BR112019000291A2 - processos inovadores para a preparação de estimuladores de guanilato ciclase solúvel - Google Patents
processos inovadores para a preparação de estimuladores de guanilato ciclase solúvelInfo
- Publication number
- BR112019000291A2 BR112019000291A2 BR112019000291A BR112019000291A BR112019000291A2 BR 112019000291 A2 BR112019000291 A2 BR 112019000291A2 BR 112019000291 A BR112019000291 A BR 112019000291A BR 112019000291 A BR112019000291 A BR 112019000291A BR 112019000291 A2 BR112019000291 A2 BR 112019000291A2
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- enhancers
- guanylate cyclase
- soluble guanylate
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
a presente invenção se refere a processos inovadores para a preparação de compostos úteis como estimuladores de guanilato ciclase solúvel (sgc). esses processos são passíveis de preparação em larga escala e produzem 3-(2-pirimidinil)pirazóis estáveis de fórmula i, incluindo o composto i, com alta pureza e altos rendimentos. a presente invenção tem a vantagem adicional de condições de reação facilitadas, sendo passível de expansão para fabricação em larga escala. a descrição também fornece novos intermediários úteis na preparação dos ditos compostos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662359453P | 2016-07-07 | 2016-07-07 | |
PCT/US2017/040810 WO2018009597A1 (en) | 2016-07-07 | 2017-07-06 | Novel processes for preparation of soluble guanylate cyclase stimulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019000291A2 true BR112019000291A2 (pt) | 2019-04-16 |
Family
ID=59416789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019000291A BR112019000291A2 (pt) | 2016-07-07 | 2017-07-06 | processos inovadores para a preparação de estimuladores de guanilato ciclase solúvel |
Country Status (16)
Country | Link |
---|---|
US (3) | US11319308B2 (pt) |
EP (2) | EP4249488A3 (pt) |
JP (1) | JP7112384B2 (pt) |
KR (1) | KR102487872B1 (pt) |
CN (1) | CN109563077A (pt) |
AU (1) | AU2017291827B2 (pt) |
BR (1) | BR112019000291A2 (pt) |
CA (1) | CA3029375A1 (pt) |
CL (2) | CL2019000016A1 (pt) |
EA (1) | EA201990237A1 (pt) |
ES (1) | ES2963563T3 (pt) |
IL (1) | IL263995B (pt) |
MA (1) | MA45603A (pt) |
MX (2) | MX2019000105A (pt) |
SG (1) | SG11201900096QA (pt) |
WO (1) | WO2018009597A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10202100168XA (en) * | 2016-07-07 | 2021-02-25 | Cyclerion Therapeutics Inc | Novel processes for preparation of soluble guanylate cyclase stimulators |
MA45603A (fr) | 2016-07-07 | 2019-05-15 | Ironwood Pharmaceuticals Inc | Nouveaux procédés de préparation de stimulateurs de la guanylate cyclase soluble |
SG11202006311SA (en) | 2018-01-10 | 2020-07-29 | Cyclerion Therapeutics Inc | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
WO2019161534A1 (en) * | 2018-02-22 | 2019-08-29 | Ironwood Pharmaceuticals, Inc. | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8969349B2 (en) | 2010-05-26 | 2015-03-03 | Sunovion Pharmaceuticals Inc. | Substituted quinoxalines and quinoxalinones as PDE-10 inhibitors |
WO2012003405A1 (en) | 2010-06-30 | 2012-01-05 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
EP2797915B1 (en) * | 2011-12-27 | 2016-07-13 | Ironwood Pharmaceuticals, Inc. | 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure |
