DK0808318T3 - Tricykliske, substituerede hexahydrobenz[e]isoindol-alfa-1-adrenerge antagonister - Google Patents
Tricykliske, substituerede hexahydrobenz[e]isoindol-alfa-1-adrenerge antagonisterInfo
- Publication number
- DK0808318T3 DK0808318T3 DK96903340T DK96903340T DK0808318T3 DK 0808318 T3 DK0808318 T3 DK 0808318T3 DK 96903340 T DK96903340 T DK 96903340T DK 96903340 T DK96903340 T DK 96903340T DK 0808318 T3 DK0808318 T3 DK 0808318T3
- Authority
- DK
- Denmark
- Prior art keywords
- alpha
- isoindole
- adrenergic antagonists
- tricyclic substituted
- substituted hexahydrobenz
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37941495A | 1995-01-27 | 1995-01-27 | |
| US08/463,528 US5597823A (en) | 1995-01-27 | 1995-06-05 | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
| PCT/US1996/000072 WO1996022992A1 (en) | 1995-01-27 | 1996-01-11 | Tricyclic substituted hexahydrobenz[e]isoindole alpha-1 adrenergic antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0808318T3 true DK0808318T3 (da) | 2000-10-16 |
Family
ID=27008615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96903340T DK0808318T3 (da) | 1995-01-27 | 1996-01-11 | Tricykliske, substituerede hexahydrobenz[e]isoindol-alfa-1-adrenerge antagonister |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5597823A (da) |
| EP (1) | EP0808318B1 (da) |
| JP (1) | JP2001504797A (da) |
| KR (1) | KR19980701700A (da) |
| AT (1) | ATE194141T1 (da) |
| AU (1) | AU705283B2 (da) |
| CA (1) | CA2211212A1 (da) |
| DE (1) | DE69609051T2 (da) |
| DK (1) | DK0808318T3 (da) |
| ES (1) | ES2149451T3 (da) |
| GR (1) | GR3034485T3 (da) |
| IL (1) | IL116405A (da) |
| MX (1) | MX9705674A (da) |
| PT (1) | PT808318E (da) |
| WO (1) | WO1996022992A1 (da) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL120302A0 (en) * | 1996-03-27 | 1997-06-10 | Pfizer | Use of alpha1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
| US6177430B1 (en) | 1997-03-27 | 2001-01-23 | Pfizer Inc | Use of α1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
| AR008395A1 (es) * | 1996-07-09 | 2000-01-19 | Astra Pharma Prod | Compuesto derivado de pirimidina, composicion farmaceutica que lo comprende, procedimiento para prepararlo, y compuesto intermediario util parallevar a cabo dicho procedimiento. |
| US5891882A (en) * | 1996-12-06 | 1999-04-06 | Abbott Laboratories | Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds |
| EP1023068A4 (en) * | 1997-06-18 | 2001-05-16 | Merck & Co Inc | ALPHA 1a ADRENORE RECEPTOR ANTAGONISTS |
| SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| WO1999048530A1 (en) * | 1998-03-23 | 1999-09-30 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
| US6410554B1 (en) | 1998-03-23 | 2002-06-25 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
| US6133275A (en) * | 1998-05-06 | 2000-10-17 | Abbott Laboratories | 3-phenylpyrrolidine alpha-1 adrenergic compounds |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| CA2340250A1 (en) * | 1998-08-20 | 2000-03-02 | Kelley L. Ford | Process for preparing regiospecific substituted pyrazine isomers |
| BRPI9913097B8 (pt) * | 1998-08-20 | 2021-05-25 | Fujifilm Toyama Chemical Co Ltd | derivado heterocíclico de carboxamida contendo nitrogênio ou um sal do mesmo |
| IL143906A0 (en) * | 1998-12-24 | 2002-04-21 | Aventis Pharmaceuticals Produs | Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds as factor xa inhibitors |
| US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
| JP2005104838A (ja) | 2003-01-09 | 2005-04-21 | Tanabe Seiyaku Co Ltd | 縮合フラン化合物 |
| US7465739B2 (en) * | 2003-06-10 | 2008-12-16 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| US7524853B2 (en) * | 2003-06-10 | 2009-04-28 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| US7754709B2 (en) * | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US7654956B2 (en) | 2004-07-13 | 2010-02-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
| BRPI0419229A (pt) * | 2004-12-13 | 2007-12-18 | Solvay Pharm Gmbh | derivados de tiofenopirimidinona substituìdos como inibidores de 17beta-hidroxiesteróide-desidrogenase, uso e composição farmacêutica |
| JP5042215B2 (ja) | 2005-05-26 | 2012-10-03 | ニューロン システムズ， インコーポレイテッド | 網膜疾患を処置するための組成物および方法 |
| JP5237798B2 (ja) * | 2005-06-23 | 2013-07-17 | アレイ バイオファーマ、インコーポレイテッド | ベンズイミダゾール化合物の調製方法 |
| MX2008005662A (es) * | 2005-11-03 | 2008-12-15 | Ilypsa Inc | Compuestos de azaindol y uso de los mismos como inhibidores de la fosfolipasa a2. |
| JP5041403B2 (ja) * | 2007-02-02 | 2012-10-03 | 国立大学法人北海道大学 | カフェイン類縁体 |
| CA2782015C (en) | 2009-12-11 | 2020-08-25 | Neuron Systems, Inc. | Topical ophthalmic compositions and methods for the treatment of macular degeneration |
| RU2015120478A (ru) | 2012-12-20 | 2017-01-25 | Альдейра Терапьютикс, Инк. | Пери-карбинолы |
| KR102243169B1 (ko) | 2013-01-23 | 2021-04-22 | 알데이라 테라퓨틱스, 아이엔씨. | 독성 알데히드 관련된 질병 및 치료 |
| CN105228989A (zh) | 2013-01-25 | 2016-01-06 | 奥尔德拉医疗公司 | 黄斑变性治疗中的新颖捕获剂 |
| EP3337486B1 (en) | 2015-08-21 | 2024-04-03 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| AU2017264697A1 (en) | 2016-05-09 | 2018-11-22 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| WO2018170476A1 (en) | 2017-03-16 | 2018-09-20 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| EP3694500A4 (en) | 2017-10-10 | 2021-06-30 | Aldeyra Therapeutics, Inc. | TREATMENT OF INFLAMMATORY DISORDERS |
| JP2021533154A (ja) | 2018-08-06 | 2021-12-02 | アルデイラ セラピューティクス， インコーポレイテッド | 多形化合物およびその使用 |
| CN112079832A (zh) * | 2020-10-30 | 2020-12-15 | 黑龙江中医药大学 | 一种治疗子宫肌瘤的药物及其制备方法 |
| CN114957090B (zh) * | 2021-12-31 | 2023-09-19 | 淮阴师范学院 | 稠合异吲哚衍生物的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049564A (en) * | 1989-11-17 | 1991-09-17 | Abbott Laboratories | 5-HT selective agents |
| GB9123857D0 (en) * | 1991-11-09 | 1992-01-02 | Smithkline Beecham Plc | Novel compounds |
-
1995
- 1995-06-05 US US08/463,528 patent/US5597823A/en not_active Expired - Fee Related
- 1995-12-15 IL IL11640595A patent/IL116405A/en not_active IP Right Cessation
-
1996
- 1996-01-11 DK DK96903340T patent/DK0808318T3/da active
- 1996-01-11 ES ES96903340T patent/ES2149451T3/es not_active Expired - Lifetime
- 1996-01-11 MX MX9705674A patent/MX9705674A/es unknown
- 1996-01-11 DE DE69609051T patent/DE69609051T2/de not_active Expired - Fee Related
- 1996-01-11 AU AU47457/96A patent/AU705283B2/en not_active Ceased
- 1996-01-11 KR KR1019970705096A patent/KR19980701700A/ko not_active Application Discontinuation
- 1996-01-11 AT AT96903340T patent/ATE194141T1/de not_active IP Right Cessation
- 1996-01-11 PT PT96903340T patent/PT808318E/pt unknown
- 1996-01-11 JP JP52286796A patent/JP2001504797A/ja active Pending
- 1996-01-11 WO PCT/US1996/000072 patent/WO1996022992A1/en not_active Application Discontinuation
- 1996-01-11 CA CA002211212A patent/CA2211212A1/en not_active Abandoned
- 1996-01-11 EP EP96903340A patent/EP0808318B1/en not_active Expired - Lifetime
-
2000
- 2000-09-26 GR GR20000402174T patent/GR3034485T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5597823A (en) | 1997-01-28 |
| CA2211212A1 (en) | 1996-08-01 |
| WO1996022992A1 (en) | 1996-08-01 |
| IL116405A0 (en) | 1996-03-31 |
| DE69609051D1 (de) | 2000-08-03 |
| EP0808318B1 (en) | 2000-06-28 |
| ATE194141T1 (de) | 2000-07-15 |
| ES2149451T3 (es) | 2000-11-01 |
| PT808318E (pt) | 2000-12-29 |
| DE69609051T2 (de) | 2001-03-22 |
| AU705283B2 (en) | 1999-05-20 |
| AU4745796A (en) | 1996-08-14 |
| KR19980701700A (ko) | 1998-06-25 |
| IL116405A (en) | 2001-09-13 |
| EP0808318A1 (en) | 1997-11-26 |
| JP2001504797A (ja) | 2001-04-10 |
| GR3034485T3 (en) | 2000-12-29 |
| MX9705674A (es) | 1997-10-31 |
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