MX2018014130A - Procedimiento e intermedios para la 6,7-alfa-epoxidacion de 4,6-dienos esteroideos. - Google Patents

Procedimiento e intermedios para la 6,7-alfa-epoxidacion de 4,6-dienos esteroideos.

Info

Publication number
MX2018014130A
MX2018014130A MX2018014130A MX2018014130A MX2018014130A MX 2018014130 A MX2018014130 A MX 2018014130A MX 2018014130 A MX2018014130 A MX 2018014130A MX 2018014130 A MX2018014130 A MX 2018014130A MX 2018014130 A MX2018014130 A MX 2018014130A
Authority
MX
Mexico
Prior art keywords
epoxidation
intermediates
dienes
steroid
alpha
Prior art date
Application number
MX2018014130A
Other languages
English (en)
Inventor
Evans Timothy
Komsta Zofia
WALLIS Laura
Charles Weymouth-Wilson Alexander
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of MX2018014130A publication Critical patent/MX2018014130A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Abstract

La invención se relaciona con un procedimiento para preparar un compuesto de formula general (Ia): (ver formula) (Ia) en donde R2, Y, R4 y R5 son como se definen en la presente, en donde la epoxidacion se lleva a cabo usando un oxidante y metiltrioxorenio como catalizador (MeReO3); la invención también se relaciona con ciertos compuestos per se; los compuestos son intermedios en la síntesis de ácidos biliares 10 sintéticos.
MX2018014130A 2016-05-18 2017-05-18 Procedimiento e intermedios para la 6,7-alfa-epoxidacion de 4,6-dienos esteroideos. MX2018014130A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1608776.9A GB201608776D0 (en) 2016-05-18 2016-05-18 Methods and compounds
PCT/GB2017/051389 WO2017199036A1 (en) 2016-05-18 2017-05-18 Process and intermediates for the 6,7-alpha-epoxidation of steroid 4,6-dienes

Publications (1)

Publication Number Publication Date
MX2018014130A true MX2018014130A (es) 2019-04-29

Family

ID=56320628

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018014130A MX2018014130A (es) 2016-05-18 2017-05-18 Procedimiento e intermedios para la 6,7-alfa-epoxidacion de 4,6-dienos esteroideos.

Country Status (15)

Country Link
US (1) US10766921B2 (es)
EP (1) EP3458467B1 (es)
JP (1) JP7034094B2 (es)
KR (1) KR102489565B1 (es)
CN (1) CN109415404B (es)
AU (1) AU2017265445B2 (es)
BR (1) BR112018073492A2 (es)
CA (1) CA3024283A1 (es)
DK (1) DK3458467T3 (es)
EA (1) EA038224B1 (es)
ES (1) ES2841324T3 (es)
GB (1) GB201608776D0 (es)
MX (1) MX2018014130A (es)
PT (1) PT3458467T (es)
WO (1) WO2017199036A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN111560045A (zh) * 2020-06-23 2020-08-21 江苏佳尔科药业集团股份有限公司 一种以ba为原料合成石胆酸的方法
CN114957368A (zh) * 2021-09-08 2022-08-30 湖南醇康医药科技有限公司 中间体化合物及其制备方法和应用
CN114957372B (zh) * 2021-12-07 2023-10-31 湖南醇康医药科技有限公司 10α-甲基-5,7-二烯甾体化合物和地屈孕酮的制备方法

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DE3902357A1 (de) 1989-01-27 1990-08-02 Hoechst Ag Verwendung von rheniumorganischen verbindungen zur oxidation von c-c-mehrfachbindungen, darauf basierende oxidationsverfahren und neue rheniumorganische verbindungen
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US20090062256A1 (en) 2001-06-01 2009-03-05 Bristol-Myers Squibb Pharma Company LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
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Also Published As

Publication number Publication date
ES2841324T3 (es) 2021-07-08
JP2019516729A (ja) 2019-06-20
KR20190007011A (ko) 2019-01-21
EP3458467B1 (en) 2020-09-30
EA201892516A1 (ru) 2019-05-31
AU2017265445B2 (en) 2020-12-03
US10766921B2 (en) 2020-09-08
CA3024283A1 (en) 2017-11-23
CN109415404A (zh) 2019-03-01
WO2017199036A1 (en) 2017-11-23
GB201608776D0 (en) 2016-06-29
JP7034094B2 (ja) 2022-03-11
PT3458467T (pt) 2021-01-05
AU2017265445A1 (en) 2018-11-15
EA038224B1 (ru) 2021-07-27
EP3458467A1 (en) 2019-03-27
CN109415404B (zh) 2022-08-26
BR112018073492A2 (pt) 2019-03-26
KR102489565B1 (ko) 2023-01-17
DK3458467T3 (da) 2020-12-14
US20190309012A1 (en) 2019-10-10

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