EP2897953B8 (en) * | 2012-09-19 | 2019-06-26 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
SI3660013T1 (sl) * | 2013-03-15 | 2022-05-31 | Cyclerion Therapeutics, Inc. | SGC stimulatorji |
EP3092231B1 (en) | 2013-12-11 | 2018-06-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
EP3194382B1 (en) * | 2014-09-17 | 2021-09-08 | Cyclerion Therapeutics, Inc. | Pyrazole derivatives as sgc stimulators |
JP2017527604A (ja) * | 2014-09-17 | 2017-09-21 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC刺激剤 |
EP3194395B1 (en) * | 2014-09-17 | 2019-12-04 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
WO2016044445A2 (en) * | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
EA201891315A1 (ru) | 2015-11-30 | 2018-12-28 | Айронвуд Фармасьютикалз, Инк. | Твердые дисперсии, содержащие стимулятор sgc |
EP3481820B1 (en) | 2016-07-07 | 2023-10-18 | Cyclerion Therapeutics, Inc. | Solid forms of an sgc stimulator |
MA45603A (fr) | 2016-07-07 | 2019-05-15 | Ironwood Pharmaceuticals Inc | Nouveaux procédés de préparation de stimulateurs de la guanylate cyclase soluble |
SG10202100168XA (en) * | 2016-07-07 | 2021-02-25 | Cyclerion Therapeutics Inc | Novel processes for preparation of soluble guanylate cyclase stimulators |
CA3086207A1 (en) * | 2017-12-19 | 2019-06-27 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
SG11202006311SA (en) * | 2018-01-10 | 2020-07-29 | Cyclerion Therapeutics Inc | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
-
2017
- 2017-07-06 MA MA045603A patent/MA45603A/fr unknown
- 2017-07-06 US US16/315,218 patent/US11319308B2/en active Active
- 2017-07-06 BR BR112019000291A patent/BR112019000291A2/pt unknown
- 2017-07-06 SG SG11201900096QA patent/SG11201900096QA/en unknown
- 2017-07-06 EA EA201990237A patent/EA201990237A1/ru unknown
- 2017-07-06 MX MX2019000105A patent/MX2019000105A/es unknown
- 2017-07-06 EP EP23185002.5A patent/EP4249488A3/en active Pending
- 2017-07-06 JP JP2019500355A patent/JP7112384B2/ja active Active
- 2017-07-06 AU AU2017291827A patent/AU2017291827B2/en active Active
- 2017-07-06 CA CA3029375A patent/CA3029375A1/en active Pending
- 2017-07-06 KR KR1020197003459A patent/KR102487872B1/ko active IP Right Grant
- 2017-07-06 EP EP17745553.2A patent/EP3481818B1/en active Active
- 2017-07-06 ES ES17745553T patent/ES2963563T3/es active Active
- 2017-07-06 CN CN201780047020.6A patent/CN109563077A/zh active Pending
- 2017-07-06 WO PCT/US2017/040810 patent/WO2018009597A1/en unknown
-
2018
- 2018-12-27 IL IL263995A patent/IL263995B/en active IP Right Grant
-
2019
- 2019-01-04 CL CL2019000016A patent/CL2019000016A1/es unknown
- 2019-01-07 MX MX2022001495A patent/MX2022001495A/es unknown
-
2022
- 2022-03-30 US US17/708,296 patent/US11773089B2/en active Active
-
2023
- 2023-01-24 CL CL2023000228A patent/CL2023000228A1/es unknown
- 2023-08-24 US US18/237,435 patent/US20240059684A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220227748A1 (en) | 2022-07-21 |
EP3481818B1 (en) | 2023-09-06 |
WO2018009597A1 (en) | 2018-01-11 |
EP4249488A2 (en) | 2023-09-27 |
EA201990237A1 (ru) | 2019-08-30 |
EP4249488A3 (en) | 2023-12-20 |
EP3481818C0 (en) | 2023-09-06 |
SG11201900096QA (en) | 2019-02-27 |
US11773089B2 (en) | 2023-10-03 |
MA45603A (fr) | 2019-05-15 |
