MX2022001495A - Procesos novedosos para preparar estimuladores de guanilato ciclasa soluble. - Google Patents

Procesos novedosos para preparar estimuladores de guanilato ciclasa soluble.

Info

Publication number
MX2022001495A
MX2022001495A MX2022001495A MX2022001495A MX2022001495A MX 2022001495 A MX2022001495 A MX 2022001495A MX 2022001495 A MX2022001495 A MX 2022001495A MX 2022001495 A MX2022001495 A MX 2022001495A MX 2022001495 A MX2022001495 A MX 2022001495A
Authority
MX
Mexico
Prior art keywords
preparation
guanylate cyclase
soluble guanylate
novel processes
processes
Prior art date
Application number
MX2022001495A
Other languages
English (en)
Inventor
Song Xue
Vishnu Vardhan Reddy Karnati
Robert C Livingston
Original Assignee
Cyclerion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyclerion Therapeutics Inc filed Critical Cyclerion Therapeutics Inc
Publication of MX2022001495A publication Critical patent/MX2022001495A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente descripción se relaciona con procesos novedosos para preparar compuestos útiles como estimuladores de guanilato ciclasa soluble (sGC). Estos procesos pueden prepararse a gran escala y producir 3-(2-pirimidinil)pirazoles de la Fórmula I, que incluye el Compuesto I, con pureza y rendimientos altos. La presente invención tiene la ventaja adicional de que incluye condiciones de reacción simples que pueden aumentarse progresivamente para la fabricación a gran escala. La descripción proporciona, además, productos intermedios novedosos útiles para preparar los compuestos.
MX2022001495A 2016-07-07 2019-01-07 Procesos novedosos para preparar estimuladores de guanilato ciclasa soluble. MX2022001495A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662359453P 2016-07-07 2016-07-07

Publications (1)

Publication Number Publication Date
MX2022001495A true MX2022001495A (es) 2022-03-11

Family

ID=59416789

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019000105A MX2019000105A (es) 2016-07-07 2017-07-06 Procesos novedosos para preparar estimuladores de guanilato ciclasa soluble.
MX2022001495A MX2022001495A (es) 2016-07-07 2019-01-07 Procesos novedosos para preparar estimuladores de guanilato ciclasa soluble.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019000105A MX2019000105A (es) 2016-07-07 2017-07-06 Procesos novedosos para preparar estimuladores de guanilato ciclasa soluble.

Country Status (16)

Country Link
US (3) US11319308B2 (es)
EP (2) EP4249488A3 (es)
JP (1) JP7112384B2 (es)
KR (1) KR102487872B1 (es)
CN (1) CN109563077A (es)
AU (1) AU2017291827B2 (es)
BR (1) BR112019000291A2 (es)
CA (1) CA3029375A1 (es)
CL (2) CL2019000016A1 (es)
EA (1) EA201990237A1 (es)
ES (1) ES2963563T3 (es)
IL (1) IL263995B (es)
MA (1) MA45603A (es)
MX (2) MX2019000105A (es)
SG (1) SG11201900096QA (es)
WO (1) WO2018009597A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7112384B2 (ja) 2016-07-07 2022-08-03 サイクレリオン・セラピューティクス，インコーポレーテッド 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法
CA3029376A1 (en) * 2016-07-07 2018-01-11 Ironwood Pharmaceuticals, Inc. Novel processes for preparation of soluble guanylate cyclase stimulators
WO2019161534A1 (en) * 2018-02-22 2019-08-29 Ironwood Pharmaceuticals, Inc. Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators
CA3087943A1 (en) 2018-01-10 2019-07-18 Cyclerion Therapeutics, Inc. Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011258217B2 (en) * 2010-05-26 2016-12-15 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
BR112012033341B1 (pt) 2010-06-30 2022-08-23 Cyclerion Therapeutics, Inc Estimulantes de sgc
US9139564B2 (en) * 2011-12-27 2015-09-22 Ironwood Pharmaceuticals, Inc. 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators
CA2885645A1 (en) * 2012-09-19 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
PT2970243T (pt) * 2013-03-15 2020-03-05 Cyclerion Therapeutics Inc Estimuladores de sgc
US20160311826A1 (en) * 2013-12-11 2016-10-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US20170298055A1 (en) * 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
AU2015317823A1 (en) * 2014-09-17 2017-03-23 Ironwood Pharmaceuticals, Inc. sGC stimulators
EA201790627A1 (ru) * 2014-09-17 2017-09-29 Айронвуд Фармасьютикалз, Инк. СТИМУЛЯТОРЫ рГЦ
JP6624616B2 (ja) * 2014-09-17 2019-12-25 サイクレリオン・セラピューティクス，インコーポレーテッド ｓＧＣ刺激剤
US20190269619A1 (en) * 2015-11-30 2019-09-05 Ironwood Pharmaceuticals, Inc. Solid dispersions comprising a sgc stimulator
JP7112384B2 (ja) 2016-07-07 2022-08-03 サイクレリオン・セラピューティクス，インコーポレーテッド 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法
CA3029376A1 (en) 2016-07-07 2018-01-11 Ironwood Pharmaceuticals, Inc. Novel processes for preparation of soluble guanylate cyclase stimulators
WO2018009609A1 (en) * 2016-07-07 2018-01-11 Ironwood Pharmaceuticals, Inc. Solid forms of an sgc stimulator
BR112020012629A2 (pt) * 2017-12-19 2020-12-01 Cyclerion Therapeutics, Inc. estimulantes de sgc
CA3087943A1 (en) * 2018-01-10 2019-07-18 Cyclerion Therapeutics, Inc. Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators

Also Published As

Publication number Publication date
KR102487872B1 (ko) 2023-01-12
US11319308B2 (en) 2022-05-03
EP3481818C0 (en) 2023-09-06
EP3481818A1 (en) 2019-05-15
US20240059684A1 (en) 2024-02-22
EA201990237A1 (ru) 2019-08-30
ES2963563T3 (es) 2024-03-27
IL263995A (en) 2019-02-28
JP2019525913A (ja) 2019-09-12
CL2019000016A1 (es) 2019-05-03
US20220227748A1 (en) 2022-07-21
EP4249488A2 (en) 2023-09-27
CL2023000228A1 (es) 2023-09-29
SG11201900096QA (en) 2019-02-27
BR112019000291A2 (pt) 2019-04-16
CN109563077A (zh) 2019-04-02
IL263995B (en) 2021-02-28
US20210323951A1 (en) 2021-10-21
JP7112384B2 (ja) 2022-08-03
MX2019000105A (es) 2019-04-22
AU2017291827B2 (en) 2021-10-21
AU2017291827A1 (en) 2019-02-07
KR20190025986A (ko) 2019-03-12
MA45603A (fr) 2019-05-15
CA3029375A1 (en) 2018-01-11
EP4249488A3 (en) 2023-12-20
US11773089B2 (en) 2023-10-03
EP3481818B1 (en) 2023-09-06
WO2018009597A1 (en) 2018-01-11

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