DK0808318T3 - Tricykliske, substituerede hexahydrobenz[e]isoindol-alfa-1-adrenerge antagonister - Google Patents
Tricykliske, substituerede hexahydrobenz[e]isoindol-alfa-1-adrenerge antagonisterInfo
- Publication number
- DK0808318T3 DK0808318T3 DK96903340T DK96903340T DK0808318T3 DK 0808318 T3 DK0808318 T3 DK 0808318T3 DK 96903340 T DK96903340 T DK 96903340T DK 96903340 T DK96903340 T DK 96903340T DK 0808318 T3 DK0808318 T3 DK 0808318T3
- Authority
- DK
- Denmark
- Prior art keywords
- alpha
- isoindole
- adrenergic antagonists
- tricyclic substituted
- substituted hexahydrobenz
- Prior art date
Links
- 239000000674 adrenergic antagonist Substances 0.000 title 1
- 239000000951 adrenergic alpha-1 receptor antagonist Substances 0.000 abstract 2
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37941495A | 1995-01-27 | 1995-01-27 | |
| US08/463,528 US5597823A (en) | 1995-01-27 | 1995-06-05 | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
| PCT/US1996/000072 WO1996022992A1 (en) | 1995-01-27 | 1996-01-11 | Tricyclic substituted hexahydrobenz[e]isoindole alpha-1 adrenergic antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0808318T3 true DK0808318T3 (da) | 2000-10-16 |
Family
ID=27008615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96903340T DK0808318T3 (da) | 1995-01-27 | 1996-01-11 | Tricykliske, substituerede hexahydrobenz[e]isoindol-alfa-1-adrenerge antagonister |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5597823A (da) |
| EP (1) | EP0808318B1 (da) |
| JP (1) | JP2001504797A (da) |
| KR (1) | KR19980701700A (da) |
| AT (1) | ATE194141T1 (da) |
| AU (1) | AU705283B2 (da) |
| CA (1) | CA2211212A1 (da) |
| DE (1) | DE69609051T2 (da) |
| DK (1) | DK0808318T3 (da) |
| ES (1) | ES2149451T3 (da) |
| GR (1) | GR3034485T3 (da) |
| IL (1) | IL116405A (da) |
| MX (1) | MX9705674A (da) |
| PT (1) | PT808318E (da) |
| WO (1) | WO1996022992A1 (da) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177430B1 (en) | 1997-03-27 | 2001-01-23 | Pfizer Inc | Use of α1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
| IL120302A0 (en) * | 1996-03-27 | 1997-06-10 | Pfizer | Use of alpha1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
| AR008395A1 (es) * | 1996-07-09 | 2000-01-19 | Astra Pharma Prod | Compuesto derivado de pirimidina, composicion farmaceutica que lo comprende, procedimiento para prepararlo, y compuesto intermediario util parallevar a cabo dicho procedimiento. |
| US5891882A (en) * | 1996-12-06 | 1999-04-06 | Abbott Laboratories | Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds |
| EP1023068A4 (en) * | 1997-06-18 | 2001-05-16 | Merck & Co Inc | ALPHA 1a ADRENORE RECEPTOR ANTAGONISTS |
| SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| AU3011299A (en) * | 1998-03-23 | 1999-10-18 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
| US6410554B1 (en) | 1998-03-23 | 2002-06-25 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
| US6133275A (en) * | 1998-05-06 | 2000-10-17 | Abbott Laboratories | 3-phenylpyrrolidine alpha-1 adrenergic compounds |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| HU227475B1 (en) | 1998-08-20 | 2011-07-28 | Toyama Chemical Co Ltd | Nitrogenous heterocyclic carboxamide derivatives or salts thereof and antiviral agents containing them |
| CA2340250A1 (en) * | 1998-08-20 | 2000-03-02 | Kelley L. Ford | Process for preparing regiospecific substituted pyrazine isomers |
| CZ20012350A3 (cs) * | 1998-12-24 | 2001-09-12 | Aventis Pharmaceuticals Products Inc. | Substituované (aminoiminomethyl nebo aminomethyl) benzoheteroarylové sloučeniny |
| US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| JP2005104838A (ja) * | 2003-01-09 | 2005-04-21 | Tanabe Seiyaku Co Ltd | 縮合フラン化合物 |
| US7754709B2 (en) * | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