CN109563077A (zh) | 2019-04-02 |
KR20190025986A (ko) | 2019-03-12 |
CL2023000228A1 (es) | 2023-09-29 |
CL2019000016A1 (es) | 2019-05-03 |
EP3481818A1 (en) | 2019-05-15 |
US20240059684A1 (en) | 2024-02-22 |
ES2963563T3 (es) | 2024-03-27 |
JP2019525913A (ja) | 2019-09-12 |
MX2019000105A (es) | 2019-04-22 |
KR102487872B1 (ko) | 2023-01-12 |
IL263995A (en) | 2019-02-28 |
IL263995B (en) | 2021-02-28 |
US20210323951A1 (en) | 2021-10-21 |
CA3029375A1 (en) | 2018-01-11 |
MX2022001495A (es) | 2022-03-11 |
AU2017291827B2 (en) | 2021-10-21 |
US11319308B2 (en) | 2022-05-03 |
AU2017291827A1 (en) | 2019-02-07 |
JP7112384B2 (ja) | 2022-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112019000291A2 (pt) | processos inovadores para a preparação de estimuladores de guanilato ciclase solúvel | |
MY172391A (en) | Processes for preparing dihydropyrimidine derivatives and intermediates thereof | |
NZ701947A (en) | Processes to produce certain 2-(pyridine-3-yl)thiazoles | |
AR118647A1 (es) | Proceso de preparación de 2-(3,5-diclorofenil)-6-benzoxazolcarboxilato de 1-deoxi-1-metilamino-d-glucitol | |
BR112022006052A2 (pt) | Processo para a preparação de protioconazol | |
BR112019000292A2 (pt) | processos inovadores para a preparação de estimuladores de guanilato ciclase solúvel | |
UA111868C2 (uk) | Спосіб одержання естерів (5-фтор-2-метил-3-хінолін-2-ілметиліндол-1-іл)-оцтової кислоти | |
MX2018014130A (es) | Procedimiento e intermedios para la 6,7-alfa-epoxidacion de 4,6-dienos esteroideos. | |
BR112018014534A2 (pt) | método e intermediário para a preparação de tulatromicina | |
CL2022000907A1 (es) | Procesos de preparación de un compuesto de fórmula ib, ic o id; y compuestos intermediarios para fabricar un compuesto de fórmula ib, ic o id (div. sol. 202001814). | |
BR112012013582A2 (pt) | processo para síntese de intermediários úteis para a produção de compostos de indazol e azaindazol substituídos | |
BR112017017066A2 (pt) | método de preparação para praziquantel e compostos intermediários do mesmo | |
CU20190035A7 (es) | Derivados sustituidos de 6-(1h-pirazol-1-il)pirimidin-4-amina | |
EA202191158A1 (ru) | Новый способ получения n,n'-бис[2-(1н-имидазол-4-ил)этил]малонамида | |
MX2021002896A (es) | Proceso para preparar 1-(3,5-diclorofenil)-2,2,2-trifluoroetanona y sus derivados. | |
MX2023004650A (es) | Un procedimiento para la preparacion de clorantraniliprol. | |
BR112023000029A2 (pt) | Método de preparação do composto de fenilisoxazolina | |
BR112012019620A2 (pt) | Processo para preparar voriconazol usando novos intermediários | |
EA202091664A1 (ru) | Новые способы и промежуточные соединения для получения стимуляторов растворимой гуанилатциклазы | |
NZ598129A (en) | Process for the preparation of cathepsin s inhibitors | |
MX2017009839A (es) | Proceso para la produccion de derivados de imidazolo condensados. | |
BR112021020407A2 (pt) | Processo para preparação de intermediários para as sínteses de derivados de vitamina a de polienos por ciclização | |
IN2014KO00147A (pt) | ||
PL400932A1 (pl) | Nowe pochodne pirolu i sposób ich otrzymywania | |
UA110455C2 (en) | METHOD FOR SPIRO-λ6-IZOTIAZOLIDYN-1,1,4-TRION |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: CYCLERION THERAPEUTICS, INC. (US) |
|
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |