaminoalcanos

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Publication number
PE20041079A1
PE20041079A1 PE2003000914A PE2003000914A PE20041079A1 PE 20041079 A1 PE20041079 A1 PE 20041079A1 PE 2003000914 A PE2003000914 A PE 2003000914A PE 2003000914 A PE2003000914 A PE 2003000914A PE 20041079 A1 PE20041079 A1 PE 20041079A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
amino
hydroxibutyl
ethylphenyl
Prior art date
Application number
PE2003000914A
Other languages
English (en)
Inventor
Michel Maillard
John Varghese
James P Beck
Shon R Pulley
Ruth Tenbrink
Robert Hughes
Eric T Baldwin
Original Assignee
Elan Pharm Inc
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, Upjohn Co filed Critical Elan Pharm Inc
Publication of PE20041079A1 publication Critical patent/PE20041079A1/es

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    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE Z ES H, (CICLOALQUIL C3-C7)0-1(ALQUILO C1-C6)-, (CICLOALQUIL C3-C7)0-1(ALQUENILO C2-C6)-, ENTRE OTROS; X ES -(C=O)-, -(C=S)-, -(SO2)-; R1 ES ALQUILO C1-C10 OPCIONALMENTE SUSTITUIDO CON 1-3 GRUPOS COMO -OH, =O, -SH, ENTRE OTROS; R2 Y R3 SON CADA UNO H, F, ALQUILO C1-C6 SUSTITUIDO O NO, ENTRE OTROS; R15 ES H, ALQUILO C1-C6, ALCOXI C1-C6, HALOALQUILO, ENTRE OTROS; Rc ES -(CH2)0-3-(CICLOALQUILO C3-C8) SUSTITUIDO CON 1-3 GRUPOS. SON COMPUESTOS PREFERIDOS: N-[(1S,2R)-3-[(3-BROMOBENCIL)AMINO]-1-(3,5-DIFLUOROBENCIL)-2-HIDROXIPROPIL]ACETAMIDA; 3-{[(2R,3S)-3-(ACETILAMINO)-4-(3,5-DIFLUOROFENIL)-2-HIDROXIBUTIL]AMINO}-3-(3-ETILFENIL)PROPANOATO DE METILO Y (3S)-3-{[(2R,3S)-3-(ACETILAMINO)-4-(3,5-DIFLUOROFENIL)-2-HIDROXIBUTIL]AMINO}-3-(3-ETILFENIL)BUTANOATO DE METILO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA EN LA QUE DICHOS COMPUESTOS RESULTANTES SON INHIBIDORES DE LA ENZIMA BETA SECRETASA UTILES EN ELTRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, DISCAPACIDAD COGNITIVA LEVE, ANGIOPATIA AMILOIDE CEREBRAL, ENTRE OTRAS
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Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050609A1 (en) * 2002-11-27 2004-06-17 Elan Pharmaceutical, Inc. Substituted ureas and carbamates
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
PE20050420A1 (es) * 2003-04-21 2005-06-13 Elan Pharm Inc Fenacilo 2-hidroxi-3-diaminoalcanos
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US20060014790A1 (en) * 2004-01-21 2006-01-19 Varghese John Methods of treatment of amyloidosis using spirocyclohexane aspartyl-protease inhibitors
US20050239836A1 (en) 2004-03-09 2005-10-27 Varghese John Substituted hydroxyethylamine aspartyl protease inhibitors
WO2005087752A2 (en) * 2004-03-09 2005-09-22 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamine aspartyl protease inhibitors
EP1734961A2 (en) * 2004-03-09 2006-12-27 Elan Pharmaceuticals, Inc. Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors
EP1734942A1 (en) * 2004-03-09 2006-12-27 Elan Pharmaceuticals, Inc. Substituted urea and carbamate, phenacyl-2-hydroxy-3-diaminoalkane, and benzamide-2-hydroxy-3-diaminoalkane aspartyl-protease inhibitors
JP2007533740A (ja) * 2004-04-22 2007-11-22 イーライ リリー アンド カンパニー Ｂａｃｅ阻害剤としてのアミド
US7585885B2 (en) 2004-04-22 2009-09-08 Eli Lilly And Company Pyrrolidine derivatives useful as BACE inhibitors
US7385085B2 (en) 2004-07-09 2008-06-10 Elan Pharmaceuticals, Inc. Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
AU2005265354A1 (en) * 2004-07-09 2006-01-26 Elan Pharmaceuticals, Inc. Oxime derivative hydroxyethylamine aspartyl-protease inhibitors
PE20060692A1 (es) * 2004-09-21 2006-07-19 Lilly Co Eli Inhibidores bace
WO2006085216A1 (en) * 2005-02-14 2006-08-17 Pfizer Products Inc. Substituted hydroxyethylamines
CN101142194B (zh) * 2005-03-14 2012-10-10 顶点制药有限责任公司 吲哚衍生物，组合物及用作β-分泌酶抑制剂的方法
JP2008535863A (ja) 2005-04-08 2008-09-04 コメンティス，インコーポレーテッド β−セクレターゼ活性を阻害する化合物およびその使用方法
JP2009511589A (ja) * 2005-10-12 2009-03-19 エラン ファーマシューティカルズ，インコーポレイテッド アリール−シクロプロピル誘導体のアスパルチルプロテアーゼ阻害剤を使用してアミロイドーシスを治療する方法
WO2007047305A1 (en) 2005-10-12 2007-04-26 Elan Pharmaceuticals, Inc. Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
US7745484B2 (en) 2005-11-21 2010-06-29 Amgen Inc. Beta-secretase modulators and methods of use
US7838676B2 (en) * 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
JP5274258B2 (ja) * 2005-11-21 2013-08-28 アムジエン・インコーポレーテツド β−セクレターゼ調節物質及び使用方法
US7872009B2 (en) 2005-11-21 2011-01-18 Amgen Inc. Beta-Secretase modulators and methods of use
CA2630459A1 (en) * 2005-11-22 2007-05-31 Pfizer Products Inc. Substituted azacycloalkanes useful for treating cns conditions
BRPI0719336A2 (pt) * 2006-11-23 2014-02-04 Novartis Ag Derivados de 2-hidróxi-1,3-diaminopropano
US8173810B2 (en) 2007-05-25 2012-05-08 Amgen Inc. Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
US8163909B2 (en) 2007-05-25 2012-04-24 Amgen Inc. Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
US7803809B2 (en) 2008-11-12 2010-09-28 Amgen Inc. Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use
DE102008039083A1 (de) 2008-08-21 2010-02-25 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Aminopyrazole und ihre Verwendung
CA2736130C (en) * 2008-09-11 2014-01-14 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use
WO2011063272A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
WO2011063233A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
EP2526092B1 (en) 2010-01-19 2014-08-06 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
US8497264B2 (en) 2010-03-15 2013-07-30 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US8883782B2 (en) 2010-03-15 2014-11-11 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use
US9346827B2 (en) 2011-02-07 2016-05-24 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
WO2013044092A1 (en) 2011-09-21 2013-03-28 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US9725469B2 (en) 2012-11-15 2017-08-08 Amgen, Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
EP3490607A4 (en) * 2016-07-29 2020-04-08 Sunovion Pharmaceuticals Inc. COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
SG11202000669VA (en) 2017-08-02 2020-02-27 Sunovion Pharmaceuticals Inc Isochroman compounds and uses thereof
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
PL243516B1 (pl) * 2020-05-20 2023-09-04 Univ Jagiellonski Nowe pochodne 9H-fluorenu lub ich farmaceutycznie dopuszczalne sole
CN113189089B (zh) * 2021-03-19 2022-05-17 四川轻化工大学 一种臭氧检测试剂及其制备装置和制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61118352A (ja) * 1984-10-29 1986-06-05 イー・アール・スクイブ・アンド・サンズ・インコーポレイテツド アミノ酸エステルおよびアミドレニン抑制剤
US5539122A (en) * 1989-05-23 1996-07-23 Abbott Laboratories Retroviral protease inhibiting compounds
US5362912A (en) * 1989-05-23 1994-11-08 Abbott Laboratories Process for the preparation of a substituted diaminodiol
EP0647268B1 (en) * 1990-06-15 2004-03-03 Scios Inc. Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease
DE69233774D1 (de) * 1991-01-21 2009-12-10 Elan Pharm Inc Prüfung und Modell für Alzheimers-Krankheit
FR2676173B1 (fr) 1991-05-06 1993-08-13 Oreal Composition cosmetique contenant un agent alcalinisant sans odeur.
WO1993014200A1 (en) * 1992-01-07 1993-07-22 Tsi Corporation Transgenic animal models for alzheimer's disease
DE4208756A1 (de) 1992-03-19 1993-09-23 Basf Ag Diaminoalkane, verfahren zu deren herstellung sowie kraftstoffe und schmierstoffe, enthaltend die diaminoalkane
US5604102A (en) * 1992-04-15 1997-02-18 Athena Neurosciences, Inc. Methods of screening for β-amyloid peptide production inhibitors
US5766846A (en) * 1992-07-10 1998-06-16 Athena Neurosciences Methods of screening for compounds which inhibit soluble β-amyloid peptide production
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DK0727419T3 (da) * 1992-12-29 2002-06-10 Abbott Lab Mellemprodukter til fremstilling af forbindelser, som inhiberer retroviral protease
ATE198622T1 (de) * 1993-10-27 2001-01-15 Elan Pharm Inc Transgene tiere, die app allele mit der schwedischen mutation beherbergen
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
US6297269B1 (en) * 1995-06-06 2001-10-02 Pfizer Inc. Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors
EP0970041A1 (de) 1996-07-03 2000-01-12 Hans Schwarzkopf GmbH & Co. KG Neue diaminoalkane und oxidationsfärbemittel
DE69828682T2 (de) * 1997-02-04 2006-04-06 The Regents Of The University Of California, Oakland Nanomolare, non-peptidische inhibitoren von cathepsin d
WO1999006369A1 (en) * 1997-08-01 1999-02-11 University Of Florida Neuraminidase inhibitors
ES2318902T3 (es) 1998-09-24 2009-05-01 PHARMACIA & UPJOHN COMPANY LLC Secretasa en la enfermedad del alzheimer.
PE20020276A1 (es) * 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
CA2410972A1 (en) * 2000-06-30 2002-01-10 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
US6846813B2 (en) * 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
BR0210122A (pt) * 2001-06-01 2004-06-15 Elan Pharm Inc Composto ou um sal farmaceuticamente aceitável do mesmo, método para o tratamento ou prevenção de uma doença, uso do composto ou de seu sal, e, método para preparar o mesmo
BR0211119A (pt) * 2001-07-11 2005-12-13 Elan Pharm Inc Composto, método de tratar um paciente que tenha, ou de prevenir um paciente de pegar, uma doença ou condição, uso de um composto, e, método para fabricar um composto
JP2005520791A (ja) * 2001-11-08 2005-07-14 イーラン ファーマスーティカルズ、インコーポレイテッド Ｎ，ｎ’−置換−１，３−ジアミノ−２−ヒドロキシプロパン誘導体
EP1453788A1 (en) * 2001-12-06 2004-09-08 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamines
US7294642B2 (en) * 2002-09-06 2007-11-13 Elan Pharmaceuticals, Inc. 1,3-Diamino-2-hydroxypropane pro-drug derivatives

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