| US7524853B2 (en) * | 2003-06-10 | 2009-04-28 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| US7465739B2 (en) * | 2003-06-10 | 2008-12-16 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US8989833B2 (en) | 2004-07-13 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
| RU2409581C2 (ru) * | 2004-12-13 | 2011-01-20 | Зольвай Фармасьютиклз Гмбх | НОВЫЕ ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ ТИОФЕНПИРИМИДИНОНА В КАЧЕСТВЕ ИНГИБИТОРОВ 17β-ГИДРОКСИСТЕРОИД-ДЕГИДРОГЕНАЗЫ |
| CN101087793B (zh) * | 2004-12-13 | 2011-09-07 | 索尔瓦药物有限公司 | 作为17β-羟基类固醇脱氢酶抑制剂的新的取代的噻吩嘧啶酮衍生物 |
| EP2336117A1 (en) | 2005-05-26 | 2011-06-22 | Neuron Systems, Inc | Heterocyclic compounds for treating retinal diseases |
| CN101248060B (zh) | 2005-06-23 | 2014-09-10 | 阵列生物制药公司 | 用于制备苯并咪唑化合物的方法 |
| WO2007056184A2 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Azaindole compounds and use thereof as phospholipase-a2 inhibitors |
| JP5041403B2 (ja) * | 2007-02-02 | 2012-10-03 | 国立大学法人北海道大学 | カフェイン類縁体 |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| HK1217325A1 (zh) | 2012-12-20 | 2017-01-06 | 奥尔德拉医疗公司 | 迫位原醇 |
| CA2898631C (en) | 2013-01-23 | 2023-06-13 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
| HK1217490A1 (zh) | 2013-01-25 | 2017-01-13 | Aldeyra Therapeutics, Inc. | 黃斑變性治療中的新穎捕獲劑 |
| CN108135907A (zh) | 2015-08-21 | 2018-06-08 | 奥尔德拉医疗公司 | 氘化化合物和其用途 |
| US11129823B2 (en) | 2016-05-09 | 2021-09-28 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| US10414732B2 (en) | 2017-03-16 | 2019-09-17 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| MX2020003425A (es) | 2017-10-10 | 2020-07-29 | Aldeyra Therapeutics Inc | Tratamiento de trastornos inflamatorios. |
| EP3833660A4 (en) | 2018-08-06 | 2022-05-11 | Aldeyra Therapeutics, Inc. | POLYMORPHIC COMPOUNDS AND THEIR USES |
| CA3137301A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
| CN112079832A (zh) * | 2020-10-30 | 2020-12-15 | 黑龙江中医药大学 | 一种治疗子宫肌瘤的药物及其制备方法 |
| CN114957090B (zh) * | 2021-12-31 | 2023-09-19 | 淮阴师范学院 | 稠合异吲哚衍生物的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049564A (en) * | 1989-11-17 | 1991-09-17 | Abbott Laboratories | 5-HT selective agents |
| GB9123857D0 (en) * | 1991-11-09 | 1992-01-02 | Smithkline Beecham Plc | Novel compounds |
-
1995
- 1995-06-05 US US08/463,528 patent/US5597823A/en not_active Expired - Fee Related
- 1995-12-15 IL IL11640595A patent/IL116405A/en not_active IP Right Cessation
-
1996
- 1996-01-11 PT PT96903340T patent/PT808318E/pt unknown
- 1996-01-11 KR KR1019970705096A patent/KR19980701700A/ko not_active Ceased
- 1996-01-11 CA CA002211212A patent/CA2211212A1/en not_active Abandoned
- 1996-01-11 AT AT96903340T patent/ATE194141T1/de not_active IP Right Cessation
- 1996-01-11 DK DK96903340T patent/DK0808318T3/da active
- 1996-01-11 WO PCT/US1996/000072 patent/WO1996022992A1/en not_active Ceased
- 1996-01-11 MX MX9705674A patent/MX9705674A/es unknown
- 1996-01-11 AU AU47457/96A patent/AU705283B2/en not_active Ceased
- 1996-01-11 ES ES96903340T patent/ES2149451T3/es not_active Expired - Lifetime
- 1996-01-11 JP JP52286796A patent/JP2001504797A/ja active Pending
- 1996-01-11 DE DE69609051T patent/DE69609051T2/de not_active Expired - Fee Related
- 1996-01-11 EP EP96903340A patent/EP0808318B1/en not_active Expired - Lifetime
-
2000
- 2000-09-26 GR GR20000402174T patent/GR3034485T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69609051D1 (de) | 2000-08-03 |
| KR19980701700A (ko) | 1998-06-25 |
| CA2211212A1 (en) | 1996-08-01 |
| IL116405A (en) | 2001-09-13 |
| DE69609051T2 (de) | 2001-03-22 |
| EP0808318A1 (en) | 1997-11-26 |
| AU4745796A (en) | 1996-08-14 |
| ATE194141T1 (de) | 2000-07-15 |
| EP0808318B1 (en) | 2000-06-28 |
| GR3034485T3 (en) | 2000-12-29 |
| AU705283B2 (en) | 1999-05-20 |
| ES2149451T3 (es) | 2000-11-01 |
| WO1996022992A1 (en) | 1996-08-01 |
| IL116405A0 (en) | 1996-03-31 |
| PT808318E (pt) | 2000-12-29 |
| JP2001504797A (ja) | 2001-04-10 |
| MX9705674A (es) | 1997-10-31 |
| US5597823A (en) | 1997-01-28 |
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