ES2149984T3 - Derivados imidazolilalquilos de imidazol(5,1-c)(1,4)benzoxazin-1-ona y su utilizacion como agentes terapeuticos. - Google Patents
Derivados imidazolilalquilos de imidazol(5,1-c)(1,4)benzoxazin-1-ona y su utilizacion como agentes terapeuticos.Info
- Publication number
- ES2149984T3 ES2149984T3 ES95917984T ES95917984T ES2149984T3 ES 2149984 T3 ES2149984 T3 ES 2149984T3 ES 95917984 T ES95917984 T ES 95917984T ES 95917984 T ES95917984 T ES 95917984T ES 2149984 T3 ES2149984 T3 ES 2149984T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- hydrogen
- imidazoly
- benzoxazin
- ona
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
COMPUESOS ANTAGONISTAS RECEPTORES 5-HT 3 NOVEDOSOS DE FORMULA (I) DONDE N ES 1,2 O 3; CADA UNO DE R,R{SUB,1} Y R{SUB,2}, QUE PUEDEN SER IGUALES O DISTINTOS, ES HIDROGENO, HALOGENO, HIDROXI, CIANO, C{SUB,1}-C{SUB,6}ALQUIL, CF{SUB,3}, C{SUB,1}-C{SUB,6}ALCOXI, C{SUB,1}-C{SUB,6}ALQUITIO, FORMIL, C{SUB,2}-C{SUB,6}ALCANOIL, CARBOXI, C{SUB,1}-C{SUB,6}ALCOXICARBONIL, NITRO, -N (R{SUB,4}R{SUB,5}) EN EL QUE CADA R{SUB,4} Y R{SUB,5} SON INDEPENDIENTEMENTE HIDROGENO, C{SUB,1}C{SUB,6}ALQUIL, FORMIL O C{SUB,2}-C{SUB,6}ALCANOIL; O UN GRUPO (R{SUB,6}R{SUB,7}) N-SO{SUB,2}, EN EL QUE CADA R{SUB,6} Y R{SUB,7} SON INDEPENDIENTEMENTE HIDROGENO O C{SUB,1}C{SUB,6}ALQUIL; R{SUB,3} ES UN GRUPO IMIDAZOLIL DE FORMULA (A) O (B), DONDE CADA R{SUB,8} Y R{SUB,10} QUE PUEDEN SER IGUALES O DISTINTAS, ES HIDROGENO, O C{SUB,1}-C{SUB,6}ALQUIL, R{SUB,9} ES HIDROGENO, C{SUB,1}-C{SUB,6}ALQUIL O UN GRUPO PROTECTOR DE NITROGENO; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9410469A GB9410469D0 (en) | 1994-05-25 | 1994-05-25 | Imidazolylalkyl derivatives of imidazo (5,1-c) (1,4) benzoxazin-1-one and process for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2149984T3 true ES2149984T3 (es) | 2000-11-16 |
Family
ID=10755687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95917984T Expired - Lifetime ES2149984T3 (es) | 1994-05-25 | 1995-05-02 | Derivados imidazolilalquilos de imidazol(5,1-c)(1,4)benzoxazin-1-ona y su utilizacion como agentes terapeuticos. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5783574A (es) |
EP (1) | EP0711296B1 (es) |
JP (1) | JP3657985B2 (es) |
CA (1) | CA2166617A1 (es) |
DE (1) | DE69517768T2 (es) |
ES (1) | ES2149984T3 (es) |
GB (1) | GB9410469D0 (es) |
WO (1) | WO1995032208A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002092606A1 (fr) * | 2001-05-15 | 2002-11-21 | Takeda Chemical Industries, Ltd. | Derives d'imidazolidine fusionnes, leur procede de preparation et d'utilisation |
CA2913805A1 (en) * | 2005-11-07 | 2007-05-18 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting physiological solubility and stability |
WO2009152289A1 (en) * | 2008-06-11 | 2009-12-17 | Indiana University Research And Technology Corporation | Methods for enhancing adsorption of molecules |
ES2755827T3 (es) * | 2013-03-15 | 2020-04-23 | Incyte Holdings Corp | Heterciclos tricíclicos como inhibidores de proteína BET |
US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
LT3674302T (lt) | 2014-04-23 | 2023-06-12 | Incyte Holdings Corporation | 1h-pirolo[2,3-c]piridin-7(6h)-onai ir pirazolo[3,4-c]piridin-7(6h)-onai kaip bet baltymų inhibitoriai |
PT3472157T (pt) | 2016-06-20 | 2023-05-30 | Incyte Corp | Formas sólidas cristalinas de um inibidor bet |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1052009B (it) * | 1975-12-30 | 1981-06-20 | Erba Carlo Spa | Imidazo 4.3 c 1.4 benzossazino imidazo 4.3 c 1.4 benzotiazino pirazo 2.1 c 1.4 benzossazino e pirazo 2.1 c 1.4 benzotiazino derivati |
DE69332019T2 (de) * | 1992-02-13 | 2002-11-28 | Upjohn Co | 4-oxo-und 4h-imidazo(5,1-c)(1,4)benzoxazine nützlich als benzodiazepinrezeptor-bindemittel. |
GB9212486D0 (en) * | 1992-06-12 | 1992-07-22 | Erba Carlo Spa | Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation |
-
1994
- 1994-05-25 GB GB9410469A patent/GB9410469D0/en active Pending
-
1995
- 1995-05-02 JP JP53000895A patent/JP3657985B2/ja not_active Expired - Fee Related
- 1995-05-02 ES ES95917984T patent/ES2149984T3/es not_active Expired - Lifetime
- 1995-05-02 US US08/578,549 patent/US5783574A/en not_active Expired - Fee Related
- 1995-05-02 CA CA002166617A patent/CA2166617A1/en not_active Abandoned
- 1995-05-02 EP EP95917984A patent/EP0711296B1/en not_active Expired - Lifetime
- 1995-05-02 WO PCT/EP1995/001650 patent/WO1995032208A1/en active IP Right Grant
- 1995-05-02 DE DE69517768T patent/DE69517768T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1995032208A1 (en) | 1995-11-30 |
EP0711296B1 (en) | 2000-07-05 |
US5783574A (en) | 1998-07-21 |
JPH09501954A (ja) | 1997-02-25 |
DE69517768T2 (de) | 2001-03-01 |
JP3657985B2 (ja) | 2005-06-08 |
EP0711296A1 (en) | 1996-05-15 |
DE69517768D1 (de) | 2000-08-10 |
CA2166617A1 (en) | 1995-11-30 |
GB9410469D0 (en) | 1994-07-